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Objective: The whole blood CRP levels, HbA1c and serum vitamin B12 levels of pregnant women with GDM in different pregnancy periods were detected, and their correlations were analyzed. Methods: Taking pregnant women as research subjects, they were divided into control group and study group according to the OGTT test results. The control group was healthy pregnant women and the study group was GDM pregnant women. The whole blood CRP levels, HbA1c and serum vitamin B12 of pregnant women in the second and third trimesters of the two groups were tested. Results: The whole blood CRP and HbA1c levels of GDM in the second and third trimesters of the study group were significantly higher than those of the control group (P<0.05). Compared with the second trimester, there was no significant change in the whole blood CRP level of the two groups in the third trimester (P>0.05), the whole blood HbA1c level of pregnant women in the control group did not change significantly (P>0.05), while the whole blood HbA1c level of the study group was significantly increased in the third trimester (P<0.05). Compared with the control group, the serum vitamin B12 levels of the study group during the second and third trimesters were significantly reduced (P<0.05); compared with the second trimester, the serum vitamin B12 levels of pregnant women in the control group did not change significantly (P>0.05), while serum vitamin B12 level in the third trimester of the study group was significantly reduced (P＜0.05). The CRP levels in the second and third trimesters of the study group were significantly positively correlated with HbA1c, and significantly negatively correlated with vitamin B12 (P<0.05). There was no correlation between CRP levels and HbA1c and vitamin B12 levels in normal pregnant women during the second and third trimesters (P>0.05). Conclusion: The whole blood CRP, HbA1c and serum vitamin B12 of GDM pregnant women were abnormal in the second and third trimesters, and the CRP level was significantly positively correlated with HbA1c, and significantly negatively correlated with the vitamin B12 level. [ABSTRACT FROM AUTHOR]