13 results on '"Alavi, Seyed Mohammad Amin"'
Search Results
2. Effects of brief cognitive behavioral therapy on mental health in substance-related disorder: a randomized controlled trial
- Author
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Alavi, Seyed Mohammad Amin, Irani, Reza Davasaz, Fattahi, Payam, and Pakseresht, Sirus
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- 2023
- Full Text
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3. The therapeutic effects of berberine for gastrointestinal cancers.
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Davoodvandi, Amirhossein, Sadeghi, Sahand, Alavi, Seyed Mohammad Amin, Alavi, Seyedeh Shaghayegh, Jafari, Ameneh, Khan, Haroon, Aschner, Michael, Mirzaei, Hamed, Sharifi, Mehran, and Asemi, Zatollah
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GASTROINTESTINAL cancer ,BERBERINE ,ANTINEOPLASTIC combined chemotherapy protocols ,DRUG therapy ,PANCREATIC cancer - Abstract
Cancer is one of the most serious human health issues. Drug therapy is the major common way to treat cancer. There is a growing interest in using natural compounds to overcome drug resistance, adverse reactions, and target specificity of certain types of drugs that may affect several targets with fewer side effects and be beneficial against various types of cancer. In this regard, the use of herbal medicines alone or in combination with the main anticancer drugs is commonly available. Berberine (BBR), a nature‐driven phytochemical component, is a well‐known nutraceutical due to its wide variety of pharmacological activities, including antioxidant, anti‐inflammatory, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and hypolipidemic. In addition, BBR exerts anticancer activities. In present article, we summarized the information available on the therapeutic effects of BBR and its mechanisms on five types of the most prevalent gastrointestinal cancers, including esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Comparison of biopsy results between two groups of cytology-negative HPV 16/18 and other types of high-risk HPV positive patients.
- Author
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Najib, Fatemeh Sadat, Hashemi, Marzieh, Alavi, Seyed Mohammad Amin, Shiravani, Zahra, Jahromi, Mojgan Akbarzadeh, and Hosseini, Seyedeh Marjan
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HUMAN papillomavirus ,CERVICAL cancer diagnosis ,CROSS-sectional method ,COLPOSCOPY ,CERVICAL intraepithelial neoplasia ,FOLLOW-up studies (Medicine) - Abstract
Cervical cancer is the fourth most common cancer among women worldwide. It is believed that Human Papilloma Virus (HPV) is responsible for 100% of cervical cancers. 200 HPV genotypes have been identified to date, of which 13--15 are high-risk HPV genotypes infecting the genital area. 218 females suffering from high-risk HPV infection and showing a negative cytology test were selected in a retrospective cross-sectional study and divided into two groups: 1. HPV 16/18 (121 women) and 2. Other highrisk HPV (OHrHPV) (97 women). The demographic and clinical data were collected from Motahari clinic, Shiraz University of Medical Sciences, between September 2020 and January 2023. The collected data were analyzed using IBM SPSS software version 26. Data analysis was carried out using chi-square, t-test, and Mann-Whitney, and p < 0.05 was defined as being statistically significant for all the aforementioned tests. The mean age for the HPV 16/18 and OHrHPV groups were 35.27 ± 7.698 and 36.58 ± 8.756, respectively. The most prevalent HPV genotype was HPV type 16 (n = 96) in the population, followed by HPV type 18 (n = 25) and HPV type 31 (n = 17). The HPV 16/18 group had 15 high-grade colposcopy results, while only four similar results were observed in the OHrHPV group (p value = 0.031). The most prevalent HPV genotype in patients with cervical intraepithelial neoplasia (CIN) 2 and CIN3 was HPV16. The cytology test failed to identify over 4% of the lesions in the OHrHPV group. Direct referral for colposcopy in the OHrHPV group results in the identification of missed diagnosed lesions and lost to follow-up patients. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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5. Choriocarcinoma in tubal pregnancy: A case report.
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Najib, Fateme Sadat, Bahrami, Samaneh, Shiravani, Zahra, and Alavi, Seyed Mohammad Amin
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CHORIOCARCINOMA ,ECTOPIC pregnancy ,CHORIONIC villi ,MOLAR pregnancy ,ADJUVANT chemotherapy ,FALLOPIAN tubes - Abstract
Key Clinical Message: Choriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma. Choriocarcinoma is a malignant epithelial tumor of the chorionic villi that often manifests after a normal or molar pregnancy. The primary tubal choriocarcinoma associated with ectopic pregnancy is extremely rare and can be misdiagnosed as an ectopic pregnancy since symptoms including vaginal bleeding, amenorrhea, elevated beta‐human chorionic gonadotropin (BHCG) levels, and pelvic pain are shared. A 34‐year‐old G4P3003 woman presented with a one‐week history of vaginal bleeding and right lower abdominal pain, which had intensified a day before admission. Clinical and paraclinical examinations pointed to a ruptured tubal pregnancy; hence, an emergency laparotomy was performed, and a right salpingectomy was carried out on the patient. However, a nonsignificant decline in BHCG level was observed, and histological examination revealed tubal choriocarcinoma; hence, a metastasis workup was carried out, yet no metastasis was detected. Six sessions of chemotherapy consisting of Etoposide, Methotrexate, Dactinomycin, Cyclophosphamide, and Vincristine (EMA‐CO) were administered without complication, in such a way that the BHCG level normalized after three sessions of chemotherapy. Evaluations after 1 year from the completion of chemotherapy revealed that the patient had no subsequent problems. Choriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Metastasis workup should be considered for all individuals with choriocarcinoma. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Borderline Brenner tumor of the ovary with mucinous metaplasia: A case report.
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Shiravani, Zahra, Bahrami, Samaneh, Najib, Fateme Sadat, and Alavi, Seyed Mohammad Amin
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OVARIAN tumors ,METAPLASIA ,COMPUTED tomography ,MUCINOUS adenocarcinoma ,OVARIAN cysts ,ABDOMINAL pain ,UTERINE hemorrhage - Abstract
Key Clinical Message: To date, there have been disparate reports regarding borderline forms of Brenner tumors, while research on concomitant mucinous proliferation is even more irregular; however, it has been observed that proper diagnosis and treatment have proven to have a favorable prognosis on the aforementioned tumor. Brenner tumor is a rare epithelial ovarian neoplasm responsible for 2%–3% of all ovarian tumors. These tumors are usually asymptomatic and can usually be found incidentally in pathological studies. They can also manifest themselves as abdominal pain or abnormal uterine bleeding. A 41‐year‐old female with a history of anemia referred to the hospital suffering from abdominal pain for at least 1 month before the referral period. Physical examination revealed a mobile palpable mass in the left lower abdomen. Ultrasound and pelvic computed tomography scan (CT scan) revealed a left ovarian complex cyst. Left salpingo‐oophorectomy was performed on the patient, and the cyst was removed. Pathological findings revealed an atypical proliferative Brenner tumor with mucinous metaplasia. To date, there have been disparate reports regarding borderline forms of Brenner tumors, while research on concomitant mucinous proliferation is even more irregular; however, it has been observed that proper diagnosis and treatment have proven to have a favorable prognosis on the aforementioned tumor. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Hybrid surgery of arteriovenous malformation and aneurysm of the sole.
- Author
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Nazari, Iraj, Mousavi, Seyyed Masoud, Zargar, Mohammad Amin, and Alavi, Seyed Mohammad Amin
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ARTERIOVENOUS malformation ,ARTERIOVENOUS fistula ,SURGERY ,TREATMENT effectiveness ,ANGIOGRAPHY - Abstract
Key Clinical Message: The study describes the successful treatment of a rare type of arteriovenous malformation (AVM) in the sole using hybrid surgery, which consists of open resection and embolization. Moreover, the possibility of utilizing ultrasound during examination in addition to angiography for the diagnosing of AVM of the sole is proposed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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8. Severe SARS‐CoV‐2 infection in a 32‐week pregnant woman treated with Remdesivir‐Dexamethasone combination therapy: A case report.
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Alavi, Seyed Mohammad Amin, Bahrami, Samaneh, Najafian, Mahin, and Hoori, Mina
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PREGNANT women , *SARS-CoV-2 , *REMDESIVIR , *COVID-19 , *PREMATURE labor - Abstract
This study shows that remdesivir and dexamethasone combination therapy can be considered as a suitable treatment choice for pregnant women infected with COVID‐19. It is worth mentioning that more studies are required to evaluate the efficacy and side effects of remdesivir monotherapy and its combination with dexamethasone during pregnancy. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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9. Percutaneous transluminal angioplasty with stenting for transplant renal artery stenosis at the anastomosis site in a young female patient: A case report.
- Author
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Nazari, Iraj, Zargar, Mohammad Amin, and Alavi, Seyed Mohammad Amin
- Abstract
Transplant renal artery stenosis (TRAS) is one of the major vascular complications and is mostly reported within six months following kidney transplant. The present case was a 16-year-old female whose blood urea nitrogen (BUN) and creatinine rose seven days after a kidney transplant. Ultrasound investigation revealed well-prefusion with a 90-degree angle anastomosis, apparent narrowing, and peak systolic velocity of 300 cm/s. Fourteen days after the transplant, with pre-and post-intervention hemodialysis and well hydration, an angiography with diluted iodinated contrast was done for the patient, which revealed >80 % narrowing at the anastomosis site. Percutaneous transluminal angioplasty (PTAS) with stenting was carried out for the patient, resulting in normal levels of BUN, creatinine, and urinary output. While the patient did not have any risk factors for TRAS and was young, an early stenosis occurred in her left internal iliac artery one week after the kidney transplant. Due to the lower accuracy of CO2 angiography, diluted iodinated contrast angiography with well hydration and pre- and post-intervention dialysis was preferred. Endovascular treatment was preferred by the patient and attending physician due to possible adhesion and complications of open surgery and the possibility of arterial rupture. Performing PTAS two weeks after the renal transplantation at the anastomosis site can be a treatment in patients with early TRAS. However, due to the higher risk of rupture at the anastomosis site, it should be carried out carefully and with consideration of the need for open surgery. • Diluted iodinated contrast with well hydration can be utilized for angiogram and angioplasty in patients with transplant renal artery stenosis. • Performing percutaneous transluminal angioplasty two weeks after the renal transplantation at the anastomosis site can be a treatment in patients with early transplant renal artery stenosis. • Due to the higher risk of rupture at the anastomosis site, percutaneous transluminal angioplasty should be carried out carefully and with consideration of the need for open surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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10. Pelvic arteriovenous malformation (AVM) with recurrent hematuria: A case report.
- Author
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Nazari, Iraj, Zargar, Mohammad Amin, Panahi, Pegah, and Alavi, Seyed Mohammad Amin
- Abstract
Arteriovenous malformation (AVM) leads to a direct connection between arterial and venous networks, in which capillary branches are not involved. Pelvic AVM is a benign and rare condition causing severe pain, hematuria, and rectal or vaginal bleeding. A 36-year-old woman presented with five months history of hematuria. Her medical history was unremarkable, and laboratory findings were all within normal ranges. Abdominopelvic computed tomography (CT) scan revealed a vascular mass in the left lateral pelvis that extended to the bladder neck and was suggestive of an AVM. The patient underwent a laparotomy for the resection of AVM. The first angiography revealed an AVM in the left internal iliac artery. The patient underwent embolization with coil and gel foam. The second angiography revealed complete obstruction of the left internal iliac artery due to multiple coils and AVM of the right internal iliac artery (RIIA), embolized with glue and lipiodol. A week later, venography revealed another left iliac vein malformation embolized with foam sclerotherapy. Forty days later, the third angiography revealed another AVM in the right iliac artery, embolized with three vials of polyvinyl alcohol (PVA). Following two months of follow-up, the symptoms did not return. The present study reported a rare case of recurrent pelvic AVM causing painless hematuria in a female patient. The lesion was treated with several angioembolization sessions. Angioembolization is one of the main therapeutic options for AVM. Appropriate material should be precisely chosen for AVM embolization regarding the AVM's location, size, and condition. • The present study describes the treatment of a rare type of recurrent pelvic arteriovenous malformation (AVM) using several angiography-based embolization sessions. • Angiography can be an effective diagnostic modality for pelvic AVM. • Appropriate material should be precisely chosen for AVM embolization regarding the location, size, and condition of the AVM. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
11. The therapeutic effects of berberine for gastrointestinal cancers.
- Author
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Davoodvandi A, Sadeghi S, Alavi SMA, Alavi SS, Jafari A, Khan H, Aschner M, Mirzaei H, Sharifi M, and Asemi Z
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- Humans, Berberine therapeutic use, Berberine pharmacology, Gastrointestinal Neoplasms drug therapy, Antineoplastic Agents therapeutic use
- Abstract
Cancer is one of the most serious human health issues. Drug therapy is the major common way to treat cancer. There is a growing interest in using natural compounds to overcome drug resistance, adverse reactions, and target specificity of certain types of drugs that may affect several targets with fewer side effects and be beneficial against various types of cancer. In this regard, the use of herbal medicines alone or in combination with the main anticancer drugs is commonly available. Berberine (BBR), a nature-driven phytochemical component, is a well-known nutraceutical due to its wide variety of pharmacological activities, including antioxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and hypolipidemic. In addition, BBR exerts anticancer activities. In present article, we summarized the information available on the therapeutic effects of BBR and its mechanisms on five types of the most prevalent gastrointestinal cancers, including esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers., (© 2023 The Authors. Asia‐Pacific Journal of Clinical Oncology published by John Wiley & Sons Australia, Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
12. Inhibitory effect of microRNA-21 on pathways and mechanisms involved in cardiac fibrosis development.
- Author
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Khalaji A, Mehrtabar S, Jabraeilipour A, Doustar N, Rahmani Youshanlouei H, Tahavvori A, Fattahi P, Alavi SMA, Taha SR, Fazlollahpour-Naghibi A, and Shariat Zadeh M
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- Humans, Animals, Myocardium pathology, Myocardium metabolism, Heart Diseases genetics, Heart Diseases metabolism, Heart Diseases pathology, Heart Diseases physiopathology, MicroRNAs metabolism, MicroRNAs genetics, Fibrosis, Signal Transduction
- Abstract
Cardiac fibrosis is a pivotal cardiovascular disease (CVD) process and represents a notable health concern worldwide. While the complex mechanisms underlying CVD have been widely investigated, recent research has highlighted microRNA-21's (miR-21) role in cardiac fibrosis pathogenesis. In this narrative review, we explore the molecular interactions, focusing on the role of miR-21 in contributing to cardiac fibrosis. Various signaling pathways, such as the RAAS, TGF-β, IL-6, IL-1, ERK, PI3K-Akt, and PTEN pathways, besides dysregulation in fibroblast activity, matrix metalloproteinases (MMPs), and tissue inhibitors of MMPs cause cardiac fibrosis. Besides, miR-21 in growth factor secretion, apoptosis, and endothelial-to-mesenchymal transition play crucial roles. miR-21 capacity regulatory function presents promising insights for cardiac fibrosis. Moreover, this review discusses numerous approaches to control miR-21 expression, including antisense oligonucleotides, anti-miR-21 compounds, and Notch signaling modulation, all novel methods of cardiac fibrosis inhibition. In summary, this narrative review aims to assess the molecular mechanisms of cardiac fibrosis and its essential miR-21 function.
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- 2024
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13. Prevalence of self-medication during COVID-19 pandemic: A systematic review and meta-analysis.
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Kazemioula G, Golestani S, Alavi SMA, Taheri F, Gheshlagh RG, and Lotfalizadeh MH
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- Humans, Prevalence, Pandemics, Quarantine, Students, COVID-19 epidemiology
- Abstract
Background: The COVID-19 pandemic and restrictions on travel and quarantine measures made people turn to self-medication (SM) to control the symptoms of their diseases. Different studies were conducted worldwide on different populations, and their results were different. Therefore, this global systematic review and meta-analysis was conducted to estimate the pooled prevalence of self-medication., Methods: In this systematic review and meta-analysis, databases of Scopus, PubMed, Embase, and Web of Science were searched without a time limit. All eligible observational articles that reported self-medication during the COVID-19 pandemic were analyzed. Heterogeneity among the studies was assessed using Cochran's Q test and I
2 statistics. A random-effects model was used to estimate the pooled prevalence of self-medication. The methodological quality of the articles was evaluated with the Newcastle-Ottawa Scale., Results: Fifty-six eligible studies were reviewed. The pooled prevalence of self-medication was 48.6% (95% CI: 42.8-54.3). The highest and lowest prevalence of self-medication was in Asia (53%; 95% CI: 45-61) and Europe (40.8%; 95% CI: 35-46.8). Also, the highest and lowest prevalence of self-medication was related to students (54.5; 95% CI: 40.8-68.3) and healthcare workers (32.5%; 16-49). The prevalence of self-medication in the general population (48.8%; 40.6-57) and in patients with COVID-19 (41.7%; 25.5-58). The prevalence of self-medication was higher in studies that collected data in 2021 than in 2020 (51.2 vs. 48%). Publication bias was not significant ( p = 0.320)., Conclusion: During the COVID-19 pandemic, self-medication was highly prevalent, so nearly half of the people self-medicated. Therefore, it seems necessary to provide public education to control the consequences of self-medication., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Kazemioula, Golestani, Alavi, Taheri, Gheshlagh and Lotfalizadeh.)- Published
- 2022
- Full Text
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