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Over 20% of mortality during acute liver failure is associated with the development of hepatic encephalopathy (HE). Thus, HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities ranging from subclinical alterations to coma. HE is caused by the diversion of portal blood into systemic circulation through portosystemic collateral vessels. Thus, the brain is exposed to intestinal-derived toxic substances. Moreover, the strategies to prevent advancement and improve the prognosis of such a liver-brain disease rely on intestinal microbial modulation. This is supported by the findings that antibiotics such as rifaximin and laxative lactulose can alleviate hepatic cirrhosis and/or prevent HE. Together, the significance of the gut-liver-brain axis in human health warrants attention. This review paper focuses on the roles of bacteria metabolites, mainly ammonia and bile acids (BAs) as well as BA receptors in HE. The literature search conducted for this review included searches for phrases such as BA receptors, BAs, ammonia, farnesoid X receptor (FXR), G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5), sphingosine-1-phosphate receptor 2 (S1PR2), and cirrhosis in conjunction with the phrase hepatic encephalopathy and portosystemic encephalopathy. PubMed, as well as Google Scholar, was the search engines used to find relevant publications.

Obesity and malnutrition both cause dysbiosis and dampen retinoic acid (RA) signaling pathways, which play pivotal roles in biological processes. The current study evaluates a hypothesis that colitis-associated dysbiosis also has systemic negative impacts on RA signaling. Thus, we studied the effects of inflammation, under a vitamin A-sufficient condition, on RA signaling using mouse colitis models induced by dextran sulfate sodium. That data showed that intestinal inflammation resulted in reduced RA signaling in the liver, brain, gut, and adipose tissues measured by analyzing the expression of genes encoding for the synthesis, oxidation, transport, and receptor of RA. The expression of RA-regulated gut homing molecules including α4β7 integrin, and CCR9, along with MADCAM1 were all reduced in colitis mice revealing compromised immunity due to reduced RA signaling. The data also showed that the development of colitis was accompanied by dysbiosis featured with reduced Lactobacillaceae and Verrucomicrobiaceae but an expansion of Erysipelotrichaceae and others. Colitis resulted in reduced butyrate-producing bacteria and increased methane-generating bacteria. Additionally, dysbiosis was associated with induced Il-1β, Ifn-γ, and Tnf-α mRNA but reduced Il-22, Il-17f, and Rorγt transcripts in the colon. Together, intestinal inflammation inhibits RA signaling in multiple organs. RA is essential in regulating various biological processes, it is critical to detect RA signaling reduction in tissues even when vitamin A deficiency is absent. Moreover, probiotics can potentially prevent dysbiosis and reverse compromised RA signaling, having systemic health benefits.

It has been inferred from large unbiased samples that |$10$| – |$15{{\ \rm per\ cent}}$| of all quasars are radio-loud (RL). Using the quasar catalogue from the Sloan Digital Sky Survey, we show that the radio-loud fraction (RLF) for high broad line (HBL) quasars, containing H β full width at half-maximum greater than 15 000 km s−1, is |$\sim 57 {{\ \rm per\ cent}}$|⁠. While there is no significant difference between the RL and radio-quiet (RQ) populations in our sample in terms of their black hole mass, Eddington ratio, and covering fraction (CF), optical continuum luminosity of the RL quasars are higher. The similarity in the distribution of their CF indicates that our analysis is unbiased in terms of the viewing angle of the HBL RL and RQ quasars. Hence, we conclude that the accretion disc luminosity of the RL quasars in our HBL sample is higher, which indicates a connection between a brighter disc and a more prominent jet. By comparing them with the non-HBL H β broad emission line quasars, we find that the HBL sources have the lowest Eddington ratios in addition to having a very high RLF. That is consistent with the theories of jet formation, in which jets are launched from low Eddington ratio accreting systems. We find that the [O iii ] narrow emission line is stronger in the RL compared to RQ quasars in our HBL sample, which is consistent with previous findings in the literature, and may be caused by the interaction of the narrow line gas with the jet. [ABSTRACT FROM AUTHOR]