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Your search keyword '"Arán, Begoña"' showing total 9 results
Start Over Author "Arán, Begoña" Publication Type Academic Journals
9 results on '"Arán, Begoña"'

8. Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene.

Author

Montero-Calle, Pilar, Flandes-Iparraguirre, María, Kuebler, Bernd, Arán, Begoña, Larequi, Eduardo, Anaut, Ilazki, Coppiello, Giulia, Aranguren, Xabier L., Veiga, Anna, Elorz, Maria Teresa Basurte, de Yébenes, Manuel García, Gavira, Juan J., Prósper, Felipe, Iglesias-García, Olalla, and Vega, Manuel M. Mazo

Abstract

Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linked to cardiac toxicity and progression toward heart failure. A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) from a patient suffering familial transthyretin amyloid cardiomyopathy carrying a c.128G>A (p.Ser43Asn) mutation in the TTR gene. This iPSC line offers a useful resource to study the disease pathophysiology and a cell-based model for therapeutic discovery. [ABSTRACT FROM AUTHOR]

Published
2023
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9. First evaluation of the European hESCreg.

Author

Borstlap, Joeri, Stacey, Glyn, Kurtz, Andreas, Elstner, Anja, Damaschun, Alexander, Arán, Begoña, and Veiga, Anna

Subjects
LETTERS to the editor, EMBRYONIC stem cells, COMPUTER network resources
Abstract

This letter to the editor discusses the European human embryonic stem cell registry (hESC), located at www.hescreg.eu.

Published
2008
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