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It is shown that the reserve of the economy, rational use and protection of the subsoil is the involvement in the production of non-standard resources through the use of metal leaching technologies, which should be combined with traditional development technologies. It was established that the optimal value of the indicators is most often achieved when a smaller part of the rich ore (up to 40%) is extracted by traditional technologies and released to the surface, and its larger part (up to 60%) -- poor, out-of-condition and out-of-balance ore is leached underground. leu. In particular, the most intensive infiltration leaching occurs in the size class of ore pieces -100 + 0 mm. For the Michurinsky deposit (SE ShidGZK, Ukraine) during underground block leaching of metals, it is recommended that the yield of such a fraction in the recovered ore is about 90%. Metals from fractions -200 + 100 mm are leached less intensively and longer. It has been proven that the main place in PBV should be occupied by the explosive preparation of ore, which ensures effective extraction of metal from stored ores with a loosening coefficient of 1.15 > Kr < 1.2, which is regulated by the volume of products produced from the ore block (up to 30%) and camera parameters (length, width and height). Due to the involvement in the production of substandard ores, the raw material base of metal extraction at the operating mines can be increased by 1.4-1.6 times. To neutralize and wash the spent ore mass, it is recommended to process it with a solution of lime and mine water through the wells of the irrigation system. Protection of the hydrogeological environment should be carried out by silting the bottom of the chamber for collecting productive solutions with a clay solution and constant monitoring of groundwater pollution in the area affected by PBV. On the basis of the received positive results of the research and implementation of technologies of PBV of metals from rock ores during the development of block 5-86, according to the recommendations issued, the same approach was used for blocks 5-84-86 and 5-88-90, as well as the industrial-experimental block 1-75-79. For the industrial use of the combined traditional technology of development of deposit reserves, it is worth considering the possibility and expediency of including in the extraction and processing of substandard and out-of-balance, in terms of the content of useful components, ores with the technologies of underground block leaching of metals. [ABSTRACT FROM AUTHOR]

The work is based on the materials of official statistical reporting, the analysis of which was carried out for 10 years, divided into two five-year periods (2009-2013 and 2014-2018). Absolute and intensive rates of morbidity and distribution of bladder cancer of the adult population of Ukraine in the regional aspect, taking into account sex were studied, the basic indicators of the prevalence of pathology were analyzed as well. The revealed unfavorable situation is characterized by a steady increase in morbidity and prevalence at a slower pace during 2014-2018. It is noteworthy the high level of morbidity in men, which is growing against the background of its stabilization among women. At the same time, there was noted the tendency in the reduced number of newly diagnosed patients during professional examinations (in 2018-16.9% against 18.0% in 2014) with diagnosis at stages I-II (72.2% vs. 74.79%), wherein every fifth has stage III-IV. With a tendency to increase in the number of registered patients ≥ 5 years (59.1% vs. 56.5%), the death rate did not change significantly within a year from the time of diagnosis (14.7% vs. 15.6%, respectively). In the structure of specialized care, (65% are patients with the first diagnosis), surgical method accounted for 37-40% by years, the combined was second (up to 20% by years), then radiation and chemotherapy, which together did not exceed 5.0%. Areas with high or low relative rates in relation to the average Ukrainian indicators for all parameters studied were identified. In the presence of regional differences, there is a need for in-depth studies of the state of the issue, including the quality and organization of care. [ABSTRACT FROM AUTHOR]

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The article presents the results of studying features ofheavy metals content - lead, cadmium, copper and zinc in the whole blood and ejaculate of fertile and infertile men. The concentration of metals in biosubstrates was determined by inverse voltamperometry method with the usage of АVА- 2. It is revealed, that maintenance of lead and cadmium practically in all biosubstrates of fertile men is 1,3-2,2 times higher as compared to the indices of infertile patients and in all investigated groups it exceeds normative levels by 1,2-6,4 times. Thus, sterile men have the expressed disbalance of copper in the organism, maintenance of which in the blood is 1,7-2,3 times higher against the analogous indices of fertile group and physiological level. Concentration of zinc in ejaculate of men with normal fertility is 9,3 times higher as compared to analogous indices of sterile men and by 30,9 times exceeds its level in blood of fertile group, this testifies to the exceptionally important role of zinc for the generative sphere of men. In biosubstrates of fertile men, living in conditions of technogenically polluted territories, concentration of zinc is by 1,2-1,5 times lower than physiological levels, this may testify to probability of forming zinc-deficient states in this contingent of population. [ABSTRACT FROM AUTHOR]