16 results on '"Eduardo Redondo Cerezo"'
Search Results
2. Tigecycline reduces tumorigenesis in colorectal cancer via inhibition of cell proliferation and modulation of immune response
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Antonio Jesús Ruiz-Malagón, Laura Hidalgo-García, María Jesús Rodríguez-Sojo, José Alberto Molina-Tijeras, Federico García, Patricia Diez-Echave, Teresa Vezza, Patricia Becerra, Juan Antonio Marchal, Eduardo Redondo-Cerezo, Martin Hausmann, Gerhard Rogler, José Garrido-Mesa, María Elena Rodríguez-Cabezas, Alba Rodríguez-Nogales, and Julio Gálvez
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Colitis-associated colorectal cancer ,Tigecycline ,β-catenin ,Cytotoxic T lymphocytes ,Microbiota ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: and Purpose: Colorectal cancer (CRC) is one of the cancers with the highest incidence in which APC gene mutations occur in almost 80% of patients. This mutation leads to β-catenin aberrant accumulation and an uncontrolled proliferation. Apoptosis evasion, changes in the immune response and microbiota composition are also events that arise in CRC. Tetracyclines are drugs with proven antibiotic and immunomodulatory properties that have shown cytotoxic activity against different tumor cell lines. Experimental approach: The effect of tigecycline was evaluated in vitro in HCT116 cells and in vivo in a colitis-associated colorectal cancer (CAC) murine model. 5-fluorouracil was assayed as positive control in both studies. Key results: Tigecycline showed an antiproliferative activity targeting the Wnt/β-catenin pathway and downregulating STAT3. Moreover, tigecycline induced apoptosis through extrinsic, intrinsic and endoplasmic reticulum pathways converging on an increase of CASP7 levels. Furthermore, tigecycline modulated the immune response in CAC, reducing the cancer-associated inflammation through downregulation of cytokines expression. Additionally, tigecycline favored the cytotoxic activity of cytotoxic T lymphocytes (CTLs), one of the main immune defenses against tumor cells. Lastly, the antibiotic reestablished the gut dysbiosis in CAC mice increasing the abundance of bacterial genera and species, such as Akkermansia and Parabacteroides distasonis, that act as protectors against tumor development. These findings resulted in a reduction of the number of tumors and an amelioration of the tumorigenesis process in CAC. Conclusion and implications: Tigecycline exerts a beneficial effect against CRC supporting the use of this antibiotic for the treatment of this disease.
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- 2023
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3. International multicenter study comparing demographics, therapy and outcomes in bleeding from Mallory Weiss tears and peptic ulcers
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Jennifer E. Tham, Lucy Lynch, Stig B. Laursen, Loren Laine, Harry R. Dalton, Jeffrey Ngu, Eduardo Redondo-Cerezo, Michael Schultz, Iain Murray, Nick Michell, Alan J. Morris, Michael M. Nielsen, and Adrian J. Stanley
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and study aims Mallory Weiss tears (MWTs) are relatively uncommon causes of upper gastrointestinal bleeding (UGIB), and patients are generally considered at low risk of poor outcome, although data are limited. There is uncertainty about use of endoscopic therapy. We aimed to describe and compare an international cohort of patients presenting with UGIB secondary to MWT and peptic ulcer bleeding (PUB). Patients and methods From an international dataset of patients undergoing endoscopy for acute UGIB at seven hospitals, we assessed patients with MWT bleeding, including the endoscopic stigmata and endoscopic therapy applied. We compared baseline parameters, rebleeding rate, and 30-day mortality between patients with MWT and PUB. Results A total of 3648 patients presented with UGIB, 125 of whom (3.4 %) had bleeding from a MWT. Those patients were younger (61 vs 69 years, P
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- 2022
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4. Percutaneous transhepatic or endoscopic ultrasound-guided biliary drainage in malignant distal bile duct obstruction using a self-expanding metal stent: Study protocol for a prospective European multicenter trial (PUMa trial).
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Daniel Schmitz, Carlos T Valiente, Markus Dollhopf, Manuel Perez-Miranda, Armin Küllmer, Joan Gornals, Juan Vila, Jochen Weigt, Torsten Voigtländer, Eduardo Redondo-Cerezo, Thomas von Hahn, Jörg Albert, Stephan Vom Dahl, Torsten Beyna, Dirk Hartmann, Franziska Franck, Francisco Javier García-Alonso, Arthur Schmidt, Albert Garcia-Sumalla, Amaia Arrubla, Markus Joerdens, Tobias Kleemann, José Ramón Aparicio Tomo, Felix Grassmann, and Jochen Rudi
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Medicine ,Science - Abstract
BackgroundEndoscopic ultrasound-guided biliary drainage (EUS-BD) was associated with better clinical success and a lower rate of adverse events (AEs) than fluoroscopy-guided percutaneous transhepatic biliary drainage (PTBD) in recent single center studies with mainly retrospective design and small case numbers (< 50). The aim of this prospective European multicenter study is to compare both drainage procedures using ultrasound-guidance and primary metal stent implantation in patients with malignant distal bile duct obstruction (PUMa Trial).MethodsThe study is designed as a non-randomized, controlled, parallel group, non-inferiority trial. Each of the 16 study centers performs the procedure with the best local expertise (PTBD or EUS-BD). In PTBD, bile duct access is performed by ultrasound guidance. EUS-BD is performed as an endoscopic ultrasound (EUS)-guided hepaticogastrostomy (EUS-HGS), EUS-guided choledochoduodenostomy (EUS-CDS) or EUS-guided antegrade stenting (EUS-AGS). Insertion of a metal stent is intended in both procedures in the first session. Primary end point is technical success. Secondary end points are clinical success, duration pf procedure, AEs graded by severity, length of hospital stay, re-intervention rate and survival within 6 months. The target case number is 212 patients (12 calculated dropouts included).DiscussionThis study might help to clarify whether PTBD is non-inferior to EUS-BD concerning technical success, and whether one of both interventions is superior in terms of efficacy and safety in one or more secondary endpoints. Randomization is not provided as both procedures are rarely used after failed endoscopic biliary drainage and study centers usually prefer one of both procedures that they can perform best.Trial registrationClinicalTrials.gov ID: NCT03546049 (22.05.2018).
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- 2022
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5. Incidence, clinical outcomes, and therapeutic approaches of capsule endoscopy-related adverse events in a large study population
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Ignacio Fernández-Urien, Cristina Carretero, Begoña González, Vicente Pons, Ángel Caunedo, Julio Valle, Eduardo Redondo-Cerezo, Antonio López-Higueras, Mariano Valdés, Pedro Menchen, Pedro Fernández, Miguel Muñoz-Navas, Javier Jiménez, and Juan Manuel Herrerías
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Capsule endoscopy ,Adverse events ,Small bowel ,Retention ,Aspiration ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Capsule endoscopy (CE) has become a first-line tool for small bowel (SB) examination. However, adverse events (AEs), such as CE retention or aspiration, may occur. The aims of this study were to evaluate incidence, clinical outcomes and therapeutic approaches of CE-related AEs in the largest series published to date. Methods: Data from 5428 procedures performed at 12 institutions between August 2001 and January 2012 were retrospectively analyzed. Baseline patient characteristics; procedure; type, localization and symptoms before/after AEs; previous patency tests performed; therapeutic management and patient's outcome were recorded. Results: The overall incidence of CE-related AEs was 1.9%: 2.0% for SB, 0.9% for esophageal and 0.5% for colon CE. The incidence of capsule retention was significantly higher than capsule aspiration (1.87% vs. 0.003%; p < 0.05), in patients suffering from inflammatory bowel disease (IBD) than in obscure GI bleeding (OGIB) (3.3% vs. 1.5%; p < 0.05) and in patients with the combination of nausea/vomiting, abdominal pain and distension. The SB was the most frequent localization of retention (88.2%). The use of patency tests -except for Patency© capsule- before CE was not a good predictor for AEs. Most of the patients with AEs developed no or mild symptoms (97%) and were managed by non-surgical methods (64.4%). Conclusions: CE-related AEs are uncommon and difficult to predict by imagiological examinations. SB retention, that is usually asymptomatic, is the most frequent AE. In absence of symptoms, non-surgical management of CE-related AEs is recommended.
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- 2015
6. Dispepsia, dispepsia funcional y criterios de Roma IV
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Antonio-M.ª Caballero-Mateos and Eduardo Redondo-Cerezo
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Prevalencia ,Dispepsia ,Dispepsia funcional ,Criterios de Roma IV ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2018
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7. Challenging Propofol Sedation in Gastrointestinal Endoscopy: High Risk Patients and High Risk Procedures
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Eduardo Redondo-Cerezo
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Sedation is increasingly becoming a must for most endoscopic procedures. Non-anesthesiologist administration of propofol is the standard of practice in many European countries. Nevertheless, despite anesthesiology societies concerns about sedation guided by endoscopist, practitioners find some limits to propofol administration, related to high risk patients or high risk and complex procedures, which can be long lasting and technically challenging. The main patient related risk factors for sedation are elderly patients, obesity, ASA≥3 patients, individuals with craniofacial abnormalities or with pharyngolaringeal tumors, patients with an acute gastrointestinal bleeding, under pain medications, sedatives, antidepressants, or who consume significant amounts of alcohol or drugs. Procedure related risk factors have more to do with the duration and complexity of the procedure than with other factors, in which considering a general anesthesia allows the endoscopist to concentrate on a difficult task. Published papers addressing the most challenging sedation groups in endoscopy are exploring and even trespassing previously assumed frontiers, and new scenarios are opening to the endoscopist, increasing his/her autonomy, reducing costs and giving patients levels of comfort previously unknown. In this review we analyse each risk group determining the ones in which a sedation protocol could be widely applied, and other in which the published evidence does not guarantee a safe endoscopist guided propofol sedation.
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- 2012
8. Keriorrea (diarrea cérea), un nuevo signo a tener en cuenta
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Antonio-M.ª Caballero-Mateos, Antonio-Damián Sánchez-Capilla, and Eduardo Redondo-Cerezo
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Keriorrea ,Diarrea cérea ,Heces naranjas ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2018
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9. Gastric outlet obstruction after the insertion of a fully filled intragastric balloon Obstrucción del vaciamiento gástrico tras la inserción de balón intragástrico relleno
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Eduardo Redondo-Cerezo, Virgilio Martos-Ruiz, Ana Matas-Cobos, Manuel Ojeda-Hinojosa, Juan Gabriel Martínez-Cara, Antonio Damián Sánchez-Capilla, Mercedes López-de-Hierro-Ruiz, and Javier de-Teresa
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2013
10. Diagnostic Yield and Impact of Capsule Endoscopy on Management of Patients with Gastrointestinal Bleeding of Obscure Origin.
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Eduardo Redondo-Cerezo, Gracia Pérez-Vigara, Angel Pérez-Sola, Carmen Gómez-Ruiz, Miriam Chicano, Natividad Sánchez-Manjavacas, Julia Morillas, José Pérez-García, and Jesús García-Cano
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ENDOSCOPY , *GASTROINTESTINAL system , *HEMORRHAGE , *PATIENTS - Abstract
Abstract This study assessed diagnostic yield and impact of capsule endoscopy on patient management. Seventy-five patients with obscure gastrointestinal bleeding were included. Clinical and followup information was collected by review of patient records and with personal contact with the referring physicians. All previous clinical information and interventions after capsule endoscopy and clinical outcome were noted. The indication was obscure-overt gastrointestinal bleeding in 36 patients (48%) and obscure-occult gastrointestinal bleeding in 39 patients (52%). Overall diagnostic yield was 66.7% considering relevant lesions. Followup was available in 31 patients. Capsule endoscopy changed clinical management in 61.4%. Multivariate analysis showed that patients with another potential source of bleeding and patients whose onset was hematochezia were not good candidates for capsule endoscopy. Capsule endoscopy has a high diagnostic yield and a positive influence on clinical management in a high proportion of patients with obscure gastrointestinal bleeding. [ABSTRACT FROM AUTHOR]
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- 2007
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11. CASE REPORT: Unusual Presentation and Diagnosis of Extraintestinal Follicular Lymphoma.
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Eduardo Redondo-Cerezo, Luis De Benito, Anastasio Serreno-Egea, and Carmen J. Gómez
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- 2004
12. Impact of an Evidence-Based Prioritization System and Electronic Consultation in Early Diagnosis of Colorectal Cancer
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Francisco Valverde-López, Marta Librero-Jiménez, Raúl Fernández-García, Teresa Vezza, Clara Heredia-Carrasco, Mercedes López de Hierro Ruiz, Julio Galvez, Rita Jiménez-Rosales, and Eduardo Redondo-Cerezo
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colorectal cancer ,patient outcomes ,electronic consultation ,healthcare communication ,telemedicine ,Medicine - Abstract
(1) Background: Colorectal cancer (CRC) is one of the most common causes of cancer. Timely diagnosis is critical, with even minor delays impacting prognosis. Primary care providers face obstacles in accessing specialist care. This study investigates the impact of implementing an electronic consultation (eConsult) system combined with a specific prioritization system on CRC diagnosis delay and tumor staging. (2) Methods: The study analyzes 245 CRC patients from November 2019 to February 2022, comparing those referred before and after the eConsult system’s implementation during the COVID-19 pandemic. Data on referral reasons, pathways, diagnosis delays, and staging were collected. Multivariate analysis aimed to identify independent risk factors for advanced staging at diagnosis. (3) Results: The eConsult system significantly reduced CRC diagnosis delay from 68 to 26 days. The majority of patients referred via eConsult presented with symptoms. Despite expedited diagnoses, no discernible difference in CRC staging emerged between eConsult and traditional referrals. Notably, patients from screening programs or with a positive fecal immunochemical test (FIT) experienced earlier-stage diagnoses. A positive FIT without symptoms and being a never-smoker emerged as protective factors against advanced-stage CRC. (4) Conclusions: This study highlights eConsult’s role in reducing CRC diagnosis delay, improving diagnostic efficiency and prioritizing urgent cases, emphasizing FIT effectiveness.
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- 2024
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13. Endoscopic ultrasound as a diagnostic and predictive tool in idiopathic acute pancreatitis.
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Valverde-López F, Ortega-Suazo EJ, Wilcox CM, Fernandez-Cano MC, Martínez-Cara JG, and Redondo-Cerezo E
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Background: Endoscopic ultrasound (EUS) is useful in the diagnostic workup of idiopathic acute pancreatitis but its role as a predictor of recurrence has not been thoroughly assessed. Our aim was to study the performance of EUS in idiopathic acute pancreatitis, its impact on the natural history of the disease, and the factors related to recurrence., Methods: Patients with idiopathic acute pancreatitis referred to our endoscopy unit were enrolled and followed, with assessment of the performance of endoscopic retrograde cholangiopancreatography (ERCP), cholecystectomy, and the incidence of recurrence. EUS findings and recurrence rates were compared between patients with a first episode or recurrent attacks and in patients with previous cholecystectomy versus those with gallbladder in situ., Results: One hundred six patients were included (mean follow up: 53.59±27.79 months). Biliary disease related to stones was the most common finding on EUS (49.1%), and patients referred for recurrent attacks showed the highest recurrence rate during follow up (57.1%). ERCP or cholecystectomy reduced recurrences to 14.3% in patients with biliary disease. Age under 65 (odds ratio [OR] 3.56, 95% confidence interval [CI] 1.21-10.44; P=0.02), previous cholecystectomy (OR 3.19, 95%CI 1.11-9.17; P=0.03), and no lithiasis on EUS (OR 2.87, 95%CI 1.04-7.87; P=0.04) were independent risks factors for recurrence., Conclusions: EUS-directed ERCP/cholecystectomy was associated with lower relapse rates in idiopathic acute pancreatitis. Along with age and gallbladder status, it provides predictive information about recurrence likelihood., Competing Interests: Conflict of Interest: None, (Copyright: © Hellenic Society of Gastroenterology.)
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- 2020
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14. Wireless capsule endoscopy: perspectives beyond gastrointestinal bleeding.
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Redondo-Cerezo E, Sánchez-Capilla AD, De La Torre-Rubio P, and De Teresa J
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- Animals, Biopsy, Capsule Endoscopes, Diffusion of Innovation, Equipment Design, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage pathology, Humans, Predictive Value of Tests, Risk Factors, Capsule Endoscopy instrumentation, Capsule Endoscopy methods, Capsule Endoscopy trends, Gastrointestinal Hemorrhage diagnosis, Intestine, Small pathology, Wireless Technology instrumentation, Wireless Technology trends
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Wireless capsule endoscopy (CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal (GI) bleeding. Over subsequent years, this technology has been refined to provide superior resolution, increased battery life, and capabilities to view different parts of the GI tract. Indeed, cases for which CE proved useful have increased significantly over the last few years, with new indications for the small bowel and technical improvements that have expanded its use to other parts of the GI tract, including the esophagus and colon. The main challenges in the development of CE are new devices with the ability to provide therapy, air inflation for a better vision of the small bowel, biopsy sampling systems attached to the capsule and the possibility to guide and move the capsule with an external motion control. In this article we review the current and new indications of CE, and the evolving technological changes shaping this technology, which has a promising potential in the coming future of gastroenterology.
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- 2014
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15. Duodenal duplication cyst and pancreas divisum causing acute pancreatitis in an adult male.
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Redondo-Cerezo E, Pleguezuelo-Díaz J, de Hierro ML, Macias-Sánchez JF, Ubiña CV, Martín-Rodríguez Mdel M, and Teresa-Galván JD
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Duodenal duplication cysts are rare congenital abnormalities which are more commonly diagnosed in infancy and childhood. However, in rare cases, these lesions can remain asymptomatic until adulthood. The combination of duplication cyst and pancreas divisum is extremely rare and both conditions have been linked with acute recurrent pancreatitis. We present the case of a 37 years-old patient who presented with repeated episodes of acute pancreatitis. By means of magnetic resonance imaging and endoscopic ultrasonography we discovered a duplication cyst whose cavity received drainage from the dorsal pancreas. After opening the cyst cavity to the duodenal lumen with a needle knife the patient presented no further episodes in the clinical follow-up. Comparable literature findings and therapeutic options for these abnormalities are discussed with regard to the presented case.
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- 2010
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16. Role of wireless capsule endoscopy in inflammatory bowel disease.
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Redondo-Cerezo E
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Capsule endoscopy (CE) offers state-of-the-art imaging of the small bowel. In Crohn's disease its clinical role is still uncertain. This report analyses the usefulness of CE in patients with suspected Cronh's disease, in patients with established Crohn's disease (when assessing severity, occult gastrointestinal bleeding and/or as a guide to therapy), in patients with inflammatory bowel disease unclassified (IBDU), and in individuals with ulcerative colitis. The first item in this group is the most important although there is no strong evidence to establish the position of CE in the diagnostic workup. In patients with established Crohn's disease, recently developed activity scores are promising tools for an accurate assessment of severity. As a guide to therapy, CE should be focused on patients with unexplained symptoms when other investigations are inconclusive. In postoperative Crohn's Disease, international consensus recommended considering CE only if ileocolonoscopy is contraindicated or unsuccessful. In the case of IBDU, studies have shown a significant proportion of patients reclassified with Crohn's disease. In this setting, CE could have a role determining small bowel involvement. The role of CE in ulcerative colitis is limited. Some authors advocate CE before colectomy for refractory cases in order to exclude Crohn's disease. In summary, CE offers a new horizon in inflammatory bowel disease, and a better knowledge of mucosal abnormalities that could offer a paradigm shift: changing from symptom-based disease activity estimation to direct mucosal healing monitoring. Nevertheless, randomized controlled studies are still needed to provide stronger evidence in this setting.
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- 2010
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