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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is involved in the pathogenesis and progression of several cancers. However, the potential effect of MALAT1 in primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) has not been elucidated. This study aimed to explore the prognostic value of MALAT1 in patients with PGI-DLBCL. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to determine the expression of MALAT1 in 90 patients with PGI-DLBCL. MALAT1 was remarkably upregulated in PGI-DLBCL tissues compared to paired adjacent non-tumor tissues (P < 0.001), and the area under the receiver operating characteristic (ROC) curve (AUC) was 0.838. MALAT1 expression was further increased in the non-germinal center B-cell-like (non-GCB), advanced stage (stages IIE-IV) and International Prognostic Index (IPI) score (3–5) groups (P = 0.01, P < 0.001 and P < 0.001, respectively). Furthermore, Kaplan–Meier analysis showed that elevated MALAT1 expression correlated with inferior overall survival (OS) and progression-free survival in PGI-DLBCL patients (P < 0.001 and P < 0.001, respectively), and our multivariate analysis results suggested that upregulation of MALAT1 and high IPI score (3–5) were two unfavorable prognostic factors for PGI-DLBCL. In conclusion, our results demonstrate that MALAT1 may serve as a novel prognostic biomarker and an ideal therapeutic target for patients with PGI-DLBCL. [ABSTRACT FROM AUTHOR]

Objective: To develop nomograms for effective prediction of cause-specific survival (CSS) and overall survival (OS) of patients who underwent radical operation for stage I-III appendiceal adenocarcinoma.Methods: Clinical information from the surveillance, epidemiology, and end results database was retrieved from 2004 to 2015 and subjected to multivariate analysis to explore variables that affect the OS and CSS. Results were used to construct nomograms to assess the 1-, 3-, and 5-year OS and CSS rates, then their calibration accuracy and discriminative power were examined using Kaplan-Meier curves, calibration plots, and C statistics.Results: Overall, 1,241 patients were included in the analysis. We found 7 and 5 factors that could independently alter the prognosis, then used for creating nomograms for evaluating the OS and CSS, respectively, with respective C-index values of 0.741 (95% confidence interval [CI]: 0.729-0.754) and 0.747 (95% CI: 0.733-0.762). Calibration and receiver operating characteristic curves further revealed excellent predictive performance.Conclusions: We successfully built highly accurate nomograms for evaluating the 1-, 3-, and 5-year CSS and OS rates in subjects who underwent radical operation for stage I-III appendiceal adenocarcinoma. Further studies, involving prospective validations, are required to validate these nomograms. [ABSTRACT FROM AUTHOR]