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The article defines the main mechanisms for correction of cognitive (mental) disorders in elderly and senile patients with fractures of the proximal thigh (FPT) and existing cognitive disorders (CD) and emotional disturbances (ED) of anxiety and depression spectrum. The aetiological characteristics of existing cognitive impairment (CI) (vascular or other genesis) in treated patients with the help of the Modified Hachinski Ischemic Scale (Hachinski et al.) Were studied using the MMSE and the battery of tests for Frontal Assessment Battery (FAB) assesses the degree of disturbance, possible areas of brain damage, and the dynamics of changes in CI through the effect of medicated correction of CI and ED. According to the results obtained in the study, it was ascertained that as a result of the correction of CD and ED of anxiety-depressive spectrum in patients with FPT and manifestations of CD and ED in the group of patients who received medication correction of CI and ED (CDa) improved cognitive abilities; reduction of objective manifestations of memory impairment and/or certain cognitive functions, significant improvement of daily activity with some restoration of existing disorders of complex activities and reduction of manifestations of dementia violations. At the same time, the psychological changes that occurred under the influence of emotional «stress traumatic» influences (surgical treatment) were significantly leveled, which was characterized by a decrease in the overall increased vulnerability of patients, their vulnerability and irritability, a significant decrease in the «affective» concentration of attention on their illness and the need for surgical interference, etc. Among them there was a significant increase in the mood and overall emotional background (compared with the period of admission to the hospital), the emergence of optimistic orientation, decrease (or complete absence) of signs of anxiety and fear and agitation. On the other hand, among the patients in the CDb, there was a deterioration of the existing CD and ED, increased general vulnerability and irritability, «affective» concentration of attention on their problem, in some – short-term psychotic loss of the auto-and alo-mental orientation, the appearance of suicidal thoughts and auto-aggressive manifestations. Also, the overall emotional background deteriorated, the mood was much worse, pessimistic orientation of the emotional background, dissatisfaction with surrounding events and individuals were observed; increased manifestations of anxiety and fear and agitation.

The chronic consumption of mycotoxin-contaminated forage tends to the weight loss of young cattle, decreasing the reproductive success of adult animals, milk yield, and tolerance to high temperatures. The aim of this paper was to study the effects of the SNP C994G in the CYP3A28 gene on the productive and reproductive characteristics of dairy and beef breeds. Cows were measured by body weight dynamics, exterior, reproduction, milk production traits, bone mineral density, bulls were analyzed estimating their progeny traits. Dairy cows received dietary betaine supplement with the measurement of homocysteine levels. Molecular genetic was performed by PCR-RFLP method. The effects of SNP C994G were shown in relation to the udder size, the constitution and birth weight of Abredin-Angus cows, as well as the fat and protein content of Ukrainian Red-and-White Dairy cows milk. The higher sensitivity of the GG genotype to less homocysteine level after the addition of betaine was shown. Given the identified correspondence, pleiotropic effects of CYP3A28 gene can be concluded. A microscopic analysis of forage supported the findings in relation to greater efficiency of the CC genotype under conditions of low mycotoxins contamination, to which CYP3A28 is selective. [ABSTRACT FROM AUTHOR]