1. Therapeutic effect of centchroman alone and in combination with glycine soya on 7,12-dimethylbenz[α]anthracene-induced breast tumor in rat
- Author
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Mishra, Rajeev, Tiwari, Ashutosh, Bhadauria, Smrati, Mishra, Jyoti, Murthy, P.K., and Murthy, P.S.R.
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BREAST tumor treatment , *ANTHRACENE , *ORAL contraceptives , *APOPTOSIS , *ESTROGEN receptors , *SOYBEAN , *TREATMENT effectiveness , *LABORATORY rats , *TUMOR growth , *THERAPEUTICS - Abstract
Abstract: Centchroman is a non-steroidal oral contraceptive and has been found to be a candidate drug for breast cancer exhibiting partial to complete remission of lesions in 40.5% of breast cancer patients. The therapeutic efficacy of centchroman was monitored alone and together with glycine soya on growth of 7,12-dimethylbenz[α]anthracene-induced breast tumor in rat. The tumor regression was monitored at different doses of centchroman alone ranging from 0 to 10mgkg−1 and with glycine soya from 1×104 to 5×104 mgkg−1 per day until 5weeks treatment. An optimum tumor treatment opus was established with varying treatment parameters including doses of therapeutic agents and treatment period. The tumors were found to be static with a strong anti-estrogenic effect. Overall our study shows that both centchroman and glycine soya alone and jointly combat with breast cancer. [Copyright &y& Elsevier]
- Published
- 2010
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