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Your search keyword '"Doubal, Fergus N."' showing total 205 results
Start Over Author "Doubal, Fergus N." Publication Type Academic Journals
205 results on '"Doubal, Fergus N."'

1. Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial

Author

Kopczak, Anna, Stringer, Michael S., van den Brink, Hilde, Kerkhofs, Danielle, Blair, Gordon W., van Dinther, Maud, Arteaga Reyes, Carmen, Jaime Garcia, Daniela, Onkenhout, Laurien, Wartolowska, Karolina A., Thrippleton, Michael J., Kampaite, Agniete, Duering, Marco, Staals, Julie, Lesnik-Oberstein, Saskia, Muir, Keith, Middeke, Martin, Norrving, Bo, Bousser, Marie-Germaine, Mansmann, Ulrich, Rothwell, Peter M., Doubal, Fergus N., van Oostenbrugge, Robert, Biessels, Geert Jan, Webb, Alastair J.S., Wardlaw, Joanna, Dichgans, Martin, André, Elisabeth, Kääb, Stefan, Anders, Hans-Joachim, Hack, Remco, Kaffe, Maria, Dewenter, Anna, Malik, Rainer, Stringer, Michael S, Blair, Gordon W, Reyes, Carmen Arteaga, Garcia, Daniela Jaime, Wartolowska, Karolina A, Thrippleton, Michael J, Muir, Keith W, Rothwell, Peter M, Doubal, Fergus N, Webb, Alastair J S, and Wardlaw, Joanna M

Published
2023
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3. Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study

Author

Sleight, Emilie, Stringer, Michael S., Clancy, Una, Arteaga, Carmen, Jaime Garcia, Daniela, Hewins, Will, Jochems, Angela C.C., Hamilton, Olivia K.L., Manning, Cameron, Morgan, Alasdair G., Locherty, Rachel, Cheng, Yajun, Liu, Xiaodi, Zhang, Junfang, Hamilton, Iona, Jardine, Charlotte, Brown, Rosalind, Sakka, Eleni, Kampaite, Agniete, Wiseman, Stewart, Valdés-Hernández, Maria C., Chappell, Francesca M., Doubal, Fergus N., Marshall, Ian, Thrippleton, Michael J., and Wardlaw, Joanna M.

Published
2023
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4. Neuroimaging standards for research into small vessel disease—advances since 2013

Author

Duering, Marco, Biessels, Geert Jan, Brodtmann, Amy, Chen, Christopher, Cordonnier, Charlotte, de Leeuw, Frank-Erik, Debette, Stéphanie, Frayne, Richard, Jouvent, Eric, Rost, Natalia S, ter Telgte, Annemieke, Al-Shahi Salman, Rustam, Backes, Walter H, Bae, Hee-Joon, Brown, Rosalind, Chabriat, Hugues, De Luca, Alberto, deCarli, Charles, Dewenter, Anna, Doubal, Fergus N, Ewers, Michael, Field, Thalia S, Ganesh, Aravind, Greenberg, Steven, Helmer, Karl G, Hilal, Saima, Jochems, Angela C C, Jokinen, Hanna, Kuijf, Hugo, Lam, Bonnie Y K, Lebenberg, Jessica, MacIntosh, Bradley J, Maillard, Pauline, Mok, Vincent C T, Pantoni, Leonardo, Rudilosso, Salvatore, Satizabal, Claudia L, Schirmer, Markus D, Schmidt, Reinhold, Smith, Colin, Staals, Julie, Thrippleton, Michael J, van Veluw, Susanne J, Vemuri, Prashanthi, Wang, Yilong, Werring, David, Zedde, Marialuisa, Akinyemi, Rufus O, Del Brutto, Oscar H, Markus, Hugh S, Zhu, Yi-Cheng, Smith, Eric E, Dichgans, Martin, and Wardlaw, Joanna M

Published
2023
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5. Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Author

Sweeney, Melanie D, Montagne, Axel, Sagare, Abhay P, Nation, Daniel A, Schneider, Lon S, Chui, Helena C, Harrington, Michael G, Pa, Judy, Law, Meng, Wang, Danny JJ, Jacobs, Russell E, Doubal, Fergus N, Ramirez, Joel, Black, Sandra E, Nedergaard, Maiken, Benveniste, Helene, Dichgans, Martin, Iadecola, Costantino, Love, Seth, Bath, Philip M, Markus, Hugh S, Salman, Rustam A, Allan, Stuart M, Quinn, Terence J, Kalaria, Rajesh N, Werring, David J, Carare, Roxana O, Touyz, Rhian M, Williams, Steve CR, Moskowitz, Michael A, Katusic, Zvonimir S, Lutz, Sarah E, Lazarov, Orly, Minshall, Richard D, Rehman, Jalees, Davis, Thomas P, Wellington, Cheryl L, González, Hector M, Yuan, Chun, Lockhart, Samuel N, Hughes, Timothy M, Chen, Christopher LH, Sachdev, Perminder, O'Brien, John T, Skoog, Ingmar, Pantoni, Leonardo, Gustafson, Deborah R, Biessels, Geert Jan, Wallin, Anders, Smith, Eric E, Mok, Vincent, Wong, Adrian, Passmore, Peter, Barkof, Frederick, Muller, Majon, Breteler, Monique MB, Román, Gustavo C, Hamel, Edith, Seshadri, Sudha, Gottesman, Rebecca F, van Buchem, Mark A, Arvanitakis, Zoe, Schneider, Julie A, Drewes, Lester R, Hachinski, Vladimir, Finch, Caleb E, Toga, Arthur W, Wardlaw, Joanna M, and Zlokovic, Berislav V

Subjects
Blood-Brain Barrier, Brain, Humans, Alzheimer Disease, Vascular Diseases, Cerebrovascular Circulation, United States, National Institute on Aging (U.S.), Amyloid beta-Peptides, White Matter, Biomarkers, Alzheimer's disease, Blood-brain barrier, Cerebral blood flow, MRI, Vascular, National Institute on Aging, Neurosciences, Clinical Sciences, Geriatrics
Abstract

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Next, we examined various imaging sequences that could be easily implemented to evaluate different types of vascular dysfunction associated with, and/or contributing to, AD pathophysiology, including changes in blood-brain barrier integrity and cerebral blood flow. Vascular imaging biomarkers of small vessel disease of the brain, which is responsible for >50% of dementia worldwide, including AD, are already established, well characterized, and easy to recognize. We suggest that these vascular biomarkers should be incorporated into the AD Research Framework to gain a better understanding of AD pathophysiology and aid in treatment efforts.

Published
2019

8. Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease

Author

Wiseman, Stewart J, Zhang, Jun-Fang, Gray, Calum, Hamid, Charlene, Valdés Hernández, Maria del C, Ballerini, Lucia, Thrippleton, Michael J, Manning, Cameron, Stringer, Michael, Sleight, Emilie, Muñoz Maniega, Susana, Morgan, Alasdair, Cheng, Yajun, Arteaga, Carmen, Jaime Garcia, Dany, Clancy, Una, Doubal, Fergus N, Dhillon, Baljean, MacGillivray, Tom, Wu, Yun-Cheng, and Wardlaw, Joanna M

Published
2023
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9. Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease

Author

Zhang, Jun-Fang, Lim, Hwee Fang, Chappell, Francesca M., Clancy, Una, Wiseman, Stewart, Valdés-Hernández, Maria C., Garcia, Daniela Jaime, Bastin, Mark E., Doubal, Fergus N., Hewins, Will, Cox, Simon R., Maniega, Susana Muñoz, Thrippleton, Michael, Stringer, Michael, Jardine, Charlotte, McIntyre, Donna, Barclay, Gayle, Hamilton, Iona, Kesseler, Lucy, Murphy, Madeleine, Perri, Carol Di, Wu, Yun-Cheng, and Wardlaw, Joanna M.

Published
2021
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11. Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project

Author

Blair, Gordon W., Stringer, Michael S., Thrippleton, Michael J., Chappell, Francesca M., Shuler, Kirsten, Hamilton, Iona, Garcia, Daniela Jaime, Doubal, Fergus N., Kopczak, Anna, Duering, Marco, Ingrisch, Michael, Kerkhofs, Danielle, Staals, Julie, van den Brink, Hilde, Arts, Tine, Backes, Walter H, van Oostenbrugge, Robert, Biessels, Geert Jan, Dichgans, Martin, and Wardlaw, Joanna M.

Published
2021
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12. Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study

Author

van den Brink, Hilde, Kopczak, Anna, Arts, Tine, Onkenhout, Laurien, Siero, Jeroen C.W., Zwanenburg, Jaco J.M., Duering, Marco, Blair, Gordon W., Doubal, Fergus N., Stringer, Michael S., Thrippleton, Michael J., Kuijf, Hugo J., de Luca, Alberto, Hendrikse, Jeroen, Wardlaw, Joanna M., Dichgans, Martin, and Biessels, Geert Jan

Published
2021
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16. Vascular dysfunction—The disregarded partner of Alzheimer's disease

Author

Sweeney, Melanie D., Montagne, Axel, Sagare, Abhay P., Nation, Daniel A., Schneider, Lon S., Chui, Helena C., Harrington, Michael G., Pa, Judy, Law, Meng, Wang, Danny J.J., Jacobs, Russell E., Doubal, Fergus N., Ramirez, Joel, Black, Sandra E., Nedergaard, Maiken, Benveniste, Helene, Dichgans, Martin, Iadecola, Costantino, Love, Seth, Bath, Philip M., Markus, Hugh S., Salman, Rustam A., Allan, Stuart M., Quinn, Terence J., Kalaria, Rajesh N., Werring, David J., Carare, Roxana O., Touyz, Rhian M., Williams, Steve C.R., Moskowitz, Michael A., Katusic, Zvonimir S., Lutz, Sarah E., Lazarov, Orly, Minshall, Richard D., Rehman, Jalees, Davis, Thomas P., Wellington, Cheryl L., González, Hector M., Yuan, Chun, Lockhart, Samuel N., Hughes, Timothy M., Chen, Christopher L.H., Sachdev, Perminder, O'Brien, John T., Skoog, Ingmar, Pantoni, Leonardo, Gustafson, Deborah R., Biessels, Geert Jan, Wallin, Anders, Smith, Eric E., Mok, Vincent, Wong, Adrian, Passmore, Peter, Barkof, Frederick, Muller, Majon, Breteler, Monique M.B., Román, Gustavo C., Hamel, Edith, Seshadri, Sudha, Gottesman, Rebecca F., van Buchem, Mark A., Arvanitakis, Zoe, Schneider, Julie A., Drewes, Lester R., Hachinski, Vladimir, Finch, Caleb E., Toga, Arthur W., Wardlaw, Joanna M., and Zlokovic, Berislav V.

Published
2019
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17. Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta‐analysis.

Author

Clancy, Una, Cheng, Yajun, Brara, Amrita, Doubal, Fergus N., and Wardlaw, Joanna M.

Abstract

INTRODUCTION: The prevalence of cerebral smallvessel disease (SVD) and vascular dementia according to workplace or domestic exposure to hazardous substances is unclear. METHODS: We included studies assessing occupational and domestic hazards/at‐risk occupations and SVD features. We pooled prevalence estimates using random‐effects models where possible, or presented a narrative synthesis. RESULTS: We included 85 studies (n = 47,743, mean age = 44·5 years). 52/85 reported poolable estimates. SVD prevalence in populations exposed to carbon monoxide was 81%(95% CI = 60‐93%; n = 1373; results unchanged in meta‐regression), carbon disulfide73% (95% CI = 54‐87%; n = 131), 1,2‐dichloroethane 88% (95% CI = 4‐100%, n = 40), toluene 82% (95% CI = 3‐100%, n = 64), high altitude 49% (95% CI = 38‐60%; n = 164),and diving 24% (95% CI = 5‐67%, n = 172). We narratively reviewed vascular dementia studies and contact sport, lead, military, pesticide, and solvent exposures as estimates were too few/varied to pool. DISCUSSION: SVD and vascular dementia may be associated with occupational/domestic exposure to hazardous substances. CRD42021297800. [ABSTRACT FROM AUTHOR]

Published
2024
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20. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Author

Sachdev, Perminder S., Lo, Jessica W., Crawford, John D., Mellon, Lisa, Hickey, Anne, Williams, David, Bordet, Régis, Mendyk, Anne-Marie, Gelé, Patrick, Deplanque, Dominique, Bae, Hee-Joon, Lim, Jae-Sung, Brodtmann, Amy, Werden, Emilio, Cumming, Toby, Köhler, Sebastian, Verhey, Frans R.J., Dong, Yan-Hong, Tan, Hui Hui, Chen, Christopher, Xin, Xu, Kalaria, Raj N., Allan, Louise M., Akinyemi, Rufus O., Ogunniyi, Adesola, Klimkowicz-Mrowiec, Aleksandra, Dichgans, Martin, Wollenweber, Frank A., Zietemann, Vera, Hoffmann, Michael, Desmond, David W., Linden, Thomas, Blomstrand, Christian, Fagerberg, Björn, Skoog, Ingmar, Godefroy, Olivier, Barbay, Mélanie, Roussel, Martine, Lee, Byung-Chul, Yu, Kyung-Ho, Wardlaw, Joanna, Makin, Stephen J., Doubal, Fergus N., Chappell, Francesca M., Srikanth, Velandai K., Thrift, Amanda G., Donnan, Geoffrey A., Kandiah, Nagaendran, Chander, Russell J., Lin, Xuling, Cordonnier, Charlotte, Moulin, Solene, Rossi, Costanza, Sabayan, Behnam, Stott, David J., Jukema, J. Wouter, Melkas, Susanna, Jokinen, Hanna, Erkinjuntti, Timo, Mok, Vincent C.T., Wong, Adrian, Lam, Bonnie Y.K., Leys, Didier, Hénon, Hilde, Bombois, Stéphanie, Lipnicki, Darren M., and Kochan, Nicole A.

Published
2017
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28. Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.

Author

Wardlaw, Joanna M., Woodhouse, Lisa J., Mhlanga, Iris I., Oatey, Katherine, Heye, Anna K., Bamford, John, Cvoro, Vera, Doubal, Fergus N., England, Timothy, Hassan, Ahamad, Montgomery, Alan, O'Brien, John T., Roffe, Christine, Sprigg, Nikola, Werring, David J., and Bath, Philip M.

Published
2023
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32. Advanced MRI in cerebral small vessel disease.

Author

van den Brink, Hilde, Doubal, Fergus N, and Duering, Marco

Subjects
*CEREBRAL small vessel diseases, *DIFFUSION magnetic resonance imaging, *LACUNAR stroke, *MAGNETIC resonance imaging
Abstract

Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. This review summarizes recent developments in advanced neuroimaging of cSVD with a focus on clinical and research applications. In the first section, we highlight how advanced structural imaging techniques, including diffusion magnetic resonance imaging (MRI), enable improved detection of tissue damage, including characterization of tissue appearing normal on conventional MRI. These techniques enable progression to be monitored and may be useful as surrogate endpoint in clinical trials. Quantitative MRI, including iron and myelin imaging, provides insights into tissue composition on the molecular level. In the second section, we cover how advanced MRI techniques can demonstrate functional or dynamic abnormalities of the blood vessels, which could be targeted in mechanistic research and early-stage intervention trials. Such techniques include the use of dynamic contrast enhanced MRI to measure blood–brain barrier permeability, and MRI methods to assess cerebrovascular reactivity. In the third section, we discuss how the increased spatial resolution provided by ultrahigh field MRI at 7 T allows imaging of perforating arteries, and flow velocity and pulsatility within them. The advanced MRI techniques we describe are providing novel pathophysiological insights in cSVD and allow improved quantification of disease burden and progression. They have application in clinical trials, both in assessing novel therapeutic mechanisms, and as a sensitive endpoint to assess efficacy of interventions on parenchymal tissue damage. We also discuss challenges of these advanced techniques and suggest future directions for research. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition.

Author

Jochems, Angela C. C., Muñoz Maniega, Susana, Clancy, Una, Jaime Garcia, Daniela, Arteaga, Carmen, Hewins, Will, Penman, Rachel, Hamilton, Olivia K. L., Czechoń, Agnieszka, Backhouse, Ellen V., Thrippleton, Michael J., Stringer, Michael S., Bastin, Mark. E., Valdés Hernández, Maria del C., Wiseman, Stewart, Chappell, Francesca M., Doubal, Fergus N., and Wardlaw, Joanna M.

Abstract

Post-stroke cognitive impairment is common and can have major impact on life after stroke. Peak-width of Skeletonized Mean Diffusivity (PSMD) is a diffusion imaging marker of white matter microstructure and is also associated with cognition. Here, we examined associations between PSMD and post-stroke global cognition in an ongoing study of mild ischemic stroke patients. We studied cross-sectional associations between PSMD and cognition at both 3-months (N = 229) and 1-year (N = 173) post-stroke, adjusted for premorbid IQ, sex, age, stroke severity and disability, as well as the association between baseline PSMD and 1-year cognition. At baseline, (mean age = 65.9 years (SD = 11.1); 34% female), lower Montreal Cognitive Assessment (MoCA) scores were associated with older age, lower premorbid IQ and higher stroke severity, but not with PSMD (βstandardized = −0.116, 95% CI −0.241, 0.009; p = 0.069). At 1-year, premorbid IQ, older age, higher stroke severity and higher PSMD (βstandardized = −0.301, 95% CI −0.434, −0.168; p < 0.001) were associated with lower MoCA. Higher baseline PSMD was associated with lower 1-year MoCA (βstandardized = −0.182, 95% CI −0.308, −0.056; p = 0.005). PSMD becomes more associated with global cognition at 1-year post-stroke, possibly once acute effects have settled. Additionally, PSMD in the subacute phase after a mild stroke could help predict long-term cognitive impairment. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Impact of White Matter Hyperintensity Changes on Cognition One Year After Mild Ischemic Stroke.

Author

Jochems, Angela CC, Maniega, Susana Muñoz, Clancy, Una, Arteaga, Carmen, Garcia, Daniela Jaime, Hewins, Will, Locherty, Rachel, Wiseman, Stewart, Hernandez, Maria del C. Valdes, Chappell, Francesca M, Stringer, Michael S, Thrippleton, Michael J, Doubal, Fergus N, and Wardlaw, Joanna M

Abstract

Background: White matter hyperintensities (WMH) are a main MRI feature of cerebral small vessel disease, and are associated with increased risk of stroke and dementia. Progression can lead to cognitive decline, but some evidence suggests that WMH can also regress. Regression might relate to better clinical outcomes, but this is not well examined yet. We explored if net WMH volume change accounts for changes in cognition 1‐year after mild ischemic stroke. We also explore tissue signatures in areas of white matter change using brain diffusion imaging. Method: In a prospective study, we assessed vascular risk factors (VRF), structural and diffusion‐tensor brain MRI and cognition (Montreal Cognitive Assessment; MoCA) at baseline (≤3 months post‐stroke) and at 1‐year. We assessed change in cognition over 1‐year using a linear mixed model. Predictors were age, sex, stroke severity (National Institutes of Health Stroke Scale; NIHSS), combined VRFs, disability (modified Rankin Score), occurrence of incidental infarct in‐between visits and WMH volume (%intracranial volume). We studied tissue areas of stable normal‐appearing white matter (NAWM), stable WMH, regressing and progressing WMH (Figure1) and measured diffusion‐tensor fractional anisotropy (FA) and mean diffusivity (MD), to assess microstructure in each area Result: At baseline, mean age = 67.5 (SD = 11.1), 66% male (N = 229), mean MoCA score = 25.0 (SD = 3.5). Between baseline and 1‐year post‐stroke, MoCA score decreased with older age (standardized B[95%CI]: ‐0.271[‐0.383; ‐0.159]) and increasing NIHSS (‐0.193[‐0.287; ‐0.099]). Areas of NAWM that progress to WMH already have lower FA and higher MD at baseline than NAWM that stays NAWM (N = 191; Figure2). WMH that regress to NAWM have higher FA and lower MD than stable WMH. At 1‐year, MD values seem higher and FA values seem lower in progressing WMH than at baseline. Conclusion: Cognition deteriorates 1 year post‐stroke with older age and higher stroke severity, but not with WMH changes, when considering net WMH volume. Areas of WMH changes exist within individuals, these areas show different underlying tissue structures before becoming apparent on conventional MRI, indicating that WMH regression is real. Separate areas of WMH progression and regression might be more sensitive to cognitive changes and potentially be intervention targets. [ABSTRACT FROM AUTHOR]

Published
2023
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