1. Prospective association between sedentary lifestyle and incidence of lung cancer in Norwegian adults: the HUNT study.
- Author
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Lin Jiang, Yi-Qian Sun, Brumpton, Ben Michael, Langhammer, Arnulf, Yue Chen, Nilsen, Tom Ivar Lund, and Xiao-Mei Mai
- Subjects
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LUNG cancer , *CALORIC expenditure , *SEDENTARY lifestyles , *DISEASE incidence , *PHYSICAL activity - Abstract
Introduction: Lung cancer is one of the most common cancer types with low survival rate all over the world. Sedentary lifestyle in general describes a series of human behaviors requiring very low energy expenditure when awake and has been suggested to increase risk of several adverse health outcomes, including cancers. Prolonged sitting which is measured by total sitting time daily is a major sedentary behavior. People who are prolonged sitting and also leisurely inactive may reflect the group of people with the most sedentary lifestyle. Aims: To investigate prospective associations of total sitting time and its combination with physical activity with incidence of lung cancer overall and histologic types. Methods: The main cohort consisted of 45,810 cancer-free adults who participated in the second survey of the Nord-Trondelag Health Study (1995-97, Norway), and were followed-up for lung cancer incidence until December 2014. Additional 12,017 subjects without information on physical activity were excluded and 33,793 subjects were left in sub-cohort. Lung cancer cases were ascertained from the Cancer Register. Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for lung cancer overall and histologic subtypes. Results: In total, 549 participants developed lung cancer during the follow-up (median 18.3 years). Total sitting time daily was not associated with the incidence of overall, small cell (SCLC) or nonsmall cell lung cancer (NSCLC) after adjustment for smoking, physical activity and other major confounders. Compared with participants sitting <8 hours per day and being physically active, participants sitting .8 hours per day and being physically inactive (no activity or .2 hours light activity per week) had increased incidence of lung cancer (overall: adjusted HR = 1.44, 95% CI: 1.07-1.94; SCLC: adjusted HR = 2.58, 95% CI: 1.23-5.41; NSCLC: adjusted HR = 1.36 with 95% CI: 0.92-2.01). Conclusions: We observed that total sitting time was not associated with lung cancer risk. Most sedentary people who are both prolonged sitting and leisurely inactive may have increased risk of lung cancer. However, our results should be interpreted with caution, as residual confounding of smoking cannot be excluded. [ABSTRACT FROM AUTHOR]
- Published
- 2018