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Your search keyword '"Jacks, Thomas M."' showing total 15 results
Start Over Author "Jacks, Thomas M." Publication Type Academic Journals
15 results on '"Jacks, Thomas M."'

5. Alendronate Binds to Tooth Root Surfaces and Inhibits Progression of Feline Tooth Resorption: A Pilot Proof-of-Concept Study.

Author

Mohn, Kenneth L., Jacks, Thomas M., Schleim, Klaus Dieter, Harvey, Colin E., Miller, Bonnie, Halley, Bruce, Feeney, William P., Hill, Susan L., and Hickey, Gerry

Subjects
CAT diseases, GINGIVITIS, BONE resorption, EUTHANASIA of animals, VETERINARY dentistry, BIOAVAILABILITY
Abstract

Tissue distribution, bioavailability, and efficacy of alendronate in preventing progression of resorption of teeth were evaluated in cats. [Butyl-4-14C-]-alendronate accumulates on subgingival tooth and alveolar bone surfaces adjacent to vascularized tissue resulting in concentration of the drug around tooth roots. Three cats were treated with a 0.03 mg/kg IV bolus of [butyl-4-14C-]-alendronate followed by blood, urine, and feces collection and euthanasia 24-hours later. Drug tissue distribution was accessed by autoradiography and sample combustion. To assess bioavailability, 12 cats were administered alendronate orally (3.0 or 9.0 mg/kg in water or 9.0 mg/kg in tuna water) and urine was collected for 24-hours. In these formulations, alendronate oral bioavailability in cats was approximately 3 %. In addition, 10 cats with radiographic evidence of pre-existing tooth resorption (14 affected teeth) were treated with vehicle or 3.0 mg/kg alendronate per os once weekly for 22-weeks and, then, 9.0 mg/kg per os twice weekly for 27-weeks in a random, masked study. Radiographic area of resorption was measured and progression scored every 3 to 4-months. [ABSTRACT FROM AUTHOR]

Published
2009
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8. An Evaluation of the Use of Escherichia Coli Serogroups as a Means of Tracing Microbial Pollution in Water.

Author

Glantz, Paul J. and Jacks, Thomas M.

Abstract

Escherichia coli serogroups were used as a means of tracing, and total and fecal coliform counts were utilized to determine the degree, location, and variations of, microbial pollution of water. In one area a lake served as a reservoir for the constant influx of coliform bacteria from two streams. Total and fecal coliforms increased from May through July, declined in August and September, and appeared subject to human and animal activity and weather. E. coli serogroups were traced upstream from the lake either via Paradise Creek or the Fish Hatchery, and through the Hatchery holding ponds to their spring water source. In the second study treated sewage effluent entering one of two branches of Spring Creek did not appear to furnish most of the total and fecal coliform bacteria as microbial pollution from other sources occurred. The E. coli serogroups isolated at the different sampling points were traced to their probable upstream source. The results of this study indicate that tracing microbial pollution by serologically identifying the E. coli strains is feasible. [ABSTRACT FROM AUTHOR]

Published
1968
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