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514 results on '"Gyan, Emmanuel"'

3. Faire vivre et grandir une communauté de chefs de service : acte 2 en hématologie

Author

Houot, Roch, Calmettes, Claire, Park, Sophie, Pascal, Laurent, Peffault de Latour, Regis, Pigneux, Arnaud, Quinquenel, Anne, Raffoux, Emmanuel, Thieblemont, Catherine, Touati, Mohamed, Trebouet, Adrien, Vaida, Ioana, Wémeau, Mathieu, Bastie, Jean-Noël, Bay, Jacques-Olivier, Cluzeau, Thomas, Cornillon, Jérôme, Damaj, Ghandi, Deconinck, Eric, Feugier, Pierre, Fornecker, Luc-Matthieu, Gay, Julie, Hermine, Olivier, Hospital, Marie Anne, Hunault, Mathilde, Jaccard, Arnaud, Jardin, Fabrice, Le Calloch, Ronan, Legros, Laurence, Leleu, Xavier, Lemonnier, François, Malfuson, Jean-Valere, Morel, Pierre, Ochmann, Marlene, Orsini-Piocelle, Frédérique, and Gyan, Emmanuel

Published
2024
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4. Epcoritamab monotherapy in patients with relapsed or refractory follicular lymphoma (EPCORE NHL-1): a phase 2 cohort of a single-arm, multicentre study

Author

Linton, Kim M, Vitolo, Umberto, Jurczak, Wojciech, Lugtenburg, Pieternella J, Gyan, Emmanuel, Sureda, Anna, Christensen, Jacob Haaber, Hess, Brian, Tilly, Hervé, Cordoba, Raul, Lewis, David John, Okada, Craig, Hutchings, Martin, Clausen, Michael Roost, Sancho, Juan-Manuel, Cochrane, Tara, Leppä, Sirpa, Chamuleau, Martine E D, Gernhardt, Diana, Altıntaş, Işıl, Liu, Yan, Ahmadi, Tahamtan, Dinh, Minh H, Hoehn, Daniela, Favaro, Elena, Elliott, Brian, Thieblemont, Catherine, and Vose, Julie M

Published
2024
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5. Outcome of patients with newly diagnosed AML admitted to the ICU, including preemptive admission – a multi-center study

Author

Desprez, Christophe, Kouatchet, Achille, Marchand, Tony, Mear, Jean Baptiste, Tadié, Jean Marc, Peterlin, Pierre, Chevalier, Patrice, Canet, Emmanuel, Couturier, Marie-Anne, Guillerm, Gaelle, Bodenes, Laetitia, Gyan, Emmanuel, Villate, Alban, Ehrmann, Stephan, Lebreton, Anne, Lester, Marie-Antoinette, Fronteau, Clémentine, Larhantec, Gaelle, André, Virginie, Riou, Jérémie, Hunault-Berger, Mathilde, Schmidt-Tanguy, Aline, and Orvain, Corentin

Published
2023
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6. Cusatuzumab plus azacitidine in newly diagnosed acute myeloid leukaemia ineligible for intensive chemotherapy (CULMINATE): part one of a randomised, phase 2, dose optimisation study

Author

Pabst, Thomas, Papayannidis, Cristina, Demirkan, Fatih, Doronin, Vadim, Fogliatto, Laura M, Guttke, Christina, Gyan, Emmanuel, Hamad, Nada, Herrera, Pilar, Hultberg, Anna, Jacobs, Julie, Johnson, Amy J, Langlois, Angélique, Ma, Xuewen, Martinelli, Giovanni, Arnan, Montserrat, Müller, Rouven, Nottage, Kerri, Ofran, Yishai, Özcan, Muhit, Samoilova, Olga, Tolbert, Jaszianne A, Trudel, Géralyn C, Xiu, Liang, Vey, Norbert, and Wei, Andrew H

Published
2023
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8. Modulation of bone marrow and peripheral blood cytokine levels by age and clonal hematopoiesis in healthy individuals

Author

Ravalet, Noémie, Guermouche, Hélène, Hirsch, Pierre, Picou, Frédéric, Foucault, Amélie, Gallay, Nathalie, Martignoles, Jean-Alain, Beaud, Jenny, Suner, Ludovic, Deswarte, Caroline, Lachot, Sébastien, Rault, Emmanuelle, Largeaud, Laëtitia, Gissot, Valérie, Béné, Marie-Christine, Gyan, Emmanuel, Delhommeau, François, and Herault, Olivier

Published
2023
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10. A Phase II prospective trial of azacitidine in steroid-dependent or refractory systemic autoimmune/inflammatory disorders and VEXAS syndrome associated with MDS and CMML

Author

Mekinian, Arsene, Zhao, Lin Pierre, Chevret, Sylvie, Desseaux, Kristell, Pascal, Laurent, Comont, Thibaut, Maria, Alexandre, Peterlin, Pierre, Terriou, Louis, D’Aveni Piney, Maud, Gourin, Marie-Pierre, Vey, Norbert, Rauzy, Odile Beyne, Grobost, Vincent, Bezanahary, Holy, Dimicoli-Salazar, Sophie, Banos, Anne, Wickenhauser, Stefan, De Renzis, Benoit, Durot, Eric, Natarajan-Amé, Shanti, Voillat, Laurent, Chermat, Fatiha, Lemaire, Karine, Jachiet, Vincent, Himberlin, Chantal, Thépot, Sylvain, Diaz, Jose Miguel Torregrosa, Frenzel, Laurent, Gyan, Emmanuel, Denis, Guillaume, Hirsch, Pierre, Kosmider, Olivier, Ades, Lionel, Fain, Olivier, and Fenaux, Pierre

Published
2022
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12. Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia

Author

Roux, Benjamin, Picou, Frédéric, Debeissat, Christelle, Koubi, Myriam, Gallay, Nathalie, Hirsch, Pierre, Ravalet, Noémie, Béné, Marie C., Maigre, Michel, Hunault, Mathilde, Mosser, Jean, Etcheverry, Amandine, Gyan, Emmanuel, Delhommeau, François, Domenech, Jorge, and Herault, Olivier

Published
2022
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13. A phase 1b study of glasdegib + azacitidine in patients with untreated acute myeloid leukemia and higher-risk myelodysplastic syndromes

Author

Sekeres, Mikkael A., Schuster, Michael, Joris, Magalie, Krauter, Jürgen, Maertens, Johan, Breems, Dimitri, Gyan, Emmanuel, Kovacsovics, Tibor, Verma, Amit, Vyas, Paresh, Wang, Eunice S., Ching, Keith, O’Brien, Thomas, Gallo Stampino, Corrado, Ma, Weidong Wendy, Kudla, Arthur, Chan, Geoffrey, and Zeidan, Amer M.

Published
2022
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14. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.

Author

Bondu, Sabrina, Alary, Anne-Sophie, Lefèvre, Carine, Houy, Alexandre, Jung, Grace, Lefebvre, Thibaud, Rombaut, David, Boussaid, Ismael, Bousta, Abderrahmane, Guillonneau, François, Perrier, Prunelle, Alsafadi, Samar, Wassef, Michel, Margueron, Raphaël, Rousseau, Alice, Droin, Nathalie, Cagnard, Nicolas, Kaltenbach, Sophie, Winter, Susann, Kubasch, Anne-Sophie, Bouscary, Didier, Santini, Valeria, Toma, Andrea, Hunault, Mathilde, Stamatoullas, Aspasia, Gyan, Emmanuel, Cluzeau, Thomas, Platzbecker, Uwe, Adès, Lionel, Puy, Hervé, Stern, Marc-Henri, Karim, Zoubida, Mayeux, Patrick, Nemeth, Elizabeta, Park, Sophie, Ganz, Tomas, Kautz, Léon, Kosmider, Olivier, and Fontenay, Michaëla

Subjects
Alternative Splicing, Amino Acid Sequence, Animals, Blood Transfusion, Cell Line, Cell Lineage, Cell Survival, Clone Cells, Erythroid Cells, Hepcidins, Homeostasis, Humans, Iron, Lenalidomide, Mice, Mutation, Myelodysplastic Syndromes, Peptide Hormones, Phosphoproteins, Protein Biosynthesis, RNA Splice Sites, RNA Splicing Factors, RNA, Messenger, Up-Regulation
Abstract

Myelodysplastic syndromes (MDS) with ring sideroblasts are hematopoietic stem cell disorders with erythroid dysplasia and mutations in the SF3B1 splicing factor gene. Patients with MDS with SF3B1 mutations often accumulate excessive tissue iron, even in the absence of transfusions, but the mechanisms that are responsible for their parenchymal iron overload are unknown. Body iron content, tissue distribution, and the supply of iron for erythropoiesis are controlled by the hormone hepcidin, which is regulated by erythroblasts through secretion of the erythroid hormone erythroferrone (ERFE). Here, we identified an alternative ERFE transcript in patients with MDS with the SF3B1 mutation. Induction of this ERFE transcript in primary SF3B1-mutated bone marrow erythroblasts generated a variant protein that maintained the capacity to suppress hepcidin transcription. Plasma concentrations of ERFE were higher in patients with MDS with an SF3B1 gene mutation than in patients with SF3B1 wild-type MDS. Thus, hepcidin suppression by a variant ERFE is likely responsible for the increased iron loading in patients with SF3B1-mutated MDS, suggesting that ERFE could be targeted to prevent iron-mediated toxicity. The expression of the variant ERFE transcript that was restricted to SF3B1-mutated erythroblasts decreased in lenalidomide-responsive anemic patients, identifying variant ERFE as a specific biomarker of clonal erythropoiesis.

Published
2019

16. Intensive chemotherapy followed by autologous stem cell transplantation in primary central nervous system lymphomas (PCNSLs). Therapeutic outcomes in real life—experience of the French Network

Author

Schenone, Laurence, Houillier, Caroline, Tanguy, Marie Laure, Choquet, Sylvain, Agbetiafa, Kossi, Ghesquières, Hervé, Damaj, Gandhi, Schmitt, Anna, Bouabdallah, Krimo, Ahle, Guido, Gressin, Remy, Cornillon, Jérôme, Houot, Roch, Marolleau, Jean-Pierre, Fornecker, Luc-Matthieu, Chinot, Olivier, Peyrade, Frédéric, Bouabdallah, Reda, Moluçon-Chabrot, Cécile, Gyan, Emmanuel, Chauchet, Adrien, Casasnovas, Olivier, Oberic, Lucie, Delwail, Vincent, Abraham, Julie, Roland, Virginie, Waultier-Rascalou, Agathe, Willems, Lise, Morschhauser, Franck, Fabbro, Michel, Ursu, Renata, Thieblemont, Catherine, Jardin, Fabrice, Tempescul, Adrian, Malaise, Denis, Touitou, Valérie, Nichelli, Lucia, Le Garff-Tavernier, Magali, Plessier, Aurélie, Bourget, Philippe, Bonmati, Caroline, Wantz-Mézières, Sophie, Giordan, Quentin, Dorvaux, Véronique, Charron, Cyril, Jabeur, Waliyde, Hoang-Xuan, Khê, Taillandier, Luc, and Soussain, Carole

Published
2022
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18. The place of the relative at the time of the announcement of cancer progression: BABEL – a mixed-methods study.

Author

Ingrand, Isabelle, Laurent, Estelle, Lecomte, Thierry, Cojocarasu, Oana, Egreteau, Joëlle, Aleba, Albert, Hureaux, José, Colombat, Philippe, Gyan, Emmanuel, and Bourgeois, Hugues

Subjects
CANCER invasiveness, DISEASE progression, ONCOLOGISTS, HEALTH, PATIENTS
Abstract

Objectives: This study aims to explore the place of the relative in these triadic consultations and how this influences communication. Methods: A mixed-methods research strategy was used. Triadic consultations for the announcement of cancer progression were recorded and following the 3 participants completed questionnaires comprising mirror-items. Recordings and answers were further investigated in a few semi-structured interviews. Comparison of quantitative responses (questionnaires) used Wilcoxon's test for matched series. Qualitative analyses (consultations, interviews) used grounded theory. Patients were over 18, followed for cancer in palliative phase, excluding brain tumors and malignant hemopathies, and presented renewed disease progression. Relatives were over 18 and authorized by the patient to participate. Results: 47 consultations (audio-recordings, answers to questionnaires) and 12 interviews conducted separately with 4 triads were collected. Half the relatives, while remaining in the background, nevertheless contributed to the discussion. For patients, the presence of a relative was considered beneficial and for oncologists it facilitated the announcement. However, symptoms perceived as intimate or private appeared difficult to express for some patients, and for relatives, prognosis was a difficult subject to broach. Although their relationship with time and their expectations may differ, patients and relatives found consultations positive. Oncologists appeared to underestimate the patient's level of understanding (P <0.001) and perceptions of the seriousness of the disease (P =0.009) but not those of relatives. They did not evaluate the relative's state of health and check what the dyad had retained. Significance of results: Training via simulation sessions should be adapted to communication involving relatives. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Teacher Questioning Strategies in Mathematical Classroom Discourse: A Case Study of Two Grade Eight Teachers in Tennessee, USA

Author

McCarthy, Peter, Sithole, Alec, McCarthy, Paul, Cho, Jea-pil, and Gyan, Emmanuel

Abstract

Teacher questioning in mathematics is an important diagnostic tool for teaching as well as measuring the academic progression and comprehension of the learner. While teacher questioning enhances student learning and self-assessment of the teacher's lesson delivery effectiveness, if not presented properly can have negative impacts on the student learning process. Identifying "good" and/or "effective" questioning strategies is a major challenge to mathematics teachers. To increase teacher effectiveness and student success in mathematics, a self-assessment of teacher questioning techniques is essential. This study examines the questioning strategies used by two grade 8 teachers, selected at random, from twelve middle school teachers each handling quadratic mathematical modeling as one of their lessons in a project. The purpose of this study was to determine the questioning strategies used by the two teachers in their mathematical classroom discourse. Each class was videotaped over a six-month period but only a section from each of the two selected classes, on quadratic modeling, was watched for about 45 minutes long for the purpose of this paper. A common theme "teacher questioning strategies" was the basis for analyzing the data. The strategies include: probing and follow-up, leading, check-listing and student-specific questioning. Findings from the study indicate that guiding teachers (pre-service and in-service) through an analysis of questions they ask and the responses they get from students during mathematical discourse, may enable them to recognize both effective and ineffective questioning strategies in their mathematical classroom discourse. This study may help both pre-service and in-service teachers as well as teacher-researchers to be well aware of their questioning practices by reflecting on the questioning strategies they use in their own mathematical classroom discourse.

Published
2016

24. What is the impact of blood pressure on neurological symptoms and the risk of ESKD in primary and secondary thrombotic microangiopathies based on clinical presentation: a retrospective study

Author

Halimi, Jean-Michel, Thoreau, Benjamin, von Tokarski, Florent, Bauvois, Adeline, Gueguen, Juliette, Goin, Nicolas, Barbet, Christelle, Cloarec, Sylvie, Mérieau, Elodie, Lachot, Sébastien, Garot, Denis, Lemaignen, Adrien, Gyan, Emmanuel, Perrotin, Franck, Pouplard, Claire, Maillot, François, Gatault, Philippe, Sautenet, Bénédicte, Rusch, Emmanuel, Frémeaux-Bacchi, Véronique, Vigneau, Cécile, Bayer, Guillaume, and Fakhouri, Fadi

Published
2022
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25. Causes of Indiscipline and Measures of Improving Discipline in Senior Secondary Schools in Ghana: Case Study of a Senior Secondary School in Sunyani

Author

Gyan, Emmanuel, Baah-Korang, Kwame, McCarthy, Paul, and McCarthy, Peter

Abstract

The purpose of the study was to determine the main causes of students' misbehaviour and measures teachers and students consider to be most appropriate for controlling the unruly behaviour of the students. Purposive, sample, of 50 teachers who held the various positions in the school, and 150 students comprising the Students Representative Council, the class prefects and the class secretaries, was used for the study. Descriptive sample survey was considered to be most appropriate method for the study. A questionnaire was used to collect data from the participants. Majority of the respondents shared the opinion that it is the students themselves who cause such acts of indiscipline. It is only with students late to school and demonstrations that the majority of the respondents attributed the causes to parents and school respectively. A careful look at the statistics of causes of acts of indiscipline on Table 1 shows that apart from the individuals themselves, the school is the next cause of most of the acts of indiscipline. The community closely follows with parents and the media being almost at par. With regard to the measures of ensuring discipline in the School, all the ten measures that were listed were considered by at least 90% of the respondents to be very important.

Published
2015

26. Gender Differences in Participation in Elective Mathematics of Senior Secondary School Students in Ghana

Author

Baah-Korang, Kwame, Gyan, Emmanuel, McCarthy, Paul, and McCarthy, Peter

Abstract

This paper aims at contributing to the body of knowledge that exists in the area of differences in participation in elective mathematics, between boys and girls in Secondary Schools in Ghana. A sample of 738 respondents from five Secondary Schools was purposively selected using purposive sampling technique. All the respondents were final year students and had studied extensively more than a half of the elective mathematics syllabus. The selected schools were made up of two single-sex female schools, one single-sex male school and one mixed-sex schools from Cape Coast municipality in the central region and one mixed-sex school, from Sekondi in the western region of Ghana. Relevant data were gathered using a set of questionnaire and an interview schedule prepared by the researchers. The analysis of the personal interviews with some of the female respondents revealed various reasons why some females were attracted to the study of elective mathematics. The study revealed that the participation of males in elective mathematics was 50.5% while that of females was 27.2% giving an indication that females participated in elective mathematics less often than their male counterparts. Suggestions for increasing female participation in senior secondary school elective mathematics were made and areas for further research on the topic have also been suggested.

Published
2015

27. Analysis of Results of Core Academic Subjects of Ghanaian Secondary Schools: Case Study of a Secondary School in Ghana

Author

McCarthy, Paul, Gyan, Emmanuel, Kwame, Baah-Korang, and McCarthy, Peter

Abstract

Educational authorities in Ghana have generally established that the performance of school leavers especially at the pre-university level offered a large room for improvement, due to so many factors. Hence, the introduction of the New Educational Reform in 1987 which led to the new system of Senior Secondary School with the first product in 1993. The study was to create awareness of whether Ghana's New Educational Reform, which has been in place since 1987, has led to improvement in performance of Senior Secondary Schools in Ghana in the area of the four core disciplines: Mathematics, Integrated Sciences, Social Studies, and English language. Two way Analysis of Variance (ANOVA) without replication was derived to determine whether significant differences existed between grades, subjects and the years involved in the study to obtain some dimensions for determining the performance of students in the institution. Social Studies and the grades C, D and E gave the institution a glorious image while Mathematics, Integrated Science and English Language and grade F, gave the institution a poor image. However, majority of the grades A and B were associated with Core Mathematics. There was no significant difference in the trend of students' performance between years in the study period. We recommend that future research spanning a period from 2006 to 2014, which has different grading system, under the West African Senior School Certificate Examination (WASSCE) grading system, be done in a comparative manner. This might include students in two or three regions of Ghana. To make the research generalizable, random samples of schools and students must be considered.

Published
2015

28. A randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL

Author

Schmitz, Norbert, Truemper, Lorenz, Bouabdallah, Krimo, Ziepert, Marita, Leclerc, Mathieu, Cartron, Guillaume, Jaccard, Arnaud, Reimer, Peter, Wagner, Eva, Wilhelm, Martin, Sanhes, Laurence, Lamy, Thierry, de Leval, Laurence, Rosenwald, Andreas, Roussel, Muriel, Kroschinsky, Frank, Lindemann, Walter, Dreger, Peter, Viardot, Andreas, Milpied, Noël, Gisselbrecht, Christian, Wulf, Gerald, Gyan, Emmanuel, Gaulard, Philippe, Bay, Jacques Olivier, Glass, Bertram, Poeschel, Viola, Damaj, Gandhi, Sibon, David, Delmer, Alain, Bilger, Karin, Banos, Anne, Haenel, Mathias, Dreyling, Martin, Metzner, Bernd, Keller, Ulrich, Braulke, Friederike, Friedrichs, Birte, Nickelsen, Maike, Altmann, Bettina, and Tournilhac, Olivier

Published
2021
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29. Oxaliplatin before autologous transplantation in combination with high-dose cytarabine and rituximab provides longer disease control than cisplatin or carboplatin in patients with mantle-cell lymphoma: results from the LyMA prospective trial

Author

Tessoulin, Benoit, Chiron, David, Thieblemont, Catherine, Oberic, Lucie, Bouadballah, Kamal, Gyan, Emmanuel, Damaj, Gandhi, Ribrag, Vincent, Gressin, Rémy, Feugier, Pierre, Casasnovas, Olivier, Zerazhi, Hacène, Lemonnier, François, Maisonneuve, Hervé, Joubert, Clementine, Van Den Neste, Eric, Lamy, Thierry, Tilly, Hervé, Moreau, Anne, Hermine, Olivier, and Le Gouill, Steven

Published
2021
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30. Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia

Author

Uy, Geoffrey L., Aldoss, Ibrahim, Foster, Matthew C., Sayre, Peter H., Wieduwilt, Matthew J., Advani, Anjali S., Godwin, John E., Arellano, Martha L., Sweet, Kendra L., Emadi, Ashkan, Ravandi, Farhad, Erba, Harry P., Byrne, Michael, Michaelis, Laura, Topp, Max S., Vey, Norbert, Ciceri, Fabio, Carrabba, Matteo Giovanni, Paolini, Stefania, Huls, Gerwin A., Jongen-Lavrencic, Mojca, Wermke, Martin, Chevallier, Patrice, Gyan, Emmanuel, Récher, Christian, Stiff, Patrick J., Pettit, Kristen M., Löwenberg, Bob, Church, Sarah E., Anderson, Erica, Vadakekolathu, Jayakumar, Santaguida, Marianne, Rettig, Michael P., Muth, John, Curtis, Teia, Fehr, Erin, Guo, Kuo, Zhao, Jian, Bakkacha, Ouiam, Jacobs, Kenneth, Tran, Kathy, Kaminker, Patrick, Kostova, Maya, Bonvini, Ezio, Walter, Roland B., Davidson-Moncada, Jan K., Rutella, Sergio, and DiPersio, John F.

Published
2021
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31. Paediatric computed tomography diagnostic reference levels in Africa: A systematic review.

Author

Gyan, Emmanuel, Subaar, Christiana, Edusei, George, and Antwi Nyarko, Linda

Subjects
*COMPUTED tomography, *ABSORBED dose, *SEARCH engines, *DATABASES, *DIAGNOSTIC imaging
Abstract

Introduction Methods Results Conclusion Improvements in computed tomography (CT) technology in terms of image quality and reduction in absorbed dose have increased its applications in medical imaging. Diagnostic reference levels (DRLs) help to identify high radiation doses that are unusually delivered to patients undergoing exposure to ionising radiation. The aim of this review was to provide an overview of published studies by African researchers towards establishing paediatric CT DRLs in Africa.The search for articles was conducted using some relevant literature search engines including PubMed, Scopus, Science Direct, Google Scholar and Web of Science. Two reviewers were involved in the article selection process which involved a three‐stage screening process of identifying; article titles, abstracts and full‐test reading.One hundred and seventy‐four articles were identified from the database, PubMed (30), Scopus (21), Google Scholar (53), Web of Science (25) and Science Direct (45). Fifty duplicated articles were excluded before screening. Twelve peer‐reviewed articles were included in this study based on the inclusion criteria. DRL values in terms of computed tomography dose index volume of head for the age groupings 0–1, 1–5, 5–10 and 10–15 were 27, 36.6, 39.5 and 47.5 mGy while the dose length product values were 461.6, 664, 872 and 978 mGy.cm respectively. The DRLs were calculated as 75th percentile of the local DRLs reported by the 12 articles included in this review.This review has shown that only few of the African countries (19%) have published studies on paediatric CT DRLs. There were variations in the DRLs published by the various authors which indicate that harmonisation and standardisation of paediatric CT protocols is essential for the optimisation of paediatric doses. [ABSTRACT FROM AUTHOR]

Published
2024
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32. JAK2 V617F polycythemia vera and essential thrombocythemia: dynamic clinical features associated with long-term outcomes

Author

Sureau, Léa, Buors, Caroline, Ianotto, Jean-Christophe, Boyer, Françoise, Tanguy-Schmidt, Aline, Roy, Lydia, Cayssials, Emilie, Cailly, Laura, Chomel, Jean-Claude, Chauveau, Aurélie, Orvain, Corentin, Mansier, Olivier, Ranta, Dana, Robles, Margot, Gyan, Emmanuel, Hérault, Olivier, Nimubona, Stanislas, Marchand, Tony, Lippert, Eric, Riou, Jérémie, Ugo, Valérie, and Luque Paz, Damien

Published
2022
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35. Bendamustine-EAM versus BEAM regimen in patients with mantle cell lymphoma undergoing autologous stem cell transplantation in the frontline setting: a multicenter retrospective study from Lymphoma Study Association (LYSA) centers

Author

Hueso, Thomas, Gastinne, Thomas, Garciaz, Sylvain, Tchernonog, Emmanuelle, Delette, Caroline, Casasnovas, René-Olivier, Durot, Eric, Houot, Roch, Tessoulin, Benoît, Tournilhac, Olivier, Malak, Sandra, Gyan, Emmanuel, Fornecker, Luc-Matthieu, Abraham, Julie, Delapierre, Baptiste, Peyrade, Frédéric, Lemal, Richard, Gressin, Rémy, Chantepie, Sylvain, Borel, Cécile, Morello, Rémy, Bouabdallah, Krimo, Ibrahim, Ahmad, Bouabdallah, Reda, Le Gouill, Steven, and Damaj, Gandhi

Published
2020
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36. Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

Author

Kouzi, Farah, Zibara, Kazem, Bourgeais, Jerome, Picou, Frederic, Gallay, Nathalie, Brossaud, Julie, Dakik, Hassan, Roux, Benjamin, Hamard, Sophie, Le Nail, Louis-Romee, Hleihel, Rita, Foucault, Amelie, Ravalet, Noemie, Rouleux-Bonnin, Florence, Gouilleux, Fabrice, Mazurier, Frederic, Bene, Marie C., Akl, Haidar, Gyan, Emmanuel, Domenech, Jorge, El-Sabban, Marwan, and Herault, Olivier

Published
2020
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43. Allogeneic Stem Cell Transplantation in Therapy-Related Myelodysplasia after Autologous Transplantation for Lymphoma: A Retrospective Study of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy

Author

Jaimes-Albornoz, Daniel, Mannone, Lionel, Nguyen-Quoc, Stéphanie, Chalandon, Yves, Chevallier, Patrice, Mohty, Mohamad, Meunier, Mathieu, Robin, Marie, Ledoux, Marie-Pierre, Guillerm, Gaëlle, Bay, Jacques-Olivier, Poiré, Xavier, Maillard, Natacha, Leclerc, Mathieu, Daguindau, Etienne, Beguin, Yves, Rubio, Marie Thérèse, and Gyan, Emmanuel

Published
2019
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44. An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes

Author

Goldberg, Stuart L, Fenaux, Pierre, Craig, Michael D, Gyan, Emmanuel, Lister, John, Kassis, Jeannine, Pigneux, Arnaud, Schiller, Gary J, Jung, JungAh, Leonard, E Jane, Fingert, Howard, and Westervelt, Peter

Subjects
Pediatric, Pediatric Cancer, Rare Diseases, Cancer, Orphan Drug, Childhood Leukemia, Clinical Research, Clinical Trials and Supportive Activities, Hematology, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Acute myeloid leukemia, Alisertib, Aurora A kinase inhibitor, Myelodysplastic syndrome, Safety
Abstract

Alisertib (MLN8237) is an investigational, oral, selective, Aurora A kinase (AAK) inhibitor. In this phase 2 trial, 57 patients with acute myeloid leukemia (AML) or high-grade myelodysplastic syndrome received alisertib 50 mg BID for 7 days in 21-day cycles. Responses in 6/35 AML patients (17% response rate with an additional 49% stable disease, 34% transfusion independence) included 1 complete response lasting >1 year. No responses were observed in MDS patients. Adverse events >30% included diarrhea, fatigue, nausea, febrile neutropenia, and stomatitis. Results suggest modest activity in AML, supporting further research to better understand how AAK inhibition may induce leukemic cell senescence.

Published
2014

47. A simplified scoring system in de novo follicular lymphoma treated initially with immunochemotherapy

Author

Bachy, Emmanuel, Maurer, Matthew J., Habermann, Thomas M., Gelas-Dore, Bénédicte, Maucort-Boulch, Delphine, Estell, Jane A., Van den Neste, Eric, Bouabdallah, Réda, Gyan, Emmanuel, Feldman, Andrew L., Bargay, Joan, Delmer, Alain, Slager, Susan L., Gomes da Silva, Maria, Fitoussi, Olivier, Belada, David, Maisonneuve, Hervé, Intragumtornchai, Tanin, Ansell, Stephen M., Lamy, Thierry, Dartigues, Peggy, Link, Brian K., Seymour, John F., Cerhan, James R., and Salles, Gilles

Published
2018
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48. Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial

Author

Ossenkoppele, Gert, Pagoni, Maria N., Söderlund, Stina, Escoffre-Barbe, Martine, Etienne, Gabriel, Dengler, Jolanta, Huguet, Francoise, von Bubnoff, Nikolas, Klamova, Hana, Faber, Edgar, Guilhot, Francois, Lotfi, Kourosh, Rea, Delphine, Brümmendorf, Tim H., de Greef, Gorgine E., Stenke, Leif, Nicolini, Franck E., Legros, Laurence, Burchert, Andreas, Voglova, Jaroslava, Charbonnier, Aude, Gyan, Emmanuel, Kunzmann, Volker, Westerweel, Peter E., Saussele, Susanne, Richter, Johan, Guilhot, Joelle, Gruber, Franz X, Hjorth-Hansen, Henrik, Almeida, Antonio, Janssen, Jeroen J W M, Mayer, Jiri, Koskenvesa, Perttu, Panayiotidis, Panayiotis, Olsson-Strömberg, Ulla, Martinez-Lopez, Joaquin, Rousselot, Philippe, Vestergaard, Hanne, Ehrencrona, Hans, Kairisto, Veli, Machová Poláková, Katerina, Müller, Martin C, Mustjoki, Satu, Berger, Marc G, Fabarius, Alice, Hofmann, Wolf-Karsten, Hochhaus, Andreas, Pfirrmann, Markus, and Mahon, Francois-Xavier

Published
2018
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49. R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma

Author

Lamy, Thierry, Damaj, Gandhi, Soubeyran, Pierre, Gyan, Emmanuel, Cartron, Guillaume, Bouabdallah, Krimo, Gressin, Rémy, Cornillon, Jérôme, Banos, Anne, Le Du, Katell, Benchalal, Mohamed, Moles, Marie-Pierre, Le Gouill, Steven, Fleury, Joel, Godmer, Pascal, Maisonneuve, Hervé, Deconinck, Eric, Houot, Roch, Laribi, Kamel, Marolleau, Jean Pierre, Tournilhac, Olivier, Branger, Bernard, Devillers, Anne, Vuillez, Jean Philippe, Fest, Thierry, Colombat, Philippe, Costes, Valérie, Szablewski, Vanessa, Béné, Marie C., Delwail, Vincent, and on behalf of the LYSA Group

Published
2018
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