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400 results on '"Chaves, Fernando"'

3. Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Author

Martínez-Martínez, Luis, Bou, Germán, Zamorano, Laura, Sánchez-Diener, Irina, Galán, Fátima, Gracia, Irene, Rodríguez, Manuel Antonio, Martín, Lina, Sánchez, Juan Manuel, Viñuela, Laura, García, M<ce:sup loc='post">a</ce:sup> Victoria, Lepe, José Antonio, Aznar, Javier, López-Hernández, Inma, Seral, Cristina, Castillo-García, Francisco Javier, López-Calleja, Ana Isabel, Aspiroz, Carmen, Iglesia, Pedro de la, Ramón, Susana, Riera, Elena, Pérez, María Cruz, Gallegos, Carmen, Calvo, Jorge, Quesada, María Dolores, Pitart, Cristina, Marco, Francesc, Hoyos, Yannick, Horcajada, Juan Pablo, Larrosa, Nieves, González, Juan José, Tubau, Fe, Capilla, Silvia, Pérez-Moreno, Mar Olga, Centelles, M<ce:sup loc='post">a</ce:sup> José, Padilla, Emma, Rivera, Alba, Mirelis, Beatriz, Rodríguez-Tarazona, Raquel Elisa, Arenal-Andrés, Noelia, Ortega, María del Pilar, Megías, Gregoria, García, Inmaculada, Colmenarejo, Cristina, González, José Carlos, Martínez, Nora Mariela, Gomila, Bárbara, Giner, Salvador, Tormo, Nuria, Garduño, Eugenio, Agulla, José Andrés, Seoane, Alejandro, Pita, Julia, Vidal, Isabel Paz, Guzmán, David Mauricio, García, Marta, Pérez del Molino, María Luisa, Barbeito, Gema, Artiles, Fernando, Azcona-Gutiérrez, José Manuel, Sáenz, Yolanda, Oteo, José Antonio, González, Ana, Villa, Jennifer, Chaves, Fernando, Cercenado, Emilia, Alarcón, Teresa, Zurita, Nelly Daniela, Gijón, Desiré, Merino, Irene, Morosini, María Isabel, Cantón, Rafael, Sánchez, María Isabel, Moreno, Laura, Yagüe, Genoveva, Leiva, José, Barrios, José Luis, Canut, Andrés, Oteo, Jesús, Cortes-Lara, Sara, Barrio-Tofiño, Ester del, López-Causapé, Carla, and Oliver, Antonio

Published
2021
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4. Oral decontamination with colistin plus neomycin in solid organ transplant recipients colonized by multidrug-resistant Enterobacterales: a multicentre, randomized, controlled, open-label, parallel-group clinical trial

Author

Armiñanzas, Carlos, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Cuadrado, Antonio, Flor, Virginia, Fábrega, Emilio, Gozalo, Mónica, Illaro, Aitziber, Rodrigo, Emilio, Fernández, Ana, Graus, Javier, Martin Dávil, Pilar, Martínez, Adolfo, Ruiz Garbajosa, Patricia, Sánchez-Díaz, Ana M., Linares, Laura, Cofan, Frederic, Marco, Francesc, Navasa, Miquel, Aranzamendi, Maitane, Blanco, María José, Agnelli Bento, Caroline, Machado, Marina, Olmedo, María, Rincón Sanz, Cristina, Rodríguez Ferrero, María Luisa, Sánchez Cámara, Luis Alberto, Vicente-Rangel, Teresa, Gracia-Ahufinger, Irene, Rodríguez, Fernando, Torre-Cisneros, Julián, Páez Vega, Aurora, Aguadov, José María, Chaves, Fernando, Resino, Elena, Fariñas, Maria Carmen, González-Rico, Claudia, Fernández-Martínez, Marta, Fortún, Jesús, Escudero-Sanchez, Rosa, Moreno, Asunción, Bodro, Marta, Muñoz, Patricia, Valerio, Maricela, Montejo, Miguel, Nieto, Javier, Ruiz-San Millan, Juan Carlos, Casafont-Morencos, Fernando, Martinez-Martínez, Luis, and Fariñas-Álvarez, Concepción

Published
2021
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11. Executive summary: Diagnosis and Treatment of Catheter-Related Bloodstream Infection: Clinical Guidelines of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) and the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC)

Author

Chaves, Fernando, Garnacho-Montero, Josèc), del Pozo, Josèc) Luis, Bouza, Emilio, Capdevila, Josèc) Antonio, de Cueto, Marina, Domínguez, M. Ángeles, Esteban, Jaime, Fernández-Hidalgo, Nuria, Fernández Sampedro, Marta, Fortún, Jesús, Guembe, María, Lorente, Leonardo, Paño, Jose Ramón, Ramírez, Paula, Salavert, Miguel, Sánchez, Miguel, and Vallèc)s, Jordi

Published
2018
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15. Mycobacterium senegaiense Infection after Implant-Based Breast Reconstruction, Spain

Author

Carretero, Octavio, Reyes, Carmen, San-Juan, Rafael, Chaves, Fernando, and Lopez-Roa, Paula

Subjects
Breast reconstruction -- Case studies -- Complications and side effects -- Care and treatment, Mycobacterium infections -- Case studies -- Development and progression -- Care and treatment, Breast cancer, Chemotherapy, Cancer treatment, Etiology (Medicine), Beef cattle, Prostheses and implants, Surgery, Carcinoma, Plastic surgery, Wounds, Bacterial infections, Radiotherapy, Skin, Pathogenic microorganisms, Infection, Health
Abstract

Mycobacterium senegalense is a rapidly growing mycobacterium that belongs to the M. fortuitum complex. These opportunistic pathogens cause posttraumatic skin and soft tissue infections, including postsurgical wound infections (1). M. [...]

Published
2020
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17. DIFERENTES FONTES DE RENDA DA AGRICULTURA FAMILIAR ACREANA: UM RETRATO A PARTIR DO CENSO AGROPECUÁRIO DE 2017.

Author

Monteiro Chaves, Fernando, da Silva Bezerra, Francisco Diétima, and da Silva Bezerra, Maria Alcirlândia

Subjects
*GROSS income, *FARM income, *INCOME, *FAMILY farms, *GOVERNMENT policy
Abstract

The income of brazilian Family Farming (AF) is currently characterized by the strong participation of non-agricultural work income sources and non-work income, a dynamic also noticeable in the state of Acre. In light of this, the present study aims to analyze the total income of Acrean family farming. The methodology adopts a descriptive approach to the data from the 2017 Agricultural Census, obtained through the Automatic Recovery System (SIDRA) of the Brazilian Institute of Geography and Statistics (IBGE). The results indicate that 64.9% of Acrean family farm total income comes from activities within the establishment (agricultural work), 2.3% from other sources of revenue, and 32.9% from pensions, pensions, and revenue obtained outside the family production unit (non-agricultural work and non-work). There is thus a strong heterogeneity within Acrean family farming, a scenario already observed in the more developed Brazilian regions. This implies the need to broaden the scope of public policies, as the demands that emerge in today's rural areas are no longer restricted to income and agricultural work. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Incubadora de empreendimentos para egressos do sistema penal, recomendações para uma reintegração social.

Author

Sena Honorato, Wilson Magdo, Cristina Alves, Tatyane, Cláudio de Sousa, André, Ribeiro Drumond Diniz, Nathália Beraldo, de Castro Chaves, Fernando, and de Souza Neto, Bezamat

Abstract

Copyright of GeSec: Revista de Gestao e Secretariado is the property of Sindicato das Secretarias e Secretarios do Estado de Sao Paulo (SINSESP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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21. Assessment of dapagliflozin effect on diabetic endothelial dysfunction of brachial artery (ADDENDA-BHS2 trial): rationale, design, and baseline characteristics of a randomized controlled trial

Author

Cintra, Riobaldo M. R., Soares, Alexandre A. S., Breder, Ikaro, Munhoz, Daniel B., Barreto, Joaquim, Kimura-Medorima, Sheila T., Cavalcante, Pamela, Zanchetta, Renata, Breder, Jessica Cunha, Moreira, Camila, Virginio, Vitor W., Bonilha, Isabella, Lima-Junior, Jose Carlos, Coelho-Filho, Otavio R., Wolf, Vaneza L. W., Guerra-Junior, Gil, Oliveira, Daniela C., Haeitmann, Rodrigo, Fernandes, Vicente H. R., Nadruz, Wilson, Chaves, Fernando R. P., Arieta, Carlos E. L., Quinaglia, Thiago, Sposito, Andrei C., and ADDENDA-BHS2 trial investigators

Published
2019
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23. Molecular epidemiology and virulence of Escherichia coli O16:H5-ST131: Comparison with H30 and H30-Rx subclones of O25b:H4-ST131

Author

Dahbi, Ghizlane, Mora, Azucena, Mamani, Rosalia, López, Cecilia, Alonso, María Pilar, Marzoa, Juan, Blanco, Miguel, Herrera, Alexandra, Viso, Susana, García-Garrote, Fernando, Tchesnokova, Veronika, Billig, Mariya, de la Cruz, Fernando, de Toro, María, González-López, Juan José, Prats, Guillermo, Chaves, Fernando, Martínez-Martínez, Luis, López-Cerezo, Lorena, Denamur, Erick, and Blanco, Jorge

Published
2014
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25. High MICs for vancomycin and daptomycin and complicated catheter-related bloodstream infections with methicillin-sensitive Staphylococcus aureus

Author

San-Juan, Rafael, Viedma, Esther, Chaves, Fernando, Lalueza, Antonio, Fortun, Jesus, Loza, Elena, Pujol, Miquel, Ardanuy, Carmen, Morales, Isabel, de Cueto, Marina, Resino-Foz, Elena, Morales-Cartagena, Alejandra, Rico, Alicia, Romero, Maria P., Orellana, Maria Angeles, Lopez-Medrano, Francisco, Fernandez-Ruiz, Mario, and Aguado, Jose Maria

Subjects
Catheterization -- Analysis -- Health aspects, Staphylococcus aureus -- Analysis -- Health aspects, Staphylococcus aureus infections -- Analysis -- Health aspects, Infection -- Analysis -- Health aspects, Vancomycin -- Analysis -- Health aspects, Health
Abstract

Staphylococcus aureus bacteremia is an issue of concern because of high rates of illness and death for this condition (1). Some studies have identified high MICs for vancomycin (defined as [...]

Published
2016
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33. Proteinuria in early referral to spectral domain optical coherence tomography for macular edema detection in type 2 diabetes individuals: results from the Brazilian diabetes study.

Author

Barreto, Joaquim, Chaves, Fernando, Fernandes, Vicente H. R., Jesus, Daniel Campos de, Nascimento, Mauricio Abujamra, Lira, Rodrigo P. C., Nadruz, Wilson, Arieta, Carlos, and Sposito, Andrei C.

Subjects
*OPTICAL coherence tomography, *TYPE 2 diabetes, *MACULAR edema, *PROTEINURIA, *DIABETIC retinopathy, *THICKNESS measurement
Abstract

Measurement of retinal thickness by optical coherence tomography (OCT) shows higher diagnostic accuracy for diabetic macular edema (DME) than fundus photography alone. The expanding gap between the rising number of type 2 diabetes (T2D) individuals and the availability of OCT devices demands a targeted selection of individuals at higher risk of DME who would benefit the most from early referral. We sought to appraise if proteinuria should be considered in a targeted referral of T2D individuals to OCT examination. This study was a cross-sectional analysis of 576 consecutive patients enrolled in the Brazilian Diabetes Study between June/2016 and December/2021 who underwent OCT exam and urinalysis to assess ME and proteinuria status, respectively. Differences in the prevalence of DME between proteinuria groups and across a range of diabetic retinopathy (DR) stages were evaluated. Among 1134 eyes included in this analysis, the prevalence of proteinuria was 22% and 18.2% of eyes had DME. Proteinuria was related to an increased prevalence of DME (13.2% vs 38.7% for control vs proteinuria, respectively; p <.001), with an OR of 4.08 [95% confidence interval (CI): 2.50–6.64, p <.001), after adjustment for covariates. Proteinuria was independently related to DME also among eyes with non-apparent DR [OR: 2.82; 95%CI: 1.34–5.93; p =.003] and non-proliferative DR (OR of 5.94, 95%CI 2.13–16.62, p <.001). Fundus photography spotted only half of the DME cases detected by OCT. In T2D individuals, early referral to OCT examination should be pursued for all individuals with concurrent proteinuria. ClinicalTrials.gov Identifier: NCT04949152 [ABSTRACT FROM AUTHOR]

Published
2022
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34. Strain-to-strain variability among Staphylococcus aureus causing prosthetic joint infection drives heterogeneity in response to levofloxacin and rifampicin.

Author

Meléndez-Carmona, María Ángeles, Mancheño-Losa, Mikel, Ruiz-Sorribas, Albert, Muñoz-Gallego, Irene, Viedma, Esther, Chaves, Fernando, Bambeke, Françoise Van, Lora-Tamayo, Jaime, and Van Bambeke, Françoise

Abstract

Introduction: Levofloxacin and rifampicin are the preferred treatment for prosthetic joint infection (PJI) caused by Staphylococcus aureus, especially when managed with implant retention (DAIR). However, a significant variability of success has been reported, which could be related to intrinsic characteristics of the microorganism. Our aim was to evaluate the variability in the anti-biofilm response to levofloxacin and rifampicin in a clinical collection of S. aureus.Material and Methods: Eleven levofloxacin- and rifampicin-susceptible S. aureus isolates causing PJI managed with DAIR were included. Levofloxacin, rifampicin and levofloxacin + rifampicin were tested in an in vitro static biofilm model in microtitre plates, where 48 h biofilms were challenged with antimicrobials during 24 h. Additionally, two genetically similar strains were tested in the CDC Biofilm Reactor, where 48 h biofilms were treated during 56 h. Antimicrobial activity was assessed by viable biofilm-embedded cells recount, and by crystal violet staining.Results: All antimicrobial regimens showed significant anti-biofilm activity, but a notable scattering in the response was observed across all strains (inter-strain coefficient of variation for levofloxacin, rifampicin and levofloxacin + rifampicin of 22.8%, 35.8% and 34.5%, respectively). This variability was tempered with the combination regimen when tested in the biofilm reactor. No correlation was observed between the minimal biofilm eradicative concentration and the antimicrobial activity. Recurrent S. aureus isolates exhibited higher biofilm-forming ability compared with strains from resolved infections (7.6 log10 cfu/cm2±0.50 versus 9.0 log10 cfu±0.07).Conclusions: Significant variability may be expected in response to levofloxacin and rifampicin among biofilm-embedded S. aureus. A response in the lower range, together with other factors of bad prognosis, could be responsible of treatment failure. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Dapagliflozin increases retinal thickness in type 2 diabetic patients as compared with glibenclamide: A randomized controlled trial

Author

Fernandes, Vicente Hidalgo Rodrigues, Chaves, Fernando R.P., Soares, Alexandre A.S., Breder, Ikaro, Kimura-Medorima, Sheila T., Munhoz, Daniel B., Cintra, Riobaldo M.R., Breder, Jessica Cunha, Barreto, Joaquim, Nadruz, Wilson, Carvalho, Luiz Sergio F., Quinaglia, Thiago, Arieta, Carlos E.L., and Sposito, Andrei C.

Published
2021
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37. VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175 clone, Spain

Author

Viedma, Esther, Juan, Carlos, Villa, Jennifer, Barrado, Laura, Orellana, M. Angeles, Sanz, Francisca, Otero, Joaquin R., Oliver, Antonio, and Chaves, Fernando

Subjects
Genes -- Health aspects, Drug resistance in microorganisms -- Health aspects, Antibacterial agents -- Health aspects, Cloning -- Health aspects, Pseudomonas aeruginosa -- Health aspects, Health
Abstract

Members of the bacterial genus Pseudomonas, especially P. aeruginosa, are among the major nosocomial pathogens because of their ubiquitous nature and ability to colonize and survive in hospital reservoirs and [...]

Published
2012
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38. High vancomycin MIC and complicated methicillin-susceptible Staphylococcus aureus bacteremia

Author

Aguado, Jose Maria, San-Juan, Rafael, Lalueza, Antonio, Sanz, Francisca, Rodriguez-Otero, Joaquin, Gomez-Gonzalez, Carmen, and Chaves, Fernando

Subjects
Blood -- Medical examination, Medical research, Medicine, Experimental, Staphylococcus aureus, Vancomycin, Staphylococcus aureus infections -- Risk factors, Bacteremia -- Risk factors, Health
Abstract

Several studies have established a relationship between high vancomycin MIC and a worse prognosis for patients with bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) (1-5). However, to our knowledge, the [...]

Published
2011
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39. Multidrug-resistant Acinetobacter baumannii harboring OXA-24 Carbapenemase, Spain

Author

Acosta, Joshi, Merino, Maria, Viedma, Esther, Poza, Margarita, Sanz, Francisca, Otero, Joaquin R., Chaves, Fernando, and Bou, German

Subjects
Drug resistance in microorganisms -- Genetic aspects, Proteobacteria -- Genetic aspects, Bacteremia -- Diagnosis -- Drug therapy -- Genetic aspects, Health
Abstract

The increasing resistance of Acinetobacter baumannii to antimicrobial drugs, including carbapenems (1-3), and resistance to desiccation and disinfectants (4) contribute to its persistence in hospital environments and propensity to cause [...]

Published
2011
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42. Microbiological and Molecular Features Associated with Persistent and Relapsing Staphylococcus aureus Prosthetic Joint Infection.

Author

Muñoz-Gallego, Irene, Ángeles Meléndez-Carmona, María, Lora-Tamayo, Jaime, Garrido-Allepuz, Carlos, Chaves, Fernando, Sebastián, Virginia, and Viedma, Esther

Abstract

Background: Persistent and relapsing prosthetic joint infection (PJI) due to Staphylococcus aureus presents a clinical challenge. This study aimed to provide an extensive description of pheno- typic and genomic changes that could be related to persistence or relapse. Methods: Initial and second S. aureus isolates from 6 cases of persistent and relapsing PJI, along with clinical isolates from 8 cases, with favorable outcome were included. All isolates were studied by phenotypic and genotypic approaches. Results: Recurrent S. aureus isolates exhibited a significant increase in adhesive capacity, invasion and persistence compared to resolved isolates. No association was found for the presence or absence of certain genes with the persistence or relapse of PJI. All sequential isolates showed identical sequence type (ST). Resistance gene loss during the infection and a great diversity of variants in different virulence genes between the pair of strains, mainly in genes encoding adhesins such as fnbA, were observed. Conclusions: S. aureus-caused relapse and persistence PJI is associated with bacterial phenotypical and genotypical adaptation. The main paths of adaptation were persistence in the intracellular compartment, and the loss of antibiotic resistance genes and variant acquisition, especially in genes encoding adhesins. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Genomic Analysis of Ceftazidime/Avibactam-Resistant GES-Producing Sequence Type 235 Pseudomonas aeruginosa Isolates.

Author

Recio, Raúl, Villa, Jennifer, González-Bodí, Sara, Brañas, Patricia, Orellana, María Ángeles, Mancheño-Losa, Mikel, Lora-Tamayo, Jaime, Chaves, Fernando, and Viedma, Esther

Subjects
GENOMICS, PSEUDOMONAS aeruginosa, KLEBSIELLA pneumoniae, NUCLEOTIDE sequencing, ASPARTIC acid, PHENOTYPES
Abstract

The emergence of ceftazidime/avibactam (CZA) resistance among Guiana extended-spectrum β-lactamase (GES)-producing Pseudomonas aeruginosa isolates has rarely been described. Herein, we analyze the phenotypic and genomic characterization of CZA resistance in different GES-producing P. aeruginosa isolates that emerged in our institution. A subset of nine CZA-resistant P. aeruginosa isolates was analyzed and compared with thirteen CZA-susceptible isolates by whole-genome sequencing (WGS). All CZA-resistant isolates belonged to the ST235 clone and O11 serotype. A variety of GES enzymes were detected: GES-20 (55.6%, 5/9), GES-5 (22.2%, 2/9), GES-1 (11.1%, 1/9), and GES-7 (11.1%, 1/9). WGS revealed the presence of two mutations within the blaGES-20 gene comprising two single-nucleotide substitutions, which caused aspartic acid/serine and leucine/premature stop codon amino acid changes at positions 165 (D165S) and 237 (L237X), respectively. No major differences in the mutational resistome (AmpC, OprD porin, and MexAB-OprM efflux pump-encoding genes) were found among CZA-resistant and CZA-susceptible isolates. None of the mutations that have been previously demonstrated to cause CZA resistance were observed. Different mutations within the blaGES-20 gene were documented in CZA-resistant GES-producing P. aeruginosa isolates belonging to the ST235 clone in our institution. Although further analysis should be performed, according to our results, other resistance mechanisms might be involved in CZA resistance. [ABSTRACT FROM AUTHOR]

Published
2022
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