20 results on '"Afinjuomo, Franklin"'
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2. Physicochemical properties of otic products for Canine Otitis Externa: comparative analysis of marketed products
- Author
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Song, Yunmei, Abdella, Sadikalmahdi, Afinjuomo, Franklin, Weir, Emily Josephine, Tan, Jin Quan Eugene, Hill, Peter, Page, Stephen W., and Garg, Sanjay
- Published
- 2023
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- View/download PDF
3. Printing a cure: A tailored solution for localized drug delivery in liver cancer treatment
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Youssef, Souha H., Ganesan, Raja, Amirmostofian, Marzieh, Kim, Sangseo, Polara, Ruhi, Afinjuomo, Franklin, Song, Yunmei, Chereda, Bradley, Singhal, Nimit, Robinson, Nirmal, and Garg, Sanjay
- Published
- 2024
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4. 3D printed bilayer mucoadhesive buccal film of estradiol: Impact of design on film properties, release kinetics and predicted in vivo performance
- Author
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Abdella, Sadikalmahdi, Afinjuomo, Franklin, Song, Yunmie, Upton, Richard, and Garg, Sanjay
- Published
- 2022
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5. Development of a novel chromatographic method for concurrent determination of 5-fluorouracil and cisplatin: Validation, greenness evaluation, and application on drug-eluting film
- Author
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Youssef, Souha H., Afinjuomo, Franklin, Song, Yunmei, and Garg, Sanjay
- Published
- 2021
- Full Text
- View/download PDF
6. Synthesis and characterization of a novel inulin hydrogel crosslinked with pyromellitic dianhydride
- Author
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Afinjuomo, Franklin, Barclay, Thomas G., Song, Yunmei, Parikh, Ankit, Petrovsky, Nikolai, and Garg, Sanjay
- Published
- 2019
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7. Development and Optimization of Imiquimod-Loaded Nanostructured Lipid Carriers Using a Hybrid Design of Experiments Approach.
- Author
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Kim, Sangseo, Abdella, Sadikalmahdi, Abid, Fatima, Afinjuomo, Franklin, Youssef, Souha H, Holmes, Amy, Song, Yunmei, Vaidya, Sachin, and Garg, Sanjay
- Published
- 2023
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8. Advanced Strategies of Drug Delivery via Oral, Topical, and Parenteral Administration Routes: Where Do Equine Medications Stand?
- Author
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Song, Yunmei, Day, Candace M., Afinjuomo, Franklin, Tan, Jin-Quan E., Page, Stephen W., and Garg, Sanjay
- Subjects
DRUG delivery systems ,CARDIOVASCULAR system ,SKIN permeability ,GASTROINTESTINAL system - Abstract
While the global market for veterinary products has been expanding rapidly, there is still a lack of specialist knowledge of equine pharmaceutics. In many cases, the basic structure of the gastrointestinal tract (GIT) and integumentary system of the horse shares similarities with those of humans. Generally, the dosage form developed for humans can be repurposed to deliver equine medications; however, due to physiological variation, the therapeutic outcomes can be unpredictable. This is an area that requires more research, as there is a clear deficiency in literature precedence on drug delivery specifically for horses. Through a careful evaluation of equine anatomy and physiology, novel drug delivery systems (NDDSs) can be developed to adequately address many of the medical ailments of the horse. In addition to this, there are key considerations when delivering oral, topical, and parenteral drugs to horses, deriving from age and species variation. More importantly, NDDSs can enhance the duration of action of active drugs in animals, significantly improving owner compliance; and ultimately, enhancing the convenience of product administration. To address the knowledge gap in equine pharmaceutical formulations, this paper begins with a summary of the anatomy and physiology of the equine gastrointestinal, integumentary, and circulatory systems. A detailed discussion of potential dosage-form related issues affecting horses, and how they can be overcome by employing NDDSs is presented. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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9. Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction.
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Abdella, Sadikalmahdi, Afinjuomo, Franklin, Song, Yunmei, Upton, Richard, and Garg, Sanjay
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HORMONE therapy , *EMULSIONS (Pharmacy) , *ESTRADIOL , *SLEEP interruptions , *BIOAVAILABILITY , *HOT flashes , *VAGINAL dryness - Abstract
The age-related loss of circulating estrogen that occurs during the menopausal transition manifests itself through a variety of symptoms including vasomotor (hot flushes and night sweats), genito-urinary syndrome (vaginal dryness and urinary symptoms), sexual dysfunction, mood, and sleep disturbance that often last longer than a decade. Furthermore, reductions in estrogen level increase the risks of chronic complications such as osteoporosis, cardiovascular disease, and cognitive decline among others, thereby affecting the quality of life of women. Although oral estrogens are the most widely used therapy for menopausal symptoms, they suffer from poor bioavailability, and there are concerns over their safety, creating a significant concern to consumers. Mucoadhesive buccal films are an innovative dosage form that offers several advantages including avoidance of the first-pass metabolism, fast onset of action, and importantly, improved patient acceptance. In the current work, we developed mucoadhesive estradiol film for hormonal replacement therapy using film-forming polymers. Two approaches, namely, co-solvency and nano-emulsion were evaluated to increase solubility and hence incorporate estradiol, a poorly water-soluble drug, into a formulation made from the hydrophilic polymer/s. The films were characterised for their mechanical and physicochemical properties. In-vitro release study showed that about 80% of the drug was released within 6 min from films prepared by the nano-emulsion approach, whereas it took about 10.5 min to get similar drug release from films prepared by the co-solvency approach. The ex-vivo permeation result indicates that about 15% of the drug permeated across the porcine buccal mucosa in the first 10 h from films prepared by the nano-emulsion approach, while permeation across porcine buccal mucosa was only observed at around 24 h from films prepared by the co-solvency method. The nano-emulsion films were evaluated for in vivo performance using a convolution technique using R software. The predicted Cmax and Tmax were found to be 740.74 ng mL−1 and 7 min, respectively, which were higher than previously reported in vivo concentration from oral tablets. The results demonstrated that mucoadhesive film of estradiol based on the nano-emulsion approach could be a promising platform for the delivery of estradiol through the buccal mucosa for the treatment of menopausal symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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10. Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers.
- Author
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Fouladian, Paris, Kohlhagen, Jarrod, Arafat, Mohammad, Afinjuomo, Franklin, Workman, Nathan, Abuhelwa, Ahmad Y., Song, Yunmei, Garg, Sanjay, and Blencowe, Anton
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- 2020
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11. Inulin and Its Application in Drug Delivery.
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Afinjuomo, Franklin, Abdella, Sadikalmahdi, Youssef, Souha H., Song, Yunmei, and Garg, Sanjay
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INULIN , *DRUG delivery systems , *CONTROLLED release drugs , *DRUG carriers , *FLEXIBLE structures , *LIPOSOMES - Abstract
Inulin's unique and flexible structure, stabilization/protective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. This, in turn, helps in increasing bioavailability, improving cellular uptake, and achieving targeted, sustained, and controlled release of drugs and biomolecules. This review focuses on the various types of inulin drug delivery systems such as hydrogel, conjugates, nanoparticles, microparticles, micelles, liposomes, complexes, prodrugs, and solid dispersion. The preparation and applications of the different inulin drug delivery systems are further discussed. This work highlights the fact that modification of inulin allows the use of this polymer as multifunctional scaffolds for different drug delivery systems. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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12. 3D Printing of Thermo-Sensitive Drugs.
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Abdella, Sadikalmahdi, Youssef, Souha H., Afinjuomo, Franklin, Song, Yunmei, Fouladian, Paris, Upton, Richard, and Garg, Sanjay
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THREE-dimensional printing ,LIGHT sources ,PRINTMAKING ,MELTING points ,STEREOLITHOGRAPHY - Abstract
Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam
® ) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations. [ABSTRACT FROM AUTHOR]- Published
- 2021
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13. Influence of Oxidation Degree on the Physicochemical Properties of Oxidized Inulin.
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Afinjuomo, Franklin, Fouladian, Paris, Barclay, Thomas G., Song, Yunmei, Petrovsky, Nikolai, and Garg, Sanjay
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INULIN , *FOURIER transform infrared spectroscopy , *THERMOGRAVIMETRY , *NUCLEAR magnetic resonance , *ULTRAVIOLET-visible spectroscopy - Abstract
This paper reports the oxidation of inulin using varying ratios of sodium periodate and the characterization of the inulin polyaldehyde. The physicochemical properties of the inulin polyaldehyde (oxidized inulin) were characterized using different techniques including 1D NMR spectroscopy, 13C Nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), differential scanning calorimetric (DSC), ultraviolet-visible spectroscopy (UV), and scanning electron microscopy (SEM). The aldehyde peak was not very visible in the FTIR, because the aldehyde functional group exists in a masked form (hemiacetal). The thermal stability of the oxidized inulin decreased with the increasing oxidation degree. The smooth spherical shape of raw inulin was destructed due to the oxidation, as confirmed by the SEM result. The 1HNMR results show some new peaks from 4.8 to 5.0 as well as around 5.63 ppm. However, no aldehyde peak was found around 9.7 ppm. This can be attributed to the hemiacetal. The reaction of oxidized inulin with tert-butyl carbazate produced a carbazone conjugate. There was clear evidence of decreased peak intensity for the proton belonging to the hemiacetal group. This clearly shows that not all of the hemiacetal group can be reverted by carbazate. In conclusion, this work provides vital information as regards changes in the physicochemical properties of the oxidized inulin, which has direct implications when considering the further utilization of this biomaterial. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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14. Influence of Polymer Composition on the Controlled Release of Docetaxel: A Comparison of Non-Degradable Polymer Films for Oesophageal Drug-Eluting Stents.
- Author
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Fouladian, Paris, Afinjuomo, Franklin, Arafat, Mohammad, Bergamin, Amanda, Song, Yunmei, Blencowe, Anton, and Garg, Sanjay
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DOCETAXEL , *POLYMER films , *POLYMERS , *MOLECULAR interactions , *DIFFERENTIAL scanning calorimetry , *YOUNG'S modulus , *POLYURETHANES - Abstract
Following the huge clinical success of drug-eluting vascular stents, there is a significant interest in the development of drug-eluting stents for other applications, such as the treatment of gastrointestinal (GI) cancers. Central to this process is understanding how particular drugs are released from stent coatings, which to a large extent is controlled by drug-polymer interactions. Therefore, in this study we investigated the release of docetaxel (DTX) from a selection of non-degradable polymer films. DTX-polymer films were prepared at various loadings (1, 5 and 10% w/w) using three commercially available polymers including poly(dimethylsiloxane) (PSi), poly (ethylene-co-vinyl acetate) (PEVA) and Chronosil polyurethane (PU). The formulations were characterised using different techniques such as photoacoustic Fourier-transform infrared (PA-FTIR) spectrophotometry, X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The effect of DTX on the mechanical properties of the films, in-vitro release, and degradation tests were also assessed. For all polymers and DTX loadings, the drug was found to disperse homogenously without crystallisation within the polymer matrix. While no specific interactions were observed between DTX and PSi or PEVA, hydrogen-bonding appeared to be present between DTX and PU, which resulted in a concentration-dependent decrease in the Young's moduli of the films due to disruption of inter-polymeric molecular interactions. In addition, the DTX-PU interactions were found to modulate drug release, providing near-linear release over 30 days, which was accompanied by a significant reduction in degradation products. The results indicate that DTX-loaded PU films are excellent candidates for drug-eluting stents for the treatment of oesophageal cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
15. Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery.
- Author
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Afinjuomo, Franklin, Barclay, Thomas G., Parikh, Ankit, Chung, Rosa, Song, Yunmei, Nagalingam, Gayathri, Triccas, Jamie, Wang, Lixin, Liu, Liang, Hayball, John D., Petrovsky, Nikolai, and Garg, Sanjay
- Subjects
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INULIN , *ISONIAZID , *PROTON magnetic resonance , *FOURIER transform infrared spectroscopy , *NUCLEAR magnetic resonance , *ANTITUBERCULAR agents - Abstract
The use of particles for monocyte-mediated delivery could be a more efficient strategy and approach to achieve intracellular targeting and delivery of antitubercular drugs to host macrophages. In this study, the potential of inulin microparticles to serve as a drug vehicle in the treatment of chronic tuberculosis using a monocytes-mediated drug targeting approach was evaluated. Isoniazid (INH) was conjugated to inulin via hydrazone linkage in order to obtain a pH-sensitive inulin-INH conjugate. The conjugate was then characterized using proton nuclear magnetic resonance (1HNMR), Fourier transform infrared spectroscopy (FTIR) as well as in vitro, cellular uptake and intracellular Mycobacterium tuberculosis (Mtb) antibacterial efficacy. The acid-labile hydrazone linkage conferred pH sensitivity to the inulin-INH conjugate with ~95, 77 and 65% of the drug released after 5 h at pH 4.5, 5.2, and 6.0 respectively. Cellular uptake studies confirm that RAW 264.7 monocytic cells efficiently internalized the inulin conjugates into endocytic compartments through endocytosis. The intracellular efficacy studies demonstrate that the inulin conjugates possess a dose-dependent targeting effect against Mtb-infected monocytes. This was through efficient internalization and cleavage of the hydrazone bond by the acidic environment of the lysosome, which subsequently released the isoniazid intracellularly to the Mtb reservoir. These results clearly suggest that inulin conjugates can serve as a pH-sensitive intracellular drug delivery system for TB treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
16. Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation.
- Author
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Wang, Lixin, Song, Yunmei, Parikh, Ankit, Joyce, Paul, Chung, Rosa, Liu, Liang, Afinjuomo, Franklin, Hayball, John D., Petrovsky, Nikolai, Barclay, Thomas G., and Garg, Sanjay
- Subjects
TARGETED drug delivery ,DOXORUBICIN ,INULIN ,CONTROLLED drugs ,DRUG development ,DRUG carriers ,CANCER cells - Abstract
Delta inulin, also known as microparticulate inulin (MPI), was modified by covalently attaching doxorubicin to its nanostructured surface for use as a targeted drug delivery vehicle. MPI is readily endocytosed by monocytes, macrophages, and dendritic cells and in this study, we sought to utilize this property to develop a system to target anti-cancer drugs to lymphoid organs. We investigated, therefore, whether MPI could be used as a vehicle to deliver doxorubicin selectively, thereby reducing the toxicity of this antibiotic anthracycline drug. Doxorubicin was covalently attached to the surface of MPI using an acid–labile linkage to enable pH-controlled release. The MPI-doxorubicin conjugate was characterized using FTIR and SEM, confirming covalent attachment and indicating doxorubicin coupling had no obvious impact on the physical nanostructure, integrity, and cellular uptake of the MPI particles. To simulate the stability of the MPI-doxorubicin in vivo, it was stored in artificial lysosomal fluid (ALF, pH 4.5). Although the MPI-doxorubicin particles were still visible after 165 days in ALF, 53% of glycosidic bonds in the inulin particles were hydrolyzed within 12 days in ALF, reflected by the release of free glucose into solution. By contrast, the fructosidic bonds were much more stable. Drug release studies of the MPI-doxorubicin in vitro, demonstrated a successful pH-dependent controlled release effect. Confocal laser scanning microscopy studies and flow cytometric analysis confirmed that when incubated with live cells, MPI-doxorubicin was efficiently internalized by immune cells. An assay of cell metabolic activity demonstrated that the MPI carrier alone had no toxic effects on RAW 264.7 murine monocyte/macrophage-like cells, but exhibited anti-cancer effects against HCT116 human colon cancer cells. MPI-doxorubicin had a greater anti-cancer cell effect than free doxorubicin, particularly when at lower concentrations, suggesting a drug-sparing effect. This study establishes that MPI can be successfully modified with doxorubicin for chemotherapeutic drug delivery. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
17. Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery.
- Author
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Afinjuomo, Franklin, Fouladian, Paris, Parikh, Ankit, Barclay, Thomas G., Song, Yunmei, and Garg, Sanjay
- Subjects
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INULIN , *CONTROLLED drugs , *FOURIER transform infrared spectroscopy , *THERMOGRAVIMETRY , *DIFFERENTIAL scanning calorimetry , *DRUG delivery systems - Abstract
Inulin-based hydrogels are useful carriers for the delivery of drugs in the colon-targeted system and in other biomedical applications. In this project, inulin hydrogels were fabricated by crosslinking oxidized inulin with adipic acid dihydrazide (AAD) without the use of a catalyst or initiator. The physicochemical properties of the obtained hydrogels were further characterized using different techniques, such as swelling experiments, in vitro drug release, degradation, and biocompatibility tests. The crosslinking was confirmed with Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). In vitro releases of 5-fluorouracil (5FU) from the various inulin hydrogels was enhanced in acidic conditions (pH 5) compared with physiological pH (pH 7.4). In addition, blank gels did not show any appreciable cytotoxicity, whereas 5FU-loaded hydrogels demonstrated efficacy against HCT116 colon cancer cells, which further confirms the potential use of these delivery platforms for direct targeting of 5-FU to the colon. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
18. Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes.
- Author
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Afinjuomo, Franklin, Barclay, Thomas G., Parikh, Ankit, Song, Yunmei, Chung, Rosa, Wang, Lixin, Liu, Liang, Hayball, John D., Petrovsky, Nikolai, and Garg, Sanjay
- Subjects
- *
INULIN , *PROTON magnetic resonance , *MONOCYTES , *FOURIER transform infrared spectroscopy , *MYCOBACTERIUM tuberculosis , *NUCLEAR magnetic resonance - Abstract
The propensity of monocytes to migrate into sites of mycobacterium tuberculosis (TB) infection and then become infected themselves makes them potential targets for delivery of drugs intracellularly to the tubercle bacilli reservoir. Conventional TB drugs are less effective because of poor intracellular delivery to this bacterial sanctuary. This study highlights the potential of using semicrystalline delta inulin particles that are readily internalised by monocytes for a monocyte-based drug delivery system. Pyrazinoic acid was successfully attached covalently to the delta inulin particles via a labile linker. The formation of new conjugate and amide bond was confirmed using zeta potential, Proton Nuclear Magnetic Resonance (1HNMR) and Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) confirmed that no significant change in size after conjugation which is an important parameter for monocyte targeting. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to establish the change in thermal properties. The analysis of in-vitro release demonstrated pH-triggered drug cleavage off the delta inulin particles that followed a first-order kinetic process. The efficient targeting ability of the conjugate for RAW 264.7 monocytic cells was supported by cellular uptake studies. Overall, our finding confirmed that semicrystalline delta inulin particles (MPI) can be modified covalently with drugs and such conjugates allow intracellular drug delivery and uptake into monocytes, making this system potentially useful for the treatment of TB. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
19. Effect of plasticizers on drug-in-adhesive patches containing 5-fluorouracil.
- Author
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Kim, Sangseo, Fouladian, Paris, Afinjuomo, Franklin, Song, Yunmei, Youssef, Souha H., Vaidya, Sachin, and Garg, Sanjay
- Subjects
- *
PRESSURE-sensitive adhesives , *FLUOROURACIL , *PLASTICIZERS , *SKIN cancer , *TENSILE strength , *THERMAL analysis - Abstract
[Display omitted] • Drug-in-adhesive patches containing 5-fluorouracil for the treatment of skin cancer. • Pressure-sensitive adhesives using Eudragit® E and plasticizers for topical application. • Solubility parameters and thermal analysis for polymer-plasticizer miscibility evaluation. Topical patches containing 5-fluorouracil (5-FU) are a feasible alternative to overcome the shortcomings of commercial cream for the treatment of non-melanoma skin cancer (NMSC). Plasticizers are a critical component of drug-in-adhesive (DIA) patches as they can significantly affect the mechanical, adhesive and drug release characteristics of the patches. Eudragit® E (EuE) is a methacrylate-based cationic copolymer capable of producing flexible and adhesive films for topical application. In this study, the effect of plasticizers on the mechanical, adhesive and 5-FU release characteristics of EuE-based patches was comprehensively evaluated. While the elongation at break (%) and adhesion of the films were significantly increased with increasing triacetin, dibutyl sebacate (DBS) and triethyl citrate (TEC) concentrations, the tensile strength showed an inverse relationship. EuE plasticized with 40% triacetin, 30% DBS or 40% w/w TEC produced elastic and adhesive films most suitable for topical application. In vitro release studies of the 5-FU-loaded patches demonstrated an initial burst release pattern during the first 10 min followed by a slow release over 120 min. In summary, this study provides important information on effect of plasticizers for preparation of EuE-based patches with desired mechanical, adhesive and release characteristics of 5-FU towards their potential application in the treatment of NMSC. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
20. pH and its applications in targeted drug delivery.
- Author
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Abdella, Sadikalmahdi, Abid, Fatima, Youssef, Souha H., Kim, Sangseo, Afinjuomo, Franklin, Malinga, Constance, Song, Yunmei, and Garg, Sanjay
- Subjects
- *
TARGETED drug delivery , *HELICOBACTER pylori infections , *DRUG delivery systems , *TRANSDERMAL medication , *CLARITHROMYCIN , *BODY fluids , *NANOMEDICINE - Abstract
[Display omitted] • pH is vital for the normal functioning of the body. • Drug targeting has been widely used to increase efficacy and reduce adverse effects. • pH variation in different tissues and change in pH in some diseased tissues has been used as an opportunity to deliver drugs. • pH-responsive drug delivery is an attractive platform for targeted drug delivery. Physiologic pH is vital for the normal functioning of tissues and varies in different parts of the body. The varying pH of the body has been exploited to design pH-sensitive smart oral, transdermal and vaginal drug delivery systems (DDS). The DDS demonstrated promising results in hard-to-treat diseases such as cancer and Helicobacter pylori infection. In some cases, a change in pH of tissues or body fluids has also been employed as a useful diagnostic biomarker. This paper aims to comprehensively review the development and applications of pH-sensitive DDS as well as recent advances in the field. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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