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2,661 results on '"Cooper, K"'

4. The Plasma Instrument for Magnetic Sounding (PIMS) on the Europa Clipper Mission

Author

Westlake, J. H., McNutt, Jr, R. L., Grey, M., Coren, D., Rymer, A. M., Cochrane, C. J., Luspay-Kuti, A., Hohlfeld, E., Seese, N., Crew, A., Liang, S., Diaz, T., Smith, H. T., Paty, C. S., Jia, X., Rogacki, S., Stevens, M. L., Kasper, J. C., Case, A. W., Slavin, J. A., Khurana, K. K., Kivelson, M. G., Shearer, C., Mandt, K. E., Asmar, K., Cooper, K., Battista, C., Kim, C., Katz, S., Kusterer, M., Brown, L., Linko, D., Schlemm, C., Jaskulek, S., Dalton, J., Caranza, R., Reynolds, E., Richardson, M., Saur, J., Krupp, N., and Roussos, E.

Published
2023
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7. The Incidence and Costs of Adverse Events Associated with Antidepressants: Results from a Systematic Review, Network Meta-Analysis and Multi-Country Economic Model

Author

Kearns B, Cooper K, Orr M, Essat M, Hamilton J, and Cantrell A

Subjects
cost analysis, side-effects, europe, treatment discontinuation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Benjamin Kearns, Katy Cooper, Martin Orr, Munira Essat, Jean Hamilton, Anna Cantrell School of Health and Related Research (SCHARR), the University of Sheffield, Sheffield, UKCorrespondence: Benjamin Kearns, SCHARR, the University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK, Tel +44 114 222 6380, Email b.kearns@sheffield.ac.ukPurpose: There is variation in the safety profile of antidepressants. Rates of adverse events along with the costs of treating them can be an important factor influencing the choice of depression treatment. This study sought to estimate the comparative safety of commonly prescribed antidepressants, and how the costs of treating these varied across European countries.Methods: A systematic literature review was conducted (in Medline, Embase, PsycINFO and CENTRAL) to identify placebo-controlled trials reporting rates of at least one type of sexual dysfunction, weight change, insomnia, anxiety, and anhedonia. Eight antidepressants were considered: duloxetine, escitalopram, fluoxetine, paroxetine, sertraline, trazodone, venlafaxine, and vortioxetine. This evidence was synthesised via Bayesian random effects network meta-analyses to provide comparative estimates of safety. A systematic search identified country-specific costs of managing depression and adverse events of antidepressants. Evidence on costs and safety was combined in an economic model to provide country-specific costs for Bulgaria, the Czech Republic, Greece, Hungary, Italy, Romania, Slovakia, Portugal, and Poland.Results: Trazodone had the lowest rates of both insomnia (odds ratio 0.66, 95% credible interval 0.31 to 1.38) and anxiety (0.13, < 0.01 to 1.80). All antidepressants were associated with increased rates of sexual dysfunction relative to placebo. Weight change was largest for fluoxetine (kg change − 1.01, − 1.40 to − 0.60) and sertraline (− 1.00, − 1.36 to − 0.65), although heterogeneity was extreme for this outcome. No evidence was identified for anhedonia. Total costs were lowest for trazodone in all nine of the countries evaluated. This was primarily due to reduced rates of treatment discontinuation.Conclusion: Trazodone generally had the best safety profile of the antidepressants evaluated. This led to healthcare costs being lowest for trazodone in all nine European countries, emphasising the importance of considering rates of adverse events when choosing a pharmacological treatment to treat symptoms of depression.Keywords: cost analysis, side-effects, Europe, treatment discontinuation

Published
2022

18. Six-Month Outcomes After High-Risk Coronary Artery Bypass Graft Surgery and Preoperative Intra-aortic Balloon Counterpulsation Use: An Inception Cohort Study

Author

Bagshaw, Sean M., Keri-Anne Cowdrey, Heidi Buhr, Frengley, Rob, Ferrier, Janet, Gilder, Eileen, Henderson, Seton, Larobina, Marco, Merthens, Jan, Morgan, Matthew, Navarra, Lean, Rudas, Máté, Turner, Lisa, Reid, Kristen, Wise, Matthew, Young, Noel, Young, Paul, McGiffin, D, Duncan, J, Kaczmarek, M, Seevanayagam, S, Shaw, M, Shardey, G, Skillington, P, Chorley, T, Baker, L, Zhang, B, Bright, C, Baker, R, Canning, N, Gilfillan, I, Kruger, R, Fayers, T, Kyte, M, Doran, C, Smith, J, Baxter, H, Seah, P, Scaybrook, S, James, A, Goodwin, K, Dignan, R, Hewitt, N, Gerrard, K, Curtis, L, Tiruvoipati, R, Broukal, N, Wolfenden, H, Muir, V, Worthington, M, Wong, C, Tatoulis, J, Wynne, R, Marshman, D, Sze, D, Wilson, M, Turner, L, Passage, J, Kolybaba, M, Fermanis, G, Newbon, P, Newcomb, A, Mack, J, Duve, K, Jansz, P, Hunter, T, Bissaker, P, Dennis, N, Burke, N, Yadav, S, Cooper, K, Chard, R, Halaka, M, Tran, L, Huq, M, Billah, B, Reid, CM, Litton, Edward, Bass, Frances, Delaney, Anthony, Hillis, Graham, Marasco, Silvana, McGuinness, Shay, Myles, Paul S., Reid, Christopher M., and Smith, Julian A.

Published
2018
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19. ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis.

Author

Cooper K Hayes, Douglas R Wilcox, Yuchen Yang, Grace K Coleman, Melissa A Brown, and Richard Longnecker

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic viral encephalitis, and despite targeted antiviral therapy, outcomes remain poor. Although the innate immune system is critical for restricting herpes simplex virus type I (HSV-1) in the brain, there is evidence that prolonged neuroinflammation contributes to HSE pathogenesis. In this study, we investigated the contribution of inflammasomes to disease pathogenesis in a murine model of HSE. Inflammasomes are signaling platforms that activate the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. We found that mice deficient in the inflammasome adaptor protein, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC), had significantly improved survival and lower levels of IL-1β and IL-18 in the brain. Importantly, this difference in survival was independent of viral replication in the central nervous system (CNS). We found that microglia, the resident macrophages of the CNS, are the primary mediators of the ASC-dependent inflammasome response during infection. Using in vitro glial infections and a murine HSE model, we demonstrate that inflammasome activation contributes to the expression of chemokine (C-C motif) ligand 6 (CCL6), a leukocyte chemoattractant. The lower concentration of CCL6 in the brains of ASC-/- mice correlated with lower numbers of infiltrating macrophages during infection. Together, these data suggest that inflammasomes contribute to pathogenic inflammation in HSE and provide a mechanistic link between glial inflammasome activation and leukocyte infiltration. The contribution of inflammasomes to survival was independent of viral replication in our study, suggesting a promising new target in combating harmful inflammation in HSE.

Published
2021
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31. Full Collection of Personal Narratives

Author

O'Leary, Gianna, Hostovsky, Paul, Ma, Yilu, Almazan, Leo, Sanchez-Herrera, Hilda, Rueda Will, Marisa, Hsieh, Elaine, Patiño, Manuel, Ratway, Felicity, Crane, Liliana, DeSouza, Laisson, Ricci, Nilsa, Pollack-Jackson, Linda, Cooper, Kelley, Rutherford-Rojas, Mateo, Moreno, Rosa C., Milkowska-Shibata, Maja, Coronado, Patricia, and Meyer, Catalina

Published
2024
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