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Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component‐resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allergenic molecules, there was a progressive development of a regulation framework that affected both in vitro diagnostics and Allergen Immunotherapy products. With a progressive understanding of underlying mechanisms associated to Allergen immunotherapy and an increasing experience of application of molecular diagnosis in daily life, we focus in analyzing the evidences of the value provided by molecular allergology in daily clinical practice, with a focus on Allergen Immunotherapy decisions. [ABSTRACT FROM AUTHOR]

Numbers of langerin+ cells among the experimental groups were similar; however, Fc RI expression in these cells tended to be higher in the oral epithelium of allergic patients (data not shown). To our knowledge, this is the first study describing an affected oral mucosa in the absence of food allergy and opens new ways of understanding barrier alterations associated with respiratory allergy. A disrupted barrier could be responsible for the progression to food allergy when the affected oral mucosa gets in direct contact with a trigger.[2] In fact, many food allergies are associated with previous respiratory sensitizations (PR10, lipid transfer proteins, profilins).[10]. [Extracted from the article]