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Arsenic contamination of soils threatens the health of millions globally through accumulation in crops. While plants detoxify arsenic via phytochelatin (PC) complexation and efflux of arsenite from roots, arsenite efflux mechanisms are not fully understood. Here, white lupin (Lupinus albus) was grown in semi-hydroponics and exudation of glutathione (GSH) derivatives and PCs in response to arsenic was scrutinised using LC-MS/MS. Inhibiting synthesis of PC precursor GSH with L-buthionine sulfoximine (BSO) or ABC transporters with vanadate drastically reduced (>22%) GSH-derivative and PC2 exudation, but not PC3 exudation. This was accompanied by arsenic hypersensitivity in plants treated with BSO and moderate sensitivity with vanadate treatment. Investigating arsenic-phytochelatin (As-PC) complexation revealed two distinct As-PC complexes, As bound to GSH and PC2 (GS-As-PC2) and As bound to PC3 (As-PC3), in exudates of As-treated lupin. Vanadate inhibited As-PC exudation, while BSO inhibited both the synthesis and exudation of As-PC complexes. These results demonstrate a role of GSH-derivatives and PC exudation in lupin arsenic tolerance and reveal As-PC exudation as a new potential mechanism contributing to active arsenic efflux in plants. Overall, this study uncovers insight into rhizosphere arsenic detoxification with potential to help mitigate pollution and reduce arsenic accumulation in crops.

The COVID-19 pandemic did not create any new problems for the working class in India but amplified those that have been prevalent for ages due to an economic system that prioritises profit. Particularly, the collecting and disposing of garbage in the Indian subcontinent has always been associated with a particular caste group, ranked low in the caste hierarchy of the Hindu social order. Though this system can be traced back to Hindu religious texts, it has long percolated into practice in other faiths, with people who converted from these communities.During the COVID-19 pandemic, the waste collectors living in informal settlements on the peripheries of New Delhi faced a peculiar exclusion from basic infrastructural amenities and the right to work. The parlance of social distancing provided an environment adverse to the manual door-to-door waste collection in which the workers were engaged. As a substitute, the state machinery employed private companies whose modus operandi is not very different from independent waste workers. However, when things were restored to normalcy, the workers continued to find themselves out of work. The Solid Waste Management Act 2016 recognises the rights of waste workers, but they are yet to be enforced. In this paper, we look at the exclusion of the waste workers from accessing the city who, by their profession, are seen as polluting the very city which they keep clean. [ABSTRACT FROM AUTHOR]

Background The involvement of older adults in research on digital health is uneven with respect to, for example, age, gender, health status, and digital skills. However, little is known regarding the effect of the uneven involvement of older adults in digital health research on researched outcomes. This study helps to fill this knowledge gap, identifies the effects of uneven involvement of older adults in digital health research on researched outcomes, and also develops a correction for this. Methods Data are retrieved from a digital health intervention for postoperative monitoring of people who underwent day surgery in Sweden. Based on field information on the recruitment process and researched outcomes for the intervention, this study (i) tested intervention effects by using 2 standard unweighted procedures in a sample of 281 individuals aged 50 years or older, and then (ii) used the information on participants, nonparticipants, and their respective probabilities to be involved in the intervention study to perform a weighting of the intervention effects for each step of selection and for the study group membership. Results The intervention effects were found to be overestimated due to overrepresentation of groups that gained from receiving the intervention. No intervention effects were found after adjustment for participation bias. Conclusions Selective participation of older adults in digital health research biases research outcomes and can lead to overestimation of intervention effects. Weighting allows researchers to correct and describe the effect of selective participation on researched outcomes. [ABSTRACT FROM AUTHOR]

Epistemic injustice is often thought of as a form of exclusion. In the same way in which there are different forms and degrees of exclusion, there are different forms and degrees of injustice. In this paper, I argue that a fundamental tool to struggle against their most robust cases is listening, i.e. having a disposition to be affected by other persons. The main idea is that listening has a collective dimension and depends on restructuring social relations. To support this, I briefly examine some of the most classic ways of conceiving hermeneutic injustice. Then I show its relation to different ways of exclusion, which leads me to propose the notion of architectural hermeneutic injustice. I show that struggling against it requires more than inclusion mechanisms and I suggest some other struggle paths, such as the promotion of a listening culture which involves the transformation of our social structures. [ABSTRACT FROM AUTHOR]

Problem, research strategy, and findings: The housing affordability crisis is exacerbating displacement and exclusion in built-up urban neighborhoods. Although new housing development might help, it faces local opposition. Researchers have struggled to inform this debate because of data challenges, so we constructed a unique database on construction and household-level mobility to determine how development affects displacement and exclusion in the subsequent 5 years in Los Angeles (a typical coastal "hot market" in California) and San Francisco (the extreme "superstar city" case in California). We found that developing new market-rate housing generally helped slightly to alleviate both displacement and exclusion pressures for low-income households in Los Angeles and helped increase in-migration into weaker market neighborhoods in San Francisco. But particularly in the hottest markets, the new market-rate units could fail to spur low- and moderate-income households' in-migration and exacerbate their out-migration. Likewise, the positive impacts of the new market-rate units may fade over time. Subsidized housing generally mitigated both exclusion and displacement slightly in most markets. Future research should examine long-term effects in a variety of contexts, controlling for the role of housing policies such as rent stabilization. Takeaway for practice: Market-rate housing development may help alleviate rent pressures locally and regionally, but it is not sufficient to address displacement and exclusion at the neighborhood level. Because new production helps to mitigate displacement and exclusion in some contexts but exacerbates it in others, planners need to understand the market and neighborhood context for development. In addition to supporting more market-rate and subsidized housing development through zoning and fiscal tools, planners should implement complementary policies such as housing preservation and tenant protections. [ABSTRACT FROM AUTHOR]

This paper examines inequality among children, demonstrating its gradual emergence within the folds of daily routines in early childhood education (ECE). Employing Rob Nixon's (2011) concept of slow violence, our focus is on the cumulative impact of practices involving exclusion. Synthesizing Nixon's framework with Deleuze (1994) and Guattari's (2000) work, we introduce the concept of micro-regimes in ECE. This approach allows us to comprehend how the intricate interplay of human and non-human elements, spanning various scales, contributes to exclusion and the unfolding of slow violence. We present an ethnographic case study detailing the unintended excluding practices that Azeeb, aged two, faces within a nursery room at a long day care centre in Australia. The results unveil a series of systematic exclusionary acts and illuminate the disjunction between normative pedagogical practices and the material realities of the nursery room, leading to an asynchronous rhythm between the paces of the toddler room and Azeeb. This misalignment gives rise to a series of cumulative exclusionary acts, epitomizing the concept of slow violence as it works at the site of a child. [ABSTRACT FROM AUTHOR]

The aim of the study is to determine whether the fear of missing out (FoMO) has a mediating role in the effect of general belongingness (acceptance, exclusion) and happiness on smartphone addiction. The study consists of 656 university students from Turkey and agreeing to participate in the study. Of the students participating in the study, 77.7% were female. The participants were between the ages of 17 and 34, with a mean age of 21.32 ± 2.08 years. In this cross-sectional research design, the relationship between smartphone addiction, fear of missing out, general belonging and happiness variables was examined. Descriptive statistical methods were used to analyze the data and partial least squares path analysis (PLS-SEM) was used to analyze the research model. FoMO has a mediating effect on the effect of acceptance, exclusion, happiness on smartphone addiction. These findings highlight the significant role of FoMO in mediating the relationship between fundamental social needs (belongingness, happiness) and smartphone addiction. This suggests that interventions aimed at reducing smartphone addiction should consider addressing not only the technological dependence but also the underlying social and emotional needs that drive it. Promoting healthy social connections and fostering a sense of belonging among young adults may be crucial in mitigating the risk of smartphone addiction. [ABSTRACT FROM AUTHOR]

Despite increased efforts to ensure diversity in genomic research, the exclusion of minority groups from data analyses and publications remains a critical issue. This paper addresses the ethical implications of these exclusions and proposes accountability for reasonableness (A4R) as a framework to promote fairness and equity in research. Originally conceived by Norman Daniels and James Sabin to guide resource allocation in the context of health policy, A4R emphasizes publicity, relevance of reasons, enforcement, and revision as essential for legitimacy and trust in the decision‐making process. The authors argue that A4R is also relevant to resource allocation in research and that, if adequately informed and incentivized by funding agencies, institutional review boards, and scientific journals, researchers are well‐positioned to assess data‐selection justifications. The A4R framework provides a promising foundation for fostering accountability in genomics and other fields, including artificial intelligence, where lack of diversity and pervasive biases threaten equitable benefit sharing. [ABSTRACT FROM AUTHOR]

In introducing the special issue, Society in the Classroom: Multilevel Perspectives on Socioeconomic Inequalities in Education, we begin by challenging the assumption that educational institutions are neutral sites merely reflecting socioeconomic inequalities that originate beyond them. Instead, we consider how socioeconomic disparities and biases pervade educational settings and may be perpetuated by the very function of privileging particular standards and practices, a function that is central to institutions serving the dominant societal classes. Compiled 20 years after the last time the Journal of Social Issues focused on the psychology of social class in the context of education, this issue takes stock of research on this topic with a focus on approaches that go beyond the individual level of analysis. Although research reported in the issue is predominantly conducted with majority ethnic samples in the United States and Western Europe, it engages with intersectional concerns by attending to power and interlocking processes of oppression. [ABSTRACT FROM AUTHOR]

The research investigated the obstacles faced by undergraduates with visual impairments while studying at a Nigerian university striving to establish an inclusive learning environment for students with disabilities. The aim was to generate empirical evidence that can inform policies at the university and other similar institutions. The research is anchored in Bronfenbrenner's ecological systems theory, and a qualitative descriptive research design was employed. Using purposive sampling, 11 (male = 7; female = 4) undergraduate students living with blindness were recruited. Data were collected using semi‐structured interviews and subjected to inductive data analysis. It was found that students encounter various challenges, emanating from peers, lecturers, the university and their families. The results demonstrate how different contexts influence the learning outcomes of students with visual impairments, warranting more comprehensive intervention programmes. [ABSTRACT FROM AUTHOR]

The brutal military crackdown in Myanmar's Rakhine state caused more than 1 million Rohingya refugees to flee to Bangladesh. By analyzing the tripartite relationship between nationalism, violence, and statelessness, this commentary examines how Myanmar's political exclusion of the Rohingya contributed to their stateless condition and led to an ongoing humanitarian crisis in the region. The study argues that the Rohingya are stateless because of Myanmar's state‐sanctioned ethnic discrimination premised on nationalist conceptions of the country as a uniquely Burmese and Buddhist nation‐state. The state systematically justifies the Rohingya's precarity within Myanmar society to promote an imagined national homogeneity. [ABSTRACT FROM AUTHOR]

Observing an association between socioeconomic status (SES) and health reliably leads to the question, "What are the pathways involved?" Despite enormous investment in research on the characteristics, behaviors, and traits of people disadvantaged with respect to health inequalities, the issue remains unresolved. We turn our attention to actions of more advantaged groups by asking people to self-report their exposure to disrespect, discrimination, exclusion, and shaming (DDES) from people above them in the SES hierarchy. We developed measures of these phenomena and administered them to a cross-sectional U.S. national probability sample (N = 1,209). Consistent with the possibility that DDES represents a pathway linking SES and health, the SES→health coefficient dropped substantially when DDES variables were controlled: 112.9% for anxiety, 43.8% for self-reported health, and 49.4% for cardiovascular-related conditions. These results illustrate a need for a relational approach emphasizing the actions of more advantaged groups in shaping health inequities. [ABSTRACT FROM AUTHOR]

This roundtable discussion concluded the conference "Roads to Exclusion: Socio-Spatial Dynamics of Mobility Infrastructures since 1800" that took place at the German Historical Institute Washington (GHI) in September 2022. The event was organised by the GHI and the Käte Hamburger Kolleg global dis:connect – Dis:connectivity in Processes of Globalisation at Ludwig Maximilian University of Munich (LMU) and brought together scholars from four continents who discussed the dynamics of inclusion and exclusion entailed in transportation infrastructures around the globe. The roundtable included four panellists – Jennifer Hart (Virginia Tech), Peter Norton (University of Virginia), Anke Ortlepp (University of Cologne) and Heidi Tworek (The University of British Columbia) – and was moderated by Roland Wenzlhuemer (LMU). Focusing on the question of what the most pressing topics in the history of transportation and infrastructure are, the panellists urged for more people-centred histories and cross-disciplinary collaboration. The discussion also revolved around the need for scholars of transportation to develop compelling narratives that can help them reach wider audiences and build pathways toward a more just, sustainable, inclusive, and mobile future. [ABSTRACT FROM AUTHOR]

This article explores production of divisions and belonging between mainstream and special education needs students in Danish primary education. The article analyses the boundary-making practices produced by teachers and materialities of schooling between mainstream education students and those with mild to moderate special needs whose schooling is divided between the mainstream classroom and special provisions within the walls of the mainstream school. The article is based on ethnographical fieldwork in two Danish public schools with teachers from 4th to 6th grade in mainstream education. Using artefacts such as empty chairs, missing names, and lavatories for specific groups of students, the analysis shows how nonhuman mundane materialities of the school and classroom do performative work in enacting divisions and belonging in mainstream education. Besides the focus on materialities, teachers' statements on students with special needs offers insights into teachers' imaginaries and perspectives on their responsibilities (or lack thereof) concerning students with special needs. Despite intentions to enhance opportunities for students with special needs to participate in mainstream classroom activities, this study's main findings suggest a strong segregation between the two groups and that teachers and materialities are reinforcing and reproducing this segregation through artefacts, (dis)placements, counterproductive imaginaries, and discursive statements. [ABSTRACT FROM AUTHOR]

This paper undertakes an analysis of Nigeria's quota-based policy for equitable higher education (HE) access with reference to the catchment criterion. HE access demand in Nigeria has far outweighed supply. With a large and diverse population and a growing HE sector, the policy sets out a range of overlapping eligibility criteria as integral to the layered processes of university application. In this paper, we examine the catchment criterion and discuss its work in achieving the national policy aims of equitable access. Drawing on the accounts of applicants, students and lecturers in focus groups and in-depth interviews, we explore how the criterion contributes to tensions around HE access. We point to the ways that depictions of a catchment population revivify historic and perhaps mythical settlement patterns that do not reflect the ethnic heterogeneity among regional residents in current times. On the one hand, the labels of 'region', 'state' or 'catchment area' homogenise distinct ethnic groups and on the other, their operation within the policy for equitable access produces profound levels of stratification, discrimination and exclusion. This leads us to conclude by proposing policy reform that more explicitly recognises the intra-national ethnic multiplicity and diversity as a means to addressing equitable access. [ABSTRACT FROM AUTHOR]

In many countries around the world, individualised budgets are replacing 'block funding' as the primary way in which disability service provision is funded. These models assume that dynamics of competition improve services for people with disabilities. This article presents the findings of research on the accessibility and inclusiveness of mainstream services for people with intellectual disabilities in four Australian cities in the wake of the rollout of individual support budgets. We use the concept of 'repair' and the conceptual framework of 'landscapes of care and support' to analyse interviews with mainstream service managers. Our findings reveal that not-for-profit organisations perform crucial tasks in persuading for-profit service providers to collaborate with them to improve their accessibility and inclusion. When these services collaborate to repair service access, not-for-profit organisations often take on associated responsibility, costs and risk to encourage reparative adjustments in for-profit services. Not-for-profit organisations are also more likely to be tasked with the relational and interpersonal work that is crucial for successful service repair. Our findings challenge assumptions that free-market competition is the main driver of more accessible and inclusive service delivery and suggest how policy can support more equitable collaborative repair work. [ABSTRACT FROM AUTHOR]

This article offers an interpretive examination of the future orientation of students in vocational schools as part of their vocational habitus. Through in-depth interviews with 30 adolescents (16 boys, 14 girls), the study identified three key future orientations: (1) the vague use of the term 'success' in the absence of an accompanying description of specific goals for achieving that success; (2) the future described through 'hard individualism'––a future replete with many challenging anticipated scenarios: constant struggles to achieve goals, lack of control, and an inability to predict reality, becoming accustomed to failures, and self-reliance; (3) preference for occupational independence or being solo self-employed, partially motivated by a desire to avoid future experiences of subordination, exploitation, and humiliation––factors characterising their current employment. The effects and implications of vocational school students' structural vulnerabilities and experiences of social exclusion on their future orientations are discussed. Further research of future orientation is critical in its role as a component of vocational habitus to achieve a complex understanding of the educational work in vocational schools. [ABSTRACT FROM AUTHOR]

Health is an integral feature of immigration, providing not only insight into population health but also a critical lens into immigrant integration and the power structure in receiving countries. The goal of this article is to chart the trajectory of scholarship on immigrants' health, focusing on the formative shift away from dominant individualistic perspectives focused on cultural and behavioral explanations toward a profoundly structural understanding of immigrants' health. Focusing primarily on the US context, we synthesize theoretical and empirical advances in structural perspectives of immigrants' health. We anchor these advances in the concept of exclusion, detailing how it undergirds structuralist perspectives of immigrants' health. We review common ways in which exclusion has been measured in the empirical literature on immigrants' health and highlight recent evidence linking exposure to exclusion to immigrants' health outcomes across the life course. We conclude by discussing key directions and challenges for future research. [ABSTRACT FROM AUTHOR]

Understanding inclusive education challenges in India involves acknowledging the complex linguistic, cultural, religious, and caste-based diversity affecting marginalized groups. Ambiguity surrounds implementing the inclusion concept, necessitating critical evaluation and adaptation to align with India's unique dynamics. Despite increased enrollment (61%), concerns persist about omitting some children from inclusive education benefits, suggesting exclusivity. The 2020 National Education Policy aims for equitable opportunities, but challenges remain in implementation and access. Interchangeable terms (e.g., inclusion vs. integration) and a lack of differentiation hinder progress. Robust research on classroom practices is vital to establish effective strategies, support families, and address diverse student needs. This multifaceted issue requires consideration of India-specific contexts. India's interpretation of inclusive education varies based on disability severity, and solutions should account for political, historical, and cultural contexts and the beliefs and experiences of disabled individuals. [ABSTRACT FROM AUTHOR]

Queer spaces have gained increasing attention academically with a range of studies exploring the construction of such spaces. This article addresses the spatial and social practices and processes that occur within these spaces that perpetuate exclusion based on race. Drawing on ethnographic data collected through semi-structured interviews and participant observations conducted in Birmingham's 'gay village', we argue that gendered perceptions of racialised masculinities and femininities create unique experiences for men and women from minoritised ethnicities. We argue that queer spaces, which are often assumed to transgress and challenge social norms actually maintain, uphold and perpetuate white, patriarchal norms and can therefore be considered a microcosm of broader society. In doing so, we advance criminological thought by adopting a zemiological framework that centres social harm rather than relying on legally defined incidents of crime. [ABSTRACT FROM AUTHOR]

Background: Coproduction is a fast‐developing approach to patient involvement. It entails health and social care services users working as equals in partnership with providers and other public institutions to produce novel research and information, usually aimed at the improvement of service planning and delivery. Methods: This paper presents two real‐life examples of attempted coproduction with a group of men with learning disabilities in England. The first case study concerns the piloting and assessment of a 'user‐friendly' version of a local authority's 'vision statement'. The second explores an attempt to secure funding to develop and evaluate a community intervention with and for people with learning disabilities. Findings: Together, these portraits capture two important and intertwined problems that afflict the field of coproduction: namely, the drive to create fast results and the challenges of time and resource allocation that service users and professionals face whenever they attempt to coproduce work in a meaningful way. Conclusions: The paper concludes with some suggestions for how policy and practice might seek to address these issues in the future. Accessible summary: Nowadays, people with learning disabilities are starting to work together with health professionals and people in universities. This is called service user involvement.In this article, we talk about a special kind of involvement: it is called coproduction, and it means that service users and professionals should work together as equal teammates.People with learning disabilities can tell professionals what services they need and how they should be cared for. They can help to create user‐friendly policies and publications. They can also make their own choices about what research should be done and how to go about it.Here, we talk about two coproduction projects which involved a community group for men with learning disabilities.We show how these two projects excluded the men and put some of them off the idea of coproduction.At the end, we give some ideas on how we might make coproduction work better. [ABSTRACT FROM AUTHOR]

Qatar has become a significant destination for migrant workers looking to escape unemployment in their home countries. However, highly active labour migration pathways create migration industries that exploit the increased supply of labour migrants, leading to trafficking. Human trafficking has been a longstanding concern in Qatar, especially with low-skilled migrant workers in the informal, domestic service and construction sectors. United Nations bodies and non-governamental organisations have criticised Qatar over the treatment of its migrant workforce, especially with concerns about trafficking for labour exploitation and forced labour. In addition to complaints of human trafficking, concerns have been raised concerning perceived racialised drivers of exploitation in Qatar. According to the former United Nations Special Rapporteur on contemporary forms of racism, racial discrimination, xenophobia and related intolerance, Ms Tendayi Achiume, Qatar battles with issues of structural racial discrimination concerning its migrant workforce. This article examines the links between race and the trafficking of migrant workers in Qatar. [ABSTRACT FROM AUTHOR]

Permanent exclusion in Scotland has been all but eradicated, with one young person permanently excluded in 2022/23, and the rate of temporary exclusion has been consistently decreasing since 2007. However, a wide range of exclusionary practices other than formal exclusion impact children and young people's access to and experiences of education. This paper explores alternative education provision (AP) in Scotland, reflects on the quality and purpose of AP, and considers the grey areas between mainstream provision, exclusion prevention work, and 'alternative' provision. We compiled an inventory of AP in two Scottish local authorities, using desk research and interviews with local and national stakeholders, then mapped the provision we identified according to purpose, programme, and mode of provision. We identified a wide array of 'alternative' educational provision including a preponderance of part-time third-sector offerings and AP provided within mainstream schools, which may reflect the current prevention-focused Scottish Government policy approach to exclusion. We raise questions around what counts as alternative, explore issues around the instability of some provision, and highlight areas that require further research to ensure that those who are directed to AP are having their statutory entitlements met and receiving a meaningful education. [ABSTRACT FROM AUTHOR]

Copyright of Çukurova Üniversitesi İlahiyat Fakültesi Dergisi (CUIFD) is the property of Cukurova Universitesi Ilahiyat Fakültesi Dergisi (CUIFD) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mainstream expectations of older age place pressure on individuals––both negative discourses focused upon frailty and isolation and successful ageing narratives that emphasize physical and mental exercise. This article considers whether older people can challenge damaging narratives through participating in the practice of modern dance. Over the course of 4 years, action research and ethnographic-based methods were used as the author worked with a dance company of seven members aged 69 to 89 as they created a modern dance piece. Data included fieldnotes, transcripts of individual interviews and group discussions and a video of the performance. A thematic analysis was applied. Moving away from a health perspective, the literature on ageing and lifestyle is advanced by in examining how the group's creativity should be understood and valued. Participants went from presenting as active agers to developing a more accepting attitude towards their ageing body. The performance refashioned the space as a site of intergenerational connectivity as the dancers and audience co-produced narratives around the artistry of the older body. An original contribution to the work on embodiment is made by revealing how older men and women use dance differently to negotiate the ageing body. Findings have wider implications for research on inclusion by showing how the embodied practice of dance helps subvert expectations of older age. [ABSTRACT FROM AUTHOR]

The aim of this research project was to evaluate the influence of exclusion as a harm-reduction intervention on parameters such as gambling behavior, motivation to seek help and several well-being measures. Gamblers, who were excluded from both land-based and online Swiss casinos, completed a written questionnaire three times, at six-month intervals. To identify possible changes due to the exclusion, gamblers who were not excluded were also surveyed. Of the 242 respondents, 55.0% (n = 133) were not banned at any time, 13.6% (n = 33) were excluded at the time of the first survey wave and remained so, while 31.4% (n = 76) of respondents were excluded for a minimum of one wave. The present study highlights the influence of exclusion on gamblers' well-being. A repeated-measures ANOVA revealed considerable improvements for the excluded gamblers with respect to the parameters of mental health, general well-being, satisfaction with finances, and severity of disordered gambling behavior. The results demonstrate that exclusion has an impact not only on reducing gambling-related harm and mental health problems but may also positively influence well-being. Alongside parameters such as the individual's financial circumstances and severity of gambling disorder, well-being parameters should be considered within the exclusion processes and further harm reduction measures. [ABSTRACT FROM AUTHOR]

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Copyright of Latino Studies is the property of Palgrave Macmillan Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

According to the widely accepted "three Es" model, the host immune system e liminates malignant cell precursors and contains microscopic neoplasms in a dynamic e quilibrium, preventing cancer outgrowth until neoplastic cells acquire genetic or epigenetic alterations that enable immune e scape. This immunoevasive phenotype originates from various mechanisms that can be classified under a novel "three Cs" conceptual framework: (1) c amouflage, which hides cancer cells from immune recognition, (2) c oercion, which directly or indirectly interferes with immune effector cells, and (3) c ytoprotection, which shields malignant cells from immune cytotoxicity. Blocking the ability of neoplastic cells to evade the host immune system is crucial for increasing the efficacy of modern immunotherapy and conventional therapeutic strategies that ultimately activate anticancer immunosurveillance. Here, we review key hallmarks of cancer immune evasion under the "three Cs" framework and discuss promising strategies targeting such immunoevasive mechanisms. Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the "three Cs" framework—camouflage, coercion, and cytoprotection—and discuss promising strategies to target these mechanisms for therapeutic purposes. [ABSTRACT FROM AUTHOR]

Despite the recent policy impetus for age-friendly cities, there is still scope for more geographical insights into ageing in low- and middle-income countries (LMICs). Cities in LMICs, such as Bengaluru (India), are witnessing an increase in the size of the older population in their peripheral urban regions, but there is relatively little understanding of the risks of exclusion in later age in these liminal zones. This study, set in a peripheral ward of Bengaluru, focuses on the experiences of exclusion/inclusion of socio-economically marginalised older adults and their access to work, health care and leisure. The research uses a multidimensional old-age exclusion framework to highlight how the domains of neighbourhood, material resources, mobility infrastructure and social relations influence the risks for social exclusion. We use a qualitative approach by combining behavioural mapping and in-depth interviews. Our findings highlight some ways in which institutionalised exclusion from civic infrastructure accentuates the precariousness of ageing. The rigidity of traditional hierarchies in peri-urban regions has meant that older adults who were poor, women and belonged to marginalised castes experience constrained mobilities to access labour markets, health care and social life, compounding their place-based exclusion. Despite social networks and solidarities, older adults on the periphery faced individualisation of risks while trying to access the basic amenities, thereby falling between the gap of the urban–rural milieu and governance. Age-friendly cities need to accommodate such hybrid transitionary urban processes, in the absence of which, active ageing in these rising peripheries can be impeded. [ABSTRACT FROM AUTHOR]

This paper is a blend of my personal narrative and the practical strategies based on theoretical frameworks that I use in my work supporting young people in schools. My work is based on the powerful message from the short story the Starfish Thrower (Eiseley, 1979). The lesson I learned from this lovely story is that I may not be able to save the entire world, but I try to make a difference one young person at a time. [ABSTRACT FROM AUTHOR]

Creating opportunities for meaningful social relationships between through collaborative learning has been suggested to facilitate all students' social inclusion. However, little attention has been given to the interaction processes leading to unsuccessful knowledge co-creation in mixed-ability peer groups including students with and without special educational needs (SEN). This study addressed this research gap by conducting multimodal conversation analyses of the social exclusion during group work of students with and without SEN, and how the students with SEN responded to their positioning as unequal learning partners. The results were based on video-recordings of 24 lessons involving fifth graders in Finnish school spaces featuring open and flexible learning environments. The results showed that although the students with SEN performed relevant on-task initiations, their contributions were misaligned by ignoring, denying, invalidating their contributions, manipulating shared learning materials, or downgrading their status as help givers. Despite this, students with SEN continued to orient toward collaborative working by persistently initiating joint activities, negotiating their task performance and struggling to ensure their right to contribute. The study underlines the importance of instructing all students to create a warm learning community in which every student has equal rights to participate and to be positively recognised. [ABSTRACT FROM AUTHOR]

With Discipline, we focus on techniques and mechanisms that advance corporeal, attitudinal, and behavioural docility and thereby contribute to contemporary processes of social differentiation and exclusion. Exploring the intersection of migration policy and welfare governance, we discuss disciplinary measures deployed at the intersection of welfare and migration regimes with the aim of understanding how internal border and welfare controls discipline poor non-citizens by criminalising certain kinds of behaviour. Drawing on concepts including micro-violence and micro-aggression, this keyword looks at bureaucratic practices, their justifications and their consequences for non-citizens, before moving on to theorise how such practices have come to permeate the wider society. Disciplinary systems of welfare governance depend on the threat of punishment: individuals are prompted to discipline themselves because they could become the object of disciplinary power at any moment. Such disciplinary techniques are efficient, productive, and subtle, and can result in the increasingly 'automatic' internalisation by non-citizens of certain kinds of behaviour. [ABSTRACT FROM AUTHOR]

Lupus anticoagulant (LA) is one of three tests identified as laboratory criteria for definite antiphospholipid syndrome (APS). The other two tests are anticardiolipin antibody (aCL) and anti-β2-glycoprotein I (aβ2GPI) antibody. The presence of LA is assessed using clot-based tests, while the presence of aCL and aβ2GPI is assessed by immunological assays. Since no test can be considered 100% sensitive or specific for LA, current guidelines recommend using two different clot-based assays reflecting different principles, with the dilute Russell viper venom time (dRVVT) and activated partial thromboplastin time (aPTT) recommended. Initially, LA-sensitive reagents are used to screen for LA, and then, in "screen-positive" samples, LA-"insensitive" reagents are used to confirm LA. Because LA assays are based on clot detection, anything that can interfere with fibrin clot development may affect test results. In particular, in addition to LA, the tests are also sensitive to the presence of a wide range of clinical anticoagulants, reflecting preanalytical issues for testing. We provide updated findings for LA testing in our geographic region, using recent data from the Royal College of Pathologists of Australasia Quality Assurance Programs, an international external quality assessment program with approximately 120 participants. Data show a wide variety of assays in use, especially for aPTT testing, and variable outcomes in reported numerical values with these assays when assessing proficiency samples. dRVVT testing mostly comprised reagents from three main manufacturing suppliers, which also showed differences in numerical values for the same homogeneous tested samples. Nevertheless, despite the use of different test reagents and processes, >98% of participants correctly identified LA-negative samples as LA-negative and LA-positive samples as LA positive. We hope our findings, reflecting on the heterogeneity of test processes and test data, help improve diagnostic testing for LA in the future. [ABSTRACT FROM AUTHOR]

Safety concerns continue to be challenging amid racially segregated communities of urban concentrated disadvantage. Although contributing factors to crime in such neighborhoods have been described, there is a lack of knowledge regarding how social isolation and perceptions of safety impact community health. This qualitative study explored how minoritized residents (N = 23) from an urban community of economic disadvantage perceived the influence of environmental and residential conditions on their health. Use of the grounded theory method produced conceptual insights into the process of how safety concerns led to fear, which created stress and prevented residents from using outdoor public spaces. Additionally, results indicated how the cyclical nature of such physical withdrawal reinforced social isolation and stigma by those outside the community, ultimately affecting residents' ability to maintain healthy living. Implications include implementing a multi-pronged public health policy that addresses safety perceptions, crime exposure, and social inclusion to improve health conditions in low-income communities. [ABSTRACT FROM AUTHOR]