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Mental ill health and sensory processing difficulties often limit participation in everyday life for adults with neurodevelopmental disabilities. Interventions using technology such as virtual reality (VR) are increasingly accessible and may mitigate these difficulties. Understanding what contributes to the successful implementation of novel interventions is important for future use and evaluation. This study aimed to explore the feasibility of implementing a VR sensory room for adults with neurodevelopmental disabilities, their carers and support staff and to explore future iterations of the product and process. Thirteen stakeholders who participated in a pilot trial of a VR sensory room were interviewed. Interviews were recorded and transcribed verbatim for thematic analysis. Eleven themes were identified which indicated that adults with neurodevelopmental disabilities found the VR sensory room to be mostly acceptable and enjoyable with usage largely consistent. Individual variation and support requirements were highlighted for each user. Future use may require modifications to the headset, in-built customisation options as well as buy-in and training for support staff. The VR Sensory room is a promising tool to support adults with neurodevelopmental disabilities and results warrant further scaled research into the impact of this tool on outcomes for adults with disabilities. Whilst adults with neurodevelopmental disabilities may experience sensory processing difficulties which impact their everyday life, there is a paucity of interventions to address these difficulties. Implementation studies offer the opportunity to explore how evidence-based interventions may be implemented to facilitate the best outcomes. A Virtual Reality Sensory Room may offer an innovative alternative to a traditional sensory room for adults with neurodevelopmental disabilities where implementation is well supported. [ABSTRACT FROM AUTHOR]

Industry 4.0 (I4.0) has proposed a significant shift in the way companies approach manufacturing. However, this new paradigm is not without faults. The integration of processes and equipment ('digitalisation') can be prohibitively expensive or too technically complex for small-to-medium enterprises (SMEs) with limited resources and technical expertise. Another barrier to digitalisation lies in the ambiguity of not knowing what precise practices to adopt to improve productivity. Although these challenges have been identified in the literature, there is still little evidence on how to tackle them. Thus, we explore how design thinking can help overcome these challenges, given that it has been used in many organisations and disciplines to deal with complex and ambiguous problems. We do so by investigating the research question 'How can designers and design thinking processes assist manufacturing SMEs' digitalisation?' We address this research question by presenting a case study of a university–industry collaboration where the authors utilised a design-thinking process to select and implement technologies to capture, process and analyse data for an Australian medical device manufacturer. By reflecting on the case study, we identified the user-centeredness of design thinking as crucial in selecting technologies for implementation that prioritised usability and brought value to all stakeholders. Furthermore, iterative prototyping was critical to scale up the required expertise and deliver a successful sustainable solution without investing vast resources. Our work suggests that designers and design thinking have the potential to help de-risk digitalisation. Finally, we suggest a framework that may assist in guiding other SMEs approaching digitalisation and provide a starting point for further design thinking research in this area. [ABSTRACT FROM AUTHOR]

This paper demonstrates the full centrifugal microfluidic integration and automation of all liquid handling steps of a 7-step fluorescence-linked immunosorbent assay (FLISA) for quantifying nitrate and nitrite levels in whole blood within about 15 min. The assay protocol encompasses the extraction of metered plasma, the controlled release of sample and reagents (enzymes, co-factors and fluorescent labels), and incubation and detection steps. Flow control is implemented by a rotationally actuated dissolvable film (DF) valving scheme. In the valves, the burst pressure is primarily determined by the radial position, geometry and volume of the valve chamber and its inlet channel and can thus be individually tuned over an extraordinarily wide range of equivalent spin rates between 1,000 RPM and 5,500 RPM. Furthermore, the vapour barrier properties of the DF valves are investigated in this paper in order to further show the potential for commercially relevant on-board storage of liquid reagents during shelf-life of bioanalytical, ready-to-use discs. [ABSTRACT FROM AUTHOR]