7 results on '"Gentry, Jessica"'
Search Results
2. A Multiplex HIV Incidence Assay for Inferring Recent HIV-1 Transmission and Time of Infection
- Author
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Curtis, Kelly A., Campbell, Ellsworth M., Hanson, Debra L., Rudolph, Donna L., Duwve, Joan, Blosser, Sara, Gentry, Jessica, Lovchik, Judy, Peters, Philip J., Owen, S. Michele, and Switzer, William M.
- Published
- 2019
- Full Text
- View/download PDF
3. Determining acceptance of domestic forage- or grain-finished beef by consumers from three southeastern U.S. states
- Author
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Cox, Ryan B., Kerth, Chris R., Gentry, Jessica G., Prevatt, Walter J., Braden, Kirk W., and Jones, William R.
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Beef -- Storage ,Food conservation -- Research ,Flavoring essences -- Research ,Food -- Protection and preservation ,Food -- Research ,Business ,Food/cooking/nutrition - Abstract
A study was conducted to determine the consumer acceptance of forage-finished and grain-finished beef in the southeastern US and the value that consumers associate with forage-finished beef. The survey data revealed a significant market for forage-fed beef in the southeastern US with one-third to one-half of consumers preferring the taste of forage-fed beef to grain-fed beef.
- Published
- 2006
4. Science Education: Biotechnology in community colleges
- Author
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DuBois, Susan, Gentry, Jessica, Strickland, Neil, Lanham, Christi, and Hall, Devon
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Biotechnology -- Study and teaching ,Science and technology ,Study and teaching - Abstract
The Biotechnology program at Mississippi Gulf Coast Community College, Jefferson Davis Campus, is designed to prepare students to enter the Biotechnology workforce. The curriculum is designed to allow students a [...]
- Published
- 2004
5. HIV Infection Linked to Injection Use of Oxymorphone in Indiana, 2014-2015.
- Author
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Peters, Philip J., Pontones, Pamela, Hoover, Karen W., Patel, Monita R., Galang, Romeo R., Shields, Jessica, Blosser, Sara J., Spiller, Michael W., Combs, Brittany, Switzer, William M., Conrad, Caitlin, Gentry, Jessica, Khudyakov, Yury, Waterhouse, Dorothy, Owen, S. Michele, Chapman, Erika, Roseberry, Jeremy C., McCants, Veronica, Weidle, Paul J., and Broz, Dita
- Subjects
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HIV infection risk factors , *EPIDEMICS , *HIV , *HEPATITIS C virus , *SEXUAL partners - Abstract
Background: In January 2015, a total of 11 new diagnoses of human immunodeficiency virus (HIV) infection were reported in a small community in Indiana. We investigated the extent and cause of the outbreak and implemented control measures.Methods: We identified an outbreak-related case as laboratory-confirmed HIV infection newly diagnosed after October 1, 2014, in a person who either resided in Scott County, Indiana, or was named by another case patient as a syringe-sharing or sexual partner. HIV polymerase (pol) sequences from case patients were phylogenetically analyzed, and potential risk factors associated with HIV infection were ascertained.Results: From November 18, 2014, to November 1, 2015, HIV infection was diagnosed in 181 case patients. Most of these patients (87.8%) reported having injected the extended-release formulation of the prescription opioid oxymorphone, and 92.3% were coinfected with hepatitis C virus. Among 159 case patients who had an HIV type 1 pol gene sequence, 157 (98.7%) had sequences that were highly related, as determined by phylogenetic analyses. Contact tracing investigations led to the identification of 536 persons who were named as contacts of case patients; 468 of these contacts (87.3%) were located, assessed for risk, tested for HIV, and, if infected, linked to care. The number of times a contact was named as a syringe-sharing partner by a case patient was significantly associated with the risk of HIV infection (adjusted risk ratio for each time named, 1.9; P<0.001). In response to this outbreak, a public health emergency was declared on March 26, 2015, and a syringe-service program in Indiana was established for the first time.Conclusions: Injection-drug use of extended-release oxymorphone within a network of persons who inject drugs in Indiana led to the introduction and rapid transmission of HIV. (Funded by the state government of Indiana and others.). [ABSTRACT FROM AUTHOR]- Published
- 2016
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6. A Multiplex HIV Incidence Assay for Inferring Recent HIV-1 Transmission and Time of Infection.
- Author
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Curtis KA, Campbell EM, Hanson DL, Rudolph DL, Duwve J, J Blosser S, Gentry J, Lovchik J, Peters PJ, Owen SM, and Switzer WM
- Subjects
- Algorithms, HIV Envelope Protein gp41 immunology, HIV Infections diagnosis, HIV Infections transmission, HIV Seropositivity epidemiology, HIV-1 immunology, Humans, Indiana epidemiology, Sensitivity and Specificity, Seroconversion physiology, HIV Antibodies immunology, HIV Antigens immunology, HIV Envelope Protein gp120 immunology, HIV Envelope Protein gp160 immunology, HIV Infections epidemiology
- Abstract
Background: Laboratory assays for determining recent HIV-1 infection are an important public health tool for aiding in the estimation of HIV incidence. Some incidence assay analytes are remarkably predictive of time since seroconversion and may be useful for additional applications, such as predicting recent transmission events during HIV outbreaks and informing prevention strategies., Methods: Plasma samples (n = 154) from a recent HIV-1 outbreak in a rural community in Indiana were tested with the customized HIV-1 Multiplex assay, based on the Bio-Rad Bio-Plex platform, which measures antibody response to HIV envelope antigens, gp120, gp160, and gp41. Assay cutoffs for each analyte were established to determine whether an individual seroconverted within 30, 60, or 90 days of the sample collection date. In addition, a novel bioinformatics method was implemented to infer infection dates of persons newly diagnosed with HIV during the outbreak., Results: Sensitivity/specificity of the HIV-1 Multiplex assay for predicting seroconversion within 30, 60, and 90 days, based on a training data set, was 90.5%/95.4%, 94.1%/90%, and 89.4%/82.9%, respectively. Of 154 new diagnoses in Indiana between December 2014 and August 2016, the majority (71%) of recent infections (≤3 months since seroconversion) were identified between February and May 2016. The epidemiologic curve derived from the bioinformatics analysis indicated HIV transmission began as early as 2010, grew exponentially in 2014, and leveled off in April 2015., Conclusions: The HIV-1 Multiplex assay has the potential to identify and monitor trends in recent infection during an epidemic to assess the efficacy of programmatic or treatment interventions.
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- 2019
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7. A large HCV transmission network enabled a fast-growing HIV outbreak in rural Indiana, 2015.
- Author
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Ramachandran S, Thai H, Forbi JC, Galang RR, Dimitrova Z, Xia GL, Lin Y, Punkova LT, Pontones PR, Gentry J, Blosser SJ, Lovchik J, Switzer WM, Teshale E, Peters P, Ward J, and Khudyakov Y
- Subjects
- Adult, Female, HIV Infections epidemiology, HIV Infections transmission, Humans, Indiana epidemiology, Male, Middle Aged, Coinfection epidemiology, Coinfection transmission, Disease Outbreaks, Hepatitis C epidemiology, Hepatitis C transmission, Oxymorphone, Rural Population, Substance Abuse, Intravenous epidemiology
- Abstract
Background: A high prevalence (92.3%) of hepatitis C virus (HCV) co-infection among HIV patients identified during a large HIV outbreak associated with injection of oxymorphone in Indiana prompted genetic analysis of HCV strains., Methods: Molecular epidemiological analysis of HCV-positive samples included genotyping, sampling intra-host HVR1 variants by next-generation sequencing (NGS) and constructing transmission networks using Global Hepatitis Outbreak and Surveillance Technology (GHOST)., Findings: Results from the 492 samples indicate predominance of HCV genotypes 1a (72.2%) and 3a (20.4%), and existence of 2 major endemic NS5B clusters involving 49.8% of the sequenced strains. Among 76 HIV co-infected patients, 60.5% segregated into 2 endemic clusters. NGS analyses of 281 cases identified 826,917 unique HVR1 sequences and 51 cases of mixed subtype/genotype infections. GHOST mapped 23 transmission clusters. One large cluster (n = 130) included 50 cases infected with ≥2 subtypes/genotypes and 43 cases co-infected with HIV. Rapid strain replacement and superinfection with different strains were found among 7 of 12 cases who were followed up., Interpretation: GHOST enabled mapping of HCV transmission networks among persons who inject drugs (PWID). Findings of numerous transmission clusters, mixed-genotype infections and rapid succession of infections with different HCV strains indicate a high rate of HCV spread. Co-localization of HIV co-infected patients in the major HCV clusters suggests that HIV dissemination was enabled by existing HCV transmission networks that likely perpetuated HCV in the community for years. Identification of transmission networks is an important step to guiding efficient public health interventions for preventing and interrupting HCV and HIV transmission among PWID. FUND: US Centers for Disease Control and Prevention, and US state and local public health departments., (Published by Elsevier B.V.)
- Published
- 2018
- Full Text
- View/download PDF
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