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Dengue is a mosquito-borne viral infection caused by dengue virus (DENV) belonging to a group of Flaviviridae. Disease is widely spread in tropical and subtropical regions of Southeast Asia, Africa and the Americas. DENV infection causes a spectrum of illness including flu-like syndrome and potentially life-threatening dengue hemorrhagic fever. Confirmation of DENV infection requires serological serum tests or detection of viral genetic material in a serum sample. There no specific treatment for dengue but symptomatic therapy should be implemented in all cases. Recently there are two modern DENV vaccines available for the people living in the countries at a risk of infection. Efficiency and safety profile of both vaccines are debatable. Dengue symptoms may imitate clinical picture of other diseases that are typical for endemic DENV regions. We present a case of 22-year-old Indonesian woman treated originally due to typhoid fever who develop the symptoms of DENV infection.

Methanol is a toxic alcohol that can imitate ethanol in smell and taste. It has many household and industrial applications but can also be present in informally-produced alcoholic beverages. Methanol poisoning feature with high mortality and may be seen due to its intentional or unintentional ingestion. Metanol does not have significant intrinsic activity but its metabolites, especially format lead to severe metabolic acidosis, visual disturbances and neurological deficit. Diagnosis is mainly based upon the typical clinical course, metabolic acidosis with high osmolar gap and detection of methanol in plasma or urine. Recent guidelines recommend therapy using the competitive alcohol dehydrogenase inhibitors - fomepizol or ethanol. In cases of severe poisoning hemodialysis should be considered. We present a case of a 39-year-old male who was considered to Emergency Department due to consumed high amount of windshield washer fluid containing methanol. Intoxicated patient was unstable with respiratory insufficiency and consciousness impairment. Despite of implemented treatment - hemodialysis, ethanol infusion and active respiratory therapy - patient died on seventh day after admission to a hospital. Methanol poisonings feature with high mortality even when the best healthcare is provided. It depends mainly on a dose of ingested alcohol and delay in admission to a hospital.

The number of Clostridium difficile infections (CDI) has significantly increased in Poland and throughout Europe. Their treatment involves the administration of metronidazole, vancomycin or fidaxomicin as indicated in current recommendations. Despite proper approach to the treatment, numerous recurrences of Clostridium difficile are reported. Fecal microflora transplant (FMT) is an alternative yet effective method of treatment of CDI. Moreover, this method is increasingly implemented in other disease entities. DESCRIPTION OF THE PROBLEM: Fecal microflora transplant (FMT) is a safe method of treating intestinal dysbiosis. The therapy is based on transferring the stool suspension from a healthy human (donor) to the patient (recipient). The transplant can be performed by oral route (through the gastric/duodenal probe) or via the rectal route (colonoscopy). The donor of the FMT material must give an informed consent to have performed numerous blood and stool tests that are included in the donor selection procedures. The day before transplant, the recipient has to take the last dose of vancomycin taken in the 14-day treatment.

Dengue is a mosquito-borne viral infection caused by dengue virus (DENV) belonging to a group of Flaviviridae. Disease is widely spread in tropical and subtropical regions of Southeast Asia, Africa and the Americas. DENV infection causes a spectrum of illness including flu-like syndrome and potentially life-threatening dengue hemorrhagic fever. Confirmation of DENV infection requires serological serum tests or detection of viral genetic material in a serum sample. There no specific treatment for dengue but symptomatic therapy should be implemented in all cases. Recently there are two modern DENV vaccines available for the people living in the countries at a risk of infection. Efficiency and safety profile of both vaccines are debatable. Dengue symptoms may imitate clinical picture of other diseases that are typical for endemic DENV regions. We present a case of 22-year-old Indonesian woman treated originally due to typhoid fever who develop the symptoms of DENV infection.

Methanol is a toxic alcohol that can imitate ethanol in smell and taste. It has many household and industrial applications but can also be present in informally-produced alcoholic beverages. Methanol poisoning feature with high mortality and may be seen due to its intentional or unintentional ingestion. Metanol does not have significant intrinsic activity but its metabolites, especially format lead to severe metabolic acidosis, visual disturbances and neurological deficit. Diagnosis is mainly based upon the typical clinical course, metabolic acidosis with high osmolar gap and detection of methanol in plasma or urine. Recent guidelines recommend therapy using the competitive alcohol dehydrogenase inhibitors - fomepizol or ethanol. In cases of severe poisoning hemodialysis should be considered. We present a case of a 39-year-old male who was considered to Emergency Department due to consumed high amount of windshield washer fluid containing methanol. Intoxicated patient was unstable with respiratory insufficiency and consciousness impairment. Despite of implemented treatment - hemodialysis, ethanol infusion and active respiratory therapy - patient died on seventh day after admission to a hospital. Methanol poisonings feature with high mortality even when the best healthcare is provided. It depends mainly on a dose of ingested alcohol and delay in admission to a hospital.

The number of Clostridium difficile infections (CDI) has significantly increased in Poland and throughout Europe. Their treatment involves the administration of metronidazole, vancomycin or fidaxomicin as indicated in current recommendations. Despite proper approach to the treatment, numerous recurrences of Clostridium difficile are reported. Fecal microflora transplant (FMT) is an alternative yet effective method of treatment of CDI. Moreover, this method is increasingly implemented in other disease entities. DESCRIPTION OF THE PROBLEM: Fecal microflora transplant (FMT) is a safe method of treating intestinal dysbiosis. The therapy is based on transferring the stool suspension from a healthy human (donor) to the patient (recipient). The transplant can be performed by oral route (through the gastric/duodenal probe) or via the rectal route (colonoscopy). The donor of the FMT material must give an informed consent to have performed numerous blood and stool tests that are included in the donor selection procedures. The day before transplant, the recipient has to take the last dose of vancomycin taken in the 14-day treatment.