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Aim:Risk, injury, failure, loss, and end stage (RIFLE); acute kidney injury network (AKIN) and kidney disease: Improving global outcomes (KDIGO) classifications are the most commonly used criteria for the diagnosis of acute kidney injury (AKI). The aim of our study was to determine the relationship between the mortality and the severity of AKI diagnosed by using RIFLE, AKIN, and KDIGO classifications in critically ill patients.Materials and Methods:Data of 1,491 patients hospitalized in tertiary intensive care unit were retrieved from electronic medical records and patients diagnosed with AKI were included in the study. AKI severity was determined according to the RIFLE, AKIN, and KDIGO classifications.Results:One hundred fifty-five patients were included in the study. The percentages of patients in risk, damage, and failure stages according to the RIFLE criteria were 14.8%, 40.0%, and 45.2%, respectively. The percentages in stage 1, 2 and 3 were 45.6%, 30.6%, and 23.8% according to the AKIN criteria and 18.7%, 21.7%, and 54.1% according to the KDIGO criteria, respectively. There was a difference in mortality between the stages of AKI determined according to the AKIN and RIFLE criteria. Mortality was found to be higher in patients in KDIGO stage 3.Conclusion:These three classifications do not consider the etiology of AKI. Therefore, it may be possible that they do not accurately reflect the relationship between mortality and AKI severity. However, the KDIGO classification, which emerged with the need arising from the inadequacy of the classifications used before it, seems to be more valid in this respect.