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Solid oxide electrolysis cells (SOECs) have captured worldwide attention as a promising energy conversion device, but durability at large current densities is still an issue. Here, the authors present an encouraging stable anode design for electrolysis at high current densities, in which a nano La0.6Sr0.4CoO3−δ (LSC) catalyst network is integrated with robust microchannels of the yttria-stabilized zirconia scaffold. Such a controlled structured electrode not only allows rapid gas diffusion, but also provides sufficient active sites as well as firm anode–electrolyte interface adhesion for achieving highly stable and efficient electrolysis. These unique advantages lead to an extremely low polarization resistance of 0.010 Ω cm2 and high durability for over 100 h at a large current density of 3.4 A cm−2 at 800 °C. The outstanding performance demonstrates that the as-prepared cell structure may be generally applicable in the design of high-efficiency energy conversion systems. [ABSTRACT FROM AUTHOR]

Acute lung injury (ALI), as a common clinical emergency, is pulmonary edema and diffuse lung infiltration caused by inflammation. The lack of non-invasive alert strategy, resulting in failure to carry out preventive treatment, means high mortality and poor prognosis. Stimulator of interferon genes (STING) is a key molecular biomarker of innate immunity in response to inflammation, but there is still a lack of STING-targeted strategy. In this study, a novel STING-targeted PET tracer, [18F]FBTA, was labeled with high radiochemical yield (79.7 ± 4.3%) and molar activity (32.5 ± 2.9 GBq/μmol). We confirmed that [18F]FBTA has a strong STING binding affinity (K d = 26.86 ± 6.79 nmol/L) and can be used for PET imaging in ALI mice to alert early lung inflammation and to assess the efficacy of drug therapy. Our STING-targeted strategy also reveals that [18F]FBTA can trace ALI before reaching the computed tomography (CT) diagnostic criteria, and demonstrates its better specificity and distribution than [18F]fluorodeoxyglucose ([18F]FDG). A novel STING-targeted PET radiotracer, [18F]FBTA, can target STING in vivo for alerting and therapeutic evaluation of acute lung injury. [Display omitted] [ABSTRACT FROM AUTHOR]

A low loss optical interconnection between optical fibers and photonic integrated circuits is critical for high performance photonic systems. In the past decade, spot size converters, subwavelength waveguide grating (SWG) structures, and different refractive index materials have been applied to allow efficient coupling between the fiber and the photonic chips. However, it is still challenging to achieve low-loss coupling when interfacing high index contrast waveguides such as SiN with SMF-28 fibers. In this work, we report a multilayer edge-coupler using SiOxN materials with different indices to allow for efficient edge coupling between SMF-28 fiber and SiN single mode waveguides. A coupling loss of 0.068 dB for the TM mode was achieved theoretically at a 1550 nm wavelength, with a 1 dB alignment tolerance offset of 2.4 μm. [ABSTRACT FROM AUTHOR]

The photonic spin Hall effect (PSHE) is analogous to the electronic spin Hall effect, which has substantial potential for optoelectronic applications. However, PSHE-based devices are rarely studied, and manipulating the PSHE by charge current has remained elusive thus far. In this paper, we demonstrate current-induced switching of PSHE in the Ce1Dy2Al0.42Fe4.58O12 thin film capping with Pt electrodes, which is mediated by spin–orbit torques at the Pt/Ce1Dy2Al0.42Fe4.58O12 interface. The results show that the transverse beam shifts related to the PSHE can be reversed by applying a small order of magnitude charge current (∼108 A·m−2) to the Pt layer in opposite directions, which predicts low dissipation in our proposed heterostructure. In addition, by applying an in-plane magnetic field, the saturation beam shifts can be increased, which can significantly enhance the switching ratio. [ABSTRACT FROM AUTHOR]

Constituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing in LUAD by employing bioinformatics analysis on the basis of the TCGA and TISIDB databases. Then the 6-gene prognostic risk score model (CA9, OIP5, TIMP1, SEC11C, FURIN, and TLR10) was constructed by conducting univariate LASSO as well as multivariate Cox regression analyses. The median risk score was taken as the threshold to classify the samples into two groups. Survival analysis revealed that the low-risk group exhibited a more favorable prognosis. Subsequently, the Cox regression analysis combined with clinical information (age, gender, and pathological stage) and the risk score of LUAD patients demonstrated the potential of this model as an independent prognostic factor. The nomogram established based on clinical information and a risk score in combination with the calibration curve indicated that this model had good predictive ability. Notable enrichment of the differential genes from the high- and low-risk groups was discovered in immune-associated processes or pathways, as shown by the GO and KEGG enrichment analyses. The combined use of single-sample gene enrichment analysis (ssGSEA) and immunophenoscore (IPS) demonstrated heightened immune infiltration and IPS scores in the low-risk group, indicating that immunotherapy was likely to show good efficacy in patients from this group. To sum up, the prognostic model of LUAD constructed based on T-cell-mediated cell killing-related genes was not only capable of screening the prognosis of LUAD patients but was also used for screening those LUAD patients with high sensitivity to immunotherapy. Our study offered novel insights into the clinical treatment and prognostic prediction of LUAD patients. [ABSTRACT FROM AUTHOR]

Submergence stress can severely affect plant growth. Orchardgrass (Dactylis glomerata L.) is an important forage grass, and the molecular mechanisms of orchardgrass to submergence stress are not well understood. The roots of the flood-tolerant cultivar "Dian Bei" were harvested at 0 h, 8 h and 24 h of submergence stress. The combined transcriptomic and metabolomic analyses showed that β-alanine metabolism, flavonoid biosynthesis, and biosynthesis of amino acid pathways were significantly enriched at 8 h and 24 h of submergence stress and were more pronounced at 24 h. Most of the flavonoid biosynthesis-related genes were down-regulated for the synthesis of metabolites such as naringenin, apigenin, naringin, neohesperidin, naringenin chalcone, and liquiritigenin in response to submergence stress. Metabolites such as phenylalanine, tyrosine, and tryptophan were up-regulated under stress. The predominant response of flavonoid and amino acids biosynthesis to submergence stress suggests an important role of these pathways in the submergence tolerance of orchardgrass. [ABSTRACT FROM AUTHOR]

Zn0.58Co2.42O4 (ZCO), which is a novel spinel oxide, has been proposed as a cathode material for proton-conducting solid oxide fuel cells (H-SOFCs) to explore the possibility of using spinel oxide cathodes for H-SOFCs. The high oxygen-ion and proton migration kinetics of ZCO, which first-principles calculations and experiments have demonstrated, allow the ZCO cell to show high cell performance without impairing the stability of the material. Further optimizing the cathode/electrolyte interface, by utilizing the relatively low melting point of ZCO, allows a record-high performance to be obtained for the ZCO cell compared with other SOFCs using a spinel oxide cathode. [ABSTRACT FROM AUTHOR]

Noncollinear antiferromagnet Weyl semimetal Mn3Sn has recently attracted great research interest. Although large anomalous Hall effect (AHE), anomalous Nernst effect (ANE), and magneto-optical effect have been observed in Mn3Sn, most studies are based on single crystals. So far, it is still challenging to grow high quality epitaxial Mn3Sn thin films with transport and optical properties comparable to their single crystal counterparts. Here, we report the structure and magneto-optical and transport properties of epitaxial Mn3Sn thin films fabricated by pulsed laser deposition (PLD). Highly oriented Mn3+xSn1−x (0001) and (11 2 ¯ 0) epitaxial films are growth on single crystalline Al2O3 and MgO substrates. Large anomalous Hall effect up to Δ ρ H = 3.02 μ Ω cm and longitudinal magneto-optical Kerr effect with |θK| = 38.1 mdeg at 633 nm wavelength are measured at 300 K, which are comparable to Mn3Sn single crystals. Our work demonstrates that high quality Mn3Sn epitaxial thin films can be fabricated by PLD, paving the way for future device applications. [ABSTRACT FROM AUTHOR]

Purpose: Sigma-1 receptor (Sig-1R), a chaperone that resides at the mitochondrion-associated endoplasmic reticulum (ER) membrane, is an ER stress biomarker. It is thought that ER stress plays a critical role in the progression of metabolic-associated fatty liver disease (MAFLD). The aim of this study was to evaluate a positron emission tomography (PET) tracer [18F]F-TZ3108 targeting Sig-1R for MAFLD. Procedures: The mouse model of MAFLD was established by feeding high-fat diet (HFD) for 12 weeks. Dynamic (0–60 min) PET/CT scans were performed after intravenous injection of 2-deoxy-2[18F]fluoro-D-glucose ([18F]-FDG) and [18F]F-TZ3108. Tracer kinetic modeling was performed for quantification of the PET/CT imaging of the liver. Post-PET biodistribution, the liver tissue western blotting (WB), and immunofluorescence (IF) were performed to compare the expression of Sig-1R levels in the organs harvested from both MAFLD and age-matched control mice. Results: The micro PET/CT imaging revealed a significantly decreased uptake of [18F]F-TZ3108 in the livers of the MAFLD group compared to the healthy controls, while the uptake of [18F]-FDG in the livers was not significantly different between the two groups. Based on the tracer kinetic modeling, the binding disassociate rate (k4) for [18F]F-TZ3108 was significantly increased in MAFLD group compared to healthy controls. The volume distribution (VT), and the non-displacement binding potential (BPND) revealed significantly decrease in MAFLD compared to healthy controls respectively. The post-PET biodistribution (%ID/g) of [18F]F-TZ3108 in the livers of MAFLD mice was significantly reduced nearly twofold than that in the livers of control mice. WB and IF experiments further confirmed the reduction of Sig-1R expression in the MAFLD group. Conclusions: The expression of Sig-1R in the liver, measured by the PET tracer, [18F]F-TZ3108, was significantly decreased in mouse model of MAFLD. The [18F]F-TZ3108 PET/CT imaging may provide a novel means of visualization for ER stress in MAFLD or other diseases in vivo. [ABSTRACT FROM AUTHOR]