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Start Over Author "David Molkentine" Publication Type Academic Journals
1 results on '"David Molkentine"'

1. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Author

Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, and Heath D. Skinner

Subjects
Science
Abstract

Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acetylation, increased homologous recombination and potential synergy between radiation and HAT inhibition in CREBBP/EP300 mutant tumors.

Published
2021
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