Search

Your search keyword '"Ieva Vasiliauskaité-Brooks"' showing total 1 results
Start Over Author "Ieva Vasiliauskaité-Brooks" Publication Type Academic Journals
1 results on '"Ieva Vasiliauskaité-Brooks"'

1. Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

Author

Ieva Vasiliauskaité-Brooks, Robert D. Healey, Pascal Rochaix, Julie Saint-Paul, Rémy Sounier, Claire Grison, Thierry Waltrich-Augusto, Mathieu Fortier, François Hoh, Essa M. Saied, Christoph Arenz, Shibom Basu, Cédric Leyrat, and Sébastien Granier

Subjects
Science
Abstract

Alkaline ceramidases (ACERs) are a class of poorly understood transmembrane enzymes controlling the homeostasis of ceramides. Here authors solve the Xray structure of human ACER3 and uncover a Ca2+ binding site providing an explanation for the known regulatory role of Ca2+ on ACER3 activity.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results