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Start Over Author "Coco N. Kapanda" Publication Type Academic Journals
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1. Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors.

Author

Coco N. Kapanda, Giulio G. Muccioli, Geoffray Labar, Jacques H. Poupaert, and Didier M. Lambert

Subjects
*MONOGLYCERIDES, *LIPASE inhibitors, *FATTY acids, *AMIDES, *HYDROLASES, *CLINICAL drug trials, *CANNABINOIDS
Abstract

Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme. [ABSTRACT FROM AUTHOR]

Published
2009
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