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The Italian Research Evaluation assessment for the period 2004-10 (VQR 2004-10) has analyzed almost 185,000 articles, books, patents, and other scientific outcomes submitted for evaluation by Italian universities and other public research bodies. This article describes the main features of this exercise, introducing its legal framework and the criteria used for evaluation. The innovative methodology that has been used for evaluation, based on a combination of peer review and bibliometric methods, is discussed and indicators for assessing the quality of participating research bodies are derived accordingly. The article also presents the main results obtained at the University level, trying to understand the existing relationship among research quality and University characteristics such as location, dimension, age, scientific specialization, and funding. [ABSTRACT FROM AUTHOR]