48 results on '"Chen, Ling Xiao"'
Search Results
2. Construction of Mn-decorated zeolitic imidazolate framework-90 nanostructure as superior oxidase-like mimic for colorimetric detection of glucose and choline
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Wang, Jia-Li, Chen, Guo-Ying, Chai, Tong-Qing, Chen, Ling-Xiao, Chen, Hua, and Yang, Feng-Qing
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- 2024
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3. Manganese coordination polymer nanoparticles with excellent oxidase-like activity for the rapidly and selectively colorimetric detection of glutathione
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Wang, Jia-Li, Chai, Tong-Qing, Chen, Ling-Xiao, Chen, Guo-Ying, Chen, Hua, and Yang, Feng-Qing
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- 2024
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4. Adenine phosphate-Cu nanozyme with multienzyme mimicking activity for efficient degrading phenolic compounds and detection of hydrogen peroxide, epinephrine and glutathione
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Chai, Tong-Qing, Chen, Guo-Ying, Chen, Ling-Xiao, Wang, Jia-Li, Zhang, Chun-Yan, and Yang, Feng-Qing
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- 2023
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5. Applications of magnetic solid‐phase extraction in the sample preparation of natural product analysis (2020–2023).
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Chen, Ling‐Xiao and Yang, Feng‐Qing
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SOLID phase extraction , *NATURAL products , *MAGNETICS , *COMPLEX matrices , *MATRIX multiplications , *ORGANIC solvents - Abstract
Sample preparation, including extraction, separation, and purification, is a vital process for natural product analysis. As an attractive sample pretreatment method, magnetic solid‐phase extraction (MSPE) has gained plenty of attention, mainly due to its simpler operation, less consumption of organic solvents, and shorter processing time than traditional SPE. This updated review is devoted to summarizing the applications of MSPE based on different magnetic nanomaterials in the analysis of various natural products in complex matrixes, such as biological samples, plants, and Chinese herbal preparations in the past four years (2020–2023). The preparation and fabrication of different materials are briefly introduced. Furthermore, the extraction mechanism and interaction forces between adsorbent and analytes are elaborated, and the advantages and disadvantages of different adsorbents coupled with various analytical methods for MSPE of different natural products are summarized. Moreover, the future trends and opportunities for MSPE in the natural product analysis are discussed. It is expected that this work can provide updated information for future research on the applications of MSPE in such fields. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Construction of a novel cuboid-shape Mn-Urea nanozyme with arsenic(V)-enhanced oxidase-like activity as a colorimetric probe for the selective detection of inorganic arsenic.
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Wang, Jia-Li, Chen, Ling-Xiao, Chen, Guo-Ying, Chai, Tong-Qing, Li, Jia-Xin, Chen, Hua, and Yang, Feng-Qing
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ARSENIC , *CARBONYL group , *FREE radicals , *RADICAL anions , *SYNTHETIC enzymes , *DETECTION limit - Abstract
The development of a facile and reliable assay for arsenic (As) detection is crucial for its pollution control, which is a well-known heavy-metal pollutant in the environment. In this work, an efficient colorimetric method was established for As(V) detection based on a novel cuboid-shape Mn-Urea nanozyme (UMnzyme) with arsenic-enhanced oxidase-like activity. The UMnzyme was prepared through the coordination of Mn ions and carbonyl groups in urea, which possesses outstanding oxidase-like activity that can generate the superoxide anion free radical (O2˙−) by catalyzing the dissolved O2, triggering the 3,3′,5,5′-tetramethylbenzidine (TMB) chromogenic reaction. Furthermore, the free oxygen atoms in UMnzyme provide potential sites to bind with As, in which the formation of As–O will not destroy the morphology and structure of UMnzyme. The capture of As by UMnzyme results in the improvement of its oxidase-like activity; therefore, a colorimetric method for As(V) detection was developed with a linear range of 12.5–250 μg L−1. The limit of detection was determined to be 2.4 μg L−1 (S/N = 3), which is lower than the threshold (10 ppb) recommended by the World Health Organization. Moreover, the developed method was applied in the detection of As(V) in environmental water, and the recoveries are 89.5–103.6%. In short, this study provides an efficient and reliable strategy for As(V) detection based on a novel Mn-based nanozyme and a new idea for the reasonable design of Mn-based nanozymes with enhanced catalytic performance. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Non-starch polysaccharide from Chinese yam activated RAW 264.7 macrophages through the Toll-like receptor 4 (TLR4)-NF-κB signaling pathway
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Li, Min, Chen, Ling-Xiao, Chen, Shao-Ru, Deng, Yong, Zhao, Jing, Wang, Ying, and Li, Shao-Ping
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- 2017
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8. Ganoderma spore powder contains little triterpenoids
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Liu, Mei-Ting, Chen, Ling-Xiao, Zhao, Jing, and Li, Shao-Ping
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- 2020
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9. Comparison of volatile compounds in different parts of fresh Amomum villosum Lour. from different geographical areas using cryogenic grinding combined HS–SPME–GC–MS
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Chen, Ling-Xiao, Lai, Yun-Feng, Zhang, Wei-Xiong, Cai, Jing, Hu, Hao, Wang, Ying, Zhao, Jing, and Li, Shao-Ping
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- 2020
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10. A Novel Molecularly Imprinted Sensor Based on CuO Nanoparticles with Peroxidase-like Activity for the Selective Determination of Astragaloside-IV.
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Chen, Guo-Ying, Chen, Ling-Xiao, Gao, Jin, Chen, Chengyu, Guan, Jianli, Cao, Zhiming, Hu, Yuanjia, and Yang, Feng-Qing
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IMPRINTED polymers ,COPPER oxide ,NANOPARTICLES ,SYNTHETIC enzymes ,MONOMERS ,DETECTORS - Abstract
In this work, dopamine (DA) was polymerized on the surface of CuO nanoparticles (CuO NPs) to form a molecularly imprinted polymer (MIP@PDA/CuO NPs) for the colorimetric detection of astragaloside-IV (AS-IV). The synthesis process of MIP is simple and easy to operate, without adding other monomers or initiators. CuO NPs has high peroxidase (POD)-like activity that can catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to generate oxidized TMB (OxTMB) in the presence of H
2 O2 , having a maximum ultraviolet-visible (UV-Vis) absorption peak at 652 nm. The AS-IV can specifically bind to the surface imprinted cavities and prevent the entry of TMB and H2 O2 , which will lead to the inhibition of the catalytic reaction. Therefore, a new approach based on the POD-like activity of MIP@PDA/CuO NPs for AS-IV detection was developed with a linear range from 0.000341 to 1.024 mg/mL. The LOD and LOQ are 0.000991 and 0.000341 mg/mL, respectively. The developed method can accurately determine AS-IV in Huangqi Granules and different batches of Ganweikang Tablets, which are similar to the results measured by HPLC-ELSD and meet the requirements of Chinese Pharmacopoeia (2020 edition) for the amount of AS-IV in Huangqi Granules. The combination of MIP with CuO NPs not only endows the detection of AS-IV with high selectivity and reliability, but also expands the application of nanozymes in the detection of small-molecule compounds that have weak UV absorption, and do not have reducibility or oxidation properties. [ABSTRACT FROM AUTHOR]- Published
- 2023
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11. Preparation of xylooligosaccharides from xylan by controlled acid hydrolysis and fast protein liquid chromatography coupled with refractive index detection
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Yang, Zhen-Yan, Wu, Ding-Tao, Chen, Cun-Wu, Cheong, Kit-Leong, Deng, Yong, Chen, Ling-Xiao, Han, Bang-Xing, Chen, Nai-Fu, Zhao, Jing, and Li, Shao-Ping
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- 2016
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12. Qualitative and quantitative analysis of specific polysaccharides in Dendrobium huoshanense by using saccharide mapping and chromatographic methods
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Deng, Yong, Chen, Ling-Xiao, Han, Bang-Xing, Wu, Ding-Tao, Cheong, Kit-Leong, Chen, Nai-Fu, Zhao, Jing, and Li, Shao-Ping
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- 2016
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13. Tris-Copper Nanozyme as a Novel Laccase Mimic for the Detection and Degradation of Phenolic Compounds.
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Chai, Tong-Qing, Wang, Jia-Li, Chen, Guo-Ying, Chen, Ling-Xiao, and Yang, Feng-Qing
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PHENOLS ,POLLUTANTS ,LACCASE ,ENVIRONMENTAL monitoring ,AMINO group - Abstract
Phenolic compounds are one of the main organic pollutants in the environment that can seriously affect ecosystems, even at very low concentrations. Due to the resistance of phenolic compounds to microorganisms, conventional biological treatment methods face challenges in effectively addressing this pollution problem. In this study, a novel laccase mimic (Tris-Cu nanozyme) is prepared using a simple and rapid synthesis strategy based on the coordination of copper ions and amino groups in Tris(hydroxymethyl)aminomethane (Tris). It is found that the Tris-Cu nanozyme exhibits good catalytic activity against a variety of phenolic compounds, the K
m , Vmax and Kcat are determined to be 0.18 mM, 15.62 μM·min−1 and 1.57 × 107 min−1 using 2,4-dichlorophenol (2,4-DP) as the substrate, respectively. Then, based on the laccase-like activity of the Tris-Cu nanozyme, a novel colorimetric method for 2,4-DP (the limit of detection (LOD) = 2.4 μM, S/N = 3) detection in the range of 10–400 μM was established, and its accuracy was verified by analyzing tap and lake water samples. In addition, the Tris-Cu nanozyme shows excellent removal abilities for six phenolic compounds in experiments. The removal percentages for 2,4-DP, 2-chlorophenol (2-CP), phenol, resorcinol, 2,6-dimethoxyphenol (2,6-DOP), and bisphenol A (BPA) are 100%, 100%, 100%, 100%, 87%, and 81% at 1 h, respectively. In the simulated effluent, the Tris-Cu nanozyme maintains its efficient catalytic activity towards 2,4-DP, with a degradation percentage of 76.36% at 7 min and a reaction rate constant (k0 ) of 0.2304 min−1 . Therefore, this metal–organic complex shows promise for applications in the monitoring and degrading of environmental pollutants. [ABSTRACT FROM AUTHOR]- Published
- 2023
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14. Short-course preoperative radiotherapy with immediate surgery versus long-course chemoradiation with delayed surgery in the treatment of rectal cancer: A systematic review and meta-analysis
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Zhou, Zhi-Rui, Liu, Shi-Xin, Zhang, Tian-Song, Chen, Ling-Xiao, Xia, Jun, Hu, Zhi-De, and Li, Bo
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- 2014
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15. Ultra-High Adsorption Capacity of Core–Shell-Derived Magnetic Zeolite Imidazolate Framework-67 as Adsorbent for Selective Extraction of Theophylline.
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Chen, Ling-Xiao, Yin, Shi-Jun, Chai, Tong-Qing, Wang, Jia-Li, Chen, Guo-Ying, Zhou, Xi, and Yang, Feng-Qing
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LANGMUIR isotherms , *THEOPHYLLINE , *ADSORPTION capacity , *FOURIER transform infrared spectroscopy , *ZEOLITES , *ADSORPTION kinetics , *METHYLXANTHINES , *GREEN tea , *SOLID phase extraction - Abstract
A core–shell-derived structural magnetic zeolite imidazolate framework-67 (Fe3O4-COOH@ZIF-67) nanocomposite was fabricated through a single-step coating of zeolite imidazolate framework-67 on glutaric anhydride-functionalized Fe3O4 nanosphere for the magnetic solid-phase extraction (MSPE) of theophylline (TP). The Fe3O4-COOH@ZIF-67 nanocomposite was characterized through scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectrometry, Fourier transform infrared spectroscopy, Zeta potential analysis, X-ray diffraction, Brunauer–Emmett–Teller, and vibrating sample magnetometer. The material has a high specific surface area and good magnetism, which maintains the regular dodecahedron structure of ZIF-67 without being destroyed by the addition of Fe3O4-COOH nanospheres. The Fe3O4-COOH@ZIF-67 can rapidly adsorb TP mainly through the strong coordination interaction between undercoordinated Co2+ on ZIF-67 and –NH from imidazole of TP. The adsorption and desorption conditions, such as the amount of adsorbent, adsorption time, pH value, and elution solvent, were optimized. The kinetics of TP adsorption on Fe3O4-COOH@ZIF-67 was found to follow pseudo-second-order kinetics. The Langmuir model fits the adsorption data well and the maximum adsorption capacity is 1764 mg/g. Finally, the developed MSPE-HPLC method was applied in the enrichment and analysis of TP in four tea samples and rabbit plasma. TP was not detected in oolong tea and rabbit plasma, and its contents in jasmine tea, black tea, and green tea are 5.80, 4.31, and 1.53 μg/g, respectively. The recoveries of spiked samples are between 74.41% and 86.07% with RSD in the range of 0.81–3.83%. The adsorption performance of Fe3O4-COOH@ZIF-67 nanocomposite was nearly unchanged after being stored at room temperature for at least 80 days and two consecutive adsorption–desorption cycles. The results demonstrate that Fe3O4-COOH@ZIF-67 nanocomposite is a promising magnetic adsorbent for the preconcentration of TP in complex samples. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Tourniquet used in anterior cruciate ligament reconstruction: a system review
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Wu, Hong, Chen, Ling-Xiao, Li, Yu-Lin, Wu, Qiang, Wu, Qiu-Li, Ning, Guang-Zhi, and Feng, Shi-Qing
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- 2014
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17. A quantitative method for polysaccharides based on endo-enzymatic released specific oligosaccharides: A case of Lentinus edodes.
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Deng, Yong, Chen, Ling-Xiao, Zhu, Bao-Jie, Zhao, Jing, and Li, Shao-Ping
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OLIGOSACCHARIDES , *SHIITAKE , *POLYSACCHARIDES , *HYDROPHILIC interaction liquid chromatography , *QUANTITATIVE research , *DISACCHARIDES , *HYDROPHILIC interactions - Abstract
Polysaccharides exhibit multiple pharmacological activities, which are closely related to their structural characteristics. Therefore, quantitative quality control of polysaccharides based on chemical properties is of importance for their applications. However, polysaccharides are mixed macromolecular compounds that are difficult to separate, and the lack of standards made direct quantification more difficult. In this study, we proposed a new quantitative method based on the released specific oligosaccharides for polysaccharides from Lentinus edodes (shiitake) and other related fungi. Specific oligosaccharides were firstly released from polysaccharides using 1,3- β -glucanase, then derivatized with 2-aminobenzamide (2-AB), which further separated by hydrophilic interaction chromatography (HILIC) and quantitatively determined by UPLC coupled with fluorescence detector (FLR). Laminaritriose was used as the universal standard for quantification of all the oligosaccharides. This method was validated according to linearity, limit of detection, limit of quantitation, precision, accuracy, repeatability and stability. In addition, the four specific oligosaccharides released from polysaccharides in L. edodes were qualitatively analyzed by extracted ion chromatogram (EIC) from UPLC-MS profiles, which were identified to be disaccharide, trisaccharide and tetrasccharide. The proposed strategy not only realized the quantitative analysis of polysaccharides by UPLC-FLR, but also could achieve the qualitative distinction of different polysaccharides. [Display omitted] • A new qualitative and quantitative method was developed for fungi polysaccharides. • Specific oligosaccharides were released from polysaccharides using a selected enzyme. • The chemical structures of released specific oligosaccharides were speculated. • This method was superior to PACE, especially the feasibility of quantification. [ABSTRACT FROM AUTHOR]
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- 2022
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18. A new nortriterpenoid and an ergostane-type steroid from the fruiting bodies of the fungus Ganoderma resinaceum.
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Chen, Xian-Qiang, Chen, Ling-Xiao, Li, Shao-Ping, and Zhao, Jing
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FUNGI , *RESEARCH methodology , *PHARMACEUTICAL chemistry , *RESEARCH funding , *STEROIDS - Abstract
One new expoxy nortriterpenoid (1) and one new ergostane-type steroid (2), together with seven known steroids (3–9), were obtained from the fruiting bodies of the fungusGanoderma resinaceum. The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. [ABSTRACT FROM PUBLISHER]
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- 2017
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19. Molecular neuron: From sensing to logic computation, information encoding, and encryption.
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Huang, Wei Tao, Chen, Ling Xiao, Lei, Jing Lei, Luo, Hong Qun, and Li, Nian Bing
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NEURONS , *NEURAL circuitry , *CONGO red (Staining dye) , *DATA encryption , *ULTRAVIOLET-visible spectroscopy - Abstract
The impressive functions of brain circuits have inspired many scientists to attempt in designing neuron analogues by using artificial molecular systems or electronic devices. However, the study of molecular neuron has not produced an equal variety of models. Here, using UV–vis absorption, fluorescence, and resonance light scattering spectroscopies for pH sensing with a common indicator—Congo red dye, we show how Congo red molecules can be used to construct molecular neuron and exhibit neuron-like behavior. Our molecular neural model uses molecular groups as ‘dendrites’ which receive and sense environmental stimuli inputs (pH), molecular matrix as ‘soma’ which acts as the summation function, and the change in optical characteristics as ‘axon’ which represents outputs. Our approach allows us to utilize simple sensing molecules as McCulloch-Pitts neuron for experimental implementation of large-scale logic computation in batch mode and to use extraordinary information density inherent in molecular neuron for alphanumeric information encoding and molecular cryptography. Our results suggest that molecules could be used as universal artificial neurons with the capability of sensing analytes or environmental stimuli, remembering patterns of molecular events, and making decisions. [ABSTRACT FROM AUTHOR]
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- 2017
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20. Tanezumab for Patients with Osteoarthritis of the Knee: A Meta-Analysis.
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Kan, Shun-Li, Li, Yan, Ning, Guang-Zhi, Yuan, Zhi-Fang, Chen, Ling-Xiao, Bi, Ming-Chao, Sun, Jing-Cheng, and Feng, Shi-Qing
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THERAPEUTIC use of monoclonal antibodies ,OSTEOARTHRITIS treatment ,OSTEOARTHRITIS ,DRUG efficacy ,MEDICATION safety ,RANDOMIZED controlled trials ,META-analysis ,PATIENTS - Abstract
Objective: Tanezumab is a new therapeutic intervention for patients with osteoarthritis (OA) of the knee. We performed the present meta-analysis to appraise the efficacy and safety of tanezumab for patients with knee OA. Methods: We systematically searched randomized controlled trials from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL). The primary outcomes were mean change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, the WOMAC physical function and patient's global assessment (PGA). Outcomes were reported as the standard mean difference (SMD) or relative risk (RR) with 95% confidence interval (CI). We assessed the pooled data using a random-effects model. Results: Of the identified studies, four were eligible and were included in this meta-analysis (N = 1839 participants). Compared with the placebo groups, tanezumab yielded a significant reduction in mean change in the WOMAC pain (SMD = 0.51, 95% CI 0.34 to 0.69, P<0.00001), the WOMAC physical function (SMD = 0.56, 95% CI 0.38 to 0.74, P<0.00001) and PGA (SMD = 0.34, 95% CI 0.22 to 0.47, P<0.00001). There was no significant difference in serious adverse events (RR = 1.06, 95% CI 0.59 to 1.92, P = 0.84) between the tanezumab and placebo groups. Tanezumab significantly increased discontinuations due to adverse events (RR = 2.89, 95% CI 1.59 to 5.26, P = 0.0005), abnormal peripheral sensations (RR = 3.14, 95% CI 2.12 to 4.66, P<0.00001), and peripheral neuropathy (RR = 6.05, 95% CI 2.32 to 15.81, P = 0.0002). Conclusion: Tanezumab can alleviate pain and improve function for patients with OA of the knee. However, considering the limited number of studies, this conclusion should be interpreted cautiously and more clinical randomized controlled trials are needed to verify the efficacy and safety of tanezumab for OA of the knee. [ABSTRACT FROM AUTHOR]
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- 2016
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21. A simple and rapid method for direct determination of Al(III) based on the enhanced resonance Rayleigh scattering of hemin-functionalized graphene-Al(III) system.
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Ling, Yu, Chen, Ling Xiao, Dong, Jiang Xue, Li, Nian Bing, and Luo, Hong Qun
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ALUMINUM , *GRAPHENE , *HEMIN , *RAYLEIGH scattering , *AQUEOUS solutions , *HYDROPHOBIC interactions - Abstract
A novel method for direct determination of Al(III) by using hemin-functionalized graphene (H-GO) has been established based on the enhancement of resonance Rayleigh scattering (RRS) intensity. The characteristics of RRS spectra, the optimum reaction conditions, and the reaction mechanism have been investigated. In this experiment, the Al(III) would exist in sol–gel Al(OH) 3 species under the condition of pH 5.9 in aqueous solutions. When H-GO existed in the solution, the sol–gel Al(OH) 3 would react with H-GO and result in enhancement of RRS intensity, owing to the enhanced hydrophobicity of H-GO surface. Therefore, a simple and rapid sensor for Al(III) was developed. The increased intensity of RRS is directly proportional to the concentration of Al(III) in the range of 10 nM–6 μM, along with a detection limit of 0.87 nM. Moreover, the sensor has been applied to determination of Al(III) concentration in real water and aspirin tablet samples with satisfactory results. Therefore, the proposed method is promising as an effective means for selective and sensitive determination of Al(III). [ABSTRACT FROM AUTHOR]
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- 2016
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22. Efficacy and Safety of Bisphosphonates for Low Bone Mineral Density After Kidney Transplantation: A Meta-Analysis.
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Shun-Li Kan, Guang-Zhi Ning, Ling-Xiao Chen, Yong Zhou, Jing-Cheng Sun, Shi-Qing Feng, Kan, Shun-Li, Ning, Guang-Zhi, Chen, Ling-Xiao, Zhou, Yong, Sun, Jing-Cheng, and Feng, Shi-Qing
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- 2016
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23. Transcutaneous Electrical Nerve Stimulation in Patients With Knee Osteoarthritis: Evidence From Randomized-controlled Trials.
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Ling-Xiao Chen, Zhi-Rui Zhou, Yu-Lin Li, Guang-Zhi Ning, Yan Li, Xiao-Bo Wang, Shi-Qing Feng, Chen, Ling-Xiao, Zhou, Zhi-Rui, Li, Yu-Lin, Ning, Guang-Zhi, Li, Yan, Wang, Xiao-Bo, and Feng, Shi-Qing
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- 2016
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24. Comparison of Short-Course Radiotherapy Versus Long-Course Radiotherapy for Treatment of Metastatic Spinal Cord Compression: A Systematic Review and Meta-Analysis.
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Song Qu, Hui-Ling Meng, Zhong-Guo Liang, Xiao-Dong Zhu, Ling Li, Ling-Xiao Chen, Zhi-Rui Zhou, Qu, Song, Meng, Hui-Ling, Liang, Zhong-Guo, Zhu, Xiao-Dong, Li, Ling, Chen, Ling-Xiao, and Zhou, Zhi-Rui
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- 2015
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25. Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis.
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Chen, Ling-Xiao, Zhou, Zhi-Rui, Li, Yu-Lin, Ning, Guang-Zhi, Zhang, Tian-Song, Zhang, Di, and Feng, Shi-Qing
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BONE density , *LUMBAR vertebrae , *FRACTURE mechanics , *OSTEOPOROSIS treatment , *META-analysis , *COMPARATIVE studies - Abstract
Context: The preferred treatment for osteoporosis in men is debated, and pairwise meta-analysis cannot obtain hierarchies of these treatments. Objective: The objective of this study was to integrate the evidence and provide hierarchies of eight drugs based on their effect on the bone mineral density in the lumbar spine (BMD in LS) and the fracture rate. Data Sources: Eligible studies were identified by searching Amed, British Nursing Index, EMBASE, PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, SIGLE, the National Technical Information Service, the National Research Register (UK), and the Current Controlled Trials databases. Study Selection: RCTs or quasi-RCTs reporting at least two drugs (two active drugs or one active drug and a placebo) used to treat osteoporosis in men were selected by two authors. Data Extraction: Two authors independently extracted the data. Data Synthesis: Thirteen studies involving 3647 patients were included. Compared with placebo therapy, zoledronate (SMDs 13.48, 95% credible intervals 11.88-15.08) yielded the most significant effect on increasing the BMD in LS, followed by alendronate (11.04, 9.68-12.41), teriparatide (20mcg) + risedronate (10.98, 8.55-13.48), risedronate (10.33, 8.68-12.01), teriparatide (20mcg) (9.33, 6.87-11.76), strontium ranelate (8.88, 7.51-10.24), ibandronate (5.49, 3.82-7.16), parathyroid hormone (1-84) (4.89, 3.12-6.62) and alfacalcidol (3.42, 1.7-5.2). Placebo therapy had a significantly higher fracture rate in contrast to risedronate (OR 2.51, 95% CrI 1.23-4.24) or zoledronate (2.92, 1.29-5.62) or teriparatide (20mcg) (4.04, 1.36-8.49) or teriparatide (40mcg) (3.5, 1.14-8.34). Zoledronate ranked first for increasing the BMD in LS, and teriparatide (20mg) was ranked first for decreasing the fracture rate. Conclusions: Zoledronate might be the best choice to increase the BMD in LS and teriparatide (20mg) might lead to the lowest fracture rate. [ABSTRACT FROM AUTHOR]
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- 2015
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26. Comparative Efficacy and Tolerability of Three Treatments in Old People with Osteoporotic Vertebral Compression Fracture: A Network Meta-Analysis and Systematic Review.
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Chen, Ling-Xiao, Li, Yu-Lin, Ning, Guang-Zhi, Li, Yan, Wu, Qiu-Li, Guo, Jin-Xiu, Shi, Hong-Yu, Wang, Xiao-Bo, Zhou, Yong, and Feng, Shi-Qing
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OSTEOPOROSIS treatment , *COMPRESSION fractures , *BONE fractures in old age , *SYSTEMATIC reviews , *VISUAL analog scale , *TREATMENT effectiveness - Abstract
Purpose: The question which kind of methods is most suitable for treating the old people for osteoporotic vertebral compression fracture is still discussed and pairwise meta-analyses cannot get hierarchies of these treatments. Our aim is to integrate the evidence to provide hierarchies of the comparative efficacy measured by the change of VAS (Visual Analogue Scale) and tolerability measured by incidence of new fractures and risk of all-cause discontinuation on three treatments (percutaneous vertebroplasty (PVP)、balloon kyphoplasty (BK) and conservative treatment(CT)). Methods: We performed a Bayesian-framework network meta-analysis of randomized controlled trials (RCTs) to compare three treatments for the old people with osteoporotic vertebral compression fracture. The eligible RCTs were identified by searching Amed, British Nursing Index, Embase, Pubmed, the Cochrane Central Register of Controlled Trials (CENTRAL), Google scholar, SIGLE, the National Technical Information Service, the National Research Register (UK) and the Current Controlled Trials databases. Data from three outcomes (e.g. VAS, risk of all-cause discontinuation and incidence of new fractures) were independently extracted by two authors. Results: A total of five RCTs were finally included into this article. PVP and BK significantly decreased VAS when compared with CT. BK had a significantly lower risk of all-cause discontinuation contrast to CT. Three treatments (BK, PVP and CT) had no significant differences in the incidence of new fractures. Conclusions: PVP may be the best way to relieve pain, CT might lead to the lowest incidence of new fractures and BK might had the lowest risk of all-cause discontinuation in old people with osteoporotic vertebral compression fracture. More large-scale and longer duration of follow-up studies are needed. [ABSTRACT FROM AUTHOR]
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- 2015
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27. The Carcinogenicity of Alendronate in Patients with Osteoporosis: Evidence from Cohort Studies.
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Chen, Ling-Xiao, Ning, Guang-Zhi, Zhou, Zhi-Rui, Li, Yu-Lin, Zhang, Di, Wu, Qiu-Li, Zhang, Tian-Song, Cheng, Lei, and Feng, Shi-Qing
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OSTEOPOROSIS , *DISEASE incidence , *CARCINOGENICITY , *ESOPHAGEAL cancer , *COLON cancer , *ALENDRONATE - Abstract
Context: Alendronate may relate to the incidence of cancers, especially esophageal and colon cancer. But the results are inconsistent in different studies. Objective: To quantify the association between the use of alendronate and the occurrence of different types of cancer. Data Sources: We searched Embase, Pubmed, CENTRAL, SIGLE and , up to 2014 June. Study Selection: Cohort studies reporting association between alendronate or bisphosphonate therapy including alendronate in patients with osteoporosis and risk of cancer were selected by two authors. Data Extraction: Two authors independently extracted the data. The Chi-square test and the I-square test were used for testing heterogeneity between studies. Data Synthesis: Eight cohort studies were included in the meta-analysis. Meta-analysis result manifested that alendronate significantly increased the incidence of lung cancer (HR 1.23, 95%CI 1.03 to 1.47, P value = 0.03), nevertheless, there was no significant difference after we excluded either Lee’s 2012 study (HR 1.17, 95%CI 0.95 to 1.44, P value = 0.13) or Chiang’s 2012 study (HR 1.47, 95%CI 1 to 2.17, P value = 0.05). For the incidence of colorectal cancer, no significant difference occurred (HR 0.91, 95%CI 0.74 to 1.13, P value = 0.39), but there was a positive relationship when we used fixed model (HR 0.85, 95%CI 0.78 to 0.93, P value = 0.004). For the incidence of liver cancer, there was no significant difference (HR 1.36, 95%CI 0.9 to 2.04, P value = 0.14), however, the result changed after we excluded Chiang’s 2012 study (HR 1.69, 95%CI 1.03 to 2.77, P value = 0.04). There was no significant difference in other types of cancer. Conclusion: Based on current evidences, alendronate therapy may be associated with a high risk of lung cancer, may with an excess risk of liver cancer, a low risk of colorectal and no related risk of other cancers. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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28. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis.
- Author
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Zhou, Ben‐Gang, Chen, Ling‐Xiao, Li, Bo, Wan, Lin‐Yan, and Ai, Yao‐Wei
- Subjects
- *
SEQUENTIAL analysis , *META-analysis , *HELICOBACTER pylori , *FALSE positive error , *SACCHAROMYCES - Abstract
Background and Aims: Whether Saccharomyces boulardii (S boulardii) as an adjuvant therapy are beneficial to H pylori eradication remains controversial. The aim of the study was to update and determine the effects of S boulardii as an adjuvant therapy on H pylori eradication rates and adverse effects. Methods: We searched PubMed, Embase, CENTRAL, and Web of Science to collect all randomized controlled trials assessing the effects of S boulardii as an adjuvant therapy for H pylori eradication from inception to February 2019. Quality of evidence was appraised using Grading of Recommendations, Assessment, Development and Evaluation system. Trial sequential analysis was performed to control the risk of type I and type II errors. Results: Eighteen trials with 3592 patients were eligible for meta‐analysis. Compared with standard eradication regimen, the S boulardii supplementation could significantly improve eradication rates [risk ratio (RR) = 1.09, 95% confidence interval (CI):1.05‐1.13; moderate quality evidence] and reduce the incidence of total side effects (RR = 0.47, 95%CI:0.36‐0.61; low quality evidence), as well as some gastrointestinal adverse effects, especially diarrhea (RR = 0.33, 95%CI:0.23‐0.47; low quality evidence) and constipation (RR = 0.37, 95%CI:0.23‐0.57; moderate quality evidence). In addition, the need for discontinuation rate in S boulardii supplementation group was significantly lower than in the control group (RR = 0.33, 95%CI:0.16‐0.69, P = .003; moderate quality evidence). The TSA results for overall eradication rates and total side effects indicated that the effects were conclusive. Conclusions: Our meta‐analysis shows that S boulardii supplementation on standard eradication therapy significantly increased H pylori eradication rates and reduced the incidence of total side effects and some gastrointestinal adverse effects during eradication therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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29. Isolation, Structural Elucidation, and α-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum.
- Author
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Chen, Xian-Qiang, Lin, Li-Gen, Zhao, Jing, Chen, Ling-Xiao, Tang, Yu-Ping, Luo, De-Lun, and Li, Shao-Ping
- Subjects
GLUCOSIDASE inhibitors ,TRITERPENOIDS ,GANODERMA ,TRADITIONAL medicine ,NUCLEAR magnetic resonance - Abstract
Ganoderma resinaceum has been used as an ethnomedicine for lowering blood sugar. To clarify the bioactive chemical constituents contributing to lower blood sugar, chemical investigation on the fruiting bodies ofGanoderma resinaceum was conducted by chromatographic techniques, and led to the isolation of 14 compounds. Their structures were elucidated as triterpenoid lactones (1 –4 and8 ) and ganoderma acids (5 –7 and9 –14 ) based on the analysis of extensive spectroscopy (mass spectrometry (MS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)) and comparison with literature data. Compounds3 ,5 ,6 , and9 –14 were evaluated forα -glucosidase inhibitory activity. Compounds1 –7 are new compounds. Compounds1 –4 and8 were characteristic of an oxaspirolactone moiety, consisting of a five-membered ether ring, a five-membered lactone ring, and a characteristic C-23 spiro carbon. It is rare for natural products that such an oxaspirolactone moiety occurred in the lanostane-type triterpenoids. Compounds5 –7 and9 –14 may be important intermediates of the biosynthetic pathways of1 –4 and8 . Compounds1 and2 showed more potent inhibitory activity againstα -glucosidase compared with the positive control drug acarbose with IC50 value of 0.75 ± 0.018 mM and 1.64 ± 0.022 mM, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2018
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30. Rivaroxaban for thromboprophylaxis after total hip or knee arthroplasty: a meta-analysis with trial sequential analysis of randomized controlled trials.
- Author
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Ning, Guang-Zhi, Kan, Shun-Li, Chen, Ling-Xiao, Shangguan, Lei, Feng, Shi-Qing, and Zhou, Yue
- Published
- 2016
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31. The Efficacy and Safety of Chemotherapy in Patients With Nonsmall Cell Lung Cancer and Interstitial Lung Disease: A PRISMA-Compliant Bayesian Meta-Analysis and Systematic Review.
- Author
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Chen, Yu Jie, Chen, Ling Xiao, Han, Mei Xiang, Zhang, Tian Song, Zhou, Zhi Rui, and Zhong, Dian Sheng
- Published
- 2015
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32. Nonsteroidal Anti-inflammatory Drugs as Prophylaxis for Heterotopic Ossification after Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.
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Kan, Shun-Li, Yang, Bo, Ning, Guang-Zhi, Chen, Ling-Xiao, Li, Yu-Lin, Gao, Shi-Jie, Chen, Xing-Yu, Sun, Jing-Cheng, and Feng, Shi-Qing
- Published
- 2015
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33. Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.
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Chen, Xian-Qiang, Zhao, Jing, Chen, Ling-Xiao, Wang, Shen-Fei, Wang, Ying, and Li, Shao-Ping
- Subjects
- *
GANODERMA , *CARBOXYLIC acids , *GLUCOSIDASES , *HYDROXY acids , *FERULIC acid - Abstract
Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum . Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-oxo-ganoderic acid Z 3 , 7-oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on α -glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α -glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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34. Chemical characterization and immunomodulatory activity of acetylated polysaccharides from Dendrobium devonianum.
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Deng, Yong, Li, Min, Chen, Ling-Xiao, Chen, Xian-Qiang, Lu, Jia-Hong, Zhao, Jing, and Li, Shao-Ping
- Subjects
- *
POLYSACCHARIDE synthesis , *UNSCENTED dendrobium , *SUBSTITUENTS (Chemistry) , *PHAGOCYTOSIS , *MONOSACCHARIDES , *IMMUNOLOGICAL adjuvants - Abstract
The chain conformation, chemical characters and immunomodulatory activity of polysaccharide from Dendrobium devonianum (DDP) were investigated. Results showed that molecular weights, polydispersity index, radius of gyrations of DDP were 3.99 × 10 5 Da 1.27, 74.1 nm, respectively. By applying the polymer solution theory, the exponent (v) values of
z 1/2 = kM w v was calculated as 0.38, which revealed that DDP existed as a globular shape in aqueous solution, and further confirmed by AFM analysis. Furthermore, the main monosaccharide compositions were Man and Glc with the ratio of 29.61:1.00. Indeed, the main glycosidic linkages were β-1,4-Manp, and substituted with acetyl groups at O-2 and O-3 position. Notably, DDP could promote the immune functions of macrophages including NO release and phagocytosis. Thus, DDP could be explored as a natural immune-stimulating agent in the health and functional food area as well as pharmaceutical industries. [ABSTRACT FROM AUTHOR]- Published
- 2018
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35. Advances in molecular basis of response to immunotherapy for penile cancer: better screening of responders.
- Author
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Xu DM, Chen LX, Zhuang XY, Han H, and Mo M
- Abstract
Penile cancer is a rare malignant tumor of the male urinary system. The treatment benefit of standard first-line chemotherapy is not ideal for patients with locally advanced or metastatic lymph nodes. Immunotherapy has brought new treatment strategies and opportunities for patients with penile cancer. At present, clinical studies on immunotherapy for penile cancer have been reported, and the results show that it is effective but not conclusive. With the development of immunotherapy and the progress of molecular research technology, we can better screen the immunotherapy response population and explore new combination treatment regimens to evaluate the best combination regimen and obtain the optimal treatment options, which is also an important research direction for the immunotherapy of penile cancer in the future., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Xu, Chen, Zhuang, Han and Mo.)
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- 2024
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36. The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer.
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Xu DM, Chen LX, Zhuang XY, Han H, and Mo M
- Subjects
- Humans, Male, Gene Expression Regulation, Neoplastic, Carcinogenesis genetics, Carcinogenesis pathology, Signal Transduction, Tumor Microenvironment immunology, Immune Checkpoint Inhibitors therapeutic use, Immune Checkpoint Inhibitors pharmacology, Penile Neoplasms pathology, Penile Neoplasms genetics, Penile Neoplasms metabolism, Suppressor of Cytokine Signaling 1 Protein genetics, Suppressor of Cytokine Signaling 1 Protein metabolism, Lymphatic Metastasis pathology, Lymphatic Metastasis genetics, Janus Kinases metabolism, STAT4 Transcription Factor metabolism, STAT4 Transcription Factor genetics, Disease Progression
- Abstract
Background: To uncover the potential significance of JAK-STAT-SOCS1 axis in penile cancer, our study was the pioneer in exploring the altered expression processes of JAK-STAT-SOCS1 axis in tumorigenesis, malignant progression and lymphatic metastasis of penile cancer. Methods: In current study, the comprehensive analysis of JAK-STAT-SOCS1 axis in penile cancer was analyzed via multiple analysis approaches based on GSE196978 data, single-cell data (6 cancer samples) and bulk RNA data (7 cancer samples and 7 metastasis lymph nodes). Results: Our study observed an altered molecular expression of JAK-STAT-SOCS1 axis during three different stages of penile cancer, from tumorigenesis to malignant progression to lymphatic metastasis. STAT4 was an important dominant molecule in penile cancer, which mediated the immunosuppressive tumor microenvironment by driving the apoptosis of cytotoxic T cell and was also a valuable biomarker of immune checkpoint inhibitor treatment response. Conclusions: Our findings revealed that the complexity of JAK-STAT-SOCS1 axis and the predominant role of STAT4 in penile cancer, which can mediate tumorigenesis, malignant progression, and lymphatic metastasis. This insight provided valuable information for developing precise treatment strategies for patients with penile cancer., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)
- Published
- 2024
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37. Rapid and sensitive detection of alkaline phosphatase and glucose oxidase activity through fluorescence and colorimetric dual-mode analysis based on CuO NPs@ZIF-8 mediated enzyme-cascade reactions.
- Author
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Chen GY, Luo ML, Chen L, Chai TQ, Wang JL, Chen LX, and Yang FQ
- Abstract
The combined application of nanozymes and natural enzymes has received widespread attention in recent years. In this work, a simple and efficient method was used to synthesize a composite material of CuO nanoparticle-modified zeolitic imidazolate framework-8 (CuO NPs@ZIF-8) with multiple enzyme activities (glucose oxidase-like and hydrolase-like activities) to detect the activity of natural enzymes through fluorescence and colorimetric (UV-vis) dual-mode detection. The hydrolase- and oxidase-like activities of CuO NPs@ZIF-8 show an acceptable affinity with l-ascorbic acid 2-phosphate trisodium (AAP) and o -phenylenediamine (OPD). Using the developed sensor, highly sensitive detection of natural enzymes glucose oxidase (GOX) and alkaline phosphatase (ALP) was achieved through both fluorescent and colorimetric analyses with a wide linear range (fluorescence for GOX: 0.86-1.23 × 10
5 mU mL-1 , UV-vis for GOX: 0.081-1.62 × 105 mU mL-1 ; fluorescence for ALP: 0.042-1.20 × 104 mU mL-1 , UV-vis for ALP: 0.0046-1.23 × 104 mU mL-1 ) and low LOQs (fluorescence for GOX: 0.86 mU mL-1 , UV-vis for GOX: 0.081 mU mL-1 ; fluorescence for ALP: 0.042 mU mL-1 , UV-vis for ALP: 0.0046 mU mL-1 ). Compared to the other fluorescent and colorimetric sensors, this sensor has better catalytic activity due to the addition of GOX and ALP, which can amplify the detection signal and improve the sensitivity. This is the first time that composite material CuO NPs@ZIF-8 with "tandem enzyme" activity was synthesized and applied in the detection of enzyme activity. Additionally, the proposed fluorescent and UV-vis platforms exhibit the capability to detect GOX and ALP in serum samples with satisfactory recovery, indicating potential application prospects in biochemical analysis., Competing Interests: The authors all have read and approved the present manuscript and declared that they have no conflicts of interest., (This journal is © The Royal Society of Chemistry.)- Published
- 2023
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38. Exercise interventions for ankylosing spondylitis: a protocol for a Bayesian network meta-analysis.
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Kan SL, Chen LX, Yuan ZF, Hu W, and Zhu RS
- Subjects
- Bayes Theorem, Humans, Treatment Outcome, Exercise Therapy methods, Spondylitis, Ankylosing therapy
- Abstract
Introduction: Ankylosing spondylitis (AS) is a universal chronic inflammatory rheumatic disease which predominantly results in chronic back pain and stiffness. However, some patients suffering from AS do not react well to pharmacological interventions. Exercise intervention has been employed for the treatment of AS and works as a complementary part of the management of AS. However, the effect of different types of exercise interventions remains unclear. The purpose of this study is to determine the relative efficacy of different types of exercise interventions for individuals with AS using a Bayesian network meta-analysis., Methods and Analysis: We will conduct a systematic literature review of randomised controlled trials that compare different types of exercise interventions for individuals with AS. PubMed, EMBASE and the Cochrane Library will be searched up to February 2019. The primary outcomes are functional capacity, pain and disease activity. The risk of bias for individual studies will be evaluated according to the Cochrane Handbook. A Bayesian network meta-analysis will be performed to compare the efficacy of different types of exercise interventions. The quality of evidence will be assessed by the Grading of Recommendations, Assessment, Development and Evaluation approach., Ethics and Dissemination: Ethical approval and patient consent are not required as this study is a meta-analysis based on published studies. The results of this network meta-analysis will be submitted to a peer-reviewed journal for publication., Prospero Registration Number: CRD42019123099., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2019
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39. Evaluation on quality consistency of Ganoderma lucidum dietary supplements collected in the United States.
- Author
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Wu DT, Deng Y, Chen LX, Zhao J, Bzhelyansky A, and Li SP
- Subjects
- Biological Products chemistry, Fungal Polysaccharides analysis, Triterpenes analysis, United States, Biological Products standards, Dietary Supplements standards, Reishi chemistry
- Abstract
Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form of dietary supplements in the United States due to its various benefits. However, the quality consistency of these products based on their label ingredients has seldom been evaluated due to the lack of a suitable toolkit. In this study, 19 batches of products of G. lucidum (Red Reishi, Reishi), herbal/mushroom supplements purchased in the United States, were evaluated based on their bioactive components including triterpenes and polysaccharides by using chromatographic methods and saccharide mapping. The results showed that the measured ingredients of only 5 tested samples (26.3%) were in accordance with their labels, which suggested the quality consistency of G. lucidum dietary supplements in the U.S. market was poor, which should be carefully investigated.
- Published
- 2017
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40. Nortriterpenoids from the Fruiting Bodies of the Mushroom Ganoderma resinaceum.
- Author
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Chen XQ, Chen LX, Zhao J, Tang YP, and Li SP
- Subjects
- Enzyme Activation drug effects, Glycoside Hydrolase Inhibitors chemistry, Glycoside Hydrolase Inhibitors pharmacology, Molecular Structure, Triterpenes pharmacology, alpha-Glucosidases metabolism, Fruiting Bodies, Fungal chemistry, Ganoderma chemistry, Triterpenes chemistry
- Abstract
Ganoderma resinaceum is usually used as ethnomedicine for immune-regulation, hyperglycemia, and liver disease. To date, only a few chemical constituents have been reported from G . resinaceum . In this study, fifteen nortriterpenoids including six new nortriterpenoids ( 1 - 6 ) and nine known analogs ( 7 - 15 ), were separated and purified from the fruiting bodies of G . resinaceum . New compounds were identified as lucidone I ( 1 ), lucidone J ( 2 ), lucidone K ( 3 ), lucidone I ( 4 ), ganosineniol B ( 5 ), and ganosineniol C ( 6 ), based on analysis of extensive spectroscopic data (high resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV)). The known compounds were assigned as lucidone A ( 7 ), lucidone B ( 8 ), lucidone H ( 9 ), lucidone E ( 10 ), lucidone F ( 11 ), lucidone D ( 12 ), lucidone C ( 13 ), ganoderense F ( 14 ), and ganosineniol A ( 15 ), by comparing their spectroscopic data with those reported in the literature. Compounds 3 , 4 , and 7 - 13 were examined for α -glucosidase inhibitory activity and display no significant activity, but the finding may support that the side chain of ganoderma triterpenoids played an important role in α -glucosidase inhibitory activity., Competing Interests: The authors declare no conflicts of interest.
- Published
- 2017
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41. Which is best for osteoporotic vertebral compression fractures: balloon kyphoplasty, percutaneous vertebroplasty or non-surgical treatment? A study protocol for a Bayesian network meta-analysis.
- Author
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Kan SL, Yuan ZF, Chen LX, Sun JC, Ning GZ, and Feng SQ
- Subjects
- Bayes Theorem, Fractures, Compression etiology, Fractures, Compression surgery, Humans, Kyphoplasty methods, Network Meta-Analysis, Osteoporotic Fractures complications, Osteoporotic Fractures surgery, Spinal Fractures etiology, Spinal Fractures surgery, Treatment Outcome, Bone Cements therapeutic use, Fractures, Compression therapy, Osteoporosis complications, Osteoporotic Fractures therapy, Spinal Fractures therapy, Vertebroplasty methods
- Abstract
Introduction: Osteoporotic vertebral compression fractures (OVCFs) commonly cause both acute and chronic back pain, substantial spinal deformity, functional disability and decreased quality of life and increase the risk of future vertebral fractures and mortality. Percutaneous vertebroplasty (PVP), balloon kyphoplasty (BK) and non-surgical treatment (NST) are mostly used for the treatment of OVCFs. However, which treatment is preferred is unknown. The purpose of this study is to comprehensively review the literature and ascertain the relative efficacy and safety of BK, PVP and NST for patients with OVCFs using a Bayesian network meta-analysis., Methods and Analysis: We will comprehensively search PubMed, EMBASE and the Cochrane Central Register of Controlled Trials, to include randomided controlled trials that compare BK, PVP or NST for treating OVCFs. The risk of bias for individual studies will be assessed according to the Cochrane Handbook. Bayesian network meta-analysis will be performed to compare the efficacy and safety of BK, PVP and NST. The quality of evidence will be evaluated by GRADE., Ethics and Dissemination: Ethical approval and patient consent are not required since this study is a meta-analysis based on published studies. The results of this network meta-analysis will be submitted to a peer-reviewed journal for publication., Prospero Registration Number: CRD42016039452; Pre-results., Competing Interests: Conflicts of Interest: None declared., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
- Published
- 2017
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42. SUSTAINABLE DEVELOPMENT OF AMOMUM VILLOSUM: A SYSTEMATIC INVESTIGATION ON THREE DIFFERENT PRODUCTION MODES.
- Author
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Lai YF, Chen LX, Chen YN, Zhao J, Leong F, Li XW, Yang Q, Li P, and Hu H
- Subjects
- Amomum growth & development, Animals, China, Conservation of Natural Resources, Gas Chromatography-Mass Spectrometry, Humans, Amomum chemistry, Drugs, Chinese Herbal chemistry
- Abstract
Background: Amomum Villosum (A. Villosum ), called Chunsharen in Chinese, is widely used in treating gastrointestinal disease. Its clinical benefits have been confirmed by both in vitro and in vivo studies. Facing the shortage of wild A. Villosum , artificial cultivating and natural fostering have been practiced in recent years. Therefore, it would be wondered whether the three different types of A. Villosum are comparable or not, particularly the herbal qualities, technological challenges, ecological impacts and economic benefits., Material and Methods: In this study, we combined quality research by using GC-MS, and field investigation to provide a systematic assessment about the three types of A. Villosum from these four aspects., Results: It found that the wild type had low output and was in an endangered situation. The artificial cultivation had larger agriculturing area with higher productivity, but faced the ecological challenges. Lastly, the natural fostering type generated the highest economic benefit and relatively low ecological impact. In addition, the natural fostering type had relatively better quality than the other types., Conclusion: Therefore, it suggests that natural fostering can be applied for long-term sustainable development of A. Villosum ., Competing Interests: Conflict of interest The authors declare that there is no conflict of interests regarding the publication of this paper.
- Published
- 2016
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43. Efficacy and Safety of Bisphosphonates for Low Bone Mineral Density After Kidney Transplantation: A Meta-Analysis.
- Author
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Kan SL, Ning GZ, Chen LX, Zhou Y, Sun JC, and Feng SQ
- Subjects
- Bone Density drug effects, Bone Density Conservation Agents pharmacology, Diphosphonates pharmacology, Humans, Randomized Controlled Trials as Topic, Bone Density Conservation Agents therapeutic use, Bone Diseases drug therapy, Diphosphonates therapeutic use, Kidney Transplantation, Postoperative Complications drug therapy
- Abstract
In patients with low bone mineral density (BMD) after kidney transplantation, the role of bisphosphonates remains unclear. We performed a systematic review and meta-analysis to investigate the efficacy and safety of bisphosphonates.We retrieved trials from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception through May 2015. Only randomized controlled trials that compared bisphosphonate-treated and control groups of patients with low bone mineral density after kidney transplantation were included. The primary outcomes were the percent change in BMD, the absolute change in BMD, and the BMD at the end of study at the lumbar spine. The results were expressed as the mean difference (MD) or relative risk (RR) with the 95% confidence interval (CI). We used a random-effects model to pool the outcomes.We included 17 randomized controlled trials with 1067 patients. Only 1 included trial was found to be at low risk of bias. The rest of the included studies were found to have high to uncertain risk of bias. Compared with the control group, those who received bisphosphonates had a significant increase in percent change in BMD (mean difference [MD] = 5.51, 95% confidence interval [CI] 3.22-7.79, P < 0.00001) and absolute change in BMD (MD = 0.05, 95% CI 0.04-0.05, P < 0.00001), but a nonsignificant increase in BMD at the end of the study (MD = 0.02, 95% CI -0.01 to 0.05, P = 0.25) at the lumbar spine. Bisphosphonates resulted in a significant improvement in percent change in BMD (MD = 4.95, 95% CI 2.57-7.33, P < 0.0001), but a nonsignificant improvement in absolute change in BMD (MD = 0.03, 95% CI -0.00 to 0.06, P = 0.07) and BMD at the end of the study (MD = -0.01, 95% CI -0.04 to 0.02, P = 0.40) at the femoral neck. No significant differences were found in vertebral fractures, nonvertebral fractures, adverse events, and gastrointestinal adverse events.Bisphosphonates appear to have a beneficial effect on BMD at the lumbar spine and do not significantly decrease fracture events in recipients. However, the results should be interpreted cautiously due to the lack of robustness and the heterogeneity among studies.
- Published
- 2016
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44. Transcutaneous Electrical Nerve Stimulation in Patients With Knee Osteoarthritis: Evidence From Randomized-controlled Trials.
- Author
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Chen LX, Zhou ZR, Li YL, Ning GZ, Li Y, Wang XB, and Feng SQ
- Subjects
- Databases, Bibliographic statistics & numerical data, Female, Humans, Male, Outcome Assessment, Health Care, Randomized Controlled Trials as Topic statistics & numerical data, Sensitivity and Specificity, Osteoarthritis, Knee therapy, Randomized Controlled Trials as Topic methods, Transcutaneous Electric Nerve Stimulation methods
- Abstract
Objectives: Transcutaneous electrical nerve stimulation (TENS) has been reported to relieve pain and improve function in patients with knee osteoarthritis. The purpose of this systematic review and meta-analysis was to evaluate the efficacy of TENS for the management of knee osteoarthritis., Methods: We searched Embase, PubMed, CENTRAL, SIGLE, PEDro, and clinicaltrials.gov, up to June 2014 for literature related to TENS used for the treatment of knee osteoarthritis. Two authors independently screened the searched records based on the title and abstract. Information including the authors, study design, mean age, sex, study population, stimulation frequency (of TENS), outcome measures, and follow-up periods were extracted by the 2 authors., Results: Eighteen trials were included in the qualitative systematic review, and 14 were included in the meta-analysis. TENS significantly decreased pain (standard mean difference, -0.79; 95% confidence interval [CI], -1.31 to -0.27; P<0.00001) compared with control groups. There was no significant difference in the Western Ontario and McMaster Universities Osteoarthritis Index (standard mean differences, -0.13; 95% CI, -0.35 to 0.1; P=0.09) or the rate of all-cause discontinuation (risk ratio, 0.77; 95% CI, 0.48 to 1.22; P=0.94) between the TENS and control groups., Discussion: TENS might relieve pain due to knee osteoarthritis. Further randomized-controlled trials should focus on large-scale studies and a longer duration of follow-up.
- Published
- 2016
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45. Comparison of Short-Course Radiotherapy Versus Long-Course Radiotherapy for Treatment of Metastatic Spinal Cord Compression: A Systematic Review and Meta-Analysis.
- Author
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Qu S, Meng HL, Liang ZG, Zhu XD, Li L, Chen LX, and Zhou ZR
- Subjects
- Humans, Motor Activity, Neoplasms mortality, Spinal Cord Compression etiology, Neoplasms complications, Radiotherapy statistics & numerical data, Spinal Cord Compression radiotherapy
- Abstract
In this study, we evaluate the efficacy of short-course radiotherapy (SCRT) versus long-course radiotherapy (LCRT) in the treatment of metastatic spinal cord compression (MSCC).PubMed, EMBASE, and Web of Science were searched up to April 2015. Relevant data were extracted based on inclusion and exclusion criteria. Methodological quality of randomized controlled trial (RCT) was evaluated using modified Jadad scale; non-RCT was evaluated using Newcastle-Ottawa Scale. Meta-analysis was performed using RevMan 5.3 software.Fourteen studies with 2239 patients were included. Results of meta-analysis showed that there were no significant differences between SCRT and long-course radiotherapy LCRT in 6-month overall survival rate (risk ratio [RR] = 0.97, 95% confidence interval [CI] 0.88, 1.07, P = 0.55), 1-year overall survival rate (RR = 0.94, 95% CI 0.85, 1.04, P = 0.22), motor function improvement (RR = 0.96, 95% CI 0.81, 1.13, P = 0.63), no change on motor function (RR = 0.98, 95% CI (0.88, 1.09), P = 0.74], and deterioration on motor function (RR = 0.96, 95% CI 0.71, 1.31, P = 0.78). Compared with SCRT, LCRT significantly increased 6-month local control rate (RR = 0.87, 95% CI 0.80, 0.95, P = 0.002), 1-year local control rate (RR = 0.83, 95% CI 0.71, 0.97, P = 0.02), and 2-year local control rate (RR = 0.83, 95% CI 0.79, 0.87, P < 0.00001).Both LCRT and SCRT provided similar survival rates and functional outcome, but LCRT showed better local control rates than SCRT. However, considering low cost and good patient's compliance, SCRT may be a better choice.
- Published
- 2015
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46. Short-course Versus Long-course Preoperative Radiotherapy plus Delayed Surgery in the Treatment of Rectal Cancer: a Meta-analysis.
- Author
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Liu SX, Zhou ZR, Chen LX, Yang YJ, Hu ZD, and Zhang TS
- Subjects
- Combined Modality Therapy, Humans, Neoadjuvant Therapy, Neoplasm Recurrence, Local pathology, Prognosis, Randomized Controlled Trials as Topic, Rectal Neoplasms pathology, Risk Factors, Time Factors, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Neoplasm Recurrence, Local therapy, Preoperative Care, Radiotherapy, Adjuvant, Rectal Neoplasms therapy
- Abstract
Background: Short-course preoperative radiation (SCRT) with delayed surgery was found to increase pathologic complete response (pCR) rates in several trials. However, there was no clear answer on whether SCRT or long-course chemo-radiotherapy (LCRT) is more effective. Therefore we conducted this meta-analysis to evaluate the safety and efficacy of SCRT versus LCRT, both with delayed surgery, for treatment of rectal cancer., Materials and Methods: The literature was searched from PubMed, EMBASE, Web of Science, Cochrane Library and clinicaltrials.gov up to November, 2014. Quality of the randomized controlled trials (RCTs) was evaluated according to the Cochrane's risk of bias tool of RCT. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to rate the level of evidence. Review Manager 5.3 was employed for statistical analysis. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated., Results: Three RCTs, with a total of 357 rectal cancer patients, were included in this systematic review. Meta- analysis results demonstrated there were no significantly differences in sphincter preservation rate, local recurrence rate, grade 3~4 acute toxicity, R0 resection rate and downstaging rate. Compared with SCRT, LCRT was associated with significant increase in the pCR rate [RR=0.49, 95%CI (0.31, 0.78), P=0.003]., Conclusions: In terms of sphincter preservation rate, local recurrence rate, grade 3~4 acute toxicity, R0 resection rate and downstaging rate, SCRT with delayed surgery is as effective as LCRT with delayed surgery for management of rectal cancer. LCRT significantly increased pCR rate compared with SCRT. Due to risk of bias and imprecision, further multi-center large sample RCTs were needed to confirm this conclusion.
- Published
- 2015
- Full Text
- View/download PDF
47. Electrochemically induced Fenton reaction of few-layer MoS2 nanosheets: preparation of luminescent quantum dots via a transition of nanoporous morphology.
- Author
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Li BL, Chen LX, Zou HL, Lei JL, Luo HQ, and Li NB
- Abstract
Electrochemically induced Fenton (electro-Fenton) reaction was used for efficient and controllable preparation of hydroxyl radicals, leading to the generation of luminescent quantum dots through etching of as-exfoliated MoS2 nanosheets. Morphologic changes of MoS2 nanosheets during the electro-Fenton reaction were monitored using transmission electron microscopy, showing that etching of MoS2 nanosheets induced by hydroxyl radicals resulted in rapid homogeneous fracturing of the sheets into small dots via a transition of nanoporous morphology. The as-generated dots with vertical dimensional thickness of ca. 0.7 nm and plane size of ca. 5 nm were demonstrated to be MoS2 quantum dots (MoS2-QDs), and their photoluminescence properties were explored based on quantum confinement, edge effect, and intrinsic characteristics. Moreover, the degree of etching and the concomitant porosity of MoS2 nanosheets could be conveniently tuned via the electro-Fenton reaction time, resulting in a new morphology of nanoporous MoS2 nanosheets, with potential new applications in various significant areas.
- Published
- 2014
- Full Text
- View/download PDF
48. [Detection and typing of caliciviruses from patients with acute diarrhea in Hangzhou area, 2009 - 2010].
- Author
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Zhuge XL, Cui DW, Wu YP, Zheng SF, Jin M, Duan ZJ, Yu F, Xu SJ, Chen LX, and Chen Y
- Subjects
- Adolescent, Caliciviridae isolation & purification, Child, Child, Preschool, China epidemiology, Genetic Variation, Genotype, Humans, Molecular Epidemiology, Norovirus genetics, Norovirus isolation & purification, Sapovirus genetics, Sapovirus isolation & purification, Caliciviridae genetics, Diarrhea virology
- Abstract
Objective: To investigate the molecular-epidemiologic characteristics and genotypes of human calicivirus (HuCVs) in acute diarrhea patients in Hangzhou from 2009 to 2010., Methods: Epidemiologic data and fecal specimens were collected from patients with acute diarrhea. HuCVs of 920 specimens were detected by PCR. PCR products of several positive samples were randomly selected and sequenced. All the sequences were analyzed, phylogenetically., Results: 201 HuCVs positive cases were identified from 920 facal specimens (21.8%). 25 isolates would include norovirus GI-type, GII-type for 170 strains and sapovirus for 11 strains. Norovirus GI-type and GII-type were detected in four specimens at the same time. Other specimens were mixed infection with norovirus GII-type and sapovirus. Genotypes of HuCVs showed that norovirus GI subtypes were GI-1 (3 strains) and GI-2 (1 strain). Norovirus GII subtypes were GII-4/2006b variant strains (7 strains), GII-2 (1 strain), GII-7 (1 strain) and GII-4/2008 variant strains (2 strains); Sapovirus subtypes were GI-2 (5 strains), GI-1 (4 strains) and GII-1 (1 strain). The prevalence rates of HuCVs were different in seasons and age groups., Conclusion: HuCVs were one of the major pathogens causing acute diarrhea. Both multiple viruses and genotypes of HuCVs were found in the specimens. GII-4/2006b variant and similar strains were identified, probably as the prevalent strains from 2009 to 2010 in Hangzhou, Zhejiang province.
- Published
- 2011
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