1. Eco-friendly Coccinia Grandis-derived excitation-dependent fluorescence of carbon dots for In-Vivo bioimaging and fluorescent ink applications.
- Author
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Karuppasamy, Bavya Devi, Perumal, Suguna, Atchudan, Raji, Sundramoorthy, Ashok K., Manoj, Devaraj, Sambasivam, Sangaraju, Karthik, Namachivayam, Kamaraj, Eswaran, Suresh Kumar, Raju, Ramalingam, Srinivasan, and Rok Lee, Yong
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QUANTUM dots , *FLUORESCENCE , *PEN drawing , *CYTOTOXINS , *BIO-imaging sensors , *INK , *CELL imaging , *IN vivo studies - Abstract
[Display omitted] • Multifunctional CDs were prepared hydrothermally from eco-friendly Coccinia Grandis. • EC-Dots exhibited uniform globular shape with an average size of 4 nm (QY of 17 %). • EC-Dots emit bright fluorescence that is dependent on the excitation wavelength. • The current research provided a new platform in the field of bioimaging. • Also, the EC-Dots are a versatile component in various types of fluorescent ink. This study adopted an eco-friendly approach for the one-step hydrothermal conversion of sustainable Coccinia grandis into well-dispersed, uniform-sized carbon dots. The resulting eco-friendly carbon dots (EC-Dots) were harnessed for bioimaging and fluorescent ink applications. EC-Dots exhibited an average size of 4 nm. Further, cytotoxicity assessments on live nematodes revealed cell viability > 95 %. In-vivo studies showed excellent uptake and their ability to emit light in multiple colors, including blue, green, and red, achieved by adjusting the excitation wavelength. Additionally, the EC-Dots exhibited robust fluorescence in aqueous solutions and exceptional resistance to photobleaching, rendering them highly effective for generating fluorescent ink for drawing and writing. Thus, this research showcases an environmentally sustainable, cost-effective, and straightforward hydrothermal method for creating biocompatible EC-Dots with diverse hydrophilic properties. These synthesized EC-Dots stand as a promising platform for applications in fluorescent ink and in vivo bioimaging, offering a high level of safety with minimal cytotoxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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