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559 results on '"Carmona, Manuel"'

2. Embodied Learning for Well-Being, Self-Awareness, and Stress Regulation: A Randomized Trial with Engineering Students Using a Mixed-Method Approach

Author

Rodríguez-Jiménez, Rosa-María, Carmona, Manuel, García-Merino, Sonia, Díaz-Ureña, Germán, and Lara Bercial, Pedro J.

Abstract

The continuous changes in our society require adapted training that encompasses both technical and competency knowledge. There is a high level of demand, especially in areas such as engineering, which can affect the mental health of students, producing high levels of stress and psychological distress, hindering self-efficacy and academic performance. Embodied learning working on self-awareness, stress reduction and self-knowledge can help to generate healthier environments. Creative therapies can be a tool to promote the prevention of health problems in this group of the population. In particular, Dance Movement Therapy has demonstrated its effectiveness in improving health in clinical and non-clinical settings. In this work, a body awareness program based on Dance Movement Therapy is developed and implemented in engineering students. Through a mixed pre-post methodology, its impact is evaluated and analyzed in an experimental group of engineering students. Psychometric tests, physiological variables and reflective diaries are used as data sources. The results show that the experimental group, compared with the control group, increased their levels of body awareness and connectedness, well-being and life satisfaction and reduced their stress levels. The results were supported by cortisol measures. Likewise, the students acknowledged having increased their levels of self-awareness and self-knowledge and considered the inclusion of these bodily approaches in higher education to be necessary.

Published
2022

3. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome.

Author

Rensing-Ehl, Anne, Neven, Bénédicte, Hadjadj, Jérôme, Hambleton, Sophie, Ronan Leahy, Timothy, Meesilpavikai, Kornvalee, Cunningham-Rundles, Charlotte, Dutmer, Cullen, Sharapova, Svetlana, Taskinen, Mervi, Chua, Ignatius, Hague, Rosie, Klemann, Christian, Kostyuchenko, Larysa, Morio, Tomohiro, Thatayatikom, Akaluck, Ozen, Ahmet, Scherbina, Anna, Bauer, Cindy, Flanagan, Sarah, Gambineri, Eleonora, Giovannini-Chami, Lisa, Heimall, Jennifer, Sullivan, Kathleen, Allenspach, Eric, Romberg, Neil, Deane, Sean, Prince, Benjamin, Rose, Melissa, Bohnsack, John, Mousallem, Talal, Jesudas, Rohith, Santos Vilela, Maria, OSullivan, Michael, Pachlopnik Schmid, Jana, Průhová, Štěpánka, Klocperk, Adam, Rees, Matthew, Su, Helen, Bahna, Sami, Baris, Safa, Bartnikas, Lisa, Chang Berger, Amy, Briggs, Tracy, Brothers, Shannon, Bundy, Vanessa, Grunebaum, Eyal, Haapaniemi, Emma, Hämäläinen, Sari, Heiskanen, Kaarina, Heiskanen-Kosma, Tarja, Hoffman, Hal, Gonzalez-Granado, Luis, Guerrerio, Anthony, Kainulainen, Leena, Kumar, Ashish, Lawrence, Monica, Levin, Carina, Martelius, Timi, Neth, Olaf, Olbrich, Peter, Palma, Alejandro, Patel, Niraj, Pozos, Tamara, Preece, Kahn, Lugo Reyes, Saúl, Russell, Mark, Schejter, Yael, Seroogy, Christine, Sinclair, Jan, Skevofilax, Effie, Suan, Daniel, Suez, Daniel, Szabolcs, Paul, Velasco, Helena, Warnatz, Klaus, Walkovich, Kelly, Worth, Austen, Seppänen, Mikko, Torgerson, Troy, Sogkas, Georgios, Ehl, Stephan, Tangye, Stuart, Cooper, Megan, Milner, Joshua, Forbes Satter, Lisa, Leiding, Jennifer, Vogel, Tiphanie, Santarlas, Valentine, Mhaskar, Rahul, Smith, Madison, Carisey, Alexandre, Vargas-Hernández, Alexander, Silva-Carmona, Manuel, Chandrakasan, Shanmuganathan, Christiansen, Mette, Cole, Theresa, Cook, Matthew, Desai, Mukesh, and Fischer, Ute

Subjects
STAT3, autoimmunity, cytopenia, gain of function, immune dysregulation, immunodeficiency, lymphoproliferation, precision medicine, Child, Humans, Autoimmunity, Cohort Studies, Gain of Function Mutation, Immune System Diseases, Immunologic Deficiency Syndromes, Mutation, STAT3 Transcription Factor, Cell Proliferation, Lymphocytes
Abstract

BACKGROUND: In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-of-function (GOF) mutations were first described to cause a novel multisystem disease of early-onset lymphoproliferation and autoimmunity. OBJECTIVE: This pivotal cohort study defines the scope, natural history, treatment, and overall survival of a large global cohort of patients with pathogenic STAT3 GOF variants. METHODS: We identified 191 patients from 33 countries with 72 unique mutations. Inclusion criteria included symptoms of immune dysregulation and a biochemically confirmed germline heterozygous GOF variant in STAT3. RESULTS: Overall survival was 88%, median age at onset of symptoms was 2.3 years, and median age at diagnosis was 12 years. Immune dysregulatory features were present in all patients: lymphoproliferation was the most common manifestation (73%); increased frequencies of double-negative (CD4-CD8-) T cells were found in 83% of patients tested. Autoimmune cytopenias were the second most common clinical manifestation (67%), followed by growth delay, enteropathy, skin disease, pulmonary disease, endocrinopathy, arthritis, autoimmune hepatitis, neurologic disease, vasculopathy, renal disease, and malignancy. Infections were reported in 72% of the cohort. A cellular and humoral immunodeficiency was observed in 37% and 51% of patients, respectively. Clinical symptoms dramatically improved in patients treated with JAK inhibitors, while a variety of other immunomodulatory treatment modalities were less efficacious. Thus far, 23 patients have undergone bone marrow transplantation, with a 62% survival rate. CONCLUSION: STAT3 GOF patients present with a wide array of immune-mediated disease including lymphoproliferation, autoimmune cytopenias, and multisystem autoimmunity. Patient care tends to be siloed, without a clear treatment strategy. Thus, early identification and prompt treatment implementation are lifesaving for STAT3 GOF syndrome.

Published
2023

4. A Rationale for Teacher Change from a Bodyfulness Paradigm: An Experience in Higher Education

Author

Rodríguez-Jiménez, Rosa-María and Carmona, Manuel

Abstract

This article presents an exploratory and interpretative study on the development of self-reflection and self-knowledge in university teachers by an embodied experience. Dance Movement Therapy and Body-Mind Centering share the fundamentals of the paradigm of embodied cognition through a first-person full-body experience. Using these principles, a training program was designed and implemented in a cohort of 22 university teachers. The article offers details of the program and the adaptations necessary to carry it out in a higher-education context. The results of the qualitative analysis that was conducted suggested that the transformative learning paradigm could be useful to explain the process carried out by the participants. With the necessary limitations, the incorporation of awareness and attentive participation in bodily states and actions manifests as a transformative element in the teacher. The participants, despite initial resistance, see possibilities for applying this knowledge in their teaching practice.

Published
2021

6. Results of the COVID-19 mental health international for the health professionals (COMET-HP) study: depression, suicidal tendencies and conspiracism

Author

N. Fountoulakis, Konstantinos, N. Karakatsoulis, Grigorios, Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Cabrera Abud, Indira Indiana, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, de Berardis, Domenico, Zamora Delgado, Sergio, de Lucena, David, de Sousa, Avinash, di Stefano, Ramona, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Paz, Gonda, Xenia, Gondek, Tomasz M., Morera González, Daniela, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, Tasdik M., Azreen Hashim, Nurul, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Yilmaz Kafali, Helin, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kopishinskaia, Svetlana, Kosenko, Korneliia, Koupidis, Sotirios A., Kovacs, Illes, Kulig, Barbara, Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Iqbal Malik, Najma, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Meza Martínez, Xarah Elenne, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Pinto da Costa, Mariana, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Vargas Ramírez, Francisca, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Reyes Flores, Elena Ninoska, Rivera-Encinas, María Teresa, Saiz, Pilar A., Sánchez de Carmona, Manuel, Saucedo Martínez, David, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva-Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vrublevska, Jelena, Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, Prezerakos, Panagiotis E., Berk, Michael, Levaj, Sarah, and Smirnova, Daria

Published
2023
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8. Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study

Author

Fountoulakis, Konstantinos N., Vrublevska, Jelena, Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Berk, Michael, Bjedov, Sarah, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Abud, Indira Indiana Cabrera, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, De Berardis, Domenico, Delgado, Sergio Zamora, De Lucena, David, De Sousa, Avinash, Di Stefano, Ramona, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Maria Paz, Gonda, Xenia, Gondek, Tomasz M., González, Daniela Morera, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, Tasdik M., Hashim, Nurul Azreen, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Kafali, Helin Yilmaz, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kosenko, Korneliia, Koupidis, Sotirios A., Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Malik, Najma Iqbal, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Martínez, Xarah Elenne Meza, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Da Costa, Mariana Pinto, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Ramírez, Francisca Vargas, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Flores, Elena Ninoska Reyes, Rivera-Encinas, María Teresa, Saiz, Pilar, de Carmona, Manuel Sánchez, Martínez, David Saucedo, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, and Smirnova, Daria

Published
2024
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20. The effect of different degrees of lockdown and self-identified gender on anxiety, depression and suicidality during the COVID-19 pandemic: Data from the international COMET-G study.

Author

Fountoulakis, Konstantinos N., Karakatsoulis, Grigorios N., Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Berk, Michael, Bjedov, Sarah, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Abud, Indira Indiana Cabrera, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, De Berardis, Domenico, Delgado, Sergio Zamora, De Lucena, David, De Sousa, Avinash, Stefano, Ramona Di, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Maria Paz, Gonda, Xenia, Gondek, Tomasz M., González, Daniela Morera, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, Tasdik M., Hashim, Nurul Azreen, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Kafali, Helin Yilmaz, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kopishinskaia, Svetlana, Kosenko, Korneliia, Koupidis, Sotirios A., Kovacs, Illes, Kulig, Barbara, Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Malik, Najma Iqbal, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Martínez, Xarah Elenne Meza, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Da Costa, Mariana Pinto, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Ramírez, Francisca Vargas, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Flores, Elena Ninoska Reyes, Rivera-Encinas, María Teresa, Saiz, Pilar, de Carmona, Manuel Sánchez, Martínez, David Saucedo, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vrublevska, Jelena, Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, Prezerakos, Panagiotis E., and Smirnova, Daria

Published
2022
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22. Results of the COVID-19 mental health international for the general population (COMET-G) study

Author

Fountoulakis, Konstantinos N, Karakatsoulis, Grigorios, Abraham, Seri, Adorjan, Kristina, Ahmed, Helal Uddin, Alarcón, Renato D., Arai, Kiyomi, Auwal, Sani Salihu, Berk, Michael, Bjedov, Sarah, Bobes, Julio, Bobes-Bascaran, Teresa, Bourgin-Duchesnay, Julie, Bredicean, Cristina Ana, Bukelskis, Laurynas, Burkadze, Akaki, Abud, Indira Indiana Cabrera, Castilla-Puentes, Ruby, Cetkovich, Marcelo, Colon-Rivera, Hector, Corral, Ricardo, Cortez-Vergara, Carla, Crepin, Piirika, De Berardis, Domenico, Zamora Delgado, Sergio, De Lucena, David, De Sousa, Avinash, Stefano, Ramona Di, Dodd, Seetal, Elek, Livia Priyanka, Elissa, Anna, Erdelyi-Hamza, Berta, Erzin, Gamze, Etchevers, Martin J., Falkai, Peter, Farcas, Adriana, Fedotov, Ilya, Filatova, Viktoriia, Fountoulakis, Nikolaos K., Frankova, Iryna, Franza, Francesco, Frias, Pedro, Galako, Tatiana, Garay, Cristian J., Garcia-Álvarez, Leticia, García-Portilla, Maria Paz, Gonda, Xenia, Gondek, Tomasz M., González, Daniela Morera, Gould, Hilary, Grandinetti, Paolo, Grau, Arturo, Groudeva, Violeta, Hagin, Michal, Harada, Takayuki, Hasan, M. Tasdik, Hashim, Nurul Azreen, Hilbig, Jan, Hossain, Sahadat, Iakimova, Rossitza, Ibrahim, Mona, Iftene, Felicia, Ignatenko, Yulia, Irarrazaval, Matias, Ismail, Zaliha, Ismayilova, Jamila, Jacobs, Asaf, Jakovljević, Miro, Jakšić, Nenad, Javed, Afzal, Kafali, Helin Yilmaz, Karia, Sagar, Kazakova, Olga, Khalifa, Doaa, Khaustova, Olena, Koh, Steve, Kopishinskaia, Svetlana, Kosenko, Korneliia, Koupidis, Sotirios A., Kovacs, Illes, Kulig, Barbara, Lalljee, Alisha, Liewig, Justine, Majid, Abdul, Malashonkova, Evgeniia, Malik, Khamelia, Malik, Najma Iqbal, Mammadzada, Gulay, Mandalia, Bilvesh, Marazziti, Donatella, Marčinko, Darko, Martinez, Stephanie, Matiekus, Eimantas, Mejia, Gabriela, Memon, Roha Saeed, Martínez, Xarah Elenne Meza, Mickevičiūtė, Dalia, Milev, Roumen, Mohammed, Muftau, Molina-López, Alejandro, Morozov, Petr, Muhammad, Nuru Suleiman, Mustač, Filip, Naor, Mika S., Nassieb, Amira, Navickas, Alvydas, Okasha, Tarek, Pandova, Milena, Panfil, Anca-Livia, Panteleeva, Liliya, Papava, Ion, Patsali, Mikaella E., Pavlichenko, Alexey, Pejuskovic, Bojana, Pinto Da Costa, Mariana, Popkov, Mikhail, Popovic, Dina, Raduan, Nor Jannah Nasution, Ramírez, Francisca Vargas, Rancans, Elmars, Razali, Salmi, Rebok, Federico, Rewekant, Anna, Flores, Elena Ninoska Reyes, Rivera-Encinas, María Teresa, Saiz, Pilar, de Carmona, Manuel Sánchez, Martínez, David Saucedo, Saw, Jo Anne, Saygili, Görkem, Schneidereit, Patricia, Shah, Bhumika, Shirasaka, Tomohiro, Silagadze, Ketevan, Sitanggang, Satti, Skugarevsky, Oleg, Spikina, Anna, Mahalingappa, Sridevi Sira, Stoyanova, Maria, Szczegielniak, Anna, Tamasan, Simona Claudia, Tavormina, Giuseppe, Tavormina, Maurilio Giuseppe Maria, Theodorakis, Pavlos N., Tohen, Mauricio, Tsapakis, Eva Maria, Tukhvatullina, Dina, Ullah, Irfan, Vaidya, Ratnaraj, Vega-Dienstmaier, Johann M., Vrublevska, Jelena, Vukovic, Olivera, Vysotska, Olga, Widiasih, Natalia, Yashikhina, Anna, Prezerakos, Panagiotis E., and Smirnova, Daria

Published
2022
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25. Harnessing the potential of community-based participatory research approaches in bipolar disorder

Author

Michalak, Erin E, Jones, Steven, Lobban, Fiona, Algorta, Guillermo Perez, Barnes, Steven J, Berk, Lesley, Berk, Michael, Hole, Rachelle, Lapsley, Sara, Maxwell, Victoria, Milev, Roumen, McManamy, John, Murray, Greg, Tohen, Mauricio, Tse, Samson, Sanchez de Carmona, Manuel, Johnson, Sheri L, The ISBD Taskforce on Community Engagement, and CREST.BD

Subjects
Health Services and Systems, Public Health, Health Sciences, Bipolar Disorder, Clinical Research, Serious Mental Illness, Brain Disorders, Mental Health, Behavioral and Social Science, Health Services, Good Health and Well Being, Bipolar disorder, Community-based participatory research, Research methods, Knowledge translation, ISBD Taskforce on Community Engagement, CREST.BD, Clinical Sciences, Clinical sciences, Health services and systems
Abstract

BackgroundDespite the rapid growth in the sophistication of research on bipolar disorder (BD), the field faces challenges in improving quality of life (QoL) and symptom outcomes, adapting treatments for marginalized communities, and disseminating research insights into real-world practice. Community-based participatory research (CBPR)-research that is conducted as a partnership between researchers and community members-has helped address similar gaps in other health conditions. This paper aims to improve awareness of the potential benefits of CBPR in BD research.MethodsThis paper is a product of the International Society for Bipolar Disorders (ISBD) Taskforce on Community Engagement which includes academic researchers, healthcare providers, people with lived experience of BD, and stakeholders from BD community agencies. Illustrative examples of CBPR in action are provided from two established centres that specialize in community engagement in BD research: the Collaborative RESearch Team to study psychosocial issues in BD (CREST.BD) in Canada, and the Spectrum Centre for Mental Health Research in the United Kingdom.Results and discussionWe describe the philosophy of CBPR and then introduce four core research areas the BD community has prioritized for research: new treatment approaches, more comprehensive outcome assessments, tackling stigma, and enhanced understanding of positive outcomes. We then describe ways in which CBPR is ideal for advancing each of these research areas and provide specific examples of ways that CBPR has already been successfully applied in these areas. We end by noting potential challenges and mitigation strategies in the application of CBPR in BD research.ConclusionsWe believe that CBPR approaches have significant potential value for the BD research community. The observations and concerns of people with BD, their family members, and supports clearly represent a rich source of information. CBPR approaches provide a collaborative, equitable, empowering orientation to research that builds on the diversity of strengths amongst community stakeholders. Despite the potential merits of this approach, CBPR is as yet not widely used in the BD research field, representing a missed opportunity.

Published
2016

27. Wavelet-based temporal models of human activity for anomaly detection in smart robot-assisted environments1.

Author

Fernandez-Carmona, Manuel, Mghames, Sariah, and Bellotto, Nicola

Subjects
HUMAN activity recognition, ANOMALY detection (Computer security), INTELLIGENT sensors, CONGREGATE housing, WAVELET transforms, HUMAN ecology
Abstract

Detecting anomalies in patterns of sensor data is important in many practical applications, including domestic activity monitoring for Active Assisted Living (AAL). How to represent and analyse these patterns, however, remains a challenging task, especially when data is relatively scarce and an explicit model is required to be fine-tuned for specific scenarios. This paper, therefore, presents a new approach for temporal modelling of long-term human activities with smart-home sensors, which is used to detect anomalous situations in a robot-assisted environment. The model is based on wavelet transforms and used to forecast smart sensor data, providing a temporal prior to detect unexpected events in human environments. To this end, a new extension of Hybrid Markov Logic Networks has been developed that merges different anomaly indicators, including activities detected by binary sensors, expert logic rules, and wavelet-based temporal models. The latter in particular allows the inference system to discover deviations from long-term activity patterns, which cannot be detected by simpler frequency-based models. Two new publicly available datasets were collected using several smart-sensors to evaluate the approach in office and domestic scenarios. The experimental results demonstrate the effectiveness of the proposed solutions and their successful deployment in complex human environments, showing their potential for future smart-home and robot integrated services. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Immunomodulatory activity of argentatins A and B isolated from guayule.

Author

Silva-Nolasco, Aniela M., de la Cruz-Morcillo, Miguel A., García-Martínez, M. Mercedes, Zalacain, Amaya, Gálvez, Beatriz G., and Carmona, Manuel

Subjects
TH2 cells, HUMAN stem cells, INSECT growth, MESENCHYMAL stem cells, IMMUNE response
Abstract

Argentatins are secondary metabolites synthesized by guayule (Parthenium argentatum A. Gray) with numerous potential medical applications. In addition to inhibiting insect growth, they are endowed with several pharmacological properties including antimicrobial and antitumorigenic activity. However, their potential as immunomodulators remains unexplored. The aim of the present study was to investigate whether argentatins can modulate the function of the immune system. Human mesenchymal stem cells were treated with argentatins and the production of several anti- and proinflammatory cytokines was evaluated. The effect of argentatins on the polarization of CD4+ T-lymphocytes and macrophages was also assessed. Results demonstrated that argentatins can modulate the production of proinflammatory cytokines and the polarization of cellular phenotypes, including Th2 lymphocytes and M1 macrophages. These findings suggest that argentatins are promising therapeutic agents in autoimmune or allergic diseases, and open new perspectives for the investigation of argentatins in immune response and in the development of more targeted and effective immunomodulatory therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Evaluating Guayule (Parthenium argentatum A. Gray) Germplasm Grown in Spain: Rubber and Resin along Three Production Cycles.

Author

Jara, Francisco Miguel, García-Martínez, María de las Mercedes, López-Córcoles, Horacio, Carrión, María Engracia, Zalacain, Amaya, and Carmona, Manuel

Subjects
GERMPLASM, ALTERNATIVE crops, RUBBER, CROPS, INDUSTRIAL management
Abstract

Rubber and resin are potentially important products of guayule (Parthenium argentatum A. Gray) that can assure the profitability of this crop as an agricultural alternative for the semi-arid areas of central and eastern Spain. This study analyzes, for the first time, the changes in rubber and resin production across 27 guayule accessions (traditional and modern) and along three cycles under the agroclimatic conditions of Castilla-La Mancha, simulating industrial management with a biannual harvest. The rubber content (% of dry mass) increased from 4.2% in one-year-old plants to 6.6% in two-year-old plants, but decreased after harvesting. Contrastingly, the rubber yield doubled in contiguous sampling, reaching a mean of 303.6 kg ha−1, with a maximum yield of 341.2 kg ha−1 after the first harvest. Three patterns of rubber production were established based on the production periods. A similar analysis was performed for resin production, which was heterogeneous across accessions belonging to the same rubber groups. In this case, three independent groups were established to classify the resin accumulation profiles following the same criteria of production periods. Here, we demonstrate that biannual harvesting has the potential to enhance rubber accumulation in summer, although more research is needed for its adaption to current harvesting techniques in this area. [ABSTRACT FROM AUTHOR]

Published
2024
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36. PD-1 blockade induces responses by inhibiting adaptive immune resistance

Author

Tumeh, Paul C, Harview, Christina L, Yearley, Jennifer H, Shintaku, I Peter, Taylor, Emma JM, Robert, Lidia, Chmielowski, Bartosz, Spasic, Marko, Henry, Gina, Ciobanu, Voicu, West, Alisha N, Carmona, Manuel, Kivork, Christine, Seja, Elizabeth, Cherry, Grace, Gutierrez, Antonio J, Grogan, Tristan R, Mateus, Christine, Tomasic, Gorana, Glaspy, John A, Emerson, Ryan O, Robins, Harlan, Pierce, Robert H, Elashoff, David A, Robert, Caroline, and Ribas, Antoni

Subjects
Aging, Parkinson's Disease, Neurosciences, Brain Disorders, Cancer, Neurodegenerative, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Adaptive Immunity, Aged, Aged, 80 and over, Biomarkers, CD8-Positive T-Lymphocytes, Cell Proliferation, Female, Gene Expression Regulation, Neoplastic, Humans, Immunotherapy, Male, Melanoma, Middle Aged, Models, Biological, Multivariate Analysis, Programmed Cell Death 1 Receptor, Treatment Outcome, General Science & Technology
Abstract

Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by which cancer tissues limit the host immune response is via upregulation of PD-1 ligand (PD-L1) and its ligation to PD-1 on antigen-specific CD8(+) T cells (termed adaptive immune resistance). Here we show that pre-existing CD8(+) T cells distinctly located at the invasive tumour margin are associated with expression of the PD-1/PD-L1 immune inhibitory axis and may predict response to therapy. We analysed samples from 46 patients with metastatic melanoma obtained before and during anti-PD-1 therapy (pembrolizumab) using quantitative immunohistochemistry, quantitative multiplex immunofluorescence, and next-generation sequencing for T-cell antigen receptors (TCRs). In serially sampled tumours, patients responding to treatment showed proliferation of intratumoral CD8(+) T cells that directly correlated with radiographic reduction in tumour size. Pre-treatment samples obtained from responding patients showed higher numbers of CD8-, PD-1- and PD-L1-expressing cells at the invasive tumour margin and inside tumours, with close proximity between PD-1 and PD-L1, and a more clonal TCR repertoire. Using multivariate analysis, we established a predictive model based on CD8 expression at the invasive margin and validated the model in an independent cohort of 15 patients. Our findings indicate that tumour regression after therapeutic PD-1 blockade requires pre-existing CD8(+) T cells that are negatively regulated by PD-1/PD-L1-mediated adaptive immune resistance.

Published
2014

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