1. Quantitative analysis of intermolecular interactions in crystalline substituted triazoles.
- Author
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Dey, Dhananjay, Seth, Saikat Kumar, Mohan, T.P., and Chopra, Deepak
- Subjects
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INTERMOLECULAR interactions , *TRIAZOLES , *ELECTRON density , *CRYSTAL lattices , *ELECTRON distribution - Abstract
• Four triazole derivatives were synthesized and characterized by the structural investigation. • Detail structural analysis provides an understanding of the effect of various substituent on the supramolecular construct. • The nature and energetics of the intermolecular interactions involved in 3D networks have been discussed and presented via inputs from different computational approaches. • Along with strong H-bonds, weak intermolecular interactions also contribute comprehensively towards the overall stability of these crystal structures. This manuscript comprehensively examines four triazole derivatives using Hirshfeld surface and fingerprint analysis, PIXEL energy for molecular pairs, lattice energies for crystal packing, atoms-in-molecules (AIM) topological analysis, and noncovalent interaction (NCI) plots for intermolecular interactions. The fingerprint plots of the Hirshfeld surface analysis provide a quantitative picture of various substituent effects on the noncovalent interactions that contribute to the crystal packing stabilization of these four structures (TN1 – TN4). The PIXEL method provides the intermolecular interaction energies for the molecular dimers observed in these structures. The nature and strength of intermolecular interactions at the (3, -1) bond critical point have been studied using the approach of atoms-in-molecules (AIM) via a topological analysis of the electron density distribution. The topology parameters suggested that the intermolecular interactions are classified as closed-shell interactions, and NCI plots were employed to identify the nature of the involved noncovalent interactions. Therefore, a detailed computational analysis renders insights into the electronic characteristics of different noncovalent interactions in the solid state of the structures in the current investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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