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This paper evaluates the perceptions of effectiveness, from those working within ARC (Assisting Rehabilitation through Collaboration); the National Integrated Offender Management (IOM) Programme in Lincolnshire. Semi-structured interviews were conducted with 20 professionals from either the ARC core team, partner agencies, or police inspectors external to ARC. The data was analysed using Thematic Analysis. Participants identified six key themes relating to the perceived effectiveness of ARC; the ARC Cohort; ARC staff; barriers; outcomes; partnerships; and the wider policing staff. The barriers faced by the ARC implementation are also faced by other IOM programmes. The core features identified to strengthen IOM implementation are better access to housing and improving mental health provision. [ABSTRACT FROM AUTHOR]

In a sealed electromagnetic relay, the change in the surface roughness mainly depends on the collision wear between the contact and the moving reed and the ablation effect of the arc on the contact surface based on the strong correlation between the contact resistance and the surface roughness of the Ag-Mg-Ni contact. With a change in contact resistance, the contact temperature increase in a hermetically sealed electromagnetic relay (HSER) is greatly affected. Under extreme overload conditions, the contact surface is severely ablated by the arc, and the roughness increases rapidly with the number of cycles, which greatly affects the contact resistance of the contact surface and the reliability of the relay. A thermal model of a relay contact system based on the surface roughness of Ag-Mg-Ni contacts was established in this paper by analyzing the effect of an arc on the surface roughness of Ag-Mg-Ni contacts under heavy overload conditions. The arc image of the Ag-Mg-Ni contact was recorded using a double-axis arc photographing platform, and the moving track of the arc center under overload conditions was drawn. This paper explored the patterns of arc center movement on the contact surface and the effects of the arc on the surface roughness of the contacts by analyzing the probabilities of the arc center appearing in various locations. A mathematical model correlating the number of contact cycles with contact resistance was established. Subsequently, a finite element simulation model for the equivalent heat source of the contact was developed. The theoretical model error was less than 10%. The accuracy of the equivalent heat source model was verified by comparing the measured data with the simulation results. [ABSTRACT FROM AUTHOR]

Background: CircRNA plays a regulatory role in multiple life processes. Circ_0122396 could participate in the regulation of age-related cataract (ARC) progression. However, the precise molecular mechanisms of circ_0122396 In ARC remain enigmatic. Methods: Circ_0122396, microRNA (miR)-23a-3p, and matrix metalloprotease (MMP)-16 (MMP16) expression levels were detected via quantitative real-time polymerase chain reaction. Western blot was used to detect the levels of MMP16 and apoptosis-related proteins. Cell counting kit-8 analysis and 5-ethynyl-2'-deoxyuridine assay were used to assess human lens epithelial cells (HLECs) proliferation. Flow cytometry was performed to determine cell apoptosis. Levels of malondialdehyde (MDA) and glutathione peroxidase (GSH-PX) were measured using commercial kits. Luciferase reporter assay, RNA immunoprecipitation (RIP) assay, and RNA pull-down assay were used to examine the interaction among circ_0122396, miR-23a-3p, and MMP16. Results: Circ_0122396 and MMP16 were down-regulated while miR-23a-3p was up-regulated in ARC. H2O2 constrained proliferation and GSH-PX level, promotes apoptosis and MDA level in HLECs, and overexpression of circ_0122396 attenuated these effects. miR-23a-3p was a direct target of circ_0122396, and MMP16 was a direct target of miR-23a-3p. The effect of circ_0122396 overexpression on H2O2-induced HLECs was reversed by miR-23a-3p, and MMP16 elevation overturned the impacts of miR-23a-3p in H2O2-induced HLECs. Conclusions: Circ_0122396 may regulate the progression of ARC via the miR-23a-3p/MMP16 pathway in H2O2-stimulated HLECs, which may serve as a potentially valuable biomarker and novel therapeutic target for ARC. [ABSTRACT FROM AUTHOR]

Although flash sintering (FS) is an effective method for rapidly preparing ceramics, FS of non-oxide ceramics at room temperature (RT) has not yet been achieved. In this study, we developed a feasible method for FS of SiC at room temperature (RT). A dog-bone-shape SiC sample prepared without using any sintering aid achieved a relative density of 96.5 % after sintering in a low-pressure Ar atmosphere for 60 s. Arc heating, which was constrained by the height of an alumina plate fixed above the sample, increased the conductivity of the sample, which then reached the stable stage of FS. The sintered sample exhibited a typical 6H–SiC crystal structure, which was consistent with that of the raw powder. The proposed FS method, based on constraining the arc using an alumina plate under a low-pressure inert gas atmosphere, provides a reference for developing further advanced RT FS strategies for non-oxide ceramics with low conductivities at RT. [ABSTRACT FROM AUTHOR]

Abstract The application of nanoscale scaffolds has become a promising strategy in vaccine design, with protein-based nanoparticles offering desirable avenues for the biocompatible and efficient delivery of antigens. Here, we presented a novel endogenous capsid-forming protein, activated-regulated cytoskeleton-associated protein (ARC), which could be engineered through the plug-and-play strategy (SpyCatcher3/SpyTag3) for multivalent display of antigens. Combined with the self-assembly capacity and flexible modularity of ARC, ARC-based vaccines elicited robust immune responses against Mpox or SARS-CoV-2, comparable to those induced by ferritin-based vaccines. Additionally, ARC-based nanoparticles functioned as immunostimulants, efficiently stimulating dendritic cells and facilitating germinal center responses. Even without adjuvants, ARC-based vaccines generated protective immune responses in a lethal challenge model. Hence, this study showed the feasibility of ARC as a novel protein-based nanocarrier for multivalent surface display of pathogenic antigens and demonstrated the potential of exploiting recombinant mammalian retrovirus-like protein as a delivery vehicle for bioactive molecules. Graphic Abstract

Explosive submarine arc volcanoes can cause tsunamis, affect climate, and pose hazards to airplanes and ships. Although 70 % of the Earth is submarine, only 15 % of Holocene arc volcanoes in the Smithsonian Global Volcanism database are submarine. Merging locations of active submarine hydrothermal vents in arcs and the above database, we found 71 unlisted submarine arc volcanoes. Using Baker [2017, doi: 10.1016/j.oregeorev.2017.02.006], only 44 % of hydrothermal vents in arcs are known. Only 77 of the vent fields are on volcanoes in the Smithsonian database. Assuming that unknown submarine arc volcanoes are present in the same proportions as unknown vents, there are ~160 as-yet undiscovered Holocene age submarine arc volcanoes. Using geophysical data, we located 291 unsurveyed seamounts 32 % of Holocene arc volcanoes are submarine.

Recently, amyloid‐β oligomers (AβOs) have been studied as the primary pathogenic substances in Alzheimer's disease (AD). Our previous study revealed that the Aβ expression level is closely related to ARC progression. Here, we demonstrated that the accumulation of AβOs in the lens epithelium of age‐related cataract (ARC) patients increased during ARC progression and that this alteration was consistent with the changes in mitochondrial function, oxidative stress, and cellular apoptosis. In vitro, human lens epithelial cells (HLECs) treated with AβOs exhibited Ca2+ dyshomeostasis, impaired mitochondrial function, elevated oxidative stress levels, and increased apoptosis. Moreover, the proapoptotic effect of AβOs was alleviated after the uptake of mitochondrial Ca2+ was inhibited. These results establish that AβOs may promote HLEC apoptosis by inducing mitochondrial Ca2+ overload, thus preliminarily revealing the possible association between the accumulation of AβOs and other pathological processes in ARC. [ABSTRACT FROM AUTHOR]

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Copyright of Orthodontie Française is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The modernization that is currently taking over across the world is resulting in numerous advancements in a variety of industries, and the most notable and apparent development is the rising use of solar energy, which has become more prevalent every day. Most companies, residences, schools, and other organizations rely mostly on solar energy as the main source of electricity. It was discovered that anti-reflective coating (ARC) had been applied to solar cells with the goal of increasing power conversion efficiency, decreasing reflection loss, and improving absorption. Although a single layer of ARC is sufficient, applying an additional layer might improve the solar cell application's effectiveness. Hence, the modeling and analysis of double layers of anti-reflection coating (ARC) with different types of materials have been investigated and evaluated using personal computer one-dimensional (PC1D) simulation software. In this study, the double-layer anti-reflection coating on the solar cell was modeled using PC1D, where this software allowed for one-dimensional simulation of the parameters required for the operation of semiconductor-based solar energy systems. The PC1D simulation reveals that SiO2/TiO2 has the highest efficiency (22.82%) and lowest reflection compared to Si3N4/TiO2 and ZnO/TiO2. Also, SiO2/TiO2 generates the highest external quantum efficiency (EQE) among ARC double layers, making it ideal for silicon solar cell applications in order to boost the solar cell's efficiency. The results for the effects of current, voltage, reflection, and EQE of the different double layers of ARC have also been studied in this paper. [ABSTRACT FROM AUTHOR]

Devonian successions in the Calliope and Yarrol provinces of the northern New England Orogen in central to northern Queensland have a lithological assemblage and depositional environments indicative of a close association with a subduction-related volcanic arc. These rocks have been interpreted as related to island arc and backarc settings based on geochemical characteristics of magmatic rocks. We present new detrital zircon ages from the Devonian to lower Carboniferous successions of the Calliope and Yarrol province successions. Most samples have no or relatively few zircon grains extracted except for samples of quartz-rich sandstone in the Middle Devonian Erebus beds of Hunter Island, located 160 km north-northwest of Rockhampton and another sample in the Rockhampton district. The samples with abundant zircon, and some with less common zircon, have prominent peaks of mid Cambrian to Ordovician ages and are consistent with derivation from the northern Thomson Orogen where igneous rocks of this age are documented in the Charters Towers Province. These data indicate a connection between the Devonian arc-flank deposits of the northern New England Orogen and the Thomson Orogen, which had previously been well established for Carboniferous deep-marine sandstones of the subduction complex (e.g. Shoalwater Formation). These results favour an east-facing continental margin arc setting in the Devonian contra to intra-oceanic island arc settings previously proposed. Detrital zircon age spectra from sampled early Carboniferous units of northern New England Orogen association indicate a pulse of felsic magmatism of that age. KEY POINTS: Devonian quartz-rich sandstones from the northern New England Orogen have abundant detrital zircon ages of mid Cambrian to Ordovician indicating a provenance connection with the Charters Towers Province of the northern Thomson Orogen. These results confirm a provenance linkage to Gondwana and imply that the Devonian tectonic setting was a continental margin arc and associated forearc basinal infill. Geochemical comparisons suggesting an island arc setting have overly influenced previous tectonic interpretations. [ABSTRACT FROM AUTHOR]

Introduction: Traumatic brain injury (TBI) is a complex pathophysiological process, and increasing attention has been paid to the important role of post‐synaptic density (PSD) proteins, such as glutamate receptors. Our previous study showed that a PSD protein Arc/Arg3.1 (Arc) regulates endoplasmic reticulum (ER) stress and neuronal necroptosis in traumatic injury in vitro. Aim: In this study, we investigated the expression, regulation and biological function of Arc in both in vivo and in vitro experimental TBI models. Results: Traumatic neuronal injury (TNI) induced a temporal upregulation of Arc in cortical neurons, while TBI resulted in sustained increase in Arc expression up to 24 h in rats. The increased expression of Arc was mediated by the activity of metabotropic glutamate receptor 5 (mGluR5), but not dependent on the intracellular calcium (Ca2+) release. By using inhibitors and antagonists, we found that TNI regulates Arc expression via Gq protein and protein turnover. In addition, overexpression of Arc protects against TBI‐induced neuronal injury and motor dysfunction both in vivo and in vitro, whereas the long‐term cognitive function was not altered. To determine the role of Arc in mGluR5‐induced protection, lentivirus‐mediated short hairpin RNA (shRNA) transfection was performed to knockdown Arc expression. The mGluR5 agonist (RS)‐2‐chloro‐5‐hydroxyphenylglycine (CHPG)‐induced protection against TBI was partially prevented by Arc knockdown. Furthermore, the CHPG‐induced attenuation of Ca2+ influx after TNI was dependent on Arc activation and followed regulation of AMPAR subunits. The results of Co‐IP and Ca2+ imaging showed that the Arc‐Homer1 interaction contributes to the CHPG‐induced regulation of intracellular Ca2+ release. Conclusion: In summary, the present data indicate that the mGluR5‐mediated Arc activation is a protective mechanism that attenuates neurotoxicity following TBI through the regulation of intracellular Ca2+ hemostasis. The AMPAR‐associated Ca2+ influx and ER Ca2+ release induced by Homer1‐IP3R pathway might be involved in this protection. [ABSTRACT FROM AUTHOR]

The use of renewable energy sources to replace conventional energy sources like fossil fuels is essential. Solar panels are the most widespread technology for clear energy production. However, is crucial to raise the efficiency of solar panels. A large portion of sunlight is reflected by the front surface of the panel and thus the use of an Anti-Reflecting Coating (ARC) has become significant in raising the efficiency of solar panels, through reducing the reflection losses. The ARCs made of natural extracts were utilized to improve the efficiency of Silicon solar panels. The natural extracts were produced from Kailashpati fruit juice and Badminton ball tree flower powder. In the synthesis of these natural extracts, monometallic gallium chloride nanoparticles were used to check their effect on the efficiency of solar power generation. The novelty of this paper is the attempt to mathematically calculate the absorbance of the ARCs, at a particular wavelength, with the use of the refractive indices and thicknesses of ideal ARCs. [ABSTRACT FROM AUTHOR]

Titanium dioxide (TiO2) has gained popularity especially in photovoltaic applications, owing to its transparency in the visible region, and scratch resistance. In this work, the potential of TiO2 as a capping layer for c-Si p-type SiNx passivated emitter and rear contact (PERC) solar cells is studied through extensive optical and device simulations. The bifacial PERC solar cell model used in this study is calibrated with an experimental device having an efficiency of 22.19%. Device simulation results show that TiO2 deposited by the mesoporous technique outperforms atmospheric pressure chemical vapor deposition (APCVD) and atomic layer deposition (ALD)-based TiO2 layers when capped over SiNx (n = 2.1) passivated solar cells. Furthermore, it is shown that the efficiency of SiNx (n = 2.1)/TiO2 based solar cells is maintained, even when the TiO2 layer thickness varies from 75 to 95 nm. To enhance the efficiency further, the type of SiNx layer (characterized by the n value), and the thicknesses of SiNx and TiO2 layers are optimized simultaneously to find the best combination of these parameters. The best front side solar cell efficiency of 22.43%, is obtained when a stack of SiNx(n = 1.99)/TiO2 (t = 58/76 nm) is used. Similarly, a rear side efficiency of 16.59% is achieved when the rear side Al2O3/SiNx stack is capped with mesoporous TiO2. These efficiencies are 0.24 and 1.25% higher, respectively, when compared to the original SiNx passivated PERC solar cell, demonstrating the prospective of using TiO2 in encapsulant-free commercial photovoltaic applications. [ABSTRACT FROM AUTHOR]

The spectacular visual displays from the aurora come from curtains of excited atoms and molecules, impacted by energetic charged particles. These particles are accelerated from great distances in Earth's magnetotail, causing them to precipitate into the ionosphere. Energetic particle precipitation is associated with currents that generate electric fields, and the end result is a dissipation of the hundreds of gigawatts to terrawatts of energy injected into Earth's atmosphere during geomagnetic storms. While much is known about how the aurora dissipates energy through Joule heating, little is known about how it does so via small‐scale plasma turbulence. Here we show the first set of combined radar and optical images that track the position of this turbulence, relative to particle precipitation, with high spatial precision. During two geomagnetic storms occurring in 2021, we unambiguously show that small‐scale turbulence (several meters) is preferentially created on the edges of auroral forms. We find that turbulence appears both poleward and equatorward of auroral forms, as well as being nestled between auroral forms in the north‐south direction. These measurements make it clear that small scale auroral plasma turbulence is an integral part of the electrical current system created by the aurora, in the sense that turbulent transport around auroral forms enhances ionospheric energy deposition through Joule heating while at the same time reducing the average strength of the electric field. Plain Language Summary: The aurora continuous to amaze the inhabitants and travelers of Earth's polar regions. Bright shifting folds of light extend down from the nightsky, appearing as green, red, or faint‐blue curtains. During geomagnetic storms the are particularly bright and dynamic, often visible in large parts of the inhabited globe. However, far from being simple displays of light, the aurora can wreak havoc on the thin gas of Earth's upper atmosphere. There, gigantic swirls of electric turbulence are excited in response to the energy that is being pumped into the atmosphere by the aurora. This plasma turbulence is detrimental to satellite communication, such as the principle operation of the GPS network, and future efforts are sorely needed to understand the when and how this turbulence appears. We present a series of photographical and radar‐based images of the aurora and its plasma turbulence, shedding light on the complex relationship between the two phenomena. The images and videos we present are accessible and interesting to a public readership. Key Points: Small‐scale auroral plasma turbulence is created preferably outside of but not far from optical auroral formsTurbulence appears both poleward and equatorward of auroral arcsStrong electric fields that trigger meter‐size E region turbulence are sometimes seen before the onset of optical aurora [ABSTRACT FROM AUTHOR]

To address the research gap concerning the risks associated with 1,3-dinitrobenzene (1,3-DNB) and to mitigate the potential for 1,3-DNB accidents, this study investigates the thermal hazards associated with 1,3-DNB under various conditions following a major accident scenario. Firstly, the thermal characteristic data of pure 1,3-DNB and under impurities conditions were obtained by experimental methods (TG-DSC, HPDSC, ARC). Next, the thermal decomposition kinetics was analyzed. Then, the mechanism of impurity action was explored by density functional theory (DFT). The findings revealed that 1,3 did not show thermal hazards under the open system. However, due to its high vapor pressure and toxicity attention should still be paid to its management. Conversely, 1,3-DNB exhibited significant exothermic properties in a closed system, posing a severe risk of explosion. Finally, when exposed to mixed acids and m-nitrochlorobenzene, 1,3-DNB demonstrated a heightened likelihood of thermal decomposition, while m-dichlorobenzene contributed to its stability. The reason was that different impurities affect the Mulliken charge, Fukui index, and frontier orbital of 1,3-DNB in distinct ways. [ABSTRACT FROM AUTHOR]

Apoptosis repressor with caspase recruitment domain (ARC) is a highly potent and multifunctional suppressor of various types of programmed cell death (PCD) (e.g. apoptosis, necroptosis, and pyroptosis) and plays a key role in determining cell fate. Under physiological conditions, ARC is predominantly expressed in terminally differentiated cells, such as cardiomyocytes and skeletal muscle cells. Its expression and activity are tightly controlled by a complicated system consisting of transcription factor (TF), non-coding RNA (ncRNA), and post-translational modification (PTM). ARC dysregulation has been shown to be closely associated with many chronic diseases, including cardiovascular disease, cancer, diabetes, and neurodegenerative disease. However, the detailed mechanisms of ARC involved in the progression of these diseases remain unclear to a large extent. In this review, we mainly focus on the regulatory mechanisms of ARC expression and activity and its role in PCD. We also discuss the underlying mechanisms of ARC in health and disease and highlight the potential implications of ARC in the clinical treatment of patients with chronic diseases. This information may assist in developing ARC-based therapeutic strategies for patients with chronic diseases and expand researchers’ understanding of ARC.

Abstract Working memory (WM) is a cognitive function important for guiding the on‐going or upcoming behavior. A memory‐related protein Arc (activity‐regulated cytoskeleton‐associated protein) is implicated in long‐term memory consolidation. Recent evidence further suggests the involvement of hippocampal Arc in spatial WM. The medial prefrontal cortex (mPFC) is a key brain region mediating WM. However, the role of mPFC Arc in WM is still uncertain. To investigate whether mPFC Arc protein is involved in WM performance, delayed non‐match to sample (DNMS) T‐maze task was performed in rats with or without blocking new synthesis of mPFC Arc. In DNMS task, a 10‐s or 30‐s delay between the sample run and the choice run was given to evaluate WM performance. To block new Arc protein synthesis during the DNMS task, Arc antisense oligodeoxynucleotides (ODNs) were injected to the bilateral mPFC. The results show that, in rats without surgery for cannula implantation and subsequent intracerebral injection of ODNs, WM was functioning well during the DNMS task with a delay of 10 s but not 30 s, which was accompanied with a significantly increased level of mPFC Arc protein, indicating a possible link between enhanced Arc protein expression and the performance of WM. After preventing the enhancement of mPFC Arc protein expression with Arc antisense ODNs, rat's WM performance was impaired. These findings support enhanced mPFC Arc protein expression playing a role during WM performance.

The pivotal role of the basolateral amygdala (BLA) in the emotional modulation of hippocampal plasticity and memory consolidation is well-established. Specifically, multiple studies have demonstrated that the activation of the noradrenergic (NA) system within the BLA governs these modulatory effects. However, most current evidence has been obtained by direct infusion of synthetic NA or beta-adrenergic agonists. In the present study, we aimed to investigate the effect of endogenous NA release in the BLA, induced by a natural aversive stimulus (coyote urine), on memory consolidation for a low-arousing, hippocampal-dependent task. Our experiments combined a weak object location task (OLT) version with subsequent mild predator odor exposure (POE). To investigate the role of endogenous NA in the BLA in memory modulation, a subset of the animals (Wistar rats) was treated with the non-selective beta-blocker propranolol at the end of the behavioral procedures. Hippocampal tissue was collected 90 min after drug infusion or after the OLT test, which was performed 24 h later. We used the obtained samples to estimate the levels of phosphorylated CREB (pCREB) and activity-regulated cytoskeleton-associated protein (Arc)—two molecular markers of experience-dependent changes in neuronal activity. The result suggests that POE has the potential to become a valuable behavioral paradigm for studying the interaction between BLA and the hippocampus in memory prioritization and selectivity. [ABSTRACT FROM AUTHOR]

This research paper presents a comprehensive numerical investigation aimed at enhancing the absorption parameters of silicon-based metamaterial inspired solar cells with anti-reflection layer integrated. This work employs the robust Finite Element Method (FEM) and introduces an Anti-Reflection Layer (ARC) into the solar cell device structure. The focal point of the investigation is a sophisticated unit solar cell design comprising a metamaterial-infused silicon layer enveloped by an essential layer of Aluminium oxide (Al2O3) ARC, and a bi-layer silicon structure serving as a PN junction. Utilizing the capabilities of ANSYS HFSS software, the study conducts elaborate simulations to examine the absorptivity properties of this complex configuration. The results remarkably showcase an absorption efficiency exceeding 75% across an expansive frequency range spanning from 490THz to 625THz. This significant achievement underscores the immense potential of this integrated approach, demonstrating its viability for achieving superior efficiency in converting incident electromagnetic waves into valuable solar energy across a diverse spectrum of frequencies. [ABSTRACT FROM AUTHOR]

The brain responds to experience through modulation of synaptic transmission, that is synaptic plasticity. An increase in the strength of synaptic transmission is manifested as long-term potentiation (LTP), while a decrease in the strength of synaptic transmission is expressed as long-term depression (LTD). Most of the studies of synaptic plasticity have been carried out by induction via electrophysiological stimulation. It is largely unknown in which behavioural tasks such synaptic plasticity occurs. Moreover, some stimuli can induce both LTP and LTD, thus making it difficult to separately study the different forms of synaptic plasticity. Two studies have shown that an aversive memory task – inhibitory avoidance learning and contextual fear conditioning – physiologically and selectively induce LTP and an LTP-like molecular change, respectively, in the hippocampus in vivo. Here, we show that a non-aversive behavioural task – exploration of new space – physiologically and selectively elicits a biochemical change in the hippocampus that is a hallmark of LTP. Specifically, we found that exploration of new space induces an increase in the phosphorylation of GluA1(Ser831), without affecting the phosphorylation of GluA1(Ser845), which are biomarkers of early-LTP and not NMDAR-mediated LTD. We also show that exploration of new space engenders the phosphorylation of the translational regulator S6K and the expression of Arc, which are features of electrophysiologically-induced late-LTP in the hippocampus. Therefore, our results show that exploration of new space is a novel non-aversive behavioural paradigm that elicits molecular changes in vivo that are analogous to those occurring during early- and late-LTP, but not during NMDAR-mediated LTD. [ABSTRACT FROM AUTHOR]

A novel methodology has been established which allows to recycle steel slag as a suitable flux for submerged arc welding. The flux produced using waste slag as a raw material has been applied to deposit beads on plates. The bead geometry is dependent on welding parameters; hence optimization of parameters is essential. In this cut throat competition, researchers are striving to minimize the cost of experimentation using various experimental and optimization techniques to reduce number of experiments for save time, money, and resources. In this article various techniques have been explored for better optimized results. The welding parameters have been optimized to obtain desired bead geometry using various optimization techniques such as genetic and teaching–learning-based optimization algorithm, and desirability. It was observed that the genetic algorithm technique provides better results having a minimum error of penetration, bead width, and reinforcement (i.e. 1.12%, 1.83%, and 2.46%, respectively), as compared with other techniques applied. It is further observed that flux manufactured from waste slag is capable to produce desired bead profile which is similar with that of the fresh flux. Recycled slag is capable to produce optimum bead geometry having maximum penetration of 11.52 mm, bead width 20.73 mm, and reinforcement 3.24 mm. [ABSTRACT FROM AUTHOR]

Separation of titanium and silicon oxides in the melt of quartz–leucoxene concentrate of the Yarega deposit under diffuse arc heating was investigated. Melting was carried out in argon at atmospheric pressure at direct current in a graphite crucible with an arc power of ≈25 kW. The crucible with the material was the anode of the arc. The arc heating was dispersed by applying an axial magnetic field. At the same time, a diffuse anode spot with a current density of 8 A/cm2 was formed on the surface of the material. The current–voltage parameters of the diffuse arc were investigated. As a result of melting, an oxide ingot consisting of two phases was obtained, one of which is enriched in titanium oxide, and the other in silicon oxide. However, the separation of these oxides did not occur completely because of the high cooling rate of the melt. Despite the low current density in the heating spot, the melt evaporated intensely. Evaporation occurred congruently. Owing to the high temperature of the bath mirror, no volatile titanium oxide evaporated along with the volatile silicon oxide. Condensation of the evaporated material occurred selectively. A condensate consisting almost entirely of SiO2 was formed in the form of powder on the cooled surfaces near the crucible. The specific surface area of the powder was 120 m2/g. The evaporated TiO2 was removed with the exhaust gas. [ABSTRACT FROM AUTHOR]

Working memory (WM) is a cognitive function important for guiding the on‐going or upcoming behavior. A memory‐related protein Arc (activity‐regulated cytoskeleton‐associated protein) is implicated in long‐term memory consolidation. Recent evidence further suggests the involvement of hippocampal Arc in spatial WM. The medial prefrontal cortex (mPFC) is a key brain region mediating WM. However, the role of mPFC Arc in WM is still uncertain. To investigate whether mPFC Arc protein is involved in WM performance, delayed non‐match to sample (DNMS) T‐maze task was performed in rats with or without blocking new synthesis of mPFC Arc. In DNMS task, a 10‐s or 30‐s delay between the sample run and the choice run was given to evaluate WM performance. To block new Arc protein synthesis during the DNMS task, Arc antisense oligodeoxynucleotides (ODNs) were injected to the bilateral mPFC. The results show that, in rats without surgery for cannula implantation and subsequent intracerebral injection of ODNs, WM was functioning well during the DNMS task with a delay of 10 s but not 30 s, which was accompanied with a significantly increased level of mPFC Arc protein, indicating a possible link between enhanced Arc protein expression and the performance of WM. After preventing the enhancement of mPFC Arc protein expression with Arc antisense ODNs, rat's WM performance was impaired. These findings support enhanced mPFC Arc protein expression playing a role during WM performance. [ABSTRACT FROM AUTHOR]

A current-limiting and consequent direct current (DC) arc interruption requires an increase in arc resistance r a r c for a DC fuse. Flattery silica (SiO2) sand has been used as an arc quenching medium in fuses for decades. However, there are few reports about a novel arc quenching medium which enables more r a r c increases compared to flattery SiO2 sand. This paper uniquely selected a novel arc quenching medium based on the following material properties: (1) electrical resistivity and thermal conductivity in the solid phase, (2) the possibility of r a r c increasing in the gas phase, (3) the possibility of electrical insulation after re-solidification, and (4) the cost of materials. As a result, we originally selected a powder mixture of silicon-nitride (Si3N4) and flattery SiO2 sand as a promising novel arc quenching medium. Therefore, DC interruption experiments were performed using a Si3N4/flattery SiO2 sand powder mixture under different Si3N4 concentration conditions. As a result of 1000 A DC arc quenching experiments, the utilization of Si3N4 powder with the flattery SiO2 sand successfully increased the arc resistance r a r c during the arc quenching process. The increasing Si3N4 concentration exhibited a further increase in r a r c during the arc quenching process. As a result of the r a r c increase, the arc quenching time was significantly shortened to 30 ms for 30 wt.% Si3N4 conditions from 54 ms for the SiO2 sand conditions. In addition, utilization of Si3N4 powder achieved high insulation resistance over few MΩ after DC arc interruption. The above results clearly indicate that utilization of Si3N4 powder with flattery SiO2 sand can increase the DC interruption performance of the fuse. [ABSTRACT FROM AUTHOR]

During the dissection of 11 stiffs, we observed the presence of an accessory muscle in the axillary fossa, known as the dorsalis major muscle arch or axillary Carl Langer muscle. This is the main anatomical variation in the walls of the axillary region. This case was reported because of the low frequency of this variation in the axillary region, and the vital importance of incorporating the possible presence of these notions into axillary curage techniques, which may find themselves modified intraoperatively. Ignorance of the dorsalis major muscle arch may be the cause of intra- and postoperative complications during axillary curage or breast reconstruction using a dorsalis major flap. [ABSTRACT FROM AUTHOR]

This study investigated if acylated ghrelin (AG) could inhibit myocardial infarction (MI)-induced apoptosis in the left ventricles (LV) of male rats and tested if this protection involves modulating ARC anti-apoptotic protein. Rats (n = 12/group) were assigned as a sham-operated, a sham + AG (100 µg/kg, 2x/d, S.C.), MI, and MI + AG. With no antioxidant activity or expression of FAS, AG inhibited caspase-3, 8, and 9 and decreased cytosolic/mitochondrial levels of cytochrome-c, Bax, Bad, and Bad-BCL-2 complex in the LVs of the sham-operated and MI-treated rats. Concomitantly, AG preserved the mitochondria structure, decreased mtPTP, and enhanced state-3 respiration in the LVs of both treated groups. These effects were associated with increased mitochondrial levels of ARC and a reduction in the activity of calcineurin. Overall, AG suppresses MI-induced ventricular apoptosis by inhibition of calcineurin, activation of ARC, and preserving mitochondria integrity. [ABSTRACT FROM AUTHOR]

Aiming at the electrical safety problem of a high-voltage lithium-ion battery system caused by an arc, and based on the establishment of a battery arc fault experimental platform, the evolution law of safety caused by an arc in the negative terminal of a battery system under different working conditions is discussed. On this basis, a battery arc evolution model based on magnetohydrodynamics is established to analyze the arc's electro-thermal coupling characteristics to further obtain the distribution of the arc's multi-physical field. The results show that the arc generated by the high-voltage grade battery pack will break down the cell's shell and form a hole, resulting in electrolyte leakage. When the loop current is 10 A, the evolution law of arc voltage and current is basically the same under different supply voltages, charges, and discharges. The accuracy of the battery arc simulation model is verified by comparing the simulation with the experimental results. The research in this paper provides a theoretical basis for the electrical safety design of lithium-ion batteries caused by the arc, fills the gaps in the field of battery system arc simulation, and is of great significance for improving the safety performance of arc protection. [ABSTRACT FROM AUTHOR]

Flame kernel generation is essential to the stability and efficiency of combustion in a spark engine. In this study, the initial process of flame kernel generation was studied in an optical spark engine. The engine was operated with the λ adjusted from 1.0 to 1.5, respectively. Meanwhile, the continuous arc motion was inventively quantified. First, the impact of single-coil and multi-coil discharge on the stability of the combustion and knocking tendency are examined. Secondly, the differences in arc development between single-coil and multi-coil discharge and the effect of the shortening phenomenon on the generation of the flame kernels are compared by optical images. Finally, arc shortening feathers (including timing, extent, and spatial location) are statistically analyzed over multiple cycles in conjunction with combustion phase. The results show that multi-coil discharge can make the flame kernels larger, which could keep the flame kernels from quenching. They also show that variations in arc shortening are linked to cycle-to-cycle fluctuations. Furthermore, a principal component analysis is done on the features of the first two arc shortenings and the CA05 phases. Precision control of the arc shortening features can greatly enhance the spark engine’s initial flame kernel stability and lower cycle-to-cycle fluctuations.

Background and aims: This research aimed to investigate the effect of 8 weeks of interval training and the use of cineole, linalool, and bourbonene on MAPK/Arc gene expression and learning in Alzheimer’s disease (AD) rats. Methods: In this experimental study, 40 AD rats were randomized into eight groups, including (1) control, (2) AD, (3) AD+aerobic training (AT), (4) AD+linalool, cineole, and bourbonene (LCB), (5) AD+AT+LCB, (6) AT+AD, (7) LCB+AD, and (8) AT+LCB+AD. AD was induced by injecting amyloid-beta (Aβ1)-42 into the hippocampus of rats. The interval training protocol was performed five days per week for eight weeks before and after AD induction. Linalool at a concentration of 25 mg/kg, cineole at a concentration of 10 µM, and β-bourbonene at a concentration of 10 µg/mL were used for eight weeks. One-way analysis of variance was used for between-group comparisons, and Tukey’s test was used for pairwise comparisons at P≤0.05. Results: AD induction caused a significant decrease in MAPK/Arc gene expression in hippocampal tissue (P=0.001). Interval exercise and consumption of three herbal drugs significantly increased gene expression of Arc (P=0.001) and MAPK (P=0.001). AD induction decreased learning (P=0.001). Interval exercise and consumption of three herbal medicines caused a significant increase in learning (P=0.001). Conclusion: Interval exercise and using three herbal medicines have more favorable effects on improving MAPK/Arc gene expression and learning in AD than each alone.

Although great progress has been made in transgenic technology, increasing the expression level and thus promising the expected phenotypes of exogenous genes in transgenic plants is still a crucial task for genetic transformation and crop engineering. Here, we conducted a comparative study of the enhancing efficiency of three putative translational enhancers, including Ω (natural leader from a plant virus), OsADH 5′ (natural leader from a plant gene), and ARC (active ribosomal RNA complementary), using the transient gene expression systems of Nicotiana benthamiana and Chirita pumila. We demonstrate that three tandem repeats of ARC (3 × ARC) are more efficient than other enhancers in expression. The enhancing efficiency of 6 × ARC is further increased, up to 130 times the expression level without the insertion of enhancers. We further evaluated the enhancing efficiency of 6 × ARC under agrobacterium-mediated transformation systems. In C. pumila, 6 × ARC significantly amplifies the phenotypic effect of CpCYC1 and CpCYC2 in repressing stamen development and yellow pigmentation. In Arabidopsis thaliana, 6 × ARC and the AtAP1 promoter work together to promote the accumulation of anthocyanin pigments in vegetative and reproductive organs. Most significantly, the fusion of 6 × ARC in a CpCYC1/2 transgenic system in C. pumila fully reveals that these genes have the complete function of repressing the yellow spots, displaying an advantage in manifesting the function of exogenous genes. This study highlights the application potential of the enhancer 6 × ARC in gene function research in plants.

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Macrocrysts (large crystals) in magmas offer a premier record of pre‐eruptive magma storage conditions encoded in their chemistry and texture. Careful study of macrocryst zoning can deconvolve the conditions of crystal growth and the relative time a magma spends in a given physical‐chemical state prior to eruption. Importantly, identifying discrete macrocryst zones requires consideration of both chemistry and texture simultaneously. Here, we employ a novel image segmentation approach to characterize zoning from 2D chemical maps of plagioclase macrocrysts. We apply the method to 15 volcanic eruptions, across three stratigraphic sections, to track statistical differences in crystal zoning through relative time at an arc volcano (Mount Liamuiga, Saint Kitts). Plagioclase from the 15 eruptions are described by 7 unique textural‐chemical zoning populations, which we term "zoning groups," each of which has a unique An# fingerprint. Two of the studied stratigraphic sections overwhelmingly record low‐An# zoning groups (ZGs), whereas the other section records mostly high‐An# ZGs, suggestive of two distinct storage conditions. Using observations from equilibrium experiments relevant to Saint Kitts bulk magma compositions, we show that differences in melt H2O are the primary drivers of the An# variability. Negative whole rock K2O versus predicted H2O trends are suggestive of ubiquitous H2O‐saturated conditions throughout the middle and upper crust, with a correlation between H2O‐saturated storage pressure (Psat) and eruptive dynamics; magmas stored in the upper‐crust (0.48 ± 0.28–1.08 ± 0.45 kbar) produce larger‐volume, pumice‐rich eruptions compared to magmas stored in the middle crust (3.29 ± 0.87–3.88 ± 1.05 kbar) which generally produce smaller‐volume, centimeter to decimeter‐thick fall deposits. Plain Language Summary: The physical and chemical conditions under which a magma, a mixture of liquid melt and solid crystals, is stored in the Earth's crust determines how it erupts on Earth's surface. A reliable record of these pre‐eruptive conditions is the complex zoning inside crystals, which consist of textural‐chemical patterns that are interpretable by petrologists. Here, we study a series of volcanic eruptions from Mount Liamuiga (Saint Kitts, Lesser Antilles) and focus on the mineral plagioclase which is present in all samples. A novel image segmentation approach was used to rapidly break down 624 crystals from 15 volcanic samples into coherent zones. By combining plagioclase zoning data with published experimental observations, we identified two distinct pre‐eruptive magma storage regions, namely a deeper (∼3.5 kbar) and a shallower (∼1 kbar) region. Over the entire pressure range, magmas are shown to coexist with a volatile phase, which has implications for the physical properties of the Earth's crust in which these magmas are stored. Shallower stored magmas produce larger‐volume, pumice‐rich eruptions compared to magmas stored deeper, which generally produce smaller‐volume centimeter‐thick to decimeter‐thick fall deposits. The information we gather is important for interpreting the monitoring signals of future volcanic unrest on Saint Kitts. Key Points: Our image segmentation method identifies zoning features in 624 plagioclase crystals that are correlated across 15 volcanic eruptionsNegatively correlated whole rock K2O and pre‐eruptive H2O demonstrates that H2O‐saturated conditions were ubiquitous prior to eruptionLarger‐volume deposits record shallower storage (0.6–0.7 kbar) than the commonest centimetric fall deposits (3.3–3.9 kbar) [ABSTRACT FROM AUTHOR]

The effect of polarity and shielding gases on the droplet transfer behavior and formation trend of cable-type welding wire gas metal arc welding was studied under the same welding parameters. An acquisition system was used to observe welding parameters, droplet transfer and arc behavior. The results showed that the arc shapes with different polarities under the same shielding gas were different. The arc length and width in direct current electrode positive (DCEP) mode were smaller than those in direct current electrode negative (DCEN) mode. For the same polarity and different shielding gases, with increasing CO2 gas content, the arc length and width gradually decreased. In DCEP mode, droplet transfer was characterized by globular and projected droplet transfer modes. The droplet transfer modes with different polarities differed under different shielding gases. The droplet transfer mode was basically the same for the same polarity. With increasing CO2 content, the weld bead formation gradually improved. [ABSTRACT FROM AUTHOR]

This paper defines a new operation through extending the idea of the 0-dimensional crossing change and Shimizu's 2-dimensional region crossing change [A. Shimizu, Region crossing change is an unknotting operation, J. Math. Soc. Jpn. 66(3) (2014) 693–708, doi:10.2969/jmsj/06630693] to a 1-dimensional version called the arc crossing change. We will also prove that the arc crossing change is an unknotting operation with the help of Gauss diagrams. [ABSTRACT FROM AUTHOR]

Arc beads generated from metal conductors by arc discharges have a risk of causing fires when contacting the combustibles. In this work, the process of arc bead generation from conductors due to arc discharge was investigated experimentally. The copper conductors with four different diameters (1.5, 2.5, 4, 6 mm2) were chosen to produce arc beads by the arc discharges with currents from 60 to 220 A. It was observed that the arc bead was generated when its gravity overcame the surface tension between the arc bead and the conductor. The diameter of the arc bead was found to increase with the conductor diameter, and an expression was established to describe this relationship. It was also found that the minimum discharge time required for the arc bead formation was negatively correlated with the discharge current, but positively correlated with the conductor diameter. The findings of this work help assess the ignition risk caused by arc beads [ABSTRACT FROM AUTHOR]

Background and aims: This research aimed to investigate the effect of 8 weeks of interval training and the use of cineole, linalool, and bourbonene on MAPK/Arc gene expression and learning in Alzheimer’s disease (AD) rats. Methods: In this experimental study, 40 AD rats were randomized into eight groups, including (1) control, (2) AD, (3) AD+aerobic training (AT), (4) AD+linalool, cineole, and bourbonene (LCB), (5) AD+AT+LCB, (6) AT+AD, (7) LCB+AD, and (8) AT+LCB+AD. AD was induced by injecting amyloid-beta (Aβ1)-42 into the hippocampus of rats. The interval training protocol was performed five days per week for eight weeks before and after AD induction. Linalool at a concentration of 25 mg/kg, cineole at a concentration of 10 µM, and β-bourbonene at a concentration of 10 µg/mL were used for eight weeks. One-way analysis of variance was used for between-group comparisons, and Tukey’s test was used for pairwise comparisons at P≤0.05. Results: AD induction caused a significant decrease in MAPK/Arc gene expression in hippocampal tissue (P=0.001). Interval exercise and consumption of three herbal drugs significantly increased gene expression of Arc (P=0.001) and MAPK (P=0.001). AD induction decreased learning (P=0.001). Interval exercise and consumption of three herbal medicines caused a significant increase in learning (P=0.001). Conclusion: Interval exercise and using three herbal medicines have more favorable effects on improving MAPK/Arc gene expression and learning in AD than each alone. [ABSTRACT FROM AUTHOR]

Igneous rocks of the Jurassic continental arc of southwest North American Cordillera crop out in the region between Cananea and Nacozari, in northeastern Sonora, Mexico. Contemporaneous igneous rocks occur farther south in the Nazas rift province; however, their tectonic affinity is debated between the southern extension of the Cordilleran arc and an origin associated with decompressive mantle melting during the Pangea breakup. We consider that the studied rocks represent the southernmost expression of the Jurassic continental arc. Four magmatic units are distinguished based on geology, U–Pb zircon geochronology, and geochemical composition. They comprise the Buenos Aires granite dated at 183.8 ± 1.1 Ma, the Mababi granite with ages of 175.5 ± 1.8, 173.5 ± 1.8, and 171.7 ± 1.0 Ma, the Elenita Formation volcanic rocks dated at 169.7 ± 1.7 Ma, and the Cerro Blanco granite dated at 162.3 ± 2.4 Ma. The studied samples correspond to highly differentiated rocks with high-silica contents (69–76 wt.%), low Mg# values (mostly <45), and alkali–calcic and peraluminous compositions suggesting crustal contamination. LREE-enriched normalized slopes with negative Eu anomalies and multielement plots characterized by well-developed negative anomalies of Nb–Ta, P, and Ti provide an unequivocal signal of the continental arc nature. In contrast to the Nazas province, where the Jurassic magmatism consists of discreet volcaniclastic sequences deposited in extensional basins with no evidence of plutonic rocks, the Jurassic continental arc of Arizona and northern Sonora forms a regionally coherent geological feature characterized by large exposures of volcanic and plutonic rocks. [ABSTRACT FROM AUTHOR]

Summary: Epilepsy is a brain disorder affecting up to 1 in 26 individuals. Despite its clinical importance, the molecular mechanisms of epileptogenesis are still far from clarified. Our previous study showed that disruption of Clock in excitatory neurons alters cortical circuits and leads to generation of focal epilepsy. In this study, a GAD-Cre;Clockflox/flox mouse line with conditional Clock gene knockout in inhibitory neurons was established. We observed that seizure latency was prolonged, the severity and mortality of pilocarpine-induced seizure were significantly reduced, and memory was improved in GAD-Cre;Clockflox/flox mice. We hypothesize that mice with CLOCK knockout in inhibitory neurons have increased threshold for seizure, opposite from mice with CLOCK knockout in excitatory neurons. Further investigation showed Clock knockout in inhibitory neurons upregulated the basal protein level of ARC, a synaptic plasticity-associated immediate-early gene product, likely through the BDNF-ERK pathway. Altered basal levels of ARC may play an important role in epileptogenesis after Clock deletion in inhibitory neurons. Although sEPSCs and intrinsic properties of layer 5 pyramidal neurons in the somatosensory cortex exhibit no changes, the spine density increased in apical dendrite of pyramidal neurons in CLOCK knockout group. Our results suggest an underlying mechanism by which the circadian protein CLOCK in inhibitory neurons participates in neuronal activity and regulates the predisposition to epilepsy.

This study proposes a cost-effective multigeneration system that integrates a supercritical carbon dioxide (sCO2) power cycle with a liquefied natural gas (LNG) regasification process. The system aims to deliver electricity, cooling, heating, and hydrogen simultaneously. Utilizing the temperature difference between the sCO2 cycle and the LNG thermal sink, an ammonia-water-based absorption refrigeration cycle (ARC) recovers waste heat from the sCO2 power cycle, producing cooling. The elevated ammonia concentration at the ARC's condenser outlet is leveraged by a heat pump system for heating production. Concurrently, cold energy from LNG is used to recover latent heat from the condenser and heat rejected from the sCO2 power cycle, providing inputs for additional electrical power through an NG turbine. The system incorporates a PEM electrolyzer (PEME) for hydrogen production. A comprehensive examination, including energy, exergy, and exergoeconomic analyses, evaluates system performance. A sensitivity analysis illustrates the impacts of key parameters. In the baseline scenario, the system achieves energy and exergy efficiencies of 62.79% and 54.89%, with a low product unit cost of 11.35 ($/GJ). The system demonstrates substantial net power output (259.184 MW), cooling capacity (88.938 MW), heating capacity (2.839 MW), and hydrogen production (391.68 kg/h). This robust performance, coupled with cost-effectiveness, positions the proposed system as a versatile and impactful solution for sustainable and environmentally friendly energy applications.

As a promising structural material, carbon fiber reinforced thermoplastic (CFRTP) has been gradually applied on aircrafts. The lightning arc adhesion characteristics of CFRTP, however, are still unclear. Therefore, the arc adhesion characteristics of CFRTP were studied by simulating the lightning test method. Based on the finite element method, the effect of CFRTP on spatial electric field was analyzed and compared with that of metal materials. It is found that for the structure containing both CFRTP and metal materials, CFRTP is possible to be attached by the lightning discharging channel, but the probability is lower than that of the metal material by 22.5%. In the process of lightning arc adhesion, single upward leader and multiple upward leaders appear on the surface of CFRTP, resulting in the corresponding single or multiple arc attachment points. Simultaneous adhesion of lightning arc on both CFRTP and metal material also occurs. The spatial electric distribution obtained by simulation is consistent with the experimental results. This paper can provide the basis for the lightning characteristics and damage response of CFRTP.

Introduction: Alzheimer's disease is a common progressive neurogenerative disease that leads to dementia and destruction of brain cells, especially in areas related to learning and memory such as the hippocampus. The role of the Arc gene in synaptic flexibility and memory consolidation has been proven and its expression is strongly influenced by neuronal activity. The aim of this study was to investigate the effect of Lactobacillus fermentum on the expression of Arc (effective in synaptic flexibility and memory consolidation) and CREB (effective in stabilizing synaptic changes during learning) genes, involved in the memory of Alzheimer's rats. Material & ethods: In this study that was conducted in 2019, 30 male Wistar rats were divided into 5 groups (control, Alzheimer and 3 groups as treatment). In the treatment groups, simultaneously with induction of Alzheimer by stereotaxic method with streptozotocin, supernatant of Lactobacillus fermentum PTCC 1744 in MRS broth with doses of 108, 107, and 106 cfu/ml was injected intraperitoneally for 21 days. After RNA extraction from hippocampus samples, cDNA was synthesized and the expression of the genes was evaluated by real-time PCR and LinReg PCR software. Findings: The data showed an increase in gene expression of Arc and CREB in the treatment groups with a dose of 106 cfu/ml compared to the Alzheimer's group and the difference was significant (P

Social isolation during adolescence can increase the risk of mental disorders. Epigenetic changes induced by chronic social isolation may serve as a mechanism underlying emotional disturbances. To test this, we exposed female mice to a post-weaning 6-week social isolation (SI) stress. We found the significantly increased methylation of histone H3 at lysine 9 (H3K9), a histone mark linked to gene repression, as well as the increased H3K9 methyltransferases SUV39H1 and SETDB1, in prefrontal cortex (PFC) of SI females. To find out potential downstream genes affected by this epigenetic alteration, we examined genes linked to neuronal and synaptic functions. Activity-dependent genes, including Arc, c-Fos and Npas4, were significantly reduced in PFC of SI females, correlated with the increased H3K9me2 occupancy around Arc enhancer. Treatment of SI females with UNC0642, a selective inhibitor of H3K9 methylation, significantly attenuated the anxiety-like behavior and elevated Arc expression. These results have revealed an epigenetic mechanism and intervention avenue for anxiety induced by chronic social isolation.

Abstract Macrocrysts (large crystals) in magmas offer a premier record of pre‐eruptive magma storage conditions encoded in their chemistry and texture. Careful study of macrocryst zoning can deconvolve the conditions of crystal growth and the relative time a magma spends in a given physical‐chemical state prior to eruption. Importantly, identifying discrete macrocryst zones requires consideration of both chemistry and texture simultaneously. Here, we employ a novel image segmentation approach to characterize zoning from 2D chemical maps of plagioclase macrocrysts. We apply the method to 15 volcanic eruptions, across three stratigraphic sections, to track statistical differences in crystal zoning through relative time at an arc volcano (Mount Liamuiga, Saint Kitts). Plagioclase from the 15 eruptions are described by 7 unique textural‐chemical zoning populations, which we term “zoning groups,” each of which has a unique An# fingerprint. Two of the studied stratigraphic sections overwhelmingly record low‐An# zoning groups (ZGs), whereas the other section records mostly high‐An# ZGs, suggestive of two distinct storage conditions. Using observations from equilibrium experiments relevant to Saint Kitts bulk magma compositions, we show that differences in melt H2O are the primary drivers of the An# variability. Negative whole rock K2O versus predicted H2O trends are suggestive of ubiquitous H2O‐saturated conditions throughout the middle and upper crust, with a correlation between H2O‐saturated storage pressure (Psat) and eruptive dynamics; magmas stored in the upper‐crust (0.48 ± 0.28–1.08 ± 0.45 kbar) produce larger‐volume, pumice‐rich eruptions compared to magmas stored in the middle crust (3.29 ± 0.87–3.88 ± 1.05 kbar) which generally produce smaller‐volume, centimeter to decimeter‐thick fall deposits.

The present study introduces a novel tri-generation system that is highly efficient and cost-effective, employing a supercritical CO2 (sCO2) Brayton cycle as the primary mover and harnessing the cooling potential from liquefied natural gas (LNG) as a heat sink. This innovative system simultaneously provides electricity, cooling, and hydrogen. By capitalizing on the substantial temperature difference between the high-temperature sCO2 power cycle and the low-temperature LNG cold source, an integrated combination of the Kalina cycle (KC) and organic Rankine cycle (ORC) is utilized. Additionally, the system incorporates a proton exchange membrane electrolyzer (PEME) and an absorption refrigeration cycle (ARC) to create a highly efficient trigeneration system. The system is rigorously evaluated through energy, exergy, and exergoeconomic analyses, which are critical for assessing performance. Additionally, this study conducts a parametric investigation to elucidate the impact of key parameters on system performance. Furthermore, optimization is performed using a genetic algorithm (GA), with the objective of maximizing energy and exergy efficiencies or minimizing the overall product cost. Results from the baseline scenario demonstrate impressive energy and exergy efficiencies of 54.38 % and 59.46 % respectively, along with a low total product unit cost of 11.642 ($/GJ), outperforming existing benchmarks in the literature. The system also provides substantial net power output, cooling capacity, and hydrogen production rates of 276.71 MW, 60.19 MW, and 176.25 kg/h, respectively. This combination of high performance and cost-effectiveness makes the proposed system a versatile choice, underscoring its significance in sustainable and environmentally friendly energy solutions.