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4,219 results on '"Huang, Xu"'

69. Surveillance and analysis of avian influenza viruses in the external environment of poultry in Anqing City， Anhui Province

Author

WU Zhaochun, HUANG Xu, WANG Jinsheng, QIAN Yezhong, WANG Jin, CHEN Jiwen, and LI Yuxin

Subjects
external environment, avian influenza virus, surveillance, Medicine
Abstract

ObjectiveTo determine the prevalence of avian influenza viruses in the external environment of poultry in Anqing City， Anhui Province， and provide scientific evidence for prevention and control of animal-derived influenza in humans.MethodsA total of 28 farmers’ markets/farms in 10 counties （cities， districts） of Anqing City， Anhui Province， were selected as surveillance sites by simple random sampling strategy. Poultry faeces and other related samples were collected for 6 consecutive weeks. Real-time fluorescence quantitative PCR was used to examine the nucleic acids of influenza A virus. Subtypes H5， H7， and H9 of avian influenza virus were further tested in the positive samples.ResultsA total of 426 specimens were collected， among which 113 tested positive with a positive rate of 26.53%. Among the positive specimens， 104 were determined to be subtype H9， accounting for 92.04%. It did not significantly differ in the positive rate between the main and non-main urban areas （χ20.05） or among the specimens collected in different weeks （χ2=7.57， P>0.05）. However， it significantly differed in the positive rate among the specimens collected in the third week and other weeks （χ2=6.89， P

Published
2023
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70. Research on Basic Management and Control System of Computing Force Network based on SRv6

Author

HUANG Xu, CHENG Meng-hong, and CHENG Zhi-yan

Subjects
computing force network, management and control, architecture design, functional research, Applied optics. Photonics, TA1501-1820
Abstract

With the new concept of computing force network being put forward, how to manage, cooperate and deploy after the integration of computing power and network has become an urgent problem for telecom operators. To better solve the problems of unified management, perceptual dispatch, and collaborative arrangement of multi-dimensional resources such as network, computing, and storage, we study from the direction of computing force network management and control. Then we investigate the overall architecture design of computing force network management and control system, the core capabilities, and the evolution of underlying network technology. Based on the principle of "the network changes with the computing force, and the network strengthens the computing force", the collaborative mode of "horizontal connection and vertical dispatch" of the computing force network is formed with the help of the management and control system capabilities. Eventually, we believe it will effectively support the development demands of computing force network business and help the development of the national "Eastern Data and Western Computing" project.

Published
2023
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84. Hypoxia-Responsive Stereocomplex Polymeric Micelles with Improved Drug Loading Inhibit Breast Cancer Metastasis in an Orthotopic Murine Model

Author

Lu, Min, Huang, Xu, Cai, Xiaohui, Sun, Jiajia, Liu, Xuemeng, Weng, Lingyan, Zhu, Li, Luo, Qianqian, and Chen, Zhongping

Subjects
Engineering, Chemical Sciences, Physical Sciences, Orphan Drug, Cancer, Breast Cancer, Rare Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Breast Neoplasms, Cell Line, Tumor, Disease Models, Animal, Drug Carriers, Drug Delivery Systems, Female, Humans, Hypoxia, Melanoma, Mice, Micelles, Polyesters, Polyethylene Glycols, Polymers, Skin Neoplasms, Melanoma, Cutaneous Malignant, breast cancer, drug delivery, hypoxia-responsiveness, polymeric micelles, stereocomplex, tumor metastasis, Nanoscience & Nanotechnology, Chemical sciences, Physical sciences
Abstract

Tumor metastasis is a leading cause of breast cancer-related death. Taxane-loaded polymeric formulations, such as Genexol PM and Nanoxel M using poly(ethylene glycol)-poly(d,l-lactide) (PEG-PLA) micelles as drug carriers, have been approved for the treatment of metastatic breast cancer. Unfortunately, the physical instability of PEG-PLA micelles, leading to poor drug loading, premature drug leakage, and consequently limited drug delivery to tumors, largely hinders their therapeutic outcome. Inspired by the enantiomeric nature of PLA, this work developed stereocomplex PEG-PLA micelles through stereoselective interactions of enantiomeric PLA, which are further incorporated with a hypoxia-responsive moiety used as a hypoxia-cleavable linker of PEG and PLA, to maximize therapeutic outcomes. The results showed that the obtained micelles had high structural stability, showing improved drug loading for effective drug delivery to tumors as well as other tissues. Especially, they were capable of sensitively responding to the hypoxic tumor environment for drug release, reversing hypoxia-induced drug resistance and hypoxia-promoted cell migration for enhanced bioavailability under hypoxia. In vivo results further showed that the micelles, especially at a high dose, inhibited the growth of the primary tumor and improved tumor pathological conditions, consequently remarkably inhibiting its metastasis to the lungs and liver, while not causing any systemic toxicity. Hypoxia-responsive stereocomplex micelles thus emerge as a reliable drug delivery system to treat breast cancer metastasis.

Published
2022

85. A New Pyrroloquinoline-Derivative-Based Fluorescent Probe for the Selective Detection and Cell Imaging of Lysine

Author

Yang, Bing, Zhou, Jiahua, Huang, Xu, Chen, Zhongping, Tian, Shu, and Shi, Yujun

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Generic health relevance, biological imaging, fluorescent probe, lysine detection, natural mineral water for drinking, pyrroloquinoline structure, Pharmacology and pharmaceutical sciences
Abstract

In this paper, a new pyrroloquinoline-derivative-based fluorescent probe, PQP-1, was prepared for the selective detection of Lys in living cells and natural mineral water for drinking. PQP-1 exhibited high selectivity, low limit of detection, and a wide pH range. PQP-1 could be successfully applied for imaging Lys in living cells and in natural mineral water for drinking. We expect that PQP-1 will expand the detection reaction mechanism and the practical biological applications of Lys.

Published
2022

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