13,043 results
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2. EBRAINS Live Papers - Interactive Resource Sheets for Computational Studies in Neuroscience.
- Author
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Appukuttan S, Bologna LL, Schürmann F, Migliore M, and Davison AP
- Subjects
- Computational Biology methods, Information Storage and Retrieval, Ecosystem, Neurosciences methods
- Abstract
We present here an online platform for sharing resources underlying publications in neuroscience. It enables authors to easily upload and distribute digital resources, such as data, code, and notebooks, in a structured and systematic way. Interactivity is a prominent feature of the Live Papers, with features to download, visualise or simulate data, models and results presented in the corresponding publications. The resources are hosted on reliable data storage servers to ensure long term availability and easy accessibility. All data are managed via the EBRAINS Knowledge Graph, thereby helping maintain data provenance, and enabling tight integration with tools and services offered under the EBRAINS ecosystem., (© 2022. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
3. Call for Papers: Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, & Neuroimaging .
- Author
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Edison P
- Subjects
- Brain diagnostic imaging, Humans, Neuroimaging, Neurology, Neurosciences
- Published
- 2022
- Full Text
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4. An analysis of neuroscience and psychiatry papers published from 2009 and 2019 outlines opportunities for increasing discovery of sex differences.
- Author
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Rechlin RK, Splinter TFL, Hodges TE, Albert AY, and Galea LAM
- Subjects
- Female, Humans, Male, Publications, Sex Characteristics, Neurosciences, Psychiatry
- Abstract
Sex differences exist in many neurological and psychiatric diseases, but these have not always been addressed adequately in research. In order to address this, it is necessary to consider how sex is incorporated into the design (e.g. using a balanced design) and into the analyses (e.g. using sex as a covariate) in the published literature. We surveyed papers published in 2009 and 2019 across six journals in neuroscience and psychiatry. In this sample, we find a 30% increase in the percentage of papers reporting studies that included both sexes in 2019 compared with 2009. Despite this increase, in 2019 only 19% of papers in the sample reported using an optimal design for discovery of possible sex differences, and only 5% of the papers reported studies that analysed sex as a discovery variable. We conclude that progress to date has not been sufficient to address the importance of sex differences in research for discovery and therapeutic potential for neurological and psychiatric disease., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
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5. Editors' Introduction: Best Papers from the 18th International Conference on Cognitive Modeling.
- Author
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Stewart TC and Myers CW
- Subjects
- Humans, Cognition, Learning, Neurosciences
- Abstract
The International Conference on Cognitive Modeling brings together researchers from around the world whose main goal is to build computational systems that reflect the internal processes of the mind. In this issue, we present the four best representative papers on this work from our 18th meeting, ICCM 2020, which was also the first meeting to be held virtually. Two of these papers develop novel techniques for building larger and more complex models using Reinforcement Learning and Learning By Instruction, respectively. The other two show how cognitive models connect to neuroscience, drawing on details of the hippocampus and cerebellum to constrain and explain the cognitive processes involved in memory and conditioning., (© 2021 Cognitive Science Society LLC.)
- Published
- 2021
- Full Text
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6. Research on bipolar disorder from India: A bibliometric analysis of papers published during 2000-19.
- Author
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Grover S, Gupta BM, and Dhawan SM
- Subjects
- Bibliometrics, Humans, India, Publications, Biomedical Research, Bipolar Disorder, Neurosciences
- Abstract
The paper examines 1037 publications on bipolar disorder (BD) during the years 2000-19 from India, as listed in the Scopus database. India's publications constituted 2.27 % share of global output (45,624 publications) in the study period of 20 years. India does not figure in the top 10 countries in terms of research output on BD. The number of publications on BD from India increased from 13 in 2000 to 107 in 2019, registering 14.44 % annual average growth, higher than world's growth of 6.02 %. India's 10-year cumulative publications increased from 264 during 2000-09 to 773 during 2010-19, registering 192.8 % absolute growth, much higher than world cumulative growth of 63.27 %. India's publications on BD averaged citation impact per paper of 14.24, which decreased from 25.38 to 10.43 from 2000-09 to 2010-19. Maximum numbers of papers from India on BD were published by researchers from National Institute of Mental Health and Neurosciences, Bangalore (222 papers),Post Graduate Institute of Medical Education and Research, Chandigarh(118 papers), and AII India Institute of Medical Sciences, New Delhi (79 papers). Lady Harding Medical College, New Delhi (36.20 and 2.54), Schizophrenia Research Foundation, Chennai (27.45 and 1.93), and King George's Medical University, Lucknow (25.21 and 1.77) were the most significant organizations in terms of citation per paper and relative citation index. Maximum number of papers were published in Indian Journal of Psychiatry (101 papers), followed by Asian Journal of Psychiatry (88 papers) and Indian Journal of Psychology Medicine (34 papers)., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
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7. The Anatomical Record Feasts on Spain's Rich History of Neuroscience in Our Latest Thematic Papers Issue.
- Author
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Laitman JT and Albertine KH
- Subjects
- History, 19th Century, History, 20th Century, Humans, Spain, Neurosciences history
- Published
- 2020
- Full Text
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8. Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART
- Author
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Ehrenberg, Alexander J, Kelberman, Michael A, Liu, Kathy Y, Dahl, Martin J, Weinshenker, David, Falgàs, Neus, Dutt, Shubir, Mather, Mara, Ludwig, Mareike, Betts, Matthew J, Winer, Joseph R, Teipel, Stefan, Weigand, Alexandra J, Eschenko, Oxana, Hämmerer, Dorothea, Leiman, Marina, Counts, Scott E, Shine, James M, Robertson, Ian H, Levey, Allan I, Lancini, Elisa, Son, Gowoon, Schneider, Christoph, Van Egroo, Maxime, Liguori, Claudio, Wang, Qin, Vazey, Elena M, Rodriguez‐Porcel, Federico, Haag, Lena, Bondi, Mark W, Vanneste, Sven, Freeze, Whitney M, Yi, Yeo‐Jin, Maldinov, Mihovil, Gatchel, Jennifer, Satpati, Abhijit, Babiloni, Claudio, Kremen, William S, Howard, Robert, Jacobs, Heidi IL, and Grinberg, Lea T
- Subjects
Neurosciences ,Dementia ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Aging ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurodegenerative ,Brain Disorders ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Humans ,Alzheimer Disease ,Brain ,Biomarkers ,Disease Progression ,Clinical Sciences ,Geriatrics - Abstract
The neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic tone, and homeostasis. Tau-associated NSS degeneration occurs early in Alzheimer's disease (AD) pathogenesis, long before the emergence of pathognomonic memory dysfunction and cortical lesions. Accumulating evidence supports the role of NSS dysfunction and degeneration in the behavioral and neuropsychiatric manifestations featured early in AD. Experimental studies even suggest that AD-associated NSS degeneration drives brain neuroinflammatory status and contributes to disease progression, including the exacerbation of cortical lesions. Given the important pathophysiologic and etiologic roles that involve the NSS in early AD stages, there is an urgent need to expand our understanding of the mechanisms underlying NSS vulnerability and more precisely detail the clinical progression of NSS changes in AD. Here, the NSS Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment highlights knowledge gaps about NSS within AD and provides recommendations for priorities specific to clinical research, biomarker development, modeling, and intervention. HIGHLIGHTS: Neuromodulatory nuclei degenerate in early Alzheimer's disease pathological stages. Alzheimer's pathophysiology is exacerbated by neuromodulatory nuclei degeneration. Neuromodulatory nuclei degeneration drives neuropsychiatric symptoms in dementia. Biomarkers of neuromodulatory integrity would be value-creating for dementia care. Neuromodulatory nuclei present strategic prospects for disease-modifying therapies.
- Published
- 2023
9. The History of Spanish Neuroscience: Thematic Papers Issue.
- Author
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De Carlos JA
- Subjects
- Animals, History, 19th Century, History, 20th Century, Humans, Spain, Neurosciences history
- Abstract
To commemorate the 100th anniversary of the creation of the Instituto Cajal, we bring this thematic issue to honor Spanish neuroscience. The issue includes several papers written by scientists, most of them being direct descendants of those who lived on the front lines of the dawn of Spanish neuroscience. These pages reflect a summary of the main achievements of this unique group of neuroscientists, all of them belonging to the Cajal School. Finally, this school of scientists became the forerunner of the modern worldwide neuroscience. Anat Rec, 303:1179-1180, 2020. © 2020 American Association for Anatomy., (© 2020 American Association for Anatomy.)
- Published
- 2020
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10. Integrating Clinical Psychiatry With Behavioral Neuroscience: Reflections and a Call for Papers.
- Author
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Kalin NH
- Subjects
- Editorial Policies, Humans, Periodicals as Topic statistics & numerical data, Neurosciences organization & administration, Psychiatry organization & administration
- Published
- 2019
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11. Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council.
- Author
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Rogers M, Boland B, Clarke S, Craven A, Fassbender C, Gill M, Hardiman O, Henshall DC, Lynch T, Mitchell K, Pender N, Rogan C, and Roche RAP
- Subjects
- Humans, Ireland, Neurosciences, Research
- Published
- 2019
- Full Text
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12. The "Big-Bang" for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia.
- Author
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Sierra A, de Castro F, Del Río-Hortega J, Rafael Iglesias-Rozas J, Garrosa M, and Kettenmann H
- Subjects
- Animals, History, 19th Century, History, 20th Century, Humans, Microglia physiology, Neurosciences history, Translating
- Abstract
The word "glia" was coined in the mid-19th century and defined as "the nerve glue". For decades, it was assumed to be a uniform matrix, until cell theorists raised the "neuron doctrine" which stipulated that nervous tissue was composed of individual cells. The term "astrocytes" was introduced in the late 19th century as a synonym for glial cells, but it was Santiago Ramón y Cajal who defined a "third element" distinct from glial cells (astrocytes) and neurons. It was not until 1919 when Pío del Río-Hortega, an alumnus of the Cajal School, introduced the modern terms we use today, and thoroughly described both "oligodendrocytes" and "microglia" to clearly distinguish them from astrocytes. In a series of four papers published that year in Spanish, Río-Hortega described the distribution and morphological phenotype of microglia. He also noted that these cells were the origin of the rod cells described earlier in pathologic tissue, and recognized that resting microglia transformed into an ameboid phenotype in different types of brain diseases and pathologies. He also noted the mesodermal origin of these cells and recognized their phagocytic capacity. We here provide the first English translation of these landmark series of papers, which paved the way for modern glial research. To heighten the value and accessibility of these classic papers and their original figures, an introduction to this critical period of neuroscience is provided, along with unpublished photographs. By adding comments to the translated text, we provide sufficient context so that contemporary scientists may fully appreciate it. GLIA 2016;64:1801-1840., (© 2016 Wiley Periodicals, Inc.)
- Published
- 2016
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13. Call for Papers for the "Classics in Chemical Neuroscience" Series.
- Author
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Lindsley CW
- Subjects
- Humans, Chemistry, Neurosciences, Periodicals as Topic
- Published
- 2016
- Full Text
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14. Highest cited papers published in Neurology India: An analysis for the years 1993-2014.
- Author
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Pandey P, Subeikshanan V, and Madhugiri VS
- Subjects
- India, Publications, Neurology trends, Neurosciences trends, Publishing trends
- Abstract
Context: The highest cited papers published in a journal provide a snapshot of the clinical practice and research in that specialty and/or region., Aims: The aim of this study was to determine the highest cited papers published in Neurology India and analyze their attributes., Setting and Design: This study was a citation analysis of all papers published in Neurology India since online archiving commenced in 1993., Methods: All papers published in Neurology India between the years 1993-2014 were listed. The number of times each paper had been cited up till the time of performing this study was determined by performing a Google Scholar search. Published papers were then ranked on the basis of total times cited since publication and the annual citation rate. Statistical Techniques: Simple counts and percentages were used to report most results. The mean citations received by papers in various categories were compared using the Student's t-test or a one-way analysis of variance, as appropriate. All analyses were carried out on SAS University Edition (SAS/STAT®, SAS Institute Inc, NC, USA) and graphs were generated on MS Excel 2016., Results: The top papers on the total citations and annual citation rate rank lists pertained to basic neuroscience research. The highest cited paper overall had received 139 citations. About a quarter of the papers published had never been cited at all. The major themes represented were vascular diseases and infections., Conclusions: The highest cited papers reflect the diseases that are of major concern in India. Certain domains such as trauma, allied neurosciences, and basic neuroscience research were underrepresented.
- Published
- 2016
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15. Getting published: how to write a successful neuroscience paper.
- Author
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Schwabe L, López-Bendito G, and Ribeiro C
- Subjects
- Peer Review standards, Neurosciences, Periodicals as Topic
- Published
- 2016
- Full Text
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16. The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors.
- Author
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Howe, James R, Merchant, Nipun B, Conrad, Claudius, Keutgen, Xavier M, Hallet, Julie, Drebin, Jeffrey A, Minter, Rebecca M, Lairmore, Terry C, Tseng, Jennifer F, Zeh, Herbert J, Libutti, Steven K, Singh, Gagandeep, Lee, Jeffrey E, Hope, Thomas A, Kim, Michelle K, Menda, Yusuf, Halfdanarson, Thorvardur R, Chan, Jennifer A, and Pommier, Rodney F
- Subjects
Humans ,Neuroendocrine Tumors ,Pancreatic Neoplasms ,Societies ,Medical ,North America ,Consensus Development Conferences as Topic ,Review Literature as Topic ,Practice Guidelines as Topic ,Surgeons ,Rare Diseases ,Cancer ,Neurosciences ,Pancreatic Cancer ,Digestive Diseases ,pancreas ,neuroendocrine ,pancreatic neuroendocrine tumor ,metastases ,neuroendocrine tumor liver metastases ,pancreatectomy ,Clinical Sciences ,Gastroenterology & Hepatology - Abstract
This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the surgical management of pancreatic neuroendocrine tumors from July 19 to 20, 2018. The group reviewed a series of questions of specific interest to surgeons taking care of patients with pancreatic neuroendocrine tumors, and for each, the available literature was reviewed. What follows are these reviews for each question followed by recommendations of the panel.
- Published
- 2020
17. Against "silent" retractions in neuroscience.
- Author
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Teixeira da Silva JA and Daly T
- Subjects
- Humans, Scientific Misconduct ethics, Editorial Policies, Neurosciences methods, Neurosciences standards, Retraction of Publication as Topic, Periodicals as Topic standards
- Abstract
When an academic paper is published in a journal that assigns a digital object identifier (DOI) to papers, this is a de facto fait accompli. Corrections or retractions are supposed to follow a specific protocol, especially in journals that claim to follow the Committee on Publication Ethics (COPE) guidelines. In this paper, we highlight a case of a new, fully open access neuroscience journal that claims to be COPE-compliant, yet has silently retracted two papers since all records, bibliometrics, and PDF files related to their existence have been deleted from the journal's website. Although this phenomenon does not seem to be common in the neurosciences, we consider that any opaque corrective measures in journals whose papers could be cited may negatively impact the wider neuroscience literature and community. Instead, we encourage transparency in retraction to promote truthfulness and trustworthiness., (© 2024 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
- Published
- 2024
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18. National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies
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Cates, Hannah M, Benca‐Bachman, Chelsie E, de Guglielmo, Giordano, Schoenrock, Sarah A, Shu, Chang, and Kallupi, Marsida
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Pharmacology and Pharmaceutical Sciences ,Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Substance Misuse ,Human Genome ,Brain Disorders ,Drug Abuse (NIDA only) ,Good Health and Well Being ,Animals ,Consensus Development Conferences as Topic ,Disease Models ,Animal ,Genomics ,Humans ,National Institute on Drug Abuse (U.S.) ,Practice Guidelines as Topic ,Substance-Related Disorders ,Translational Research ,Biomedical ,United States ,addiction models ,big data ,drug ,genetic variants ,GWAS ,opioids ,substance use disorders ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Neurosciences - Abstract
The National Institute on Drug Abuse Genetics and Epigenetics Cross-Cutting Research Team convened a diverse group of researchers, clinicians, and healthcare providers on the campus of the University of California, San Diego, in June 2018. The goal was to develop strategies to integrate genetics and phenotypes across species to achieve a better understanding of substance use disorders through associations between genotypes and addictive behaviors. This conference (a) discussed progress in harmonizing large opioid genetics cohorts, (b) discussed phenotypes that are used for genetics studies in humans, (c) examined phenotypes that are used for genetics studies in animal models, (d) identified synergies and gaps in phenotypic analyses of human and animal models and (e) identified strategies to integrate genetics and genomics data with phenotypes across species. The meeting consisted of panels that focused on phenotype harmonization (Dr. Laura Bierut, Dr. Olivier George, Dr. Dan Larach and Dr. Sesh Mudumbai), translating genetic findings between species (Dr. Elissa Chesler, Dr. Gary Peltz and Dr. Abraham Palmer), interpreting and understanding allelic variations (Dr. Vanessa Troiani and Dr. Tamara Richards) and pathway conservation in animal models and human studies (Dr. Robert Hitzemann, Dr. Huda Akil and Dr. Laura Saba). There were also updates that were provided by large consortia (Dr. Susan Tapert, Dr. Danielle Dick, Dr. Howard Edenberg and Dr. Eric Johnson). Collectively, the conference was convened to discuss progress and changes in genome-wide association studies.
- Published
- 2019
19. Why we publish papers reporting findings we may not believe.
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Della Sala, Sergio and Grafman, Jordan
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SCIENTIFIC literature ,PUBLISHING ,RESEARCH ,NEUROSCIENCES ,NEUROLOGY - Published
- 2024
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20. National Association of Medical Examiners position paper: Recommendations for the investigation and certification of deaths in people with epilepsy
- Author
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Middleton, Owen, Atherton, Daniel, Bundock, Elizabeth, Donner, Elizabeth, Friedman, Daniel, Hesdorffer, Dale, Jarrell, Heather, McCrillis, Aileen, Mena, Othon J, Morey, Mitchel, Thurman, David, Tian, Niu, Tomson, Torbjörn, Tseng, Zian, White, Steven, Wright, Cyndi, and Devinsky, Orrin
- Subjects
Neurosciences ,Brain Disorders ,Neurodegenerative ,Epilepsy ,Good Health and Well Being ,Coroners and Medical Examiners ,Death Certificates ,Death ,Sudden ,Humans ,United States ,autopsy ,death investigation ,epilepsy ,mortality ,sudden unexpected death in epilepsy ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilepsy as a cause of or contributor to death. Thus it is likely that death certificates significantly underrepresent the true number of deaths in which epilepsy was a factor. To address this, members of the National Association of Medical Examiners, North American SUDEP Registry, Epilepsy Foundation SUDEP Institute, American Epilepsy Society, and the Centers for Disease Control and Prevention constituted an expert panel to generate evidence-based recommendations for the practice of death investigation and autopsy, toxicological analysis, interpretation of autopsy and toxicology findings, and death certification to improve the precision of death certificate data available for public health surveillance of epilepsy-related deaths. The recommendations provided in this paper are intended to assist medical examiners, coroners, and death investigators when a sudden unexpected death in a person with epilepsy is encountered.
- Published
- 2018
21. National Association of Medical Examiners Position Paper: Recommendations for the Investigation and Certification of Deaths in People with Epilepsy
- Author
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Middleton, Owen L, Atherton, Daniel S, Bundock, Elizabeth A, Donner, Elizabeth, Friedman, Daniel, Hesdorffer, Dale C, Jarrell, Heather S, McCrillis, Aileen M, Mena, Othon J, Morey, Mitchel, Thurman, David J, Tian, Niu, Tomson, Torbjörn, Tseng, Zian H, White, Steven, Wright, Cyndi, and Devinsky, Orrin
- Subjects
Epilepsy ,Neurodegenerative ,Prevention ,Brain Disorders ,Neurosciences ,Good Health and Well Being ,Forensic pathology ,SUDEP ,Sudden unexpected death in epilepsy - Abstract
Sudden unexpected death of an individual with epilepsy (SUDEP) can pose a challenge to death investigators, as most deaths are unwitnessed and the individual is commonly found dead in bed. Anatomic findings (e.g., tongue/lip bite) are commonly absent and of varying specificity, limiting the evidence to implicate epilepsy as a cause of or contributor to death. Thus, it is likely that death certificates significantly underrepresent the true number of deaths in which epilepsy was a factor. To address this, members of the National Association of Medical Examiners, North American SUDEP Registry, Epilepsy Foundation SUDEP Institute, American Epilepsy Society, and the Centers for Disease Control and Prevention convened an expert panel to generate evidence-based recommendations for the practice of death investigation and autopsy, toxicological analysis, interpretation of autopsy and toxicology findings, and death certification to improve the precision of death certificate data available for public health surveillance of epilepsy-related deaths. The recommendations provided in this paper are intended to assist medical examiners, coroners, and death investigators when a sudden, unexpected death in a person with epilepsy is encountered.
- Published
- 2018
22. Causation in neuroscience: keeping mechanism meaningful.
- Author
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Ross LN and Bassett DS
- Subjects
- Humans, Cognition, Brain, Philosophy, Neurosciences, Mental Disorders
- Abstract
A fundamental goal of research in neuroscience is to uncover the causal structure of the brain. This focus on causation makes sense, because causal information can provide explanations of brain function and identify reliable targets with which to understand cognitive function and prevent or change neurological conditions and psychiatric disorders. In this research, one of the most frequently used causal concepts is 'mechanism' - this is seen in the literature and language of the field, in grant and funding inquiries that specify what research is supported, and in journal guidelines on which contributions are considered for publication. In these contexts, mechanisms are commonly tied to expressions of the main aims of the field and cited as the 'fundamental', 'foundational' and/or 'basic' unit for understanding the brain. Despite its common usage and perceived importance, mechanism is used in different ways that are rarely distinguished. Given that this concept is defined in different ways throughout the field - and that there is often no clarification of which definition is intended - there remains a marked ambiguity about the fundamental goals, orientation and principles of the field. Here we provide an overview of causation and mechanism from the perspectives of neuroscience and philosophy of science, in order to address these challenges., (© 2024. Springer Nature Limited.)
- Published
- 2024
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23. Systems Neuroscience's 2022 Top Papers: An Editorial Summary.
- Author
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Slavin, Konstantin V.
- Subjects
HYPNOTISM ,BRAIN stimulation ,TRANSCRANIAL alternating current stimulation ,TRANSCUTANEOUS electrical nerve stimulation ,NEUROSCIENCES ,VAGUS nerve stimulation - Abstract
This document is an editorial summary of the top cited papers in the field of Systems Neuroscience in 2022. The top ten papers cover a range of topics including tinnitus, obesity, and neuromodulation. The papers come from authors all over the world, representing diverse perspectives. Some notable findings include the lack of therapeutic benefit of a specific stimulation modality for tinnitus, the potential improvement of tinnitus treatment through an enriched acoustic environment, the impact of psychological and sociodemographic factors on tinnitus-related distress, the potential benefits of aerobic exercise for individuals with mild cognitive impairment, the importance of considering insular epilepsy during surgical planning, the functional changes in brain activity induced by hypnosis, the effects of transcranial alternating current stimulation on motor cortex oscillation and inhibition, the effects of transcutaneous vagus nerve stimulation on autonomic responses, the neuroplastic capacity of different brain stimulation modalities, and the lack of association between obesity and executive functioning. These papers provide valuable insights into various aspects of Systems Neuroscience and are worth exploring for researchers and individuals interested in these topics. [Extracted from the article]
- Published
- 2024
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24. Review of papers describing neuroinformatics software.
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De Schutter E, Ascoli GA, and Kennedy DN
- Subjects
- Peer Review, Research, Periodicals as Topic, Computational Biology, Editorial Policies, Informatics, Neurosciences, Software
- Published
- 2009
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25. Introduction to papers from the conference on 'Neuroscience and analytical psychology: archetypes, intentionality, action and symbols'.
- Author
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Vezzoli C
- Subjects
- Cognition physiology, Humans, Mental Processes physiology, Neurons physiology, Congresses as Topic, Neurosciences, Psychoanalysis
- Published
- 2009
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26. Practice, politics, and papers.
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Wijdicks EF
- Subjects
- Humans, Critical Care organization & administration, Editorial Policies, Neurosciences organization & administration, Periodicals as Topic
- Published
- 2009
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27. Reviewing multi-disciplinary papers: a challenge in neuroscience?
- Author
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De Schutter E
- Subjects
- Animal Experimentation standards, Animals, Computational Biology standards, Computer Simulation standards, Computer Simulation trends, Humans, Interdisciplinary Communication, Models, Theoretical, Nervous System Physiological Phenomena, Neurosciences standards, Peer Review, Research standards, Computational Biology trends, Neurosciences trends, Peer Review, Research trends
- Published
- 2008
- Full Text
- View/download PDF
28. Textpresso for neuroscience: searching the full text of thousands of neuroscience research papers.
- Author
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Müller HM, Rangarajan A, Teal TK, and Sternberg PW
- Subjects
- Access to Information, Animals, Computational Biology organization & administration, Computational Biology trends, Humans, Information Storage and Retrieval methods, Information Storage and Retrieval trends, Internet organization & administration, Internet trends, Neurosciences organization & administration, Neurosciences trends, Publishing trends, Semantics, Software, Computational Biology methods, Databases as Topic organization & administration, Databases as Topic trends, Neurosciences methods, Periodicals as Topic trends
- Abstract
Textpresso is a text-mining system for scientific literature. Its two major features are access to the full text of research papers and the development and use of categories of biological concepts as well as categories that describe or relate objects. A search engine enables the user to search for one or a combination of these categories and/or keywords within an entire literature. Here we describe Textpresso for Neuroscience, part of the core Neuroscience Information Framework (NIF). The Textpresso site currently consists of 67,500 full text papers and 131,300 abstracts. We show that using categories in literature can make a pure keyword query more refined and meaningful. We also show how semantic queries can be formulated with categories only. We explain the build and content of the database and describe the main features of the web pages and the advanced search options. We also give detailed illustrations of the web service developed to provide programmatic access to Textpresso. This web service is used by the NIF interface to access Textpresso. The standalone website of Textpresso for Neuroscience can be accessed at http://www.textpresso.org/neuroscience/.
- Published
- 2008
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29. The concept of brain plasticity--Paillard's systemic analysis and emphasis on structure and function (followed by the translation of a seminal paper by Paillard on plasticity).
- Author
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Will B, Dalrymple-Alford J, Wolff M, and Cassel JC
- Subjects
- Adaptation, Physiological physiology, Animals, Brain cytology, Brain growth & development, France, History, 20th Century, Humans, Models, Neurological, Periodicals as Topic history, Brain physiology, Neuronal Plasticity physiology, Neurosciences history
- Abstract
Although rejected for the most part of the 20th Century, the idea of brain plasticity began to receive wide acceptance from the 1970s. Yet there has been relatively little theoretical comment on the definition and use of "plasticity" in the field of neurobiology. An early exception to this lack of critical reflection on neural plasticity was provided by Jacques Paillard in a seminal paper that he published in 1976 [Paillard J. Réflexions sur l'usage du concept de plasticité en neurobiology. J Psychol 1976;1:33-47]. As this valuable contribution was published in French, the present authors provide an English adaptation to help convey his ideas to an international audience, together with a contemporary commentary on this paper. Paillard's definition of the term "plasticity" is probably as pertinent today as it was 30 years ago, especially in terms of its relevance to multiple levels of analysis of brain function (molecular, cellular, systemic). Sadly, Jacques Paillard died in 2006; our comments therefore also include a brief biographical tribute to this outstanding neuroscientist.
- Published
- 2008
- Full Text
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30. Codman Award Paper: self-efficacy of staff nurses for health promotion counselling of patients at risk for stroke.
- Author
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Mayer C, Andrusyszyn MA, and Iwasiw C
- Subjects
- Adult, Education, Nursing, Continuing organization & administration, Female, Follow-Up Studies, Health Knowledge, Attitudes, Practice, Health Services Needs and Demand, Humans, Inservice Training organization & administration, Male, Manuals as Topic standards, Middle Aged, Nurse's Role, Nursing Education Research, Program Evaluation, Programmed Instructions as Topic standards, Risk Factors, Stroke etiology, Surveys and Questionnaires, Teaching Materials standards, Attitude of Health Personnel, Counseling education, Counseling standards, Health Promotion standards, Neurosciences education, Nursing Staff, Hospital education, Nursing Staff, Hospital psychology, Self Efficacy, Stroke prevention & control
- Abstract
The effect of nurses' confidence to counsel patients at risk of stroke in selected health promotion areas: smoking cessation, exercise and nutrition was examined. Bandura's (1986) self-efficacy and Knowles' adult learning theories provided the theoretical underpinnings for the study. This was a quasi-experimental design in which neuroscience nurses (N = 23) from a quaternary hospital completed questionnaires prior to, immediately after, and 2 months post completion of a self-directed learning manual (SDL). The researcher-designed manual was designed to enhance learning about the risk factors for stroke and the importance of stroke prevention. Along with reflective activities and pre-post test, strategies for counseling high-risk, stroke-prone individuals in the areas of smoking cessation, exercise, and nutrition were also integrated. The Health Promotion Counseling Self-Efficacy Scale (Tresolini, Saluja, and Stritter, 1995), consisting of 10 self-efficacy subscales relating to self-confidence in knowledge and ability to counsel in health promotion areas, was used to capture the nurses' self-report of self-efficacy. Using a 5-point Likert Scale, nurses also rated their amount of agreement or disagreement about health promotion counseling in practice. Overall, self-efficacy levels for both knowledge and counseling increased significantly (p < .01) from pre-to immediately post completion of the manual, and decreased slightly at two-month follow-up. This pattern was evident in all health promotion areas measured except for knowledge in exercise (p = .015). Nurses' attitudes about aspects of health promotion practices correlated significantly (p < 05) at two-month follow-up with all health promotion areas. Results of this study support the usefulness of a self-directed learning manual as a teaching strategy for health promotion counseling of individuals at risk of stroke.
- Published
- 2005
31. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology
- Author
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Scheffer, Ingrid E, Berkovic, Samuel, Capovilla, Giuseppe, Connolly, Mary B, French, Jacqueline, Guilhoto, Laura, Hirsch, Edouard, Jain, Satish, Mathern, Gary W, Moshé, Solomon L, Nordli, Douglas R, Perucca, Emilio, Tomson, Torbjörn, Wiebe, Samuel, Zhang, Yue‐Hua, and Zuberi, Sameer M
- Subjects
Epilepsy ,Neurodegenerative ,Neurosciences ,Brain Disorders ,Neurological ,Humans ,International Agencies ,Terminology as Topic ,Classification ,Epilepsy syndromes ,Terminology ,Etiology ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding of the epilepsies and their underlying mechanisms following the major scientific advances that have taken place since the last ratified classification in 1989. As a critical tool for the practicing clinician, epilepsy classification must be relevant and dynamic to changes in thinking, yet robust and translatable to all areas of the globe. Its primary purpose is for diagnosis of patients, but it is also critical for epilepsy research, development of antiepileptic therapies, and communication around the world. The new classification originates from a draft document submitted for public comments in 2013, which was revised to incorporate extensive feedback from the international epilepsy community over several rounds of consultation. It presents three levels, starting with seizure type, where it assumes that the patient is having epileptic seizures as defined by the new 2017 ILAE Seizure Classification. After diagnosis of the seizure type, the next step is diagnosis of epilepsy type, including focal epilepsy, generalized epilepsy, combined generalized, and focal epilepsy, and also an unknown epilepsy group. The third level is that of epilepsy syndrome, where a specific syndromic diagnosis can be made. The new classification incorporates etiology along each stage, emphasizing the need to consider etiology at each step of diagnosis, as it often carries significant treatment implications. Etiology is broken into six subgroups, selected because of their potential therapeutic consequences. New terminology is introduced such as developmental and epileptic encephalopathy. The term benign is replaced by the terms self-limited and pharmacoresponsive, to be used where appropriate. It is hoped that this new framework will assist in improving epilepsy care and research in the 21st century.
- Published
- 2017
32. "Stress" is 80 Years Old: From Hans Selye Original Paper in 1936 to Recent Advances in GI Ulceration.
- Author
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Szabo, Sandor, Yoshida, Masashi, Filakovszky, Janos, and Juhasz, Gyorgy
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Biomedical and Clinical Sciences ,Clinical Sciences ,Rare Diseases ,Neurosciences ,Behavioral and Social Science ,Adrenal Cortex ,Animals ,Disease Models ,Animal ,General Adaptation Syndrome ,Glucocorticoids ,History ,20th Century ,Humans ,Peptic Ulcer ,Rats ,Stress ,Physiological ,Stress ,history ,distress ,eustress ,stress triad ,gastric and duodenal ulcers ,cysteamine ,propionitrile ,dopamine ,MPTP ,Parkinson's disease ,angiogenic growth factors ,sucralfate ,BPC-157 ,Pharmacology and Pharmaceutical Sciences ,Medicinal & Biomolecular Chemistry ,Pharmacology and pharmaceutical sciences - Abstract
The first scientific publication on 'general adaption syndrome', or as we know today 'biologic stress' has been published in Nature in 1936 by the 29-year old Hans Selye. His results in that short publication that contained no references or illustrations, were based on experiments in rats that were exposed to severe insults/ stressors, but his idea about a 'nonspecific bodily response' originated from his observations of sick patients whom he had seen as a medical student and young clinician. Autopsy of stressed rats revealed three major, grossly visible changes: hyperemia and enlargement of the adrenals, atrophy of the thymus and lymph nodes as well as hemorrhagic gastric erosions/ulcers (the "stress triad"). Based on this and additional observations, he concluded that the key master organ in stress reactions is the adrenal cortex (although he also accepted the limited and short lasting effect of catecholamines released from the adrenal medulla) which stimulated by an increased secretion of ACTH, secreted by the anterior pituitary gland. He thus identified the first molecular mediators of the stress reaction, i.e., steroids released from the adrenal cortex that we call today glucocorticoids, based on his classification and naming of steroids. At the end of a very productive life in experimental medicine, Selye recognized that under both unpleasant and demanding stressors as well as positive, rewarding stimuli adrenal cortex releases the same glucocorticoids and only certain brain structures may distinguish the stimuli under distress and eustress - terms he introduced in 1974, that also contained his last definition of stress: the nonspecific response of the body on any demand on it. After brief description of the history of stress research, the rest of this review is focused on one element of stress triad, i.e., gastroduodenal ulceration, especially its pathogenesis, prevention and treatment. Following a short description of acute gastroprotection, discovered by one of Selye's students, we discuss new molecular mediators of gastroduodenal ulceration like dopamine and new drugs that either only heal (very potently, on molar basis) or prevent and heal ulcers like sucralfate derivatives and the relatively new peptide BPC-157. We conclude that despite the extensive and multidisciplinary research on stress during the last 80 years, a lot of basic and clinical research is needed to better understand the manifestations, central and peripheral molecular regulators of stress response, especially the modes of prevention/management of distress or its transformation into eustress and the treatment of stress-related diseases.
- Published
- 2017
33. Neurology comes of age. The Herrick-Meyer scientific papers initiating a more rational approach to neurology and psychobiology.
- Author
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ROOFE PG
- Subjects
- Humans, Neurology, Neurosciences, Paper, Science
- Published
- 1963
34. A comparison of actual and paper-and-pencil versions of the water jar test of rigidity.
- Author
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WRIGHTSMAN LS Jr and BAUMEISTER AA
- Subjects
- Biological Psychiatry, Neurosciences, Paper, Psychological Tests, Water
- Published
- 1961
- Full Text
- View/download PDF
35. Making the Best Out of IT: Design and Development of Exergames for Older Adults With Mild Neurocognitive Disorder – A Methodological Paper
- Author
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Patrick Manser and Eling D. de Bruin
- Subjects
cognition ,development ,exercise ,exergames ,neurosciences ,technology ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Utilizing information technology (IT) systems, for example in form of computerized cognitive screening or exergame-based (also called active videogames) training, has gained growing interest for supporting healthy aging and to detect, prevent and treat neurocognitive disorders (NCD). To ameliorate the effectiveness of exergaming, the neurobiological mechanisms as well as the most effective components for exergame-based training remain to be established. At the same time, it is important to account for the end-users’ capabilities, preferences, and therapeutic needs during the design and development process to foster the usability and acceptance of the resulting program in clinical practice. This will positively influence adherence to the resulting exergame-based training program, which, in turn, favors more distinct training-related neurobiological effects.Objectives and Methods: This methodological paper describes the design and development process of novel exergame-based training concepts guided by a recently proposed methodological framework: The ‘Multidisciplinary Iterative Design of Exergames (MIDE): A Framework for Supporting the Design, Development, and Evaluation of Exergames for Health’ (Li et al., 2020).Case Study: A step-by-step application of the MIDE-framework as a specific guidance in an ongoing project aiming to design, develop, and evaluate an exergame-based training concept with the aim to halt and/or reduce cognitive decline and improve quality of life in older adults with mild neurocognitive disorder (mNCD) is illustrated.Discussion and Conclusion: The development of novel exergame-based training concepts is greatly facilitated when it is based on a theoretical framework (e.g., the MIDE-framework). Applying this framework resulted in a structured, iterative, and evidence-based approach that led to the identification of multiple key requirements for the exergame design as well as the training components that otherwise may have been overlooked or neglected. This is expected to foster the usability and acceptance of the resulting exergame intervention in “real life” settings. Therefore, it is strongly recommended to implement a theoretical framework (e.g., the MIDE-framework) for future research projects in line with well-known checklists to improve completeness of reporting and replicability when serious games for motor-cognitive rehabilitation purposes are to be developed.
- Published
- 2021
- Full Text
- View/download PDF
36. Functional neuroimaging as a catalyst for integrated neuroscience.
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Finn ES, Poldrack RA, and Shine JM
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- Humans, Brain diagnostic imaging, Brain physiology, Brain physiopathology, Cognitive Neuroscience methods, Cognitive Neuroscience trends, Phenotype, Functional Neuroimaging trends, Neurosciences methods, Neurosciences trends, Magnetic Resonance Imaging trends
- Abstract
Functional magnetic resonance imaging (fMRI) enables non-invasive access to the awake, behaving human brain. By tracking whole-brain signals across a diverse range of cognitive and behavioural states or mapping differences associated with specific traits or clinical conditions, fMRI has advanced our understanding of brain function and its links to both normal and atypical behaviour. Despite this headway, progress in human cognitive neuroscience that uses fMRI has been relatively isolated from rapid advances in other subdomains of neuroscience, which themselves are also somewhat siloed from one another. In this Perspective, we argue that fMRI is well-placed to integrate the diverse subfields of systems, cognitive, computational and clinical neuroscience. We first summarize the strengths and weaknesses of fMRI as an imaging tool, then highlight examples of studies that have successfully used fMRI in each subdomain of neuroscience. We then provide a roadmap for the future advances that will be needed to realize this integrative vision. In this way, we hope to demonstrate how fMRI can help usher in a new era of interdisciplinary coherence in neuroscience., (© 2023. Crown.)
- Published
- 2023
- Full Text
- View/download PDF
37. Reconstructing computational system dynamics from neural data with recurrent neural networks.
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Durstewitz D, Koppe G, and Thurm MI
- Subjects
- Animals, Humans, Neural Networks, Computer, Artificial Intelligence, Neurosciences
- Abstract
Computational models in neuroscience usually take the form of systems of differential equations. The behaviour of such systems is the subject of dynamical systems theory. Dynamical systems theory provides a powerful mathematical toolbox for analysing neurobiological processes and has been a mainstay of computational neuroscience for decades. Recently, recurrent neural networks (RNNs) have become a popular machine learning tool for studying the non-linear dynamics of neural and behavioural processes by emulating an underlying system of differential equations. RNNs have been routinely trained on similar behavioural tasks to those used for animal subjects to generate hypotheses about the underlying computational mechanisms. By contrast, RNNs can also be trained on the measured physiological and behavioural data, thereby directly inheriting their temporal and geometrical properties. In this way they become a formal surrogate for the experimentally probed system that can be further analysed, perturbed and simulated. This powerful approach is called dynamical system reconstruction. In this Perspective, we focus on recent trends in artificial intelligence and machine learning in this exciting and rapidly expanding field, which may be less well known in neuroscience. We discuss formal prerequisites, different model architectures and training approaches for RNN-based dynamical system reconstructions, ways to evaluate and validate model performance, how to interpret trained models in a neuroscience context, and current challenges., (© 2023. Springer Nature Limited.)
- Published
- 2023
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- View/download PDF
38. Proposal for a Mechanistic Disease Conceptualization in Clinical Neurosciences: The Neural Network Components (NNC) Model.
- Author
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Nassan M
- Subjects
- Humans, Neural Networks, Computer, Psychiatry, Mental Disorders classification, Neurosciences
- Abstract
Abstract: Clinical neurosciences, and psychiatry specifically, have been challenged by the lack of a comprehensive and practical framework that explains the core mechanistic processes of variable psychiatric presentations. Current conceptualization and classification of psychiatric presentations are primarily centered on a non-biologically based clinical descriptive approach. Despite various attempts, advances in neuroscience research have not led to an improved conceptualization or mechanistic classification of psychiatric disorders. This perspective article proposes a new-work-in-progress-framework for conceptualizing psychiatric presentations based on neural network components (NNC). This framework could guide the development of mechanistic disease classification, improve understanding of underpinning pathology, and provide specific intervention targets. This model also has the potential to dissolve artificial barriers between the fields of psychiatry and neurology., (Copyright © 2024 President and Fellows of Harvard College.)
- Published
- 2024
- Full Text
- View/download PDF
39. 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
- Author
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Weiner, Michael W, Veitch, Dallas P, Aisen, Paul S, Beckett, Laurel A, Cairns, Nigel J, Cedarbaum, Jesse, Green, Robert C, Harvey, Danielle, Jack, Clifford R, Jagust, William, Luthman, Johan, Morris, John C, Petersen, Ronald C, Saykin, Andrew J, Shaw, Leslie, Shen, Li, Schwarz, Adam, Toga, Arthur W, Trojanowski, John Q, and Initiative, Alzheimer's Disease Neuroimaging
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Clinical Research ,Biomedical Imaging ,Brain Disorders ,Dementia ,Acquired Cognitive Impairment ,Neurodegenerative ,Neurosciences ,Alzheimer's Disease ,Aging ,Prevention ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,4.1 Discovery and preclinical testing of markers and technologies ,Neurological ,Alzheimer Disease ,Biomarkers ,Brain ,Early Diagnosis ,Humans ,Multicenter Studies as Topic ,Nootropic Agents ,Radionuclide Imaging ,Alzheimer's Disease Neuroimaging Initiative ,Alzheimer's disease ,Amyloid ,Biomarker ,Mild cognitive impairment ,Tau ,Clinical Sciences ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing, longitudinal, multicenter study designed to develop clinical, imaging, genetic, and biochemical biomarkers for the early detection and tracking of Alzheimer's disease (AD). The initial study, ADNI-1, enrolled 400 subjects with early mild cognitive impairment (MCI), 200 with early AD, and 200 cognitively normal elderly controls. ADNI-1 was extended by a 2-year Grand Opportunities grant in 2009 and by a competitive renewal, ADNI-2, which enrolled an additional 550 participants and will run until 2015. This article reviews all papers published since the inception of the initiative and summarizes the results to the end of 2013. The major accomplishments of ADNI have been as follows: (1) the development of standardized methods for clinical tests, magnetic resonance imaging (MRI), positron emission tomography (PET), and cerebrospinal fluid (CSF) biomarkers in a multicenter setting; (2) elucidation of the patterns and rates of change of imaging and CSF biomarker measurements in control subjects, MCI patients, and AD patients. CSF biomarkers are largely consistent with disease trajectories predicted by β-amyloid cascade (Hardy, J Alzheimer's Dis 2006;9(Suppl 3):151-3) and tau-mediated neurodegeneration hypotheses for AD, whereas brain atrophy and hypometabolism levels show predicted patterns but exhibit differing rates of change depending on region and disease severity; (3) the assessment of alternative methods of diagnostic categorization. Currently, the best classifiers select and combine optimum features from multiple modalities, including MRI, [(18)F]-fluorodeoxyglucose-PET, amyloid PET, CSF biomarkers, and clinical tests; (4) the development of blood biomarkers for AD as potentially noninvasive and low-cost alternatives to CSF biomarkers for AD diagnosis and the assessment of α-syn as an additional biomarker; (5) the development of methods for the early detection of AD. CSF biomarkers, β-amyloid 42 and tau, as well as amyloid PET may reflect the earliest steps in AD pathology in mildly symptomatic or even nonsymptomatic subjects and are leading candidates for the detection of AD in its preclinical stages; (6) the improvement of clinical trial efficiency through the identification of subjects most likely to undergo imminent future clinical decline and the use of more sensitive outcome measures to reduce sample sizes. Multimodal methods incorporating APOE status and longitudinal MRI proved most highly predictive of future decline. Refinements of clinical tests used as outcome measures such as clinical dementia rating-sum of boxes further reduced sample sizes; (7) the pioneering of genome-wide association studies that leverage quantitative imaging and biomarker phenotypes, including longitudinal data, to confirm recently identified loci, CR1, CLU, and PICALM and to identify novel AD risk loci; (8) worldwide impact through the establishment of ADNI-like programs in Japan, Australia, Argentina, Taiwan, China, Korea, Europe, and Italy; (9) understanding the biology and pathobiology of normal aging, MCI, and AD through integration of ADNI biomarker and clinical data to stimulate research that will resolve controversies about competing hypotheses on the etiopathogenesis of AD, thereby advancing efforts to find disease-modifying drugs for AD; and (10) the establishment of infrastructure to allow sharing of all raw and processed data without embargo to interested scientific investigators throughout the world.
- Published
- 2015
40. Consensus paper of the WFSBP task force on biological markers: Biological markers for alcoholism
- Author
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Hashimoto, Eri, Riederer, Peter Franz, Hesselbrock, Victor M, Hesselbrock, Michie N, Mann, Karl, Ukai, Wataru, Sohma, Hitoshi, Thibaut, Florence, Schuckit, Marc A, and Saito, Toshikazu
- Subjects
Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Behavioral and Social Science ,Substance Misuse ,Genetics ,Brain Disorders ,Alcoholism ,Alcohol Use and Health ,Neurosciences ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Mental health ,Good Health and Well Being ,Alcoholism ,Biomarkers ,Consensus ,Humans ,alcohol ,biochemical markers ,abuse ,alcohol dependence ,alcohol use disorder ,Clinical Sciences ,Psychiatry ,Clinical sciences ,Biological psychology - Abstract
ObjectivesThis article presents an overview of the current literature on biological markers for alcoholism, including markers associated with the pharmacological effects of alcohol and markers related to the clinical course and treatment of alcohol-related problems. Many of these studies are well known, while other studies cited are new and still being evaluated.MethodsIn this paper we first describe known biomarkers of alcohol-related disorders, review their features and the problems involved in their use. We then consider future developments on biomarkers and their possible impact on the field.ResultsMore recent findings cited include the work on type 7 adenylcyclase (AC) polymorphism and its lower expression levels in female alcoholics. Neuroimaging studies involving biomarkers have also reported brain volume reductions of gray and white matter, including amygdala and subcortical regions in alcoholic patients, while a high association between the copy number variations (CNVs) in 6q14.1/5q13.2 and alcohol dependence has more recently been identified in genetic studies.ConclusionsIn addition to their possible importance for diagnosis, biomarkers may have utility for predicting prognosis, progression of the disorder, the development of new treatments, and monitoring treatment effects. Although such findings should be verified in independent studies, the search for new biomarkers is continuing. Several potential candidate biomarkers have been found recently in blood, imaging, and genetic studies with encouraging results.
- Published
- 2013
41. From the Editors: Our paper (first) anniversary and launching Epilepsia's new look
- Author
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Mathern, Gary W, Beninsig, Laurie, and Nehlig, Astrid
- Subjects
Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Anniversaries and Special Events ,Editorial Policies ,Epilepsy ,Humans ,Periodicals as Topic ,Neurology & Neurosurgery ,Clinical sciences - Published
- 2014
42. How to Revise Science Using Neuroscience: Applications to Online Learning
- Author
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Belham, Flávia Schechtman, Wilks, Stephen, and Elvidge, Mimi
- Abstract
This presentation to the ASE Annual Conference 2018 discussed how research in neuroscience can help in the learning of science both in the classroom and online.
- Published
- 2018
43. The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
- Author
-
Weiner, Michael W, Veitch, Dallas P, Aisen, Paul S, Beckett, Laurel A, Cairns, Nigel J, Green, Robert C, Harvey, Danielle, Jack, Clifford R, Jagust, William, Liu, Enchi, Morris, John C, Petersen, Ronald C, Saykin, Andrew J, Schmidt, Mark E, Shaw, Leslie, Shen, Li, Siuciak, Judith A, Soares, Holly, Toga, Arthur W, Trojanowski, John Q, and Initiative, Alzheimer's Disease Neuroimaging
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Neurodegenerative ,Aging ,Brain Disorders ,Biomedical Imaging ,Prevention ,Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Acquired Cognitive Impairment ,Clinical Research ,Alzheimer's Disease ,Neurosciences ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Neurological ,Alzheimer Disease ,Early Diagnosis ,Humans ,Multicenter Studies as Topic ,Neuroimaging ,United States ,Clinical and Health Psychology ,Mental Health ,Post-Traumatic Stress Disorder (PTSD) ,Traumatic Brain Injury (TBI) ,Physical Injury - Accidents and Adverse Effects ,Traumatic Head and Spine Injury ,Anxiety Disorders ,Injuries and accidents ,Good Health and Well Being ,Afghan Campaign 2001- ,Biomarkers ,Blast Injuries ,Brain Damage ,Chronic ,Brain Injuries ,Databases ,Factual ,Government Programs ,Iraq War ,2003-2011 ,Military Medicine ,Military Personnel ,National Institute of Neurological Disorders and Stroke (U.S.) ,Risk Factors ,Stress Disorders ,Post-Traumatic ,United States Department of Defense ,United States Department of Veterans Affairs ,Veterans Health ,Alzheimer's disease ,Risk factors ,Military medicine ,Traumatic brain injury ,Posttraumatie stress disorder ,Tau ,Beta-amyloid ,Apolipoprotein E e4 ,Alzheimer's Disease Neuroimaging Initiative ,Vietnam ,Veterans ,Chronic traumatic encephalopathy ,Blast injury ,Clinical Sciences ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.
- Published
- 2013
44. Nervous Fictions: Literary Form and the Enlightenment Origins of Neuroscience: Jeff Keiser. Charlottesville: University of Virginia Press, 2020, 324 pp., $45.00 (e-book). ISBN: 978-0-8139-4479-1; $45.00 (paper). ISBN: 978-0-8139-4478-4; $85.00 (cloth). ISBN: 978-0-8139-4477-7
- Author
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Finger, Stanley
- Subjects
- *
LITERARY form , *FICTION , *ENLIGHTENMENT , *NEUROSCIENCES , *CORPUS callosum - Abstract
In Keiser's words, "each work depicts, in a knowingly ridiculous manner, a natural philosopher digging into brain matter in the hope of exposing the mechanisms that make the mind tick" (pp. 143-144). Keiser's focus is not on how the nerves and various brain structures appear during a dissection, which is straightforward and verifiable. Locke did not partake in the kinds of fictions Willis, Cavendish, and others were promoting about the nerve spirits. [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
45. Harmful uses of patentable neurotechnology: a new regulatory approach : Proposing a framework safeguarding human rights and social responsibility for patented applications of neuroscience.
- Author
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Nadler RR, Spranger TM, Rotenberg A, Barretto TA, Hansmann J, Hemmer A, Kiss ZH, Madden JD, Strong MJ, and Illes J
- Subjects
- Humans, Neurosciences ethics, Neurosciences legislation & jurisprudence, Human Rights legislation & jurisprudence, Patents as Topic legislation & jurisprudence, Patents as Topic ethics, Social Responsibility
- Published
- 2024
- Full Text
- View/download PDF
46. Contemporary Perspectives on Aggressive Behavior: Exploring Trends across the Lifespan -- Brief Report on the 22nd Workshop on Aggression, 2017, Limassol, Cyprus
- Author
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Stavrinides, Panayiotis, Fanti, Kostas, Charalampous, Kyriakos, Demetriou, Chara, Hadjicharalambous, Maria-Zoe, and Solomontos-Kountouri, Olga
- Abstract
The 22nd Workshop on Aggression was held in Limassol, the 2nd second largest urban area in Cyprus, in November 22-25, 2017, and was organized by the University of Cyprus. There were five keynote speakers, eight symposia, nine paper sessions and one poster session. In total, 78 high quality individual papers were presented, covering a broad area of research fields in accordance to the theme of the workshop. The thematic focus of the 22nd Workshop on Aggression 2017 was "Contemporary perspectives on aggressive behavior: Exploring trends across the lifespan". The conference aimed to present the latest research and stimulate interdisciplinary research mainly in the fields of: (1) conventional and cyber forms of aggression; (2) personality and environmental factors of aggression; (3) neuroscience and aggression; and (4) prevention and intervention programs of aggression.
- Published
- 2018
- Full Text
- View/download PDF
47. Nick Dubin: Asperger Syndrome and Anxiety—A Guide to Successful Stress Management: Jessica Kingsley Publishers, London, 2009, 222 pp., ISBN 978-1-84310-895-5, $19.95 (paper)
- Author
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Bhatara, Anjali
- Subjects
Psychology ,Public Health/Gesundheitswesen ,Neurosciences ,Child and School Psychology ,Pediatrics - Published
- 2010
48. L. Leventhal-Belfer: Why do I have to? A Book for Children Who Find Themselves Frustrated by Everyday Rules: Jessica Kingsley Publishers, London, UK, 2008, 79 pp, ISBN 978-1-84310-891-7. $9.95 (paper)
- Author
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Kuriakose, Sarah
- Subjects
Psychology ,Public Health/Gesundheitswesen ,Neurosciences ,Child and School Psychology ,Pediatrics - Published
- 2010
49. Commentary to the paper double neural tube defect: a case report and discussions on neural tube development by V. Ravindran
- Author
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Pang, Dachling
- Subjects
Medicine & Public Health ,Neurosciences ,Neurosurgery - Published
- 2010
50. S. Hendrickx: Love, Sex & Long-Term Relationships: What People with Asperger Syndrome Really Really Want: Jessica Kingsley Publishers, London, UK, 2008, 144 pp, ISBN 978-1-84310-605-0. $19.95 (paper)
- Author
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Drahota, Amy
- Subjects
Psychology ,Public Health/Gesundheitswesen ,Neurosciences ,Child and School Psychology ,Pediatrics - Published
- 2010
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