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The continuous development of Educational Data Mining (EDM) and Learning Analytics (LA) technologies has provided more effective technical support for accurate early warning and interventions for student academic performance. However, the existing body of research on EDM and LA needs more empirical studies that provide feedback interventions, and more attention should be paid to primary and secondary school students. This study proposed a data-driven precision teaching intervention mechanism combining EDM and LA technologies. The proposed mechanism aims to assist teachers in predicting students' academic performance and implementing corresponding interventions. This approach enables early warnings and reminders for students in crisis, and offers teaching assistance and support tailored to students at different levels. A quasi-experimental design was employed to examine the impact of the data-driven precision teaching intervention mechanism on secondary school students' learning outcomes. A total of 142 seventh-grade students participated in the intervention experiment, with an experimental group (50) receiving the data-driven precision teaching intervention, control group2 (48) receiving a group intervention stratified by teacher experience, and control group1 (44) receiving a traditional group intervention. Posttest data were collected after three rounds of intervention. Compared to the two control groups, students in the experimental group demonstrated superior academic achievement, intrinsic motivation, self-efficacy, and meta-cognitive awareness. These findings indicate that the data-driven precision teaching intervention approach positively impacted students' academic development, and effectively promoted their personalized learning. The findings provide pedagogical insights into the application of EDM in conjunction with LA prediction and actionable interventions.

Divergence of cis-regulatory elements drives species-specific traits1, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains unclear. Here we investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset and mouse using single-cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome and chromosomal conformation profiles from a total of over 200,000 cells. From these data, we show evidence that divergence of transcription factor expression corresponds to species-specific epigenome landscapes. We find that conserved and divergent gene regulatory features are reflected in the evolution of the three-dimensional genome. Transposable elements contribute to nearly 80% of the human-specific candidate cis-regulatory elements in cortical cells. Through machine learning, we develop sequence-based predictors of candidate cis-regulatory elements in different species and demonstrate that the genomic regulatory syntax is highly preserved from rodents to primates. Finally, we show that epigenetic conservation combined with sequence similarity helps to uncover functional cis-regulatory elements and enhances our ability to interpret genetic variants contributing to neurological disease and traits.

We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure of Paired-Tag has hindered its general adoption in the community. To address this bottleneck, we developed a droplet-based Paired-Tag protocol that is faster and more accessible than the previous method. Using cultured mammalian cells and primary brain tissues, we demonstrate its superior performance at identifying candidate cis-regulatory elements and associating their dynamic chromatin state to target gene expression in each constituent cell type in a complex tissue.

Abstract The effectiveness and longevity of IoT infrastructures heavily depend on the limitations posed by communication, multi-hop data transfers, and the inherent difficulties of wireless links. In dealing with these challenges, routing, and data transmission procedures are critical. Among the fundamental concerns are the attainment of energy efficiency and an ideal distribution of loads among sensing devices, given the restricted energy resources at the disposal of IoT devices. To meet these challenges, the present research suggests a novel hybrid energy-aware IoT routing approach that mixes the Particle Swarm Optimization (PSO) algorithm and fuzzy clustering. The approach begins with a fuzzy clustering algorithm to initially group sensor nodes by their geographical location and assign them to clusters determined by a certain probability. The proposed method includes a fitness function considering energy consumption and distance factors. This feature guides the optimization process and aims to balance energy efficiency and data transmission distance. The hierarchical topology uses the advanced PSO algorithm to identify the cluster head nodes. The MATLAB simulator shows that our method outperforms previous approaches. Various metrics have demonstrated significant improvements over DEEC and LEACH. The method reduces energy consumption by 52% and 16%, improves throughput by 112% and 10%, increases packet delivery rates by 83% and 15%, and extends the network lifespan by 48% and 27%, respectively, compared to DEEC and LEACH approaches.

Research Findings: This study examined whether physical coercion and psychological control by mothers and fathers can influence preschoolers' use of physical and relational aggression, and whether the relations are moderated by children's effortful control in a Hong Kong Chinese sample. Data were collected from a sample of 168 children (88 girls; M = 60.97 months, SD = 5.51 months) and their parents twice, six months apart. At Time 1, mothers and fathers reported on their spouse's, as well as their own use of physical coercion and psychological control, and a puzzle box task was administered to assess child effortful control. At Time 2, mothers, fathers, and teachers completed questionnaires to assess child physical and relational aggression. Results show that mothers' physical coercion was associated with child physical and relational aggression. In contrast, fathers' physical coercion was significantly related to child physical aggression but its relation with child relational aggression was not statistically significant, and both these two associations were moderated by effortful control. Practice or Policy: These results suggest that general intervention efforts are needed to prevent aggression among children of physically coercive parents, and particularly among children with low effortful control and physically coercive fathers.

In this study, the future snowmelt runoff in the chilly northeast region’s Tangwang River Basin was simulated and predicted using the SWAT model, which was built and used based on the NEX-GDDP-CMIP6 climate model. This study conducted a detailed analysis of the spatial and temporal distribution characteristics of snowmelt runoff using high-resolution DEM, land use, and soil data, along with data from historical and future climatic scenarios. Using box plots and the Bflow digital filtering approach, this study first determined the snowmelt runoff period before precisely defining the snowmelt periods. Sensitivity analysis and parameter rate determination ensured the simulation accuracy of the SWAT model, and the correlation coefficients of the total runoff validation period and rate period were 0.75 and 0.76, with Nashiness coefficients of 0.75 for both. The correlation coefficients of the snowmelt runoff were 0.73 and 0.74, with Nashiness coefficients of 0.7 and 0.68 for both, and the model was in good agreement with the measured data. It was discovered that while temperatures indicate an increasing tendency across all future climate scenarios, precipitation is predicted to increase under the SSP2-4.5 scenario. The SSP2-4.5 scenario predicted a decreasing trend regarding runoff, while the SSP1-2.6 and SSP5-8.5 scenarios showed an increasing trend with little overall change and the SSP5-8.5 scenario even showed a decrease of 6.35%. These differences were evident in the monthly runoff simulation projections. Overall, the findings point to the possibility that, despite future climate change having a negligible effect on the hydrological cycle of the Tangwang River Basin, it may intensify and increase the frequency of extreme weather events, creating difficulties for the management of water resources and the issuing of flood warnings. For the purpose of planning water resources and studying hydrological change in this basin and other basins in cold regions, this study offers a crucial scientific foundation. An in-depth study of snowmelt runoff is of great practical significance for optimizing water resource management, rational planning of water use, spring flood prevention, and disaster mitigation and prevention, and provides valuable data support for future research on snowmelt runoff.