6 results on '"Adams, Neill James"'
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2. A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis.
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Carullo, Nazareno, Divenuto, Francesca, Marascio, Nadia, Adams, Neill James, Giancotti, Aida, Comi, Nicolino, Faga, Teresa, Bolignano, Davide, Coppolino, Giuseppe, Serapide, Francesca, Costa, Chiara, Torti, Carlo, Matera, Giovanni, Quirino, Angela, and Andreucci, Michele
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INTERSTITIAL nephritis ,ACUTE kidney failure ,BLOOD cell count ,KIDNEY failure ,ASCARIS lumbricoides ,KIDNEY physiology - Abstract
Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia, microhaematuria and mild proteinuria. A full blood count revealed leucocytosis with eosinophilia. A stool parasitological examination revealed fertilised eggs of Ascaris lumbricoides. Tubulointerstitial nephropathy secondary to A. lumbricoides infection was suspected. A percutaneous renal biopsy was not performed since the patient refused the anti-platelet therapy discontinuation. Mebendazole, albendazole and prednisone therapy was administered. After worm eradiation and discharge, recovery from the parasitosis, absence of pruritus and eosinophilia, and progressive improvement of renal function were observed, strongly suggesting a causal relationship between Ascaris infection and AIN. Parasite infection should be considered in the differential diagnosis of unexplained renal failure because early diagnosis and treatment are necessary to avoid irreversible complications. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Evaluation of IL-35, as a Possible Biomarker for Follow-Up after Therapy, in Chronic Human Schistosoma Infection.
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Marascio, Nadia, Loria, Maria Teresa, Pavia, Grazia, Peronace, Cinzia, Adams, Neill James, Campolo, Morena, Divenuto, Francesca, Lamberti, Angelo Giuseppe, Giancotti, Aida, Barreca, Giorgio Settimo, Mazzitelli, Maria, Trecarichi, Enrico Maria, Torti, Carlo, Perandin, Francesca, Bisoffi, Zeno, Quirino, Angela, and Matera, Giovanni
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SCHISTOSOMA ,SCHISTOSOMA haematobium ,HELMINTHIASIS ,REGULATORY B cells ,HELMINTH hosts - Abstract
The host response to helminth infections is characterized by systemic and tissue-related immune responses that play a crucial role in pathological diseases. Recently, experimental studies have highlighted the role of regulatory T (Tregs) and B (Bregs) cells with secreted cytokines as important markers in anti-schistosomiasis immunity. We investigated the serical levels of five cytokines (TNFα, IFN-γ, IL-4, IL-10 and IL-35) in pre- and post-treatment samples from chronic Schistosoma infected patients to identify potential serological markers during follow-up therapy. Interestingly, we highlighted an increased serum level of IL-35 in the pre-therapy samples (median 439 pg/mL for Schistosoma haematobium and 100.5 pg/mL for Schistsoma mansoni infected patients) compared to a control group (median 62 pg/mL and 58 pg/mL, respectively, p ≤ 0.05), and a significantly lower concentration in post-therapy samples (181 pg/mL for S. haematobium and 49.5 pg/mL for S. mansoni infected patients, p ≤ 0.05). The present study suggests the possible role of IL-35 as a novel serological biomarker in the evaluation of Schistosoma therapy follow-up. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Molecular characterization of Schistosoma infections in African migrants: identification of a Schistosoma haematobium-bovis hybrid in bladder biopsies.
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Marascio, Nadia, Loria, Maria Teresa, Lamberti, Angelo Giuseppe, Pavia, Grazia, Adams, Neill James, Quirino, Angela, Divenuto, Francesca, Mazzitelli, Maria, Greco, Giuseppe, Trecarichi, Enrico Maria, Perandin, Francesca, Bisoffi, Zeno, Webster, Bonnie L, Liberto, Maria Carla, Torti, Carlo, and Matera, Giovanni
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SCHISTOSOMIASIS diagnosis ,AFRICANS ,NOMADS ,BLADDER ,TREMATODA ,BIOPSY ,ANIMALS - Abstract
The I S. haematobium cox1 i data from all samples matched the common H1 haplotypes found across mainland Africa.[7] The I cox1 i data from the bladder biopsy identified both I S. bovis i and I S. haematobium i mitochondrial DNA. Keywords: ITS2; cox1; Schistosoma hybrid; phylogenetic analysis EN ITS2 cox1 Schistosoma hybrid phylogenetic analysis 1 3 3 11/09/22 20221001 NES 221001 Schistosomiasis is a neglected tropical disease affecting up to 90% of people living in Africa.[1] The emergence of natural inter I Schistosoma i species hybrids clearly highlights potential risks of mixing between human and animal infections, enhancing transmission and the spread of new strains.[2] In particular, I Schistosoma haematobium i and I Schistosoma bovis i are closely related, are known to hybridize and also share snail intermediate hosts of the genus I Bulinus i .[3] The I S. haematobium-bovis i hybrid diagnosis in patients plays an important role in explaining unusual morbidities and disease outcomes together with the potential risk of introduction into non-endemic areas I . i [2],[4] Herein, to identify the potential presence of I S. haematobium-bovis i hybrids, we molecularly characterized typical and atypical eggs, presumed to be I S. haematobium i , collected from young African migrants. [Extracted from the article]
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- 2022
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5. Early gastric cancer: A challenge in Western countries.
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Chiarello MM, Fico V, Pepe G, Tropeano G, Adams NJ, Altieri G, and Brisinda G
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- Early Detection of Cancer, Gastric Mucosa diagnostic imaging, Gastric Mucosa pathology, Gastric Mucosa surgery, Gastroscopy, Humans, Lymph Node Excision, Stomach Neoplasms pathology, Stomach Neoplasms surgery
- Abstract
Early gastric cancer (EGC) is an invasive carcinoma involving only the stomach mucosa or submucosa, independently of lymph node status. EGC represents over 50% of cases in Japan and in South Korea, whereas it accounts only for approximately 20% of all newly diagnosed gastric cancers in Western countries. The main classification systems of EGC are the Vienna histopathologic classification and the Paris endoscopic classification of polypoid and non-polypoid lesions. A careful endoscopic assessment is fundamental to establish the best treatment of EGC. Generally, EGCs are curable if the lesion is completely removed by endoscopic resection or surgery. Some types of EGC can be resected endoscopically; for others the most appropriate treatment is surgical resection and D2 lymphadenectomy, especially in Western countries. The favorable oncological prognosis, the extended lymphadenectomy and the reconstruction of the intestinal continuity that excludes the duodenum make the prophylactic cholecystectomy mandatory to avoid the onset of biliary complications., Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest., (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
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- 2022
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6. Postoperative mortality and morbidity after D2 lymphadenectomy for gastric cancer: A retrospective cohort study.
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Brisinda G, Chiarello MM, Crocco A, Adams NJ, Fransvea P, and Vanella S
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- Aged, Gastrectomy adverse effects, Humans, Lymph Node Excision adverse effects, Lymphatic Metastasis, Morbidity, Retrospective Studies, Stomach Neoplasms surgery
- Abstract
Background: Surgery for gastric cancer is a complex procedure and lymphadenectomy is often mandatory. Postoperative mortality and morbidity after curative gastric cancer surgery is not insignificant., Aim: To evaluate the factors determining mortality and morbidity in a population of patients undergoing R0 resection and D2 lymphadenectomy for gastric cancer., Methods: A retrospective analysis of clinical data and pathological characteristics (age, sex, primary site of the tumor, Lauren histotype, number of positive lymph nodes resected, number of negative lymph nodes resected, and depth of invasion as defined by the standard nomenclature) was conducted in patients with gastric cancer. For each patient we calculated the Kattan's score. We arbitrarily divided the study population of patients into two groups based on the nomogram score (< 100 points or ≥ 100 points). Prespecified subgroups in these analyses were defined according to age (≤ 65 years or > 65 years), and number of lymph nodes retrieved (≤ 35 lymph nodes or > 35 lymph nodes). Uni- and multivariate analysis of clinical and pathological findings were performed to identify the factors affecting postoperative mortality and morbidity., Results: One-hundred and eighty-six patients underwent a curative R0 resection with D2 lymphadenectomy. Perioperative mortality rate was 3.8% (7 patients); a higher mortality rate was observed in patients aged > 65 years ( P = 0.002) and in N+ patients ( P = 0.04). Following univariate analysis, mortality was related to a Kattan's score ≥ 100 points ( P = 0.04) and the presence of advanced gastric cancer ( P = 0.03). Morbidity rate was 21.0% (40 patients). Surgical complications were observed in 17 patients (9.1%). A higher incidence of morbidity was observed in patients where more than 35 lymph nodes were harvested ( P = 0.0005)., Conclusion: Mortality and morbidity rate are higher in N+ and advanced gastric cancer patients. The removal of more than 35 lymph nodes does not lead to an increase in mortality., Competing Interests: Conflict-of-interest statement: No conflict of interest., (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
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- 2022
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