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Background and aims: The thyroid, impacted by lifestyle factors like diet and physical activity, is crucial for overall health. Selenium, an essential antioxidant supplement, plays a key role in thyroid gland function. This study aimed to explore the combined effects of an eight-week moderate-intensity interval training (MIIT) regimen and selenium supplementation on thyroid hormone levels, lipid profile, and overall quality of life (QOL) in women with hypothyroidism. Methods: In this quasi-experimental study, 46 women diagnosed with hypothyroidism were randomly assigned to one of four groups: placebo, supplement-only, exercise plus supplement, and exercise plus placebo. Selenium supplementation dosage was set at 200 micrograms per day. MIIT program spanned eight weeks, with three sessions weekly lasting 20-30 minutes each, maintaining an intensity of 60-80% of the maximum heart rate. Pre- and post-intervention assessments included anthropometric measurements [weight, body mass index (BMI), waist-to-hip ratio (WHR), and body fat percentage], QOL evaluations, thyroid hormone levels, lipid profile analysis, and Creactive protein (CRP). Results: Significant interactions over time were observed within the groups, particularly in CRP levels, lipid profile parameters (excluding total cholesterol), thyroid hormone levels, QOL metrics, and some anthropometric indices (excluding WHR) (p=0.001). Conclusion: The combination of MIIT and selenium supplementation demonstrated favorable outcomes, including reduced lipid profile levels, increased thyroid hormone levels, and enhanced QOL. This integrated approach shows promise in effectively enhancing thyroid function in women managing hypothyroidism. [ABSTRACT FROM AUTHOR]