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Your search keyword '"Cai, Weibo"' showing total 855 results
Start Over Author "Cai, Weibo" Publication Type Academic Journals
855 results on '"Cai, Weibo"'

9. Nanomaterial-based contrast agents

Author

Hsu, Jessica C., Tang, Zhongmin, Eremina, Olga E., Sofias, Alexandros Marios, Lammers, Twan, Lovell, Jonathan F., Zavaleta, Cristina, Cai, Weibo, and Cormode, David P.

Published
2023
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31. More than meets the eye: 2-[18F]FDG PET-based radiomics predicts lymph node metastasis in colorectal cancer patients to enable precision medicine.

Author

Huang, Wenpeng, Son, Mai Hong, Ha, Le Ngoc, Kang, Lei, and Cai, Weibo

Subjects
RADIOMICS, LYMPHATIC metastasis, COLORECTAL cancer, INDIVIDUALIZED medicine, EYE tracking, METASTASIS, MEDICAL equipment
Abstract

This article discusses the use of radiomics, a method that involves extracting imaging features from radiologic images, to predict lymph node metastasis (LNM) in colorectal cancer (CRC) patients. The study found that radiomics analysis using 2-[18F]FDG PET-based imaging was more effective in predicting LNM compared to traditional CT and PET reports. The study also highlighted the need for standardization in radiomics workflow and the development of automated segmentation tools. While promising, further research and validation in larger clinical trials are needed before radiomics can be integrated into routine clinical practice. [Extracted from the article]

Published
2024
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32. Brachytherapy at the nanoscale with protein functionalized and intrinsically radiolabeled [169Yb]Yb2O3 nanoseeds.

Author

Ghosh, Sanchita, Patra, Sourav, Younis, Muhsin H., Chakraborty, Avik, Guleria, Apurav, Gupta, Santosh K., Singh, Khajan, Rakhshit, Sutapa, Chakraborty, Sudipta, Cai, Weibo, and Chakravarty, Rubel

Subjects
LUNGS, RADIOISOTOPE brachytherapy, COMPUTED tomography, NEUTRON irradiation, NUCLEAR reactors, TUMOR growth, ARACHNOID cysts
Abstract

Purpose: Classical brachytherapy of solid malignant tumors is an invasive procedure which often results in an uneven dose distribution, while requiring surgical removal of sealed radioactive seed sources after a certain period of time. To circumvent these issues, we report the synthesis of intrinsically radiolabeled and gum Arabic glycoprotein functionalized [169Yb]Yb2O3 nanoseeds as a novel nanoscale brachytherapy agent, which could directly be administered via intratumoral injection for tumor therapy. Methods: 169Yb (T½ = 32 days) was produced by neutron irradiation of enriched (15.2% in 168Yb) Yb2O3 target in a nuclear reactor, radiochemically converted to [169Yb]YbCl3 and used for nanoparticle (NP) synthesis. Intrinsically radiolabeled NP were synthesized by controlled hydrolysis of Yb3+ ions in gum Arabic glycoprotein medium. In vivo SPECT/CT imaging, autoradiography, and biodistribution studies were performed after intratumoral injection of radiolabeled NP in B16F10 tumor bearing C57BL/6 mice. Systematic tumor regression studies and histopathological analyses were performed to demonstrate therapeutic efficacy in the same mice model. Results: The nanoformulation was a clear solution having high colloidal and radiochemical stability. Uniform distribution and retention of the radiolabeled nanoformulation in the tumor mass were observed via SPECT/CT imaging and autoradiography studies. In a tumor regression study, tumor growth was significantly arrested with different doses of radiolabeled NP compared to the control and the best treatment effect was observed with ~ 27.8 MBq dose. In histopathological analysis, loss of mitotic cells was apparent in tumor tissue of treated groups, whereas no significant damage in kidney, lungs, and liver tissue morphology was observed. Conclusions: These results hold promise for nanoscale brachytherapy to become a clinically practical treatment modality for unresectable solid cancers. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Nuclear medicine radiomics in digestive system tumors: Concept, applications, challenges, and future perspectives.

Author

Huang, Wenpeng, Tao, Zihao, Younis, Muhsin H., Cai, Weibo, and Kang, Lei

Subjects
RADIOMICS, DIGESTIVE organs, NUCLEAR medicine, IMAGE analysis, ARTIFICIAL intelligence
Abstract

Radiomics aims to develop novel biomarkers and provide relevant deeper subvisual information about pathology, immunophenotype, and tumor microenvironment. It uses automated or semiautomated quantitative analysis of high‐dimensional images to improve characterization, diagnosis, and prognosis. Recent years have seen a rapid increase in radiomics applications in nuclear medicine, leading to some promising research results in digestive system oncology, which have been driven by big data analysis and the development of artificial intelligence. Although radiomics advances one step further toward the non‐invasive precision medical analysis, it is still a step away from clinical application and faces many challenges. This review article summarizes the available literature on digestive system tumors regarding radiomics in nuclear medicine. First, we describe the workflow and steps involved in radiomics analysis. Subsequently, we discuss the progress in clinical application regarding the utilization of radiomics for distinguishing between various diseases and evaluating their prognosis, and demonstrate how radiomics advances this field. Finally, we offer our viewpoint on how the field can progress by addressing the challenges facing clinical implementation. [ABSTRACT FROM AUTHOR]

Published
2023
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