1. Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma.
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Tha, Khin Khin, Katscher, Ulrich, Yamaguchi, Shigeru, Stehning, Christian, Terasaka, Shunsuke, Fujima, Noriyuki, Kudo, Kohsuke, Kazumata, Ken, Yamamoto, Toru, Van Cauteren, Marc, and Shirato, Hiroki
- Subjects
GLIOMAS ,ELECTRICAL conductivity measurement ,MAGNETIC resonance imaging ,CONTRAST-enhanced magnetic resonance imaging ,CEREBROSPINAL fluid - Abstract
Objectives: This study noninvasively examined the electrical conductivity (σ) characteristics of diffuse gliomas using MRI and tested its validity.Methods: MRI including a 3D steady-state free precession (3D SSFP) sequence was performed on 30 glioma patients. The σ maps were reconstructed from the phase images of the 3D SSFP sequence. The σ histogram metrics were extracted and compared among the contrast-enhanced (CET) and noncontrast-enhanced tumour components (NCET) and normal brain parenchyma (NP). Difference in tumour σ histogram metrics among tumour grades and correlation of σ metrics with tumour grades were tested. Validity of σ measurement using this technique was tested by correlating the mean tumour σ values measured using MRI with those measured ex vivo using a dielectric probe.Results: Several σ histogram metrics of CET and NCET of diffuse gliomas were significantly higher than NP (Bonferroni-corrected p ≤ .045). The maximum σ of NCET showed a moderate positive correlation with tumour grade (r = .571, Bonferroni-corrected p = .018). The mean tumour σ measured using MRI showed a moderate positive correlation with the σ measured ex vivo (r = .518, p = .040).Conclusions: Tissue σ can be evaluated using MRI, incorporation of which may better characterise diffuse gliomas.Key Points: • This study tested the validity of noninvasive electrical conductivity measurements by MRI. • This study also evaluated the electrical conductivity characteristics of diffuse glioma. • Gliomas have higher electrical conductivity values than the normal brain parenchyma. • Noninvasive electrical conductivity measurement can be helpful for better characterisation of glioma. [ABSTRACT FROM AUTHOR]- Published
- 2018
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