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INTRODUCCIÓN: la identificación de obesidad durante la infancia es complicada debido a que la talla sigue incrementándose y la composición corporal está cambiando constantemente; actualmente su diagnóstico se realiza por medio de los patrones de crecimiento propuestos por la Organización Mundial de la Salud (OMS); sin embargo, se han propuesto diversos indicadores antropométricos para una detección equivalente. OBJETIVO: determinar la precisión diagnóstica del perímetro de cintura, el índice cintura-talla y el índice cintura-cadera para la identificación de sobrepeso y obesidad infantil. MATERIAL Y MÉTODOS: estudio transversal y analítico con una muestra de 1,001 escolares (9-11 años) de ambos géneros. Se hicieron las mediciones antropométricas (peso, talla, perímetro de cintura y perímetro de cadera) y se calculó el índice de masa corporal, índice cintura-talla e índice cintura-cadera. Se evaluó la correlación de los índices antropométricos vs. el índice de masa corporal y se efectuó un análisis de curvas ROC tomando como variable de estudio el perímetro de cintura, índice cintura talla e índice cintura-cadera y como parámetro de referencia los percentiles de índice de masa corporal (OMS, 2007). Se obtuvieron la sensibilidad, especificidad, las áreas bajo la curva, el valor predictivo positivo y negativo de los indicadores antropométricos y los puntos de corte que identifican sobrepeso y obesidad. RESULTADOS: el perímetro de cintura y el índice cintura talla tienen una alta correlación positiva (r = 0.75, 0.69, respectivamente; p < 0.001), pero la correlación fue débil para el índice cintura-cadera (r = 0.23; p < 0.001). El perímetro de cintura e índice cintura-talla mostraron grandes áreas bajo la curva, sensibilidad, especificidad, valor predictivo positivo y valor predictivo negativo para la identificación de obesidad infantil. CONCLUSIÓN: el perímetro de cintura y el índice cintura talla tienen un alto poder predictivo para identificar obesidad infantil, no así para sobrepeso. Los puntos de corte sugeridos para el diagnóstico de obesidad infantil entre 9 y 11 años son de 70 cm para perímetro de cintura y 0.5 para índice cintura-talla en ambos géneros.

Background: PAI-1 is the main inhibitor of fibrinolysis. Increase in PAI-1 levels has been associated with the risk of coronary disease; however, there are few studies on the relationship between subclinical atherosclerosis and PAI-1 levels., Objective: The aim of this study was to analyze the relationship between PAI-1 level and carotid intima-media thickness in premenopausal and postmenopausal women without apparent cardiovascular disease., Material and Methods: A cross-sectional study was conducted in 142 women aged 45 to 60 years with no history of cardiovascular disease. Anthropometric and laboratory measurements were performed, including PAI-1 levels. All participants underwent a B-Mode ultrasound to measure intima-media thickness. Subclinical atherosclerosis was considered when intima-media thickness was ≥ 0.7 mm and/or an atheromatous plaque was observed., Results: Postmenopausal women had greater intima-media thickness than premenopausal women (0.688 ± 0.129 vs. 0.621 ± 0.113 mm; p < 0.05). Compared to women with normal intima-media thickness, women with subclinical atherosclerosis had higher PAI-1 levels (23.2 ± 13.7 vs. 30.4 ± 20.7 ng/ml; p < 0.05). In all participants, intima-media thickness correlated with PAI-1 (r = 0.302; p = 0.01) and with age (r = 0.358; p = 0001)., Conclusions: An increase in intima-media thickness was observed in postmenopausal women compared with premenopausal women. Asymptomatic women with increased intima-media thickness had higher PAI-1 levels. These findings suggest that fibrinolytic activity is low in the subclinical stage of atherosclerosis.

Introduction and Objectives: Epicardial adipose tissue has been associated with several obesity-related parameters and with insulin resistance. Echocardiographic assessment of this tissue is an easy and reliable marker of cardiometabolic risk. However, there are insufficient studies on the relationship between epicardial fat and insulin resistance during the postmenopausal period, when cardiovascular risk increases in women. The objective of this study was to examine the association between epicardial adipose tissue and visceral adipose tissue, waist circumference, body mass index, and insulin resistance in postmenopausal women., Methods: A cross sectional study was conducted in 34 postmenopausal women with and without metabolic syndrome. All participants underwent a transthoracic echocardiogram and body composition analysis., Results: A positive correlation was observed between epicardial fat and visceral adipose tissue, body mass index, and waist circumference. The values of these correlations of epicardial fat thickness overlying the aorta-right ventricle were r = 0.505 (P < .003), r = 0.545 (P < .001), and r = 0.515 (P < .003), respectively. Epicardial adipose tissue was higher in postmenopausal women with metabolic syndrome than in those without this syndrome (mean [standard deviation], 544.2 [122.9] vs 363.6 [162.3] mm(2); P = .03)., Conclusions: Epicardial fat thickness measured by echocardiography was associated with visceral adipose tissue and other obesity parameters. Epicardial adipose tissue was higher in postmenopausal women with metabolic syndrome. Therefore, echocardiographic assessment of epicardial fat may be a simple and reliable marker of cardiovascular risk in postmenopausal women., (Copyright © 2013 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.)