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Your search keyword '"Foletto, Mirto"' showing total 285 results
Start Over Author "Foletto, Mirto" Publication Type Academic Journals
285 results on '"Foletto, Mirto"'

1. Bariatric Surgery for Patients with Overweight/Obesity. A Comprehensive Grading Methodology and Network Metanalysis of Randomized Controlled Trials on Weight Loss Outcomes and Adverse Events

Author

De Luca, Maurizio, Zese, Monica, Silverii, Giovanni Antonio, Ragghianti, Benedetta, Bandini, Giulia, Forestieri, Pietro, Zappa, Marco Antonio, Navarra, Giuseppe, Foschi, Diego, Musella, Mario, Sarro, Giuliano, Pilone, Vincenzo, Facchiano, Enrico, Foletto, Mirto, Olmi, Stefano, Raffelli, Marco, Bellini, Rosario, Gentileschi, Paolo, Cerbone, Maria Rosaria, Grandone, Ilenia, Berardi, Giovanna, Di Lorenzo, Nicola, Lucchese, Marcello, Piazza, Luigi, Casella, Giovanni, Manno, Emilio, Zaccaroni, Alberto, Balani, Alessandro, Mannucci, Edoardo, and Monami, Matteo

Published
2023
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3. Trends and safety of bariatric revisional surgery in Italy: multicenter, prospective, observational study

Author

Di Biasio, Alberto, Trotta, Manuela, Di Capua, Francesco, Bianciardi, Emanuela, Campanelli, Michela, Sensi, Bruno, Arolfo, Simone, Salzano, Antonio, Oldani, Alberto, Mancini, Rudj, Fiorello, Luigi, Filippone, Emanuela, Rottoli, Matteo, Veroux, Gastone, Celiento, Marta, Boru, Cristian E., Marinari, Giuseppe M., Olmi, Stefano, Gentileschi, Paolo, Morino, Mario, Anselmino, Marco, Foletto, Mirto, Bernante, Paolo, Piazza, Luigi, Perrotta, Nicola, Morganti, Riccardo, and Silecchia, Gianfranco

Published
2023
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9. Revisional Surgery After One Anastomosis/Minigastric Bypass: an Italian Multi-institutional Survey

Author

Musella, Mario, Vitiello, Antonio, Susa, Antonio, Greco, Francesco, De Luca, Maurizio, Manno, Emilio, Olmi, Stefano, Raffaelli, Marco, Lucchese, Marcello, Carandina, Sergio, Foletto, Mirto, Pizza, Francesco, Bardi, Ugo, Navarra, Giuseppe, Schettino, Angelo Michele, Gentileschi, Paolo, Sarro, Giuliano, Chiappetta, Sonja, Tirone, Andrea, Berardi, Giovanna, Velotti, Nunzio, Foschi, Diego, Zappa, Marco, and Piazza, Luigi

Published
2022
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10. Esophageal and gastric malignancies after bariatric surgery: a retrospective global study

Author

Gallardo, Carlos Sosa, Agustin, Cataldo, Wright, Fernando, Fuente, Ignacio, Carbajo, Miguel, Cal, Patricio, Chisholm, Jacob, Kow, Lilian, Tan, Michael H.L., Gan, Philip, Gananadha, Sivakumar, Felsenreich, Daniel M., Prager, Gerhard, Matthys, Chris, Himpens, Jacques M., Focquet, Marc A.M.R.M., Ramos, Almino, Nato, Manoel Galvano, Vidal, Thiago, Andalib, Amin, Siblini, Aya, Ferri, Lorenzo, Abdarabo, Lina, Nevo, Yehonatan, Pescarus, Radu, Yang, Wah, Hamed, Hosam, Liagre, Arnaud, Bergeat, Damien, Marie, De Montrichard, Martini, Francesco, Regis, François, Genser, Laurent, Skalli, Mehdi, Nedelcu, Marius, Smejkal, Milan, Kassir, Radwan, Nicolas, Regenet, Stier, Christine, Nedelcut, Dan-Sebastian, Christodoulidis, Grigorios, Vennapusa, Amar, Kermansaravi, Mohammad, Raziel, Asnat, Sakran, Nasser, Oldani, Alberto, Boru, Cristian Eugeniu, Mécheri, Fouzia, Ciccarese, Francesca, Cesana, Giovanni Carlo, Musella, Mario, Uccelli, Matteo, Foletto, Mirto, Auricchio, Pasquale, Olmi, Stefano, Seki, Yosuke, Kasteleijn, Anne, Van 'T Hof, Gerhard, Apers, Jan A., Hart, Judith W.H., Van De Sande, Justin S.L., Takkenberg, Marijn, Feskens, Pierre B.G.M., Snoekx, Rob, Plat, Victor D., Sandvik, Jorunn, Kalinowski, Piotr, Nabais, Celso, Al-Bahrani, Ahmed Z., Al Zoubi, Mohammad, Bettonica, Carla, Osorio, Javier, Tejedor-Tejada, Javier, Sanz, Lourdes M., Cuadrado, Marta, Moorjani, Rajesh Gianchandani, Yannick, Fringeli, Suter, Michel, Borbély, Yves, Joerg, Zehetner, Barajas-Gamboa, Juan S., Kroh, Matthew, Kisiel, Aaron P., Kamocka, Anna, Immanuel, Arul, Sgromo, Bruno, Gopinath, Bussa, Khoo, David, Mukherjee, Samrat, Pournaras, Dimitrios, Underwood, Tim, Griffiths, Ewen A., Miller, Glenn V., Jaretzke, Helen, Dmitrewski, Jan, Wadley, Martin S., Al-Housni, Ragad, Gillies, Richard S., Singhal, Rishi, Preston, Shaun R., Robinson, Steven John, Hawkins, William J., Adamo, Marco, El Kalaawy, Mohamed, Gossage, James, Crawford, Christopher B., Jaruvongvanich, Veeravich, Parmar, Chetan, Zakeri, Roxanna, Abouelazayem, Mohamed, Shin, Thomas H., Aminian, Ali, Mahmoud, Tala, Abu Dayyeh, Barham K., Wee, Melissa Y., Fischer, Laura, Daams, Freek, and Mahawar, Kamal

Published
2022
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13. Laparoscopic bariatric surgery is safe during phase 2–3 of COVID-19 pandemic in Italy: A multicenter, prospective, observational study

Author

Silecchia, Gianfranco, Boru, Cristian E., M. Marinari, Giuseppe, Gentileschi, Paolo, Morino, Mario, Olmi, Stefano, Foletto, Mirto, Bernante, Paolo, Morganti, Riccardo, Tascini, Carlo, Anselmino, Marco, Bianciardi, Emanuela, Campanelli, Michela, Fiorello, Luigi, Mancini, Rudj, Oldani, Alberto, Rottoli, Matteo, Salzano, Antonio, and Trotta, Manuela

Published
2021
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17. Mitochondrial Ca2+ signaling is a hallmark of specific adipose tissue-cancer crosstalk.

Author

De Mario, Agnese, Trevellin, Elisabetta, Piazza, Ilaria, Vindigni, Vincenzo, Foletto, Mirto, Rizzuto, Rosario, Vettor, Roberto, and Mammucari, Cristina

Subjects
BREAST, ADIPOSE tissues, MITOCHONDRIA, TRIPLE-negative breast cancer, TISSUE culture, ESOPHAGEAL cancer, CANCER cells
Abstract

Obesity is associated with increased risk and worse prognosis of many tumours including those of the breast and of the esophagus. Adipokines released from the peritumoural adipose tissue promote the metastatic potential of cancer cells, suggesting the existence of a crosstalk between the adipose tissue and the surrounding tumour. Mitochondrial Ca2+ signaling contributes to the progression of carcinoma of different origins. However, whether adipocyte-derived factors modulate mitochondrial Ca2+ signaling in tumours is unknown. Here, we show that conditioned media derived from adipose tissue cultures (ADCM) enriched in precursor cells impinge on mitochondrial Ca2+ homeostasis of target cells. Moreover, in modulating mitochondrial Ca2+ responses, a univocal crosstalk exists between visceral adipose tissue-derived preadipocytes and esophageal cancer cells, and between subcutaneous adipose tissue-derived preadipocytes and triple-negative breast cancer cells. An unbiased metabolomic analysis of ADCM identified creatine and creatinine for their ability to modulate mitochondrial Ca2+ uptake, migration and proliferation of esophageal and breast tumour cells, respectively. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Bariatric surgery and the COVID-19 pandemic: SICOB recommendations on how to perform surgery during the outbreak and when to resume the activities in phase 2 of lockdown

Author

Navarra, Giuseppe, Komaei, Iman, Currò, Giuseppe, Angrisani, Luigi, Bellini, Rosario, Cerbone, Maria Rosaria, Di Lorenzo, Nicola, De Luca, Maurizio, Foletto, Mirto, Gentileschi, Paolo, Musella, Mario, Nannipieri, Monica, Piazza, Luigi, Olmi, Stefano, Pilone, Vincenzo, Raffaelli, Marco, Sarro, Giuliano, Vitiello, Antonio, Zappa, Marco Antonio, and Foschi, Diego

Published
2020
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20. Soluble P2X7 Receptor Plasma Levels in Obese Subjects before and after Weight Loss via Bariatric Surgery.

Author

Di Vincenzo, Angelo, Granzotto, Marnie, Graziani, Andrea, Crescenzi, Marika, Foletto, Mirto, Prevedello, Luca, Capone, Federico, Vettor, Roberto, and Rossato, Marco

Subjects
WEIGHT loss, BARIATRIC surgery, OBESITY, SLEEVE gastrectomy, BODY weight
Abstract

Obesity is a systemic disease frequently associated with important complications such as type 2 diabetes and cardiovascular diseases. It has also been proven that obesity is a disease associated with chronic low-grade systemic inflammation and that weight loss improves this low-grade chronic inflammatory condition. The P2X7 purinergic receptor (P2X7R), belonging to the family of the receptors for extracellular ATP, is a main player in inflammation, activating inflammasome and pro-inflammatory cytokine production. In this study, we evaluated the plasma levels of soluble P2X7R (sP2X7R) measured in a group of obese patients before and one year after bariatric surgery. Furthermore, we evaluated the relation of sP2X7R to inflammatory marker plasma levels. We enrolled 15 obese patients who underwent laparoscopic sleeve gastrectomy, evaluating anthropometric parameters (weight, height, BMI and waist circumference) before and after surgery. Moreover, we measured the plasma levels of inflammatory markers (CRP, TNFα and IL-6) before and after weight loss via bariatric surgery. The results of our study show that one year after bariatric surgery, obese patients significantly decrease body weight with a significant decrease in CRP, TNF-alfa and IL-6 plasma levels. Similarly, after weight loss, obese subjects showed a significant reduction in sP2X7R plasma levels. Moreover, before surgery, plasma levels of sP2X7R were inversely related with those of CRP, TNF-alfa and IL-6. Given the role of P2X7R in inflammation, we hypothesized that, in obese subjects, sP2X7R could represent a possible marker of chronic low-grade inflammation, hypothesizing a possible role as a mediator of obesity complications. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Trends and safety of bariatric revisional surgery in Italy: multicenter, prospective, observational study.

Author

Boru, Cristian E., Marinari, Giuseppe M., Olmi, Stefano, Gentileschi, Paolo, Morino, Mario, Anselmino, Marco, Foletto, Mirto, Bernante, Paolo, Piazza, Luigi, Perrotta, Nicola, Morganti, Riccardo, and Silecchia, Gianfranco

Abstract

Revisional bariatric surgery (RBS) represents a further solution for patients who experience inadequate weight loss (IWL) following primary bariatric surgery (BS) or significant weight regain (WR) following initial satisfactory response. RBS guidelines are lacking; however, an increased trend in further BS offerings has been reported recently. Analyze trend, mortality, complication, readmission, and reoperation rates for any reason at 30 days after RBS in Italy. Ten Italian high-volume BS centers (university hospitals and private centers). Prospective, observational, multicenter study enrolling patients undergoing RBS between October 1, 2021, and March 31, 2022, registering reasons for RBS, technique, mortality, intraoperative and perioperative complications, readmissions, and reinterventions for any reason. Patients undergoing RBS during the same calendar interval in 2016–2020 were considered control patients. A total of 220 patients were enrolled and compared with 560 control-group patients. Mortality was.45% versus.35% (n.s), with an overall mortality of.25%, while open surgery or conversion to open surgery was registered in 1%. No difference was found for mortality, morbidity, complications, readmission (1.3%), and reoperation rates (2.2%). IWL/WR was the most frequent cause, followed by gastroesophageal reflux disease; Roux-en-Y gastric bypass was the most used revisional procedure (56%). Sleeve gastrectomy was the most revised procedure in the study group, while gastric banding was the most revised in the control group. RBS represents up to 9% of the total BS in the Italian participating centers. Laparoscopy represents the standard approach for RBS, which appears safe. Current Italian trends show a shift toward sleeve gastrectomy being the most revised procedure and Roux-en-Y gastric bypass being the most frequent revisional procedure. • prospective multicenter observational study on revisional bariatric surgery RBS • 222 patients enrolled 01.10.21–31.03.22, compared with 560 patients control group • RBS is safe with acceptable mortality and morbidity, performed 99% laparoscopically • Sleeve is the most revised and RY gastric bypass the most used revisional procedure [ABSTRACT FROM AUTHOR]

Published
2023
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25. Characterization of subcutaneous and omental adipose tissue in patients with obesity and with different degrees of glucose impairment

Author

Belligoli, Anna, Compagnin, Chiara, Sanna, Marta, Favaretto, Francesca, Fabris, Roberto, Busetto, Luca, Foletto, Mirto, Dal Prà, Chiara, Serra, Roberto, Prevedello, Luca, Da Re, Chiara, Bardini, Romeo, Mescoli, Claudia, Rugge, Massimo, Fioretto, Paola, Conci, Scilla, Bettini, Silvia, Milan, Gabriella, and Vettor, Roberto

Published
2019
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28. Body Weight Reduction by Bariatric Surgery Reduces the Plasma Levels of the Novel Orexigenic Gut Hormone Insulin-like Peptide 5 in Patients with Severe Obesity.

Author

Di Vincenzo, Angelo, Crescenzi, Marika, Granzotto, Marnie, Zancaner, Sara, Fabris, Roberto, Foletto, Mirto, Prevedello, Luca, Capone, Federico, Vettor, Roberto, and Rossato, Marco

Subjects
WEIGHT loss, LEPTIN, BARIATRIC surgery, APPETITE stimulants, REGULATION of body weight, GASTROINTESTINAL hormones, PEPTIDE hormones, GASTRIC bypass
Abstract

Insulin-like factor 5 (INSL5), a novel hormone secreted by the enteroendocrine cells of the distal colon, has been implicated in appetite and body weight regulation in animals given its orexigenic properties. We investigated basal INSL5 plasma levels in a group of morbidly obese subjects before and after laparoscopic sleeve gastrectomy. Furthermore, we analyzed the expression of INSL5 in human adipose tissue. Before bariatric surgery, obese subjects showed basal INSL5 plasma levels that were positively correlated with BMI, fat mass, and leptin plasma levels. After weight loss by laparoscopic sleeve gastrectomy, INSL5 plasma levels in obese subjects were significantly lower than those observed before surgery. Finally, we did not detect any expression of the INSL5 gene in human adipose tissue, both at the mRNA and protein levels. The present data show that subjects with obesity have INSL5 plasma levels positively correlating with adiposity markers. After bariatric surgery, INSL5 plasma levels decreased significantly, and this decrease was not directly due to the loss of adipose tissue since this tissue does not express INSL5. Considering the orexigenic properties of INSL5, the reduction of its plasma levels after bariatric surgery in obese subjects could participate in the still unclear mechanisms leading to appetite reduction that characterize bariatric surgery procedures. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Analysis of Walking Economy after Sleeve Gastrectomy in Patients with Severe Obesity.

Author

Vecchiato, Marco, Faggian, Sara, Quinto, Giulia, Battista, Francesca, Foletto, Mirto, Di Vincenzo, Angelo, Bettini, Silvia, Gasperetti, Andrea, Busetto, Luca, Ermolao, Andrea, and Neunhaeuserer, Daniel

Subjects
MORBID obesity, SLEEVE gastrectomy, EXERCISE tests, WEIGHT loss, WALKING speed, OBESITY
Abstract

Simple Summary: Patients with obesity have a higher energy cost of walking than normal-weight subjects. Can bariatric surgery help these patients to improve their walking economy? In this study, a group of patients underwent cardiopulmonary exercise testing one month before and six months after laparoscopic sleeve gastrectomy and their parameters were registered at three different submaximal protocol stages. As well as significant weight loss, improvements in walking economy were evident as early as six months after bariatric surgery even when patients were grouped by gender and obesity class. These changes result in less impairment when performing daily physical activities. Background: Obesity is associated with a higher energy cost of walking which affects activities of daily living. Bariatric surgery with sleeve gastrectomy (SG) has beneficial effects on weight loss and comorbidities. Purpose: The aim of this study was to analyze the impact of SG on walking economy in subjects with severe obesity. Methods: This observational cohort study included all patients with morbid obesity who were considered suitable candidates for SG between June 2017 and June 2019. Each patient underwent an incremental cardiopulmonary exercise test on a treadmill (modified Bruce protocol) one month before and six months after SG. Data on the energy cost of walking were recorded during three protocol stages (stage 0—slow flat walking: speed 2.7 km/h, slope 0%; stage ½—slow uphill walking: speed 2.7 km/h, slope 5%; stage 1—fast uphill walking: speed 4.0 km/h, slope 8%). Results: 139 patients with morbid obesity (78% women; age 44.1 ± 10.7 years; BMI 42.5 ± 4.7 kg/m2) were included in the study. At six months post-SG, patients presented with a significantly decreased body weight (−30.5 ± 17.2 kg; p < 0.05), leading to an average BMI of 31.6 ± 4.2 kg/m2. The net energy cost of walking (measured in J/m and J/kg/m) of the subjects was lower compared to pre-SG at all three protocol stages. This improvement was also confirmed when the subjects were grouped by gender and obesity classes. Conclusion: After a significant weight loss induced by SG, regardless of the severity of obesity and gender, patients exhibited a lower energy expenditure and an improved walking economy. These changes make it easier to perform daily routines and may facilitate an increase in physical activity. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Mechanical Behavior of Subcutaneous and Visceral Abdominal Adipose Tissue in Patients with Obesity.

Author

Fontanella, Chiara Giulia, Toniolo, Ilaria, Foletto, Mirto, Prevedello, Luca, and Carniel, Emanuele Luigi

Abstract

The mechanical characterization of adipose tissues is important for various medical purposes, including plastic surgery and biomechanical applications, such as computational human body models for the simulation of surgical procedures or injury prediction, for example, in the evaluation of vehicle crashworthiness. In this context, the measurement of human subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) mechanical properties in relation to subject characteristics may be really relevant. The aim of this work was to properly characterize the mechanical response of adipose tissues in patients with obesity. Then, the data were exploited to develop a reliable finite element model of the adipose tissues characterized by a constitutive material model that accounted for nonlinear elasticity and time dependence. Mechanical tests have been performed on both SAT and VAT specimens, which have been harvested from patients with severe obesity during standard laparoscopic sleeve gastrectomy intervention. The experimental campaign included indentation tests, which permitted us to obtain the initial/final indentation stiffnesses for each specimen. Statistical results revealed a higher statistical stiffness in SAT than in VAT, with an initial/final indentation stiffness of 1.65 (SD ± 0.29) N/30.30 (SD ± 20) N compared to 1.29 (SD ± 0.30) N/21.00 (SD ± 16) N. Moreover, the results showed that gender, BMI, and age did not significantly affect the stiffness. The experimental results were used in the identification of the constitutive parameters to be inserted in the constitutive material model. Such constitutive characterization of VAT and SAT mechanics can be the starting point for the future development of more accurate computational models of the human adipose tissue and, in general, of the human body for the optimization of numerous medical and biomechanical procedures and applications. [ABSTRACT FROM AUTHOR]

Published
2022
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