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Your search keyword '"Hansen, Morten Lock"' showing total 278 results
Start Over Author "Hansen, Morten Lock" Publication Type Academic Journals
278 results on '"Hansen, Morten Lock"'

1. Two decades of SVT ablation in Denmark: a trend towards higher age, more comorbidity, and less prior use of antiarrhythmic and rate-limiting pharmacotherapy—a nationwide registry-based Danish study

Author

Middelfart, Charlotte, Tønnesen, Jacob, Zörner, Christopher R., Da Riis-Vestergaard, Lise, Pham, Maria Hang Xuan, Pallisgaard, Jannik Langtved, Ruwald, Martin H., Rasmussen, Peter Vibe, Johannessen, Arne, Hansen, Jim, Worck, Rene, Gislason, Gunnar, and Hansen, Morten Lock

Published
2024
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14. Disparities in the access to atrial fibrillation ablation in Denmark: who gets ablated, who neglected?

Author

Zörner, Christopher R, Tønnesen, Jacob, Riis-Vestergaard, Lise Da, Middelfart, Charlotte, Hein, Regitze, Rasmussen, Peter Vibe, Ruwald, Martin H, Gislason, Gunnar, and Hansen, Morten Lock

Abstract

Aims Atrial fibrillation (AF) is a common arrhythmia associated with reduced quality of life that can lead to serious complications such as stroke and heart failure. Ablation is a safe and effective treatment for AF but is not offered equally to all patients. The aim of this study is to identify demographic groups more or less likely to undergo AF ablation. Methods and results All patients with newly diagnosed AF between 2010 and 2018 were identified in the Danish nationwide registries. The association between gender, age, level of education and attachment to the job market, and the likelihood of receiving AF ablation was investigated using multivariable Cox proportional hazard analysis. Cumulative incidence was calculated using the Aalen–Johansen estimator. A total of 176 248 patients were included. Men were more likely to receive ablation than women (7% vs. 3%). Patients aged 25–44 and 45–64 were most likely to receive ablation, while only 0.7% of patients aged 80 or above received ablation. The rate of ablation significantly decreased with decreasing level of education. Full-time employed patients were most likely to receive ablation, followed by self-employed, unemployed, on sick leave, undergoing education, and early retired patients. Retired patients were the least likely to receive ablation (3%). Conclusion This study found that women, older patients, patients with lower levels of education, and patients on social benefits are less likely to receive AF ablation. These findings suggest that there are significant social and economic disparities in AF ablation treatment in Denmark. [ABSTRACT FROM AUTHOR]

Published
2024
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17. General anaesthesia compared to conscious sedation for first-time atrial fibrillation catheter ablation—a Danish nationwide cohort study.

Author

Riis-Vestergaard, Lise Da, Tønnesen, Jacob, Ruwald, Martin H, Zörner, Christopher R, Middelfart, Charlotte, Hein, Regitze, Johannessen, Arne, Hansen, Jim, Worck, Rene Husted, Gislason, Gunnar, and Hansen, Morten Lock

Abstract

Aims Catheter ablation (CA) is a well-established treatment option for atrial fibrillation (AF), where sedation and analgesia are pivotal for patient comfort and lesion formation. The impact of anaesthesia type on AF recurrence rates remains uncertain. This study aimed to examine AF recurrence rates depending on conscious sedation (CS) vs. general anaesthesia (GA) during CA. Methods and results Utilizing nationwide data from the Danish healthcare registries, we conducted this cohort study involving adults (≥18 years) undergoing first-time CA for AF between 2010 and 2018. Patients were categorized by anaesthesia type (CS or GA), with the primary endpoint being AF recurrence, defined by a composite endpoint of either antiarrhythmic drug (AAD) prescriptions, AF-related hospital admissions, electrical cardioversions, or AF re-ablation. The impact of anaesthesia type was evaluated using multivariable Cox proportional hazards analysis. The study cohort comprised 7957 (6421 CS and 1536 GA) patients. Persistent AF, hypertension, and heart failure, as well as use of AAD, were more prevalent in the GA group. Cumulative incidences of recurrent AF were higher in the CS group at 1 (46% vs. 37%) and at 5 (68% vs. 63%) years. Multivariate analysis revealed CS as significantly associated with increased risk of AF recurrence at 5-year follow-up [hazard ratio 1.26 (95% confidence interval 1.15–1.38)], consistent across paroxysmal and persistent AF subtypes. Conclusion This nationwide cohort study suggests a higher risk of AF recurrence with CS during CA compared to GA. These results advocate for considering GA as the preferred anaesthesia type for improved CA outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Understanding the incidence of atrial fibrillation and stroke in hypertrophic cardiomyopathy patients: insights from Danish nationwide registries.

Author

Zörner, Christopher R, Schjerning, Anne-Marie, Jensen, Morten Kvistholm, Christensen, Alex Hørby, Tfelt-Hansen, Jacob, Tønnesen, Jacob, Riis-Vestergaard, Lise Da, Middelfart, Charlotte, Rasmussen, Peter Vibe, Gislason, Gunnar, and Hansen, Morten Lock

Abstract

Aims The treatment of atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) can be challenging since AF aggravates symptoms and increases the risk of stroke. Which factors contribute to the development of AF and stroke in HCM remains unknown. The aim of this study was to determine the incidence of AF and stroke in HCM patients and identify the risk factors. Methods and results Using Danish national registries, all HCM patients from 2005 to 2018 were included. The association between HCM, incident AF, and stroke was investigated using multivariable Cox proportional hazards analysis. Cumulative incidences were calculated using the Aalen–Johansen estimator. Among the 3367 patients without prevalent AF, 24% reached the endpoint of incident AF with death as a competing risk. Median follow-up time was 4 years. Atrial fibrillation incidence was equal between sexes and increased for patients with ischaemic heart disease [IHD; hazard ratio (HR) 1.33, 95% confidence interval (CI) 1.08–1.63], hypertension (HT) (HR 1.36, 95% CI 1.14–1.67), and obstructive HCM (HR 1.27, 95% CI 1.05–1.52). Seven per cent developed stroke, with no difference detected stratifying for the presence of AF. Sub-analysis revealed that when AF was treated with oral anticoagulants (OACs), stroke was less likely (HR 0.4, 95% CI 0.18–0.86, P = 0.02). However, 34% of patients were not receiving adequate anticoagulation following AF diagnosis. Conclusion Obstructive HCM, HT, and IHD were associated with increased risk of AF. Prevalent AF alone was not predictive of stroke; however, AF patients treated with OAC were significantly less likely to develop stroke, suggesting that this development is driven by the protective effect of OAC. Despite this, 34% of patients did not receive OAC. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Effect of early cryoballoon ablation on atrial fibrillation recurrence—A Danish nationwide register study.

Author

Hein, Regitze, Riis‐Vestergaard, Lise Da, Tønnesen, Jacob, Zörner, Christopher Ryan, Rasmussen, Peter Vibe, Ruwald, Martin Huth, Johannessen, Arne, Worck, René Husted, Hansen, Jim, Middelfart, Charlotte, Gislason, Gunnar Hilmar, and Hansen, Morten Lock

Subjects
RISK assessment, RESEARCH funding, CLINICAL trials, CRYOSURGERY, TREATMENT effectiveness, PATIENT care, LONGITUDINAL method, ATRIAL fibrillation, DISEASE relapse, CONFIDENCE intervals, TIME, PROPORTIONAL hazards models, REGRESSION analysis
Abstract

Introduction: Cryoballoon ablation is a safe and efficient rhythm control strategy in atrial fibrillation (AF) patients. The impact of time from diagnosis to ablation is unclear. The aim of this study was to examine the impact of timing of first‐time cryoballoon ablation on AF recurrence in a nationwide cohort of AF patients. Methods and Results: From nationwide registers, all AF patients ≥18 years of age who underwent first‐time AF cryoballoon ablation in Denmark from 2012 to 2018 were included. The AF patients were stratified by ablation timing: Early group (≤1 year after AF diagnosis), intermediate group (1–3 years after AF diagnosis), and late group (≥3 years after AF diagnosis). By adjusted Cox regression models, the effect of timing on AF recurrence was examined. This study included 1064 AF patients with a median age of 63 years. Most patients were male (66%) and had paroxysmal AF (67%). The 1‐year risk of AF recurrence increased from 31% in the early group to 41% and 44% in the intermediate and late group. The hazard ratios (95% confidence intervals) were 1.28 (0.95, 1.74) in the intermediate group and 1.42 (1.09, 1.86) in the late group when compared to the early group. Continuous diagnosis‐to‐ablation time seemed to have the greatest impact on AF recurrence within the first 2 years. Conclusion: In AF patients undergoing cryoballoon ablation, late timing of ablation was associated with a significantly higher AF recurrence rate when compared to early timing of ablation. These findings support early cryoballoon ablation to improve the outcomes after ablation. [ABSTRACT FROM AUTHOR]

Published
2024
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29. PREVALENCE AND PROGNOSTIC IMPORTANCE OF ISCHEMIC HEART DISEASE AMONG PATIENTS WITH ATRIAL FIBRILLATION UNDERGOING CATHETER ABLATION: A NATIONWIDE DANISH COHORT STUDY

Author

Espersen, Caroline, Modin, Daniel, Johansen, Niklas Dyrby, Johannessen, Arne, Hansen, Jim, Eskesen, Kristian, Iversen, Allan Zeeberg, Worck, Rene, Ruwald, Martin Huth, Hansen, Morten Lock, Gislason, Gunnar H., Estepar, Raul San Jose, Marcus, Gregory M., and Biering-Sorensen, Tor

Published
2024
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34. Short- and long-term risk of atrial fibrillation recurrence after first time ablation according to body mass index: a nationwide Danish cohort study.

Author

Tønnesen, Jacob, Pallisgaard, Jannik, Ruwald, Martin H, Rasmussen, Peter Vibe, Johannessen, Arne, Hansen, Jim, Worck, Rene Husted, Zörner, Christopher R, Riis-Vestergaard, Lise, Middelfart, Charlotte, Gislason, Gunnar, and Hansen, Morten Lock

Abstract

Aims Overweight is associated with increased risk of atrial fibrillation (AF), but the impact of overweight and AF recurrence after ablation is less clear. Despite this, an increasing number of AF ablations are carried out in overweight patients. We investigated the impact of body mass index (BMI) on AF recurrence rates after ablation. Methods and results Through Danish nationwide registers, all patients undergoing first-time AF ablation between 2010 and 2018 were identified. Exposure of interest was BMI. The primary outcome was recurrent AF, defined from either any usage of antiarrhythmic medication, AF hospitalization, cardioversion, or re-ablation. A total of 9188 patients were included. Median age and interquartile range was 64 (60–75) in the normal-weight group and 60 (53–66) in the morbidly obese. There was an increase in comorbidity burden with increasing BMI, including a higher prevalence of heart failure, chronic obstructive pulmonary disease, diabetes, and hypertension. At 1- and 5-year follow ups, recurrence rates of AF increased incrementally by BMI categories. The hazard ratios and 95% confidence intervals of recurrent AF after ablation were 1.15 (1.07–1.23), 1.18 (1.09–1.28), and 1.26 (1.13–1.41) in overweight, obese, and morbidly obese, respectively, compared with normal-weight patients. Procedure duration and X-ray dose exposure also increased with increasing BMI. Conclusion Following AF ablation, recurrence rates of AF increased incrementally with increasing BMI. Therefore, aggressive weight management pre ablation in overweight patients could potentially provide substantial benefits and improve short- and long-term outcomes after ablation. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Cardiac arrhythmias in patients hospitalized with COVID-19: The ACOVID study

Author

Zareini, Bochra, Rajan, Deepthi, El-Sheikh, Mohammed, Jensen, Mads Hashiba, Højbjerg Lassen, Mats Christian, Skaarup, Kristoffer, Hansen, Morten Lock, Biering-Sørensen, Tor, Jabbari, Reza, Kirk, Ole, Tfelt-Hansen, Jakob, Nielsen, Olav Wendelboe, Lindegaard, Birgitte, Tønder, Niels, Pedersen, Lars Kliesch, Ulrik, Charlotte Suppli, Ellekvist, Peter, Stæhr Jensen, Jens Ulrik, Schou, Morten, Gislason, Gunnar, and Lamberts, Morten

Published
2021
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42. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)Endorsed by the European Respiratory Society (ERS)

Author

Konstantinides, Stavros V., Torbicki, Adam, Agnelli, Giancarlo, Danchin, Nicolas, Fitzmaurice, David, Galiè, Nazzareno, Gibbs, J. Simon R., Huisman, Menno V., Humbert, Marc, Kucher, Nils, Lang, Irene, Lankeit, Mareike, Lekakis, John, Maack, Christoph, Mayer, Eckhard, Meneveau, Nicolas, Perrier, Arnaud, Pruszczyk, Piotr, Rasmussen, Lars H., Schindler, Thomas H., Svitil, Pavel, Vonk Noordegraaf, Anton, Zamorano, Jose Luis, Zompatori, Maurizio, Zamorano, Jose Luis, Achenbach, Stephan, Baumgartner, Helmut, Bax, Jeroen J., Bueno, Hector, Dean, Veronica, Deaton, Christi, Erol, Çetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno, Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F., Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, Erol, Çetin, Jimenez, David, Ageno, Walter, Agewall, Stefan, Asteggiano, Riccardo, Bauersachs, Rupert, Becattini, Cecilia, Bounameaux, Henri, Büller, Harry R., Davos, Constantinos H., Deaton, Christi, Geersing, Geert-Jan, Sanchez, Miguel Angel Gómez, Hendriks, Jeroen, Hoes, Arno, Kilickap, Mustafa, Mareev, Viacheslav, Monreal, Manuel, Morais, Joao, Nihoyannopoulos, Petros, Popescu, Bogdan A., Sanchez, Olivier, Spyropoulos, Alex C., Skoro-Sajer, Nika, Najafov, Ruslan, Sudzhaeva, Svetlana, De Pauw, Michel, Baraković, Fahir, Tokmakova, Mariya, Skoric, Bosko, Rokyta, Richard, Hansen, Morten Lock, Elmet, Märt, Harjola, Veli-Pekka, Meyer, Guy, Chukhrukidze, Archil, Rosenkranz, Stephan, Androulakis, Aristides, Forster, Tamás, Fedele, Francesco, Sooronbaev, Talant, Maca, Aija, Ereminiene, Egle, Micallef, Josef, Andreasen, Arne, Kurzyna, Marcin, Ferreira, Daniel, Petris, Antoniu Octavian, Dzemeshkevich, Sergey, Asanin, Milika, Šimkova, Iveta, Anguita, Manuel, Christersson, Christina, Kostova, Nela, Baccar, Hedi, Sade, Leyla Elif, Parkhomenko, Alexander, and Pepke-Zaba, Joanna

Published
2014
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47. Accuracy of the ICD-10 discharge diagnosis for syncope

Author

Ruwald, Martin Huth, Hansen, Morten Lock, Lamberts, Morten, Kristensen, Søren Lund, Wissenberg, Mads, Olsen, Anne-Marie Schjerning, Christensen, Stefan Bisgaard, Vinther, Michael, Køber, Lars, Torp-Pedersen, Christian, Hansen, Jim, and Gislason, Gunnar Hilmar

Published
2013
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