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p53 pathway is important in tumorigenesis. However, no study has been performed to specifically investigate the role of p53 pathway genes in bladder cancer (BLCA). In this study, transcriptomics data of muscle invasive bladder cancer patients (n = 411) from The Cancer Genome Atlas (TCGA) were investigated. Using the hallmark p53 pathway gene set, the Non-Negative Matrix factorization (NMF) analysis identified two subtypes (C1 and C2). Clinical, survival, and immunological analysis were done to validate distinct characteristics of the subtypes. Pathway enrichment analysis showed the subtype C1 with poor prognosis having enrichment in genes of the immunity related pathways, where C2 subtype with better prognosis being enriched in genes of the steroid synthesis and drug metabolism pathways. A signature gene set consisting of MDGA2, GNLY, GGT2, UGT2B4, DLX1, and DSC1 was created followed by a risk model. Their expressions were analyzed in RNA extracted from the blood and matched tumor tissues of BLCA patients (n = 10). DSC1 had significant difference of expression (p = 0.005) between the blood and tumor tissues in our BLCA samples. Contrary to the usual normal bladder tissue to blood ratio, DLX1 expression was lower (p = 0.02734) in tumor tissues than in blood. Being the first research of p53 pathway related signature gene set in bladder cancer, this study potentially has a substantial impact on the development of biomarkers for BLCA.

The application of cross-linking resin is an effective method for improving and controlling dimensional stability, such as the shrinkage of viscose single jersey knits. However, such treatment often leads to a significant deterioration in the bursting strength of treated fabrics. In this regard, resin treatment using a softening agent can be an additional potential solution for retaining the bursting strength of treated fabrics. Resin treatment is one kind of chemical finishing process that inhibits cellulosic textile fibre swelling during wetting, provides fibre resistance to deformation and prevents shrinkage. The key objective of this study was to model the effect of resin-finishing process variables for predicting the shrinkage control and bursting strength of viscose single jersey knitted fabrics. The MATLAB (Version 8.2.0.701) fuzzy expert system was used to model the optimum resin and softener concentrations, as well as the best curing time for the prediction of maximum shrinkage control with a minimum loss in fabric bursting strength. The optimal process variables were found to be a resin concentration of 75 g/l, a softener concentration of 45 g/l and a curing time of 225 seconds. The fuzzy expert model developed in this study was validated using experimental data. It was found that the model has the ability and accuracy to predict fabric shrinkage and bursting strength effectively in the non-linear field.

We propose and study a scheme combining the finite element method and machine learning techniques for the numerical approximations of coupled nonlinear forward–backward stochastic partial differential equations (FBSPDEs) with homogeneous Dirichlet boundary conditions. Precisely, we generalize the pioneering work of Dunst and Prohl [SIAM J. Sci. Comp., 38(2017), 2725–2755] by considering general nonlinear and nonlocal FBSPDEs with more inclusive coupling; self-contained proofs are provided and different numerical techniques for the resulting finite dimensional equations are adopted. For such FBSPDEs allowing for non-Lipschitz nonlinearity on unknown variables, we prove the existence and uniqueness of the strong solution as well as of the weak solution. Then, the finite element method in the spatial domain leads to approximations of FBSPDEs by finite-dimensional forward–backward stochastic differential equations which are numerically computed by using some deep learning-based schemes. A strong convergence analysis is addressed for the spatial discretization of coupled FBSPDEs under an additional Lipschitz assumption, and the numerical examples, including both decoupled and coupled cases, indicate that our methods are quite efficient. [ABSTRACT FROM AUTHOR]

In this research work, Galerkin and collocation methods have been introduced for approximating the solution of FIE of 2nd kind using LH (product of Laguerre and Hermite) polynomials which are considered as basis functions. Also, a comparison has been done between the solutions of Galerkin and collocation method with the exact solution. Both of these methods show the outcome in terms of the approximate polynomial which is a linear combination of basis functions. Results reveal that performance of collocation method is better than Galerkin method. Moreover, five different polynomials such as Legendre, Laguerre, Hermite, Chebyshev 1st kind and Bernstein are also considered as a basis functions. And it is found that all these approximate solutions converge to same polynomial solution and then a comparison has been made with the exact solution. In addition, five different set of collocation points are also being considered and then the approximate results are compared with the exact analytical solution. It is observed that collocation method performed well compared to Galerkin method. [ABSTRACT FROM AUTHOR]

Automatic classification of colon and lung cancer images is crucial for early detection and accurate diagnostics. However, there is room for improvement to enhance accuracy, ensuring better diagnostic precision. This study introduces two novel dense architectures (D1 and D2) and emphasizes their effectiveness in classifying colon and lung cancer from diverse images. It also highlights their resilience, efficiency, and superior performance across multiple datasets. These architectures were tested on various types of datasets, including NCT-CRC-HE-100K (set of 100,000 non-overlapping image patches from hematoxylin and eosin (H&E) stained histological images of human colorectal cancer (CRC) and normal tissue), CRC-VAL-HE-7K (set of 7180 image patches from N = 50 patients with colorectal adenocarcinoma, no overlap with patients in NCT-CRC-HE-100K), LC25000 (Lung and Colon Cancer Histopathological Image), and IQ-OTHNCCD (Iraq-Oncology Teaching Hospital/National Center for Cancer Diseases), showcasing their effectiveness in classifying colon and lung cancers from histopathological and Computed Tomography (CT) scan images. This underscores the multi-modal image classification capability of the proposed models. Moreover, the study addresses imbalanced datasets, particularly in CRC-VAL-HE-7K and IQ-OTHNCCD, with a specific focus on model resilience and robustness. To assess overall performance, the study conducted experiments in different scenarios. The D1 model achieved an impressive 99.80 % accuracy on the NCT-CRC-HE-100K dataset, with a Jaccard Index (J) of 0.8371, a Matthew's Correlation Coefficient (MCC) of 0.9073, a Cohen's Kappa (Kp) of 0.9057, and a Critical Success Index (CSI) of 0.8213. When subjected to 10-fold cross-validation on LC25000, the D1 model averaged (avg) 99.96 % accuracy (avg J, MCC, Kp, and CSI of 0.9993, 0.9987, 0.9853, and 0.9990), surpassing recent reported performances. Furthermore, the ensemble of D1 and D2 reached 93 % accuracy (J, MCC, Kp, and CSI of 0.7556, 0.8839, 0.8796, and 0.7140) on the IQ-OTHNCCD dataset, exceeding recent benchmarks and aligning with other reported results. Efficiency evaluations were conducted in various scenarios. For instance, training on only 10 % of LC25000 resulted in high accuracy rates of 99.19 % (J, MCC, Kp, and CSI of 0.9840, 0.9898, 0.9898, and 0.9837) (D1) and 99.30 % (J, MCC, Kp, and CSI of 0.9863, 0.9913, 0.9913, and 0.9861) (D2). In NCT-CRC-HE-100K, D2 achieved an impressive 99.53 % accuracy (J, MCC, Kp, and CSI of 0.9906, 0.9946, 0.9946, and 0.9906) with training on only 30 % of the dataset and testing on the remaining 70 %. When tested on CRC-VAL-HE-7K, D1 and D2 achieved 95 % accuracy (J, MCC, Kp, and CSI of 0.8845, 0.9455, 0.9452, and 0.8745) and 96 % accuracy (J, MCC, Kp, and CSI of 0.8926, 0.9504, 0.9503, and 0.8798), respectively, outperforming previously reported results and aligning closely with others. Lastly, training D2 on just 10 % of NCT-CRC-HE-100K and testing on CRC-VAL-HE-7K resulted in significant outperformance of InceptionV3, Xception, and DenseNet201 benchmarks, achieving an accuracy rate of 82.98 % (J, MCC, Kp, and CSI of 0.7227, 0.8095, 0.8081, and 0.6671). Finally, using explainable AI algorithms such as Grad-CAM, Grad-CAM++, Score-CAM, and Faster Score-CAM, along with their emphasized versions, we visualized the features from the last layer of DenseNet201 for histopathological as well as CT-scan image samples. The proposed dense models, with their multi-modality, robustness, and efficiency in cancer image classification, hold the promise of significant advancements in medical diagnostics. They have the potential to revolutionize early cancer detection and improve healthcare accessibility worldwide.

Fish classification leads to the automated machine-based fish separation system. In terms of classification and real-time data monitoring, deep learning and the Internet of Things (IoT) each provides an efficient solution. This paper focuses on the development of an embedded system based on the principles of Deep Learning and IoT. The proposed methodology is classified into interconnected parts. The first part describes the working principles of DL with along the dataset building, model analysis and overall system architecture. A new dataset from eight different Bangladeshi fish species. In the process of DL, First, two sets of datasets have been created namely, setup-1(S1) containing original images and setup-2(S2) containing Unsharp masked photos. Then, seven conventional ImageNet pertained state-of-the-art deep learning models on both benchmarking setups: InceptionV3, Xception, DenseNet121, DenseNet169, DenseNet201, InceptionResNetV2, and ResNet152V2. In the process of IoT, the architectural design of a smart contained has been deployed with the aid of several kinds of sensors and microcontrollers. This research has found satisfactory results with the DL models and IoT-based components. The best benchmark accuracy for setup-1 was 96% for all of the DenseNet121, DenseNet169, and DenseNet201 architecture, and for setup-2, it was 96% for the Xception model. Finally, we have constructed a hybrid (CNN + Convolutional LSTM) model, for which the accuracy was 97%, outperforming all of the abovementioned state-of-the-art methods. Besides, the research has performed some experiments with the IoT-based Solution. Though the proposed solution has exhibited some drawbacks, but it can be practicable in real-time solutions.

Deep learning (DL) has gradually taken the lead as the most effective approach in the agricultural fields due to the early identification and classification of plant species and diseases for improving the quality of crop production because of recent technological breakthroughs, which have had a significant impact on agriculture. Plenty of complicated problems in farming, including species classification, plant disorder identification, yield approximation, and weather and soil moisture prediction, are made simple using deep neural networks. Thus, this proposed study aims to classify Brassica Napus (B. Napus) rapeseed species based on their most significant features, like flowers, leaves, and packets. The study has adopted two types of rapeseed such as B. Rapa and B. Alba. Five contemporary deep learning-based Convolutional Neural Network (CNN) models have also been assessed for distinguishing rapeseed species. These models are DenseNet201, VGG19, InceptionV3, Xception, and ResNet50. Initially, the researchers collected data from the agricultural field, and then image pre-processing is performed to create our dataset. After that, CNN models were applied to this dataset and enumerated the experimental data accordingly. Our DenseNet201 model successfully classified both species with the highest accuracy of 100% for flowers and 97% for both packets and leaves. A comprehensive analysis with companion studies confirmed the efficacy of our preferred paradigm for the near future. Nevertheless, future studies will compare these methodologies to data from a separate metabolomics dataset from comparable crops.

Medicinal plants have been used to treat diseases since ancient times. Plants used as raw materials for herbal medicine are known as medicinal plants [2]. The U. S. Forest Service estimates that 40% of pharmaceutical drugs in the Western world are derived from plants [1]. Seven thousand medical compounds are derived from plants in the modern pharmacopeia. Herbal medicine combines traditional empirical knowledge with modern science [2]. A medicinal plant is considered an important source of prevention against various diseases [2]. The essential medicine component is extracted from different parts of the plants [8]. In underdeveloped countries, people use medicinal plants as a substitute for medicine. There are various species of plants in the world. Herbs are one of them, which are of different shapes, colors, and leaves [5]. It is difficult for ordinary people to recognize these species of herbs. People use more than 50000 plants in the world for medicinal purposes. There are 8000 medicinal plants in India with evidence of medicinal properties [7]. Automatic classification of these plant species is important because it requires intensive domain knowledge to manually classify the proper species. Machine learning techniques are extensively used in classifying medicinal plant species from photographs, which is challenging but intriguing to academics. Artificial Neural Network classifiers’ effective performance depends on the quality of the image dataset [4]. This article represents a medicinal plant dataset: an image dataset of ten different Bangladeshi plant species. Images of medicinal plant leaves were from various gardens, including the Pharmacy Garden at Khwaja Yunus Ali University and the Khwaja Yunus Ali Medical College & Hospital in Sirajganj, Bangladesh. Images were collected by taking pictures with high-resolution mobile phone cameras. Ten medicinal species, 500 images per species are included in the data set, namely, Nayantara (Catharanthus roseus), Pathor kuchi (Kalanchoe pinnata), Gynura procumbens (Longevity spinach), Bohera (Terminalia bellirica), Haritaki (Terminalia chebula), Thankuni (Centella asiatica), Neem (Azadirachta indica), Tulsi (Ocimum tenniflorum), Lemon grass (Cymbopogon citratus), and Devil backbone (Euphorbia tithymaloides). This dataset will benefit researchers applying machine learning and computer vision algorithms in several ways. For example, training and evaluation of machine learning models with this well-curated high-quality dataset, development of new computer vision algorithms, automatic medicinal plant identification in the field of botany and pharmacology for drug discovery and conservation, and data augmentation. Overall, this medicinal plant image dataset can provide researchers in the field of machine learning and computer vision with a valuable resource to develop and evaluate algorithms for plant phenotyping, disease detection, plant identification, drug development, and other tasks related to medicinal plants.

This research addresses the lack of publicly available datasets for Bangladeshi medicinal plants by presenting a comprehensive dataset comprising 5000 images of ten species collected under controlled conditions. To improve performance, several preprocessing techniques were employed, such as image selection, background removal, unsharp masking, contrast-limited adaptive histogram equalization, and morphological gradient. Then, we applied five state-of-the-art deep learning models to achieve benchmark performance on the dataset: VGG16, ResNet50, DenseNet201, InceptionV3, and Xception. Among these models, DenseNet201 demonstrated the highest accuracy of 85.28%. In addition to benchmarking the deep learning models, three novel neural network architectures were developed: dense-residual–dense (DRD), dense-residual–ConvLSTM-dense (DRCD), and inception-residual–ConvLSTM-dense (IRCD). The DRCD model achieved the highest accuracy of 97%, surpassing the benchmark performances of individual models. This highlights the effectiveness of the proposed architectures in capturing complex patterns and dependencies within the data. To further enhance classification accuracy, an ensemble approach was adopted, employing both hard ensemble and soft ensemble techniques. The hard ensemble achieved an accuracy of 98%, while the soft ensemble achieved the highest accuracy of 99%. These results demonstrate the effectiveness of ensembling techniques in boosting overall classification performance. The outcomes of this study have significant implications for the accurate identification and classification of Bangladeshi medicinal plants. This research provides valuable resources for traditional medicine, drug discovery, and biodiversity conservation efforts. The developed models and ensemble techniques can aid researchers, botanists, and practitioners in accurately identifying medicinal plant species, thereby facilitating the utilization of their therapeutic potential and contributing to the preservation of biodiversity.