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Reduction in herbicide usage without compromising yields can lead to less environmental harm and lower production costs. Field trials were conducted to appraise the efficacy of reduced doses (25, 50, and 75% of the label dose) of a post emergence sulfonylurea herbicide [Atlantis 3.6WG (iodo+mesosulfuron)] to control weeds in wheat (Triticum aestivum L.) fields of Punjab, Pakistan. Below-labeled-doses were quite effective in suppressing total weed density (72-95%) and biomass (83-94%), and wheat grain yield was increased by 22 to 48% over the weedy control, while label dose of iodo+mesosulfuron improved yield by 53%. Iodo+mesosulfuron at 25 and 50% of the label dose inhibited grass weeds by 43 to 64%, albeit their biomass was suppressed by > 80% over control. Wheat yields for reduced herbicide doses (50 and 75%) were not different with label dose. Economic analysis revealed that the maximum marginal rate of return was recorded for 50% of the label herbicide dose and was followed by that observed for 25% of the label dose. Reduced doses of herbicide can be an effective tool in minimizing herbicide inputs and lowering production costs in wheat production without compromising yields. [ABSTRACT FROM AUTHOR]