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6 results on '"Gloria Brombo"'

1. Neutrophil–Lymphocytes Ratio as Potential Early Marker for Alzheimer’s Disease

Author

Carlo Cervellati, Dario Pedrini, Pietro Pirro, Paola Guindani, Carlo Renzini, Gloria Brombo, and Giovanni Zuliani

Subjects
Pathology, RB1-214
Abstract

Background. Neutrophil–lymphocyte ratio (NLR) is a noninvasive, inexpensive, and easily applicable marker of inflammation. Since immune dysregulation leading to inflammation is regarded as a hallmark of dementia, in particular Alzheimer’s disease (AD), we decided to investigate the potentials of NLR as a diagnostic and predictive biomarker in this clinical setting. Materials and Methods. NLR was measured in the blood of patients with AD (n = 103), amnestic type mild cognitive impairment (aMCI, n = 212), vascular dementia (VAD, n = 34), and cognitively healthy Controls (n = 61). One hundred twelve MCI patients underwent a regular clinical follow-up. Over a 36-months median follow-up, 80 remained stable, while 32 progressed to overt dementia. Results. NLR was higher in patients with aMCI or dementia compared to Controls; however, the difference was statistically significant only for aMCI (+13%, p=0.04) and AD (+20%, p=0.03). These results were confirmed by multivariate logistic analysis, which showed that high NLR was associated with an increase in the likelihood of receiving a diagnosis of aMCI (odd ratio (OR): 2.58, 95% confidence interval (CI): 1.36–4.89) or AD (OR: 3.13, 95%CI: 1.47–6.70), but not of VAD. NLR did not differ when comparing stable vs. progressing aMCI. Conclusions. This is the first report showing that NLR is significantly increased in MCI and AD but not in VAD. We also found that NLR was unable to predict the conversion from aMCI to AD. Further research on larger cohorts is warranted to definitely ascertain the application of NLR as a possible marker for aMCI and AD.

Published
2024
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2. Cerebral Blood Flow in Alzheimer’s Disease: A Meta-Analysis on Transcranial Doppler Investigations

Author

Marco Zuin, Alessandro De Vito, Tommaso Romagnoli, Michele Polastri, Eleonora Capatti, Cristiano Azzini, Gloria Brombo, and Giovanni Zuliani

Subjects
Alzheimer’s Disease, cerebral flow, transcranial Doppler, Geriatrics, RC952-954.6
Abstract

Background: Cerebrovascular hemodynamic impairment has been reported in Alzheimer’s disease (AD). We performed a systematic review and meta-analysis to investigate changes in cerebral blood flow (CBF) in AD patients. Methods: Data were obtained by searching MEDLINE and Scopus for all investigations published between 1 January 2011 and 1 November 2021, comparing the cerebrovascular hemodynamic between AD patients and cognately healthy age-matched controls, using transcranial Doppler (TCD) ultrasound. Results: Twelve studies, based on 685 patients [395 with AD and 290 age-matched cognitively healthy controls, with a mean age of 71.5 and 72.1 years, respectively] were included in the analysis. A random effect model revealed that AD patients, in the proximal segments of the middle cerebral artery (MCA), have a significantly lower CBF velocity, compared to controls (MD: −7.80 cm/s, 95%CI: −10.78 to −5.13, p < 0.0001, I2 = 71.0%). Due to a significant Egger’s test (t = 3.12, p = 0.008), a trim-and-fill analysis was performed, confirming the difference (MD: −11.05 cm/s, 95%CI: –12.28 to −9.82, p < 0.0001). Meta-regression analysis demonstrated that the mean CBF at the proximal MCA was directly correlated with arterial hypertension (p = 0.03) and MMSE score (p < 0.001), but inversely correlated with age (p = 0.01). In AD patients, the pulsatility index was significantly higher compared to controls (MD: 0.16, 95%CI: 0.07 to 0.25, p < 0.0001, I2: 84.5%), while the breath-holding index test results were significant lower (MD: −1.72, 95%CI: −2.53 to −0.91, p < 0.001, I2: 85.4%). Conclusions: AD patients have a significant impairment in relation to their cerebrovascular perfusion, suggesting that cerebrovascular hemodynamic deterioration, evaluated using TCD, may be a useful diagnostic tool.

Published
2024
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3. Prognostic value of anemia in terms of disability and mortality in hospitalized geriatric patients: results from the CRIME study

Author

Gloria Brombo, Marta Dianin, Lara Bianchi, Andrea Corsonello, Antonio Cherubini, Carmelinda Ruggiero, Graziano Onder, and Stefano Volpato

Subjects
Elderly, anemia, disability, mortality., Geriatrics, RC952-954.6
Abstract

Anemia, a common concern in geriatric population, is associated with several negative outcomes. The aim of this study was to investigate the independent prognostic value of anemia in the year after hospital discharge, analyzing its association with disability and mortality in a sample of older hospitalized patients. We evaluated 896 in-hospital older patients enrolled in the CRiteria to Assess Appropriate Medication Use among Elderly Complex Patients (CRIME) study, with assessment of hemoglobin levels at hospital admission and with follow-up data. We analyzed the risk of developing disability (in patients without pre-existing disability in activities of the daily living) and the likelihood of death (in the entire sample) in the 12 months after discharge according to presence and degree of anemia (defined by sex-specific World Health Organization criteria). Mean age of study participants was 81.2±7.4 years, 57.8% had prevalent anemia. In unadjusted analysis, anemia was strongly associated with functional status and survival. Nevertheless, the increased risk of disability and death was influenced by the coexistence of several clinical conditions associated with anemia. Indeed, using multivariate logistic regression analysis adjusted for potential confounders, the association with disability was strongly attenuated [severe anemia odds ratio (OR) 1.86, 95% confidence interval (CI): 0.96-3.58, mild-moderate anemia OR 1.05, 95% CI: 0.62-1.80] and the relationship with mortality was no longer significant [severe anemia hazard ratio (HR) 1.13, 95% CI: 0.73-1.75, mild-moderate anemia HR 1.14, 95% CI: 0.78-1.67]. In older hospitalized patients, anemia, despite not influencing mortality, might have a significant disabling effect. Anemia should not be considered as an inevitable epiphenomenon of aging but a condition able to worsen the quality of life.

Published
2016
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4. Association of soluble Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) with central adiposity and low-density lipoprotein cholesterol.

Author

Gloria Brombo, Stefano Volpato, Paola Secchiero, Angelina Passaro, Cristina Bosi, Giovanni Zuliani, and Giorgio Zauli

Subjects
Medicine, Science
Abstract

ObjectiveTumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), in addition to having a prognostic value in patients with cardiovascular disease, seems to interact with adiposity, insulin resistance and other cardiovascular risk factors. However, the results of previous clinical studies, focused on the association of TRAIL with selected metabolic or anthropometric indices were inconclusive. The aim of this study was to further investigate how soluble TRAIL concentrations independently correlate with major cardiovascular risk factors, including lipid, glycemic and anthropometric features.Materials/methodsWe examined the associations between serum soluble TRAIL concentrations, measured by ELISA, and lipid, glycemic and anthropometric features in 199 subjects recruited at our Metabolic Outpatient Clinic.ResultsSoluble TRAIL concentrations had a significant and direct correlation with total cholesterol (p = 0.046), LDL-cholesterol (p = 0.032), triglycerides (p = 0.01), body mass index (p = 0.046), waist circumference (p = 0.008), fat mass (p = 0.056) and insulin (p = 0.046) and an inverse correlation with HDL-cholesterol (p = 0.02). In multivariable regression analyses adjusted for potential confounders (age, gender, C-reactive protein, HDL-cholesterol, triglycerides, waist circumference, and insulin), TRAIL levels continued to have an independent correlation with LDL-cholesterol and waist circumference (r(2) = 0.04).ConclusionsSerum TRAIL levels were weakly but significantly and independently associated with waist circumference, a marker of visceral adiposity, and with LDL-cholesterol. Further studies are needed to clarify the biological basis of these relationships.

Published
2013
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5. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Rispoli, Vincenzo, Malara, Alba, Spadea, Fausto, Di Cello, Serena, Ceravolo, Francesco, Fabiano, Francesco, Chiaradia, Giuseppe, Gabriele, Amedeo, Lenino, Peluso, Andrea, Taristano, Settembrini, Vincenzo, Capomolla, Domenico, Citrino, Antonella, Scriva, Antonietta, Bruno, Irene, Secchi, Roberto, De Martino, Eugenio, Muccinelli, Roberto, Lupi, Gerardo, Paonessa, Patrizio, Fabbri, Andrea, Passuti, Maria Teresa, Castellari, Sofia, Po, Andrea, Gaggioli, Guido, Varesi, Massimo, Moneti, Paolo, Capurso, Sebastiano, Latini, Vincenzo, Ghidotti, Stefano, Riccardelli, Francesco, Macchi, Maurizio, Rigo, Rosaria, Claudio, Pascale, Angelo, Bosio, Flavio, Cerrato, Benedetta, Bardelli, Boffelli, Stefano, Cassinadri, Angela, Franzoni, Simone, Spazzini, Elena, Andretto, Daniela, Tonini, Gabriele, Andreani, Laura, Coralli, Mirco, Balotta, Antonio, Cancelliere, Roberto, Ballardini, Giorgio, Simoncelli, Margherita, Mancini, Annarita, Strazzacapa, Mara, Fabio, Stefano, De Filippi, Francesco, Giudice, Chiara, Dentizzi, Cosimo, Azzini, Margherita, Cazzadori, Marco, Mastroeni, Valeria, Bertassello, Paolo, Claudia Benati, Helena Santana, Nesta, Elisa, Tobaldini, Chiara, Guerini, Fabio, Elena, Tambara, Mombelloni, Paolo, Fontanini, Fulvio, Gabriella, Lassa, Pizzorni, Crosio, Oliverio, Martina, Del Grosso, Luciano Luca, Giavedoni, Cristina, Bidoli, Giuliano, Mazzei, Bruno, Corsonello, Andrea, Fusco, Sergio, Vena, Silvio, De Vuono, Tommaso, Maiuri, Giorgio, Luca, Fimognari Filippo, Andrea, Arone, Giovanni, Sgrò, Rossella, Nicolazzo, Castegnaro, Eugenio, De Rosa, Salvatore, Sechi, Rossella Bazzano, Benvenuti, Enrico, Del Lungo, Ilaria, Giardini, Sante, Giulietti, Chiara, Mauro, Di Bari, Eleonora, Barghini, Martina, Paoli, Irene, Fiordelli, Riccardo, Barucci, Federica, Sgrilli, Ilaria, Del Lungo, Bertoletti, Erik, D'Amico, Ferdinando, Caronzolo, Francesco, Grippa, Alessandro, Lombardo, Giuseppina, Pipicella, Tiziana, Antonino, Saitta, Francesco, Corica, Valeria, Prestipino Giarritta, Daniela, Larosa, Domenico, Cucinotta, Giorgio, Basile, March, Albert, Nitti, Maria Teresa, Felici, Alessandro, Pavan, Silvia, Piazzani, Fabrizio, Lunelli, Alessandra, Dimori, Sergio, Margotta, Alessandro, Soglia, Tiziano, Postacchini, Demetrio, Brunelli, Roberto, Santini, Silvia, Francavilla, Monia, Macchiati, Ilenia, Sorvillo, Francesca, Giuli, Cinzia, Mecocci, Patrizia, Longo, Annalisa, Perticone, Francesco, Addesi, Desireè, Rosa, Paola Cerra, Bencardino, Giuseppe, Falbo, Tania, Grillo, Nadia, Marco, Filice, Mirella, Flippo, Fantò, Fausto, Isaia, Gianluca, Pezzilli, Stella, Bergamo, Daniele, Furno, Elisabetta, Rrodhe, Sokol, Lucarini, Simonetta, Dijk, Babette, Dall'Acqua, Francesca, Cappelletto, Francesco, Calvani, Donatella, Becheri, Dimitri, Giuseppe, Mottino, Costanza, Mitidieri, Vito, Antonio, Francesca, Bartalucci, Magherini, Lorenza, Novella, Malin, Franca, Boni, Lucia Gambardella, Paoli Martina, Valente, Carlo, Ilaria, Bracali, Alice, Foschini, Bo, Mario, Porrino, Paola, Ceci, Giacomo, Giuliana, Bottignole, Michela, Tibaldi, Eleonora, Coppo, Ettore, Evaristo, Camellini, Cinzia, Servello, Adriana, Grassi, Alessandro, Rozzini, Renzo, Tironi, Sara, Grassi, Maria Grazia, Troisi, Elio, Carlo, Caltagirone, Simona Gabriella, Di Santo, Flaminia, Franchini, Federica, Ratto, Beatrice, Pavoni, Sofia, Toniolo, Gabutto, Anna, Quazzo, Loredana, Rosatello, Annalisa, Suraci, Domenico, Tagliabue, Benedetta, Perrone, Chiara, Ferrara, Lucia, Castagna, Alberto, Tremolada, Maria Luisa, Giuseppe, Castoldi, Stefano, Barbero, Davide, Oltramonti, Piano, Simonetta, Serviddio, Gaetano, Lo Buglio, Aurelio, Gurrera, Tiziana, Merlo, Valeria, Rovai, Carla, Cotroneo, Antonino Maria, Carlucci, Rosaria, Abbaldo, Anna, Monzani, Fabio, Qasem, Ahmad Amedeo, Bini, Giacomo, Tafuto, Silvia, Galli, Giovanni, Bruni, Amalia Cecilia, Mancuso, Giovanna, Mancuso, Gerardo, Calipari, Daniela, Giuseppe Massimiliano, De Luca, Bernardini, Bruno, Corsini, Carla, Michele, Ciccarelli, Sara, Dal Farra, Cagnin, Annachiara, Fragiacomo, Federica, Pompanin, Sara, Piero, Amodio, Marco, Cagnin, Zurlo, Amedeo, Guerra, Gianluca, Pala, Marco, Menozzi, Luca, Gatti, Chiara Delli, Magon, Stefania, Roberto, Manfredini, Alfredo, De Giorgi, Fabio, Fabbian, Ruana, Tiseo, Elisa, Misurati, Benedetta, Boari, Christian, Molino, Marco, Pala, Massimo, Gallerani, Di Francesco, Vincenzo, Faccioli, Silvia, Pellizzari, Luca, Giorgia, Fontana, Barbagallo, Giuseppe, Lunardelli, Maria Lia, Martini, Emilio, Ferrari, Eleonora, Macchiarulo, Maria, Corneli, Maria, Bacci, Monica, Battaglia, Giuseppe, Anastasio, Luigi, Lo Storto, Mario Sostene, Seresin, Chiara, Simonato, Matteo, Loreggian, Michele, Cestonaro, Fausta, Durando, Mario, Latella, Raffaele, Mazzoleni, Marta, Russo, Giuseppe, Ponte, Martino, Valchera, Alessandro, Salustri, Giuseppe, Petritola, Donatella, Costa, Alfredo, Sinforiani, Elena, Cotta, Matteo Ramusino, Pizio, Renato Nicola, Cester, Alberto, Formilan, Marino, Pietro, Bonometto, Carbone, Pasqualina, Cazzaniga, Ilaria, Appollonio, Ildebrando, Cereda, Diletta, Stabile, Andrea, Xhani, Rubjona, Acampora, Roberto, Tremolizzo, Lucio, Federico, Pieruzzi, Antonio, Ciaccio, Valerio, Pontecorvi, Cesare, Burti, Zhirajr, Mokini, Giovanni, Vitale, Maria, Amigoni, Mariaelena, Sparacino, Bottacchi, Edo, Bucciantini, Elisabetta, Di Giovanni, Marco, Franchi, Fabrizio, Lucchetti, Lucio, Mariani, Claudio, Grande, Giulia, Rapazzini, Piero, Marco, Mauri, Romanelli, Giuseppe, Marengoni, Alessandra, Franco, Nicosia, Alessio, Margola, Stefano, Bonardelli, Nicola, Latronico, Laura, Porcella, Nazario, Portolani, Carlo, Concoreggi, Chiara, Grassini, Soccorso, Pronto, Andrea, Salvi, Luca, Bianchetti, Francesca, Spagnoli, Roberto, Apuzzo, Marco, Fontanella, Anna, Ceraso, Francesco, Castelli, Fugazza, Luciano, Guerrini, Chiara, De Paduanis, Giovanna, Iallonardo, Lucia, Palumbo, Pasquale, Zuliani, Giovanni, Ortolani, Beatrice, Capatti, Eleonora, Soavi, Cecilia, Bianchi, Lara, Francesconi, Daniela, Miselli, Agata, Gloria, Brombo, Tommaso, Romagnoli, Chiara, Pazzaglini, Agata, Miselli Maria, Marco, Dall'Agata, Luca, Menozzi, Gianluca, Guerra, Suardi, Teresa, Mazzone, Andrea, Zaccarini, Cinzia, Manuela, Riva, Mirra, Gianluca, Muti, Ettore, Bottura, Renato, Gianpaolo, Moretti, Secreto, Piero, Bisio, Erika, Cecchettani, Marco, Naldi, Tamara, Pallavicino, Alessandra, Pugliese, Michela, Iozzo, Rosaria Cosima, Grassi, Guido, Michele, Bombelli, Raffaella, Dell'Oro, Fosca, Quarti Trevano, Giorgio, Giussani Carlo, Giovanni, Paternò, Ernesto, Contro, Mannironi, Antonio, Giorli, Elisa, Oberti, Sara, Fierro, Brigida, Piccoli, Tommaso, Giacalone, Fabio, Mandas, Antonella, Serchisu, Luca, Costaggiu, Diego, Pinna, Elisa, Orrù, Francesca, Mannai, Martina, Cordioli, Zeno, Pelizzari, Luca, Turcato, Emanuela, Arduini, Pietro, Cacace, Carlo, Chiloiro, Roberta, Cimino, Rosella, Ruberto, Carmen, Giovanni, Ruotolo, Pietro, Gareri, Laura, Greco, Alberto, Castagna, Carmen, Ruberto, Santo, Pierluigi Dal, Andriolli, Antonino, Burattin, Giuseppe, Rossi, Laura, Andreolli Antonino, Cervati Giovanna, Giuseppe, Catalano, Tezza, Fabiana, Maddalena, Pizzardini, Laura, Stievano, Crippa, Patrizia, Aloisio, Paola, Di Monda, Tiziana, Malighetti, Alessandro, Galbassini, Gloria, Salutis, Domus, Ivaldi, Claudio, Russo, Anna Maria, Bennati, Ettore, Pino, Elisabetta, Zavarise, Gianmaria, Pesci, Alberto, Suigo, Giulia, Faverio, Paola, Andrea, Gori, Sabrina, Perego, Zanasi, Massimo, Moniello, Giovanni, Rostagno, Carlo, Cartei, Alessandro, Polidori, Gianluca, Ungar, Andrea, Melis, Maria Ramona, Martellini, Eleonora, Enrico, Mossello, Monica, Torrini, Antonella, Giordano, Giovanna, Leone, Migliorini, Marta, Caramelli, Francesca, Battiston, Bruno, Berardino, Maurizio, Cavallo, Simona, Alessandro, Massè, Anna, Santoro, Lombardi, Bruna, D'Ippolito, Pierpaolo, Furini, Angela, Villani, Daniele, Clara, Raimondi, Guarneri, Massimo, Paolucci, Stefano, Bassi, Andrea, Coiro, Paola, De Angelis, Domenico, Morone, Giovanni, Venturiero, Vincenzo, Palleschi, Lorenzo, Raganato, Paolo, Di Niro, Giuseppina, Rosa, Casini Anna, Loredana, Bove, Imoscopi, Alessandra, Isaia, Giancarlo, Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, Antonella, Provenzano, Giuseppe, Mari, Daniela, Romano, Federica Ylenia, Rosini, Francesca, Mansi, Marta, Rossi, Silvia, Geriatria, Alex Riccardelli, Inzaghi, Lorenzo, Bonini, Giulia, Rossi, Paolo, Potena, Alfredo, Lichii, Mihaela, Candiani, Tiziana, Grimaldi, William, Bertani, Emiliano, Alessandra, Porta, Calogero, Pietro, Pinto, Daniela, Bernardi, Roberto, Nicolino, Francesco, Galetti, Caterina, Gianstefani, Alice, Giulia, Corvalli, Lorenzo, Mulazzani, Odetti, Patrizio, Monacelli, Fiammetta, Prefumo, Matteo, Fiammetta, Monacelli, Canepa, Marta, Minaglia, Cecilia, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Prestano, Raffaele, Dalise, Anna Maria, Barra, Davide, Bosco, Livio Dal, Asprinio, Vincenzo, Dallape, Luciana, Perina, Elisa, Incalzi, Raffaele Antonelli, Bartoli, Isaura Rossi, Pluderi, Alice, Maina, Antonella, Pecoraro, Elisabetta, Sciarra, Michela, Prudente, Angela, Paola, Maina, Francesca, Mete, Manuel, Ventura, Luisella, Cesari, Maria, Pernigotti Luigi, Tina, Santangelo, Benini, Lucia, Levato, Francesco, Mhiuta, Victor, Alius, Florin, Davidoaia, Diana, Giardini, Vittorio, Garancini, Mattia, Bellamoli, Claudio, Terranova, Luciano, Bozzini, Claudia, Tosoni, Paolo, Provoli, Emma, Cascone, Luisa, Dioli, Andrea, Ferrarin, Gianfranco, Bucci, Adelmo, Bua, Guido, Fenu, Sara, Bianchi, Giovanna, Casella, Silvia, Romano, Valentina, Maurizio, Poli, Mascherona, Ilenia, Belotti, Gloria, Cavaliere, Sabina, Cuni, Estella, Merciuc, Nina, Oberti, Rosella, Veneziani, Silvia, Capoferri, Emanuela, De Bernardi, Elisabetta, Colombo, Katia, Bravi, Marco, Nicoletta, Negrinotti, D'Arcangelo, Paolo, Montenegro, Nicola, Montanari, Roberto, Lamanna, Pierpaolo, Gasperini, Beatrice, Isabella, Montesi, Stefania, Diotallevi, Gaia, Altobelli, Filippo, Calcinaro, Palamà, Chiara, Di Emidio, Chiara, Scarpini, Elio, Arighi, Andrea, Fumagalli, Giorgio, Basilico, Paola, De Amicis Margherita, Migone, Marta, Mancarella, Diletta, Maira, Granata, Antonino, Ranalli, Claudia, Cammilli, Alessandra, Cavallini, Maria Chiara, Tricca, Manola, Natella, Daniela, Gabbani, Luciano, Tesi, Francesca, Martella, Letizia, Imbrici, Rosalba, Guerrini, Gianbattista, Scotuzzi, Anna Maria, Sozzi, Ferdinando, Valenti, Luigi, Chiarello, Antonino, Monia, Monella, Pilotto, Alberto, Prete, Camilla, Senesi, Barbara, Meta, Anna Cristina, Pendenza, Enrico, Pasqualetti, Giuseppe, Polini, Antonio, Tognini, Sara, Ballino, Elena, Cherubini, Antonio, Dell'Aquila, Giuseppina, Gasparrini, Pina Maria, Marotti, Elisabetta, Migale, Monica, Scrimieri, Antonia, Falsetti, Lorenzo, Salvi, Aldo, Toigo, Gabriele, Ceschia, Giuliano, Rosso, Alessia, Tongiorgi, Chiara, Scarpa, Cristina, Maurizio, Pacchioni, De Dominicis, Luigino, Pucci, Eugenio, Renzi, Sara, Cartechini, Elisabetta, Tomassini, Pia Francesca, Del Gobbo, Maurizio, Ugenti, Francesca, Romeo, Pasquale, Nardelli, Anna, Lauretani, Fulvio, Visioli, Sandra, Montanari, Ilaria, Ermini, Francesca, Giordano, Antonio, Pigato, Giorgio, Simeone, Emilio, Barbujani, Mario, Giampieri, Marina, Amoruso, Raffaele, Piccinini, Maristella, Ferrari, Camilla, Gambetti, Claudio, Sfrappini, Mario, Semeraro, Letizia, Striuli, Rinaldo, Mariani, Claudia, Pelliccioni, Giuseppe, Marinelli, Donatella, Fabi, Katia, Rossi, Tommaso, Pesallaccia, Martina, Sabbatini, Debora, Gobbi, Beatrice, Cerqua, Raffaella, Tagliani, Giancarla, Schlauser, Elena, Caser, Luciano, Caramello, Elisa, Sandigliano, Franca, Rosso, Giorgio, Ferrari, Alberto, Bendini, Chiara, Luisa, Davoli Maria, Casella, Monica, Prampolini, Raffaella, Scevola, Moreno, Vitale, Enrico, Roberto, Brugiolo, Carlo, Fagherazzi, Sergio, Fusco, Alberto, Scarpa, Daniela, Zara, Giulia, Bertozzo, Serena, Granziera, Michele, Barazzuol, Maugeri, Domenico, Sorace, Rosaria, Anzaldi, Massimiliano, De Gesu, Roberto, Morrone, Giuseppe, Davolio, Federica, Fabbo, Andrea, Palmieri, Marina, Zoli, Marco, Forti, Paola, Pirazzoli, Luca, Fabbri, Elisa, Terenzi, Laura, Bergolari, Federica, Wenter, Christian, Ruffini, Ingrid, Insam, Miriam, Abraham, Elisabeth, Kirchlechner, Christine, Cucinotta, Domenico, Antonino, Lasco, Basile, Giorgio, Grazia, Arena Maria, Parise, Pasquale, Boccali, Andrea, Amici, Serena, Gambacorta, Maurizia, Lasagni, Anna, Lovati, Roberto, Giovinazzo, Francesca, Kimak, Elzbieta, Zappa, Paolo, Medici, Francesco, Lo Castro, Marika, Mauro, Flavia, De Luca, Alessandro, Sancesario, Giuseppe, Martorana, Alessandro, Scaricamazza, Beatrice, Toniolo, Sofia, Di Lorenzo, Francesco, Liguori, Claudio, Lasco, Antonino, Vita, Natale, Giomi, Mirna, Forte, Floriana, Padovani, Alessandro, Rozzini, Luca, Ceraso, Anna, Salvatore, Caratozzolo, Cottino, Maria, Vitali, Silvia, Marelli, Eleonora, Tripi, Gabriele, Miceli, Salvatore, Urso, Giovanni, Grioni, Giuseppe, Vezzadini, Giuliana, Misaggi, Giulia, Forlani, Chiara, Avanzi, Stefano, Serena, Saulle, Claudia, Casarini, Marilena, Viggiano, Alberto, Luisa, Diego, Ghianda, Alessandro, Giordano, Iemolo, Francesco, Giordano, Antonello, Sanzaro, Enzo, D'Asta, Gabriele, Proietto, Maria, Carnemolla, Anna, Razza, Grazia, Spadaro, Daniela, Bertolotti, Marco, Mussi, Chiara, Neviani, Francesca, Roberto, Chiesa, Valentina, Guerzoni, Linda, Morselli, Francesca, Venturelli, Tarozzi, Adriano, Balestri, Francesca, Mannarino, Giulio, Bigolari, Michela, Natale, Alessia, Grassi, Simona, Bottaro, Cinzia, Stefanelli, Sara, Bovone, Ugo, Tortorolo, Umberto, Quadri, Roberto, Leone, Giuseppe, Ponzetto, Maria, Frasson, Paola, Annoni, Giorgio, Bellelli, Giuseppe, Bruni, Adriana, Confalonieri, Roberto, Corsi, Maurizio, Moretti, Daniela, Teruzzi, Fabiola, Umidi, Simona, Mazzola, Paolo, Perego, Sabrina, Persico, Ilaria, Olivieri, Giulia, Bonfanti, Alessandra, Hajnalka, Szabò, Galeazzi, Marianna, Massariello, Francesca, Anzuini, Alessandra, Caffarra, Paolo, Barocco, Federica, Spallazzi, Marco, Paolo, Ceda Gian, Simonetta, Morganti, Andrea, Artoni, Chioatto, Paolo, Bortolamei, Sandra, Soattin, Lucia, Ruotolo, Giovanni, Beneamino, Borelli, Giuseppe, Barilaro, Bertazzoli, Marco, Rota, Elisabetta, Adobati, Annamaria, Scarpa, Alberto, Granziera, Serena, Zuccher, Paola, Fabbro, Angela Dal, Zara, Daniela, Lo Nigro, Ambra, Franchetti, Lorena, Toniolo, Marika, Marcuzzo, Cinzia, Rollone, Marco, Guerriero, Fabio, Sgarlata, Carmelo, Massè, Alessandro, Zatti, Giovanni, Piatti, Massimiliano, Graci, Jole, Benati, Giuseppe, Boschi, Federica, Biondi, Mario, Fiumi, Nicoletta, Erika, Tamburini, Locatelli, Sergio Mario, Mauri, Sabrina, Beretta, Mauro, Margheritis, Laura, Desideri, Giovanbattista, Liberatore, Ester, Carucci, Anna Cecilia, Bonino, Paolo, Caput, Margherita, Antonietti, Maria Paola, Polistena, Giuseppe, De la Pierre, Franz, Mari, Marcello, Massignani, Paola, Tombesi, Fabio, Selvaggio, Fabio, Verbo, Brunella, Bodoni, Paolo, Marchionni, Niccolò, Mossello, Enrico, Sabatini, Tony, Mussio, Eleonora, Magni, Eugenio, Bianchetti, Angelo, Crucitti, Andrea, Titoldini, Giulia, Cossu, Beatrice, Fascendini, Sara, Licini, Cristina, Tomasoni, Angela, Calderazzo, Massimo, Daniela, Tropiano, Valentina, Laganà, Melotti, Rita Maria, Lilli, Albina, Buda, Simona, Adversi, Marco, Noro, Gabriele, Turco, Renato, Ubezio, M Chiara, Mantovani, Anna Roberta, Viola, Maria Cristina, Serrati, Carlo, Pretta, Stefano, Infante, Maria, Gentile, Simona, Morandi, Alessandro, D'Ambrosio, Viviana, Mazzanti, Paolo, Brambilla, Cristina, Sportelli, Silvia, Platto, Caterina, Faraci, Bianca, Quattrocchi, Daniela, Pernigotti, Luigi Maria, Pisu, Cristina, Sicuro, Francesca, Zagnoni, Piergiuseppe, Ghiglia, Stefania, Mosca, Massimiliano, Corazzin, Ileana, Deola, Mariangela, Biagini, Carlo Adriano, Bencini, Francesca, Cantini, Claudia, Tonon, Elisabetta, Pierinelli, Silvia, Onofrj, Marco, Thomas, Astrid, Filomena, Borbone, Bonanni, 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Published
2020
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6. The Relationship of Hemoglobin Levels, Delirium and Cognitive Status in Hospitalized Geriatric Patients: Results from the CRIME Study.

Author

Brombo G, Bianchi L, Savino E, Magon S, Cherubini A, Corsonello A, Zuliani G, Onder G, and Volpato S

Abstract

Objective: Delirium is a frequent clinical complication in geriatric patients admitted to the hospital, because of the simultaneous presence and synergistic effect of predisposing and precipitating factors. Also anaemia is a common concern in geriatric population. The aim of this study was to investigate the association between anaemia (precipitating factor) and delirium in a sample of Italian older hospitalized patients with different degree of cognitive impairment (predisposing factor)., Design, Setting, Participants: Cross-sectional analysis of 1069 participants enrolled in the CRIME study, with assessment of hemoglobin levels at hospital admission., Measurements: Delirium was assessed using DSM-IV criteria, whereas cognitive status was categorized as dementia, cognitive impairment or normal, according to clinical history, specific treatment and MMSE score. Anaemia was defined according to sex-specific WHO criteria. The association of hemoglobin levels and delirium was investigated with multivariable logistic regression models., Results: Mean age of study participants was 81.4±7.2 years, 52.2% had prevalent anaemia, 6.1% had delirium. According to cognitive status 20.8% had dementia and 40.9% had cognitive impairment. Overall there was no association between anaemia and delirium. However, among patients with cognitive impairment (MMSE <24, no dementia) anaemia was significantly associated with the likelihood of delirium (p<0.006). Multivariate logistic regression analysis, adjusted for potential confounders, showed in these patients a graded increased risk of delirium according to anaemia severity with an almost six-fold increased risk of delirium in moderate-severe anaemia (OR 5.95, 95% CI:1.15-30.73)., Conclusion: In older patients with cognitive impairment moderate-severe anaemia is independently associated with the likelihood of delirium. Further studies should investigate if anaemia correction would translate in delirium risk reduction., Competing Interests: G. Brombo, L. Bianchi, E. Savino, S. Magon, A. Cherubini, A. Corsonello, G. Zuliani, G. Onder, and S. Volpato declare no conflict of interest.

Published
2015
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