197 results on '"Hellinga, Homme W."'
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2. Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching
3. Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium
4. Computational Design of a Biologically Active Enzyme
5. Computational Design of Receptors for an Organophosphate Surrogate of the Nerve Agent Soman
6. Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I
7. The Crystal Structure of Human Protein Farnesyltransferase Reveals the Basis for Inhibition by CaaX Tetrapeptides and Their Mimetics
8. Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins
9. Conversion of a Maltose Receptor into a Zinc Biosensor by Computational Design
10. Rational Design of Nascent Metalloenzymes
11. The Rational Design and Construction of a Cuboidal Iron--Sulfur Protein
12. Construction of a Catalytically Active Iron Superoxide Dismutase by Rational Protein Design
13. Thermally controlled intein splicing of engineered DNA polymerases provides a robust and generalizable solution for accurate and sensitive molecular diagnostics.
14. Structural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and Ribonucleotides
15. Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis
16. Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity
17. Retraction
18. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens
19. Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
20. Multifactorial Determinants of Protein Expression in Prokaryotic Open Reading Frames
21. Structural Analysis of Semi-specific Oligosaccharide Recognition by a Cellulose-binding Protein of Thermotoga maritima Reveals Adaptations for Functional Diversification of the Oligopeptide Periplasmic Binding Protein Fold
22. Structural Adaptations that Modulate Monosaccharide, Disaccharide, and Trisaccharide Specificities in Periplasmic Maltose-Binding Proteins
23. Structural Analysis of a Periplasmic Binding Protein in the Tripartite ATP-independent Transporter Family Reveals a Tetrameric Assembly That May Have a Role in Ligand Transport
24. Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design
25. Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
26. Rational design of a calcium-binding protein
27. Computational design of receptor and sensor proteins with novel functions
28. The Crystal Structure of a Thermophilic Glucose Binding Protein Reveals Adaptations that Interconvert Mono and Di-saccharide Binding Sites
29. Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design
30. Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein–protein interactions directly from DNA
31. Quantitation of protein–protein interactions by thermal stability shift analysis
32. Discovery of Thermostable, Fluorescently Responsive Glucose Biosensors by Structure-Assisted Function Extrapolation.
33. In the wake of two retractions, a request for investigation
34. Structure-based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose-binding protein
35. Protein fabrication automation
36. Construction of a Blue Copper analogue through iterative rational protein design cycles demonstrates principles of molecular recognition in metal center formation
37. Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design
38. Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center
39. Engineering biosensors by introducing fluorescent allosteric ssignal transducers: construction of a novel glucose sensor
40. Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins
41. Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates
42. Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms
43. Periplasmic binding proteins: a versatile superfamily for protein engineering
44. Mapping staphylococcal nuclease conformation using an EDTA-Fe derivative attached to genetically engineered cysteine residues
45. Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry
46. Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position
47. Engineering key components in a synthetic eukaryotic signal transduction pathway
48. Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics
49. Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes
50. Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle
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