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Interrogating the genetic make-up of schistosome larvae (i.e., eggs, miracidia, and cercariae) originating from definitive or intermediate snail hosts with molecular DNA methods has, by noting unexpected interspecies hybrids, started a revolution in our appraisal of African schistosomiasis [[1]-[4]]. This clearly calls for further genetic scrutiny of schistosome infections in all definitive hosts locally, especially where multi-species coinfections are suspected as well as stepped-up environmental surveillance of infections in local snails for expanded schistosome-snail host ranges. Development of low-cost species and hybrid-specific DNA screening assays is now important to enable more rapid detection of hybrid schistosomes or the detection of genetic signatures of nonhuman schistosomes within clinical samples [[26]], particularly in relation to any changes in pathology or treatment efficacy. [Extracted from the article]