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Your search keyword '"Fang, Zhi"' showing total 2,073 results
Start Over Author "Fang, Zhi" Publication Type Academic Journals
2,073 results on '"Fang, Zhi"'

4. Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Author

Ambalavanan, Amirthagowri, Chang, Le, Choi, Jihoon, Zhang, Yang, Stickley, Sara A., Fang, Zhi Y., Miliku, Kozeta, Robertson, Bianca, Yonemitsu, Chloe, Turvey, Stuart E., Mandhane, Piushkumar J., Simons, Elinor, Moraes, Theo J., Anand, Sonia S., Paré, Guillaume, Williams, Janet E., Murdoch, Brenda M., Otoo, Gloria E., Mbugua, Samwel, Kamau-Mbuthia, Elizabeth W., Kamundia, Egidioh W., Gindola, Debela K., Rodriguez, Juan M., Pareja, Rossina G., Sellen, Daniel W., Moore, Sophie E., Prentice, Andrew M., Foster, James A., Kvist, Linda J., Neibergs, Holly L., McGuire, Mark A., McGuire, Michelle K., Meehan, Courtney L., Sears, Malcolm R., Subbarao, Padmaja, Azad, Meghan B., Bode, Lars, and Duan, Qingling

Published
2024
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12. Prevalence and genetic diversity of Anaplasma and Ehrlichia in ticks and domesticated animals in Suizhou County, Hubei Province, China

Author

Ju Tang, Jiao Xu, Xiao-hui Liu, Fang-zhi Lv, Qiu-ju Yao, Xiao-Fan Zhou, Hui-ya Lu, Tian-mei Yu, Ze-zheng Jiang, Xiao-zhou Jin, Fang Guo, and Xue-jie Yu

Subjects
Anaplasma, Ehrlichia, Ticks, Goats, China, Medicine, Science
Abstract

Abstract Anaplasma and Ehrlichia are tick-borne bacterial pathogens that cause anaplasmoses and ehrlichioses in humans and animals. In this study, we examined the prevalence of Anaplasma and Ehrlichia species in ticks and domesticated animals in Suizhou County, Hubei Province in the central China. We used PCR amplification and DNA sequencing of the 16S rRNA, groEL, and gltA genes to analyze. We collected 1900 ticks, including 1981 Haemaphysalis longicornis and 9 Rhipicephalus microplus, 159 blood samples of goats (n = 152), cattle (n = 4), and dogs (n = 3) from May to August of 2023. PCR products demonstrated that Anaplasma bovis, Anaplasma capra, and an Ehrlichia species were detected in the H. longicornis with the minimum infection rates (MIR) of 1.11%, 1.32%, and 0.05%, respectively; A. bovis, A. capra, and unnamed Anaplasma sp. were detected in goats with an infection rate of 26.31%, 1.31% and 1.97%, respectively. Anaplasma and Ehrlichia species were not detected from cattle, dogs and R. microplus ticks. The genetic differences in the groEL gene sequences of the Anaplasma in the current study were large, whereas the 16S rRNA and gltA gene sequences were less disparate. This study shows that ticks and goats in Suizhou County, Hubei Province carry multiple Anaplasma species and an Ehrlichia species, with relatively higher infection rate of A. bovis in goats. Our study indicates that multiple Anaplasma and Ehrlichia species exist in ticks and goats in the central China with potential to cause human infection.

Published
2024
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16. SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

Author

Hui Qian, Chen-Hong Ding, Fang Liu, Shi-Jie Chen, Chen-Kai Huang, Meng-Chao Xiao, Xia-Lu Hong, Ming-Chen Wang, Fang-Zhi Yan, Kai Ding, Ya-Lu Cui, Bai-Nan Zheng, Jin Ding, Cheng Luo, Xin Zhang, and Wei-Fen Xie

Subjects
Medicine, Biology (General), QH301-705.5
Abstract

Abstract The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YAP are not fully understood. In this study, we have uncovered a crucial role of SOX9 in the activation of YAP. SOX9 promotes the nuclear translocation of YAP by direct interaction. Importantly, we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of YAP. Additionally, we have discovered a novel asymmetrical dimethylation of YAP at Arg-124 (YAP-R124me2a) catalyzed by PRMT1. YAP-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple cancers. Furthermore, we disrupted the interaction between SOX9 and YAP using a competitive peptide, S-A1, which mimics an α-helix of SOX9 containing Asp-125. S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor growth. This study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

Published
2024
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31. TLR9 regulates the autophagy–lysosome pathway to promote dendritic cell maturation and activation by activating the TRAF6‐cGAS‐STING pathway

Author

Ying Liu, Fang‐Zhi Wei, Yu‐Wei Zhan, Ru Wang, Bi‐Yao Mo, and Shu‐Dian Lin

Subjects
autophagy–lysosome pathway, dendritic cells, systemic lupus erythematosus, TLR9, TRAF6‐cGAS‐STING pathway, Medicine (General), R5-920
Abstract

Abstract Dysregulated maturation and activation of dendritic cells (DCs) play a significant role in the progression of systemic lupus erythematosus (SLE). The autophagy–lysosome pathway has been identified as a potential mechanism to inhibit DC activation and maturation, but its precise workings remain unclear. We investigated the role and regulatory mechanism of TLR9 in modulating the autophagy–lysosome pathway and DCs activation. The mRNA and protein expressions were assessed using qRT‐PCR and/or western blot. NZBW/F1 mice was used to construct a lupus nephritis (LN) model in vivo. Cell apoptosis was analyzed by TUNEL staining. Flow cytometry was adopted to analyze DCs surface markers. Lyso‐tracker red staining was employed to analyze lysosome acidification. Levels of anti‐dsDNA, cytokines, C3, C4, urine protein and urine creatinine were examined by ELISA. The results showed that TLR9 was markedly increased in SLE patients, and its expression was positively correlated with SLEDAI scores and dsDNA level. Conversely, TLR9 expression showed a negative correlation with C3 and C4 levels. Loss‐of function experiments demonstrated that TLR9 depletion exerted a substantial inhibition of renal injury, inflammation, and DCs numbers. Additionally, upregulation of TLR9 promoted DCs maturation and activation through activation of autophagy and lysosome acidification. Further investigation revealed that TLR9 targeted TRAF6 to activate the cGAS‐STING pathway. Rescue experiments revealed that inactivation of the cGAS/STING signaling pathway could reverse the promoting effects of TLR9 upregulation on DCs maturation, activation, and autophagy–lysosome pathway. Overall, our findings suggested that TLR9 activated the autophagy–lysosome pathway to promote DCs maturation and activation by activating TRAF6‐cGAS‐STING pathway, thereby promoting SLE progression.

Published
2023
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