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Your search keyword '"Huang, Rong-Wei"' showing total 7 results
Start Over Author "Huang, Rong-Wei" Publication Type Academic Journals
7 results on '"Huang, Rong-Wei"'

7. Modulation of plasmacytoid dendritic cell and CD4+ T cell differentiation accompanied by upregulation of the cholinergic anti-inflammatory pathway induced by enterovirus 71.

Author

Li, Li, Huang, Rong-Wei, Liu, Xiao-Ning, Xiang, Xiao-Yi, Zhou, Yuan-Tao, Feng, Xing-Xing, Tao, Lv-Yuan, Yu, Jia, Qin Yi, Wang, Yan-Chun, and Liu, Xiao-Mei

Subjects
*T cell differentiation, *T cells, *DENDRITIC cells
Abstract

Enterovirus 71 (EV71) is a neurotropic enterovirus associated with hand, foot, and mouth disease (HFMD) fatalities. In this study, we investigated the impact of EV71 on plasmacytoid dendritic cells (pDCs) and CD4+ T cells. The results showed that pDCs were promptly activated, secreting interferon (IFN)-α and inducing CD4+ T cell proliferation and differentiation during early EV71 infection. This initiated adaptive immune responses and promoted proinflammatory cytokine production by CD4+ T cells. Over time, viral nucleic acids and proteins were synthesized in pDCs and CD4+ T cells. Concurrently, the cholinergic anti-inflammatory pathway (CAP) was activated, exhibiting an anti-inflammatory role. With constant viral stimulation, pDCs and CD4+ T cells showed reduced differentiation and cytokine secretion. Defects in pDCs were identified as a key factor in CD4+ T cell tolerance. CAP had a more significant regulatory effect on CD4+ T cells than on pDCs and was capable of inhibiting inflammation in these cells. [ABSTRACT FROM AUTHOR]

Published
2024
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