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Abstract In the study of obesity and diabetes, mice are widely used for experimental research, and fasting is a common procedure used to reset metabolism in mouse models. The fasting duration for experimental mice varies greatly in nutritional and metabolic studies, ranging from 2 to 48 h. This study aims to assess the optimal fasting duration for mice fed low- and high-fat diets over a short period of time. C57BL/6J mice were fed a low-fat diet (LFD) or high-fat diet (HFD) and fasted for 4, 6, 8, 10, 12, or 24 h. The effects of different conditions after fasting on the metabolic level of mice were explored, and the data were collected for analysis. Our data indicate that fasting has inconsistent effects on mice fed a low-fat or high-fat diet. To compare the metabolic differences between mice in different dietary levels and thereby secure better scientific data, mice should fast for 6 h in animal experiments. Fasting for 6 h is also recommended when comparing glucose tolerance with insulin tolerance.

Abstract Background The aim of this study is to analyze the trend of acute onset of chronic cor pulmonale at Chenggong Hospital of Kunming Yan’an Hospital between January 2018 and December 2022.Additionally, the study will compare the application of the ARIMA model and Holt-Winters model in predicting the number of chronic cor pulmonale cases. Methods The data on chronic cor pulmonale cases from 2018 to 2022 were collected from the electronic medical records system of Chenggong Hospital of Kunming Yan’an Hospital. The ARIMA and Holt-Winters models were constructed using monthly case numbers from January 2018 to December 2022 as training data. The performance of the model was tested using the monthly number of cases from January 2023 to December 2023 as the test set. Results The number of acute onset of chronic cor pulmonale in Chenggong Hospital of Kunming Yan’an Hospital exhibited a downward trend overall from 2018 to 2022. There were more cases in winter and spring, with peaks observed in November to December and January of the following year. The optimal ARIMA model was determined to be ARIMA (0,1,1) (0,1,1)12, while for the Holt-Winters model, the optimal choice was the Holt-Winters multiplicative model. It was found that the Holt-Winters multiplicative model yielded the lowest error. Conclusion The Holt-Winters multiplicative model predicts better accuracy. The diagnosis of acute onset of chronic cor pulmonale is related to many risk factors, therefore, when using temporal models to fit and predict the data, we must consider such factors’ influence and try to incorporate them into the models.

Abstract Relaxor ferroelectrics are highly desired for pulse-power dielectric capacitors, however it has become a bottleneck that substantial enhancements of energy density generally sacrifice energy efficiency under superhigh fields. Here, we demonstrate a novel concept of highly polarizable concentrated dipole glass in delicately-designed high-entropy (Bi1/3Ba1/3Na1/3)(Fe2/9Ti5/9Nb2/9)O3 ceramic achieved via substitution of multiple heterovalent ferroelectric-active principal cation species on equivalent lattice sites. The atomic-scaled polar heterogeneity of dipoles with different polar vectors between adjacent unit cells enables diffuse reorientation process but disables appreciable growth with electric fields. These unique features cause superior recoverable energy density of ~15.9 J cm−3 and efficiency of ~93.3% in bulk ceramics. We also extend the highly polarizable concentrated dipole glass to the prototype multilayer ceramic capacitor, which exhibits record-breaking recoverable energy density of ~26.3 J cm−3 and efficiency of ~92.4% with excellent temperature and cycle stability. This research presents a distinctive approach for designing high-performance energy-storage dielectric capacitors.

In the domain of aerodynamic physical parameter identification, conventional optimization algorithms are often limited by falling into local optima. To overcome this limitation, a novel adaptive PSO-SO algorithm based on Sobol sequences (SAPSO-SO) algorithm is proposed in this study. The algorithm integrates particle swarm optimization algorithms and snake optimization algorithms, utilizing Sobol sequences for initialization, which enhances the global search and local development ability of the algorithm by adaptively adjusting the inertia weights and learning factors. In addition, this study introduced a local optimal discriminant mechanism and a local search function to further enhance the optimization performance of the algorithms. In this study, the small interval constant method was used to subdivide the trajectory, relying on the three-degree-of-freedom ballistic model to identify the starting ballistic parameters and aerodynamic physical parameters of each small interval. The performances of the snake optimization algorithm, particle swarm optimization algorithm, C-K method, and SAPSO-SO algorithm in the identification of ballistic physical parameters were compared using the full ballistic simulation data of a high-speed rotating projectile as measurement data. The results show that the SAPSO-SO algorithm demonstrates excellent accuracy and effectiveness, especially in noisy simulation data, where its recognition accuracy is improved by 7.79% over the C-K method, highlighting its superior anti-noise performance and global optimization capability. It is comprehensively analyzed that the SAPSO-SO algorithm has strong global optimization potential in theory and shows a high degree of accuracy and stability in practical applications, independent of the selection of initial parameters.

Abstract Background The development of rosacea is suggested to be closely associated with lipid metabolism, inflammation, and anxiety/depression. Gamma linolenic acid (GLA) is a key factor participating in lipid metabolism, which is also confirmed to regulate the inflammatory response. However, the associations of serum GLA levels with rosacea severity and psychological status still remain unclear. Objective and limitations of the study The present study aimed to investigate the associations of gamma linolenic acid (GLA), a key factor participating in lipid metabolism and the inflammatory response, with rosacea severity and psychological status. The present study still had some limitations. First, this study is a cross-sectional study and does not provide longitudinal evidence about the relationship between GLA and rosacea; Second, the cohort in this study is also relatively small, and a larger cohort is needed in further investigation to reveal the potential role of lipid metabolism in the pathogenesis of rosacea. Methods A total of 62 rosacea patients were consecutively recruited. Patient’s Self-Assessment (PSA) scale and Clinician Erythema Assessment (CEA) as well as 7-item Generalized Anxiety Disorder (GAD-7) and 9-item Patient Health Questionnaire (PHQ-9) were conducted to evaluate the degree of erythema severity and anxiety/depression, respectively. Serum GLA levels were determined by gas chromatography mass. Results Lower levels of serum GLA in rosacea patients were observed (p < 0.001), and subgroup analysis revealed that patients with higher-level GLA had lower scores of PSA, CEA, GAD-7 and PHQ-9. Moreover, Spearman correlation analysis uncovered that serum GLA levels were negatively associated with PSA, CEA, GAD-7 as well and PHQ-9 scores, respectively. Linear regression model found that serum GLA levels at baseline were a predictive factor for prognosis of clinical outcomes after 1-month conventional treatment. Conclusion The present study indicates that lower levels of serum GLA in rosacea patients are negatively associated with the degree of erythema and anxiety/depression status.

Abstract Hypoxia-inducible factor 1 (HIF1) is critically important for driving angiogenesis and tumorigenesis. Linear ubiquitin chain assembly complex (LUBAC), the only known ubiquitin ligase capable of catalyzing protein linear ubiquitination to date, is implicated in cell signaling and associated with cancers. However, the role and mechanism of LUBAC in regulating the expression and function of HIF1α, the labile subunit of HIF1, remain to be elucidated. Herein we showed that LUBAC increases HIF1α protein expression in cultured cells and tissues of human lung cancer and enhances HIF1α DNA-binding and transcriptional activities, which are dependent upon LUBAC enzymatic activity. Mechanistically, LUBAC increases HIF1α stability through antagonizing HIF1α decay by the chaperone-mediated autophagy (CMA)-lysosome pathway, thereby potentiating HIF1α activity. We further demonstrated that HIF1α selectively interacts with HOIP (the catalytic subunit of LUBAC) primarily in the cytoplasm. LUBAC catalyzes linear ubiquitination of HIF1α at lysine 362. Linear ubiquitination shields HIF1α from interacting with heat-shock cognate protein of 70 kDa and lysosome-associated membrane protein type 2 A, two components of CMA. Consequently, linear ubiquitination confers protection against CMA-mediated destruction of HIF1α, increasing HIF1α stability and activity. We found that prolyl hydroxylation is not a perquisite for LUBAC’s effects on HIF1α. Functionally, LUBAC facilitates proliferation, clonogenic formation, invasion and migration of lung cancer cells. LUBAC also boosts angiogenesis and exacerbates lung cancer growth in mice, which are greatly compromised by inhibition of HIF1α. This work provides novel mechanistic insights into the role of LUBAC in regulating HIF1α homeostasis, tumor angiogenesis and tumorigenesis of lung cancer, making LUBAC an attractive therapeutic target for cancers.

To solve the problem of difficulty in predicting the impact point clearly and promptly during projectile flight, this paper proposes an improved ballistic-impact-point prediction method. A certain type of high-spinning tailed projectile is taken as the research object for online real-time landing point prediction research. This study comprehensively utilizes the real-time radar measurement data and the geomagnetic data measured by the bomb-carried geomagnetic sensor. It applies the four-degree-of-freedom ballistic model to predict the landing point. First, the roll angular velocity is calculated based on the geomagnetic data, after which the radar real-time measurement data are segmentally fitted using the improved crayfish algorithm. Then, the fitted parameters are substituted into the four-degree-of-freedom ballistic model. Finally, the C-K method is used to identify the aerodynamic parameters, and the identified aerodynamic parameters are used for fallout prediction. The simulation results show a small deviation between the predicted and actual impact points using the improved ballistic-impact-point prediction method.

In order to reduce the actual impact of a saline–alkali environment on maize production in semi-arid areas, it is particularly important to use the combined fertilization strategy of Trichoderma microbial fertilizer and nitrogen fertilizer. The purpose of this study was to investigate the effects of different concentrations of nitrogen fertilizer combined with Trichoderma on improving the structural characteristics and ecological functions of maize rhizosphere microbial community in semi-arid saline–alkali soil. Through the microbiome analysis of maize rhizosphere soil samples with 60 kg N·ha−1 (N1) and 300 kg N·ha−1 (N2) nitrogen fertilizer combined with Trichoderma (T1) and without Trichoderma (T0), we found that the combination of Trichoderma and different concentrations of nitrogen fertilizer significantly affected the structure of bacterial and fungal communities. The results of this study showed that the combination of Trichoderma and low-concentration nitrogen fertilizer (N1T1) could improve soil nutritional status and enhance its productivity potential, revealing the relationship between beneficial and harmful fungal genera, microbial diversity and abundance, and crop biomass, which is of great significance for improving agricultural production efficiency and sustainable development.

Aimed at addressing the strong nonlinearity and strong external disturbances that cause flight control issues in conventional guided projectiles, as well as the slow response and structural vibrations that often occur in sliding mode control systems, which have a detrimental impact on the control effect and ultimate hit precision, a new type of fast and robust control algorithm with a unidirectional mode has been designed. The objective is to design an optimized aerodynamic shape for the projectile and to establish a dynamic model of the roll channel and a motion model of the entire trajectory. The dynamics of a new global terminal sliding mode are proposed, and an adaptive parameter term is realized by calculating the state of the critical sliding mode surface, which ensures that the tracking error converges within a finite time. Its combination with an adaptive approaching law is used to further speed up convergence while damping the structural vibration of the system. The bias error of the roll angle is constructed as the controller and simulation calculations are conducted on the basis of the aforementioned framework. The stability and time convergence of the control system are demonstrated through Lyapunov theory. The results indicate that, in comparison to the conventional terminal sliding mode controller, the designed controller exhibits a markedly rapid convergence rate and stronger robustness in tracking the command signal. Moreover, it also maintains a stable motion attitude of the projectile throughout the entire process. The superior control effect under different guidance schemes and the strong external disturbances also further reflect the anti-jamming capability and tracking performance of the system.

Abstract Data on the safety and immunity of a heterologous booster (fourth dose) after three-doses of inactivated SARS-CoV-2 vaccine in Chinese adults are limited. We evaluate the safety and immunogenicity of Ad5-nCoV in a randomized, double-blind, parallel-controlled phase 4 clinical trial in Zhejiang, China (NCT05373030). Participants aged 18–80 years (100 per group), administered three doses of inactivated SARS-CoV-2 vaccine ≥6 months earlier, are enrolled and randomized 1:1 into two groups, which are administered intramuscular Ad5-nCoV or inactivated SARS-CoV-2 vaccine (CoronaVac or Covilo). All observed adverse reactions are predictable and manageable. Ad5-nCoV elicits significantly higher RBD-specific IgG levels, with a geometric mean concentration of 2924.0 on day 14 post-booster, 7.8-fold that of the inactivated vaccine. Pseudovirus-neutralizing antibodies to Omicron BA.4/5 show a similar pattern, with geometric mean titers of 228.9 in Ad5-nCoV group and 65.5 in inactivated vaccine group. Ad5-nCoV booster maintains high antibody levels on day 90, with seroconversion of 71.4%, while that of inactivated vaccine is 5.2%, almost pre-booster levels. A fourth Ad5-nCoV vaccination following three-doses of inactivated SARS-CoV-2 vaccine is immunogenic, tolerable, and more efficient than inactivated SARS-CoV-2 vaccine. Ad5-nCoV elicits a stronger humoral response against Omicron BA.4/5 and maintains antibody levels for longer than homologous boosting.

ObjectiveTo provide both empirical support and a theoretical framework for systematically improving and optimizing the cognitive capabilities of college students through physical activity, while considering the mediating and regulating impacts of self-efficacy and negative emotion.MethodsThe study employed an overall random sampling method, examining 500 college students from five universities in Jiangsu Province using the Physical Activity Rating Scale (PARS-3), Adult Executive Function Scale (ADEXI), Positive and Negative Emotion Scale (PANAS), and General Self-Efficacy Scale (GSES).ResultsThe findings indicated that the average age of the participants was 18.41 ± 0.73 years, encompassing 215 male students (43%), and 185 female students (57%). Engagement in physical activity was significantly and positively correlated with executive function (β = 0.246, p

Fast and accurate infrared (IR) sea–sky line region (SSLR) detection can improve the early warning capability of the small targets that appear in the remote sea–sky junction. However, the traditional algorithms struggle to achieve high precision, while the learning-based ones have low detection speed. To overcome these problems, a novel learning-based algorithm is proposed; rather than detecting the sea–sky line first, the proposed algorithm directly provides SSLR, which mainly consists of three parts: Firstly, an IR sea–sky line region detection module (ISRDM) is proposed, which combines strip pooling and the connection mode of a cross-stage partial network to extract the features of the SSLR target, with an unbalanced aspect ratio, more specifically, thus improving the detection accuracy. Secondly, a lightweight backbone is presented to reduce the parameters of the model and, therefore, improve the inference speed. Finally, a Detection Head Based on the spatial-aware attention module (SAMHead) is designed to enhance the perception ability of the SSLR and further reduce the inference time. Extensive experiments conducted on three datasets with more than 26,000 frames show that the proposed algorithm achieved approximately 80% average precision (AP), outperforms the state-of-the-art algorithms in accuracy, and can realize real-time detection.

Microcatheters capable of active guidance have been proven to be effective and efficient solutions to interventional surgeries for cardiovascular and cerebrovascular diseases. Herein, a novel microcatheter made of two biocompatible materials, shape memory alloy (SMA) and polyethylene (PE), is proposed. It consists of a reconfigurable distal actuator and a separate polyethylene catheter. The distal actuator is created via embedding U-shape SMA wires into the PE base, and its reconfigurability is mainly dominated by the shape memory effect (SME) of SMA wires, as well as the effect of thermal mismatch between the SMA and PE base. A mathematical model was established to predict the distal actuator’s deformation, and the analytical solutions show great agreement with the finite element results. Structural optimization of such microcatheters was carried out using the verified analytical model, followed by fabrication of some typical prototypes. Experimental testing of their mechanical behaviors demonstrates the feasibility of the structural designs, and the reliability and accuracy of the mathematical model. The active microcatheter, together with the prediction model, will lay a solid foundation for rapid development and optimization of active navigation strategies for vascular interventions.

IntroductionThis study aimed to develop and assess a deep-learning model based on CT images for distinguishing infectivity in patients with pulmonary tuberculosis (PTB).MethodsWe labeled all 925 patients from four centers with weak and strong infectivity based on multiple sputum smears within a month for our deep-learning model named TBINet's training. We compared TBINet's performance in identifying infectious patients to that of the conventional 3D ResNet model. For model explainability, we used gradient-weighted class activation mapping (Grad-CAM) technology to identify the site of lesion activation in the CT images.ResultsThe TBINet model demonstrated superior performance with an area under the curve (AUC) of 0.819 and 0.753 on the validation and external test sets, respectively, compared to existing deep learning methods. Furthermore, using Grad-CAM, we observed that CT images with higher levels of consolidation, voids, upper lobe involvement, and enlarged lymph nodes were more likely to come from patients with highly infectious forms of PTB.ConclusionOur study proves the feasibility of using CT images to identify the infectivity of PTB patients based on the deep learning method.

To predict long term device aging under use bias, models extracted from voltage accelerated tests must be extrapolated into the future. The traditional model uses a power law, to linearly fit the test data on a log-log plot, and then extrapolates aging kinetics. The challenge is that the measured data do not always follow a straight line on the log-log plot, calling the accuracy of such prediction into question. Although there are models that can fit test data well in this case, their prediction capability for future aging is typically not verified. The key advance of this work is the development of a methodology for extracting models that can verifiably predict future aging over a wide (Vg, Vd) bias space, when aging kinetics do not follow a simple power law. This is achieved by experimentally separating aging into four types of traps and modelling each of them by a straight line individually. The applicability of this methodology is verified on 3 different CMOS processes where it can predict aging at least 3 orders of magnitude into the future. The contributions of each type of traps across the (Vg, Vd) space are mapped. It is also shown that good fitting with test data does not warrant good prediction, so that good fitting should not be used as the only criterion for validating a model.

The Yellow River (YR) is famous for its ‘hanging river’ due to the high sedimentation rate in the lower reaches. Reservoir sediment retention (RSR) and water–sediment regulation (WSR) of the Xiaolangdi Reservoir (XLDR) contribute to mitigating the siltation and adjusting the bankfull channel geometry in the lower Yellow River (LYR). However, few studies have been conducted to quantify the contribution of RSR and WSR to medium-sized channel shaping. In this paper, we analyzed the temporal and spatial variations of bankfull discharge (BFD) in the LYR, established empirical expressions between the BFD and the previous five-year average discharge above 2,000 m3/s and the incoming sediment coefficient during flood seasons, and then constructed three different water and sediment scenarios to quantify the contribution of the WSR of the XLDR to medium-sized channel shaping in the LYR. Calculated results indicated that WSR accounted alone for 68%–94% of the medium-sized channel shaping, with RSR contributing 6%–32%. The contribution of WSR to the recovery of medium-sized channels increased with time and became stabilized eventually. Along the LYR, such contribution also increased from 68% to 97% and eventually became stabilized in narrow reaches, reaching over 90%. The results will lay a solid technical foundation for the WSR of the XLDR, river regulation downstream of the reservoir, and sediment disposal of the YR. HIGHLIGHTS The contributions of RSR and WSR to the medium-sized channel shaping of the LYR were 88% and 12% respectively in the period 2002–2015.; Contribution rate of WSR to medium-sized channel shaping increased first and then became stabilized with time.; The influence of WSR on medium-sized channel shaping increased and eventually became stabilized in narrow reaches along the LYR.;

Dried instant rice noodles are a convenience food, and they have shown rapid development in recent years. However, there are many disadvantages of dried instant rice noodles, such as long rehydration time, high turbidity of soup, high break rate, poor taste, and disappointing textural properties. In this study, to overcome these disadvantages, freeze-dried rice noodles were prepared at freezing temperatures of −10, −20, and −40 ℃ by the vacuum freeze-drying process, which were called FDRN10, FDRN20, and FDRN40, respectively. The factors that affected the rehydration quality of freeze-dried rice noodles were investigated by analyzing the rehydration speed, microstructure, starch retrogradation, and texture characteristics at different water temperatures. The results showed that FDRN10 had the highest water content of the three freeze-dried rice noodles for the same water temperature and rehydration time. This indicated that the rehydration speed of FDRN10 was the fastest. The microstructures of the external surface and cross section were observed. FDRN10 had the loosest structure and largest aperture. The diameter of the aperture of FDRN10 was 72.58 µm, which was four times larger than that of FDRN40. This microstructure led to FDRN10 showing good water absorption. Differential scanning calorimetry showed that the enthalpy of FDRN10 was 92.98 J/g. The enthalpy of FDRN40 was the lowest (12.39 J/g). Thus, FDRN10 had the highest level of starch retrogradation among the three freeze-dried rice noodle samples, and the lowest level of starch water-absorbing swelling. Hardness analysis showed that the hardness value of FDRN10 decreased with increasing water temperature for the same rehydration time. The texture characteristics of FDRN10 were the closest to those of fresh rice noodles after rehydrating with water at 70 ℃ for 8 min. The above results indicate that the freezing temperature and rehydration temperature play important roles in the quality of freeze-dried rice noodles. This study provides an innovative process for improvement of instant-rice-noodle production.

Sediment accumulation is severe in the Lower Yellow River. Improving sediment-transport efficiency is an important way to save water resources. In this study, we analyzed the sediment-transport efficiency at different sediment concentrations and discharge levels using data from 306 non-overbank floods in the lower reaches of the Yellow River from 1960 to 2016. When the sediment concentrations were below 20 kg/m3, 60 kg/m3, and greater than 100 kg/m3, the clear water volumes for transporting sediment were above 50 m3/t, approximately 16 m3/t, and less than 10 m3/t, respectively. Given current scheduling, the Xiaolangdi Reservoir can lower its water level and increase non-overbank large water flows with an outflow discharge of >3,000 m3/s when the incoming water flow has a sediment concentration of >60 kg/m3. Mathematical modeling indicates that, for an incoming sediment load of 600 million tons in the Middle Yellow River, the average sediment-transport water volume at the downstream Huayuankou Station decreased by 27%, Optimized scheduling at the Xiaolangdi Reservoir could reduce the sedimentation in the downstream channel by 1.1 billion tons more than current scheduling, and extend the reservoir's sediment-trapping period by ten years. These findings can be applied widely in sandy rivers. HIGHLIGHTS The sediment-transport efficiency and associated sediment-transport clear water volume in the lower reaches of the Yellow River were modeled in this study.; The sediment-transport clear water volume of the river channel decreased with increasing sediment concentration.; Optimizing operation of Xiaolangdi Reservoir can improve the sediment-transport efficiency and reduce sedimentation in the Lower Yellow River.;

Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our understanding about the influence of intestinal microbiota on host tryptophan metabolism is limited. Thus, we established germ-free (GF) pig models to systemically explore the influence of intestinal microbiota on tryptophan metabolism. Five GF pigs were kept in GF conditions throughout the experiment (GF group). Six GF pigs were transplanted with fecal microbiota from donor sows to act as control pigs. Compared with control pigs, the GF pigs had remarkable alterations in tryptophan metabolism. The differential metabolites (P

Abstract Background We designed a new surgical procedure to treat benign prostatic hyperplasia(BPH). In order to verify its effectiveness and safety, we constructed this randomized controlled trial to compare the efficacy of our innovative enucleation technique- photoselective sharp enucleation of the prostate (PSEP), with a front-firing 532-nm laser and the traditional technique-photoselective vaporization of the prostate (PVP) in the treatment of BPH. Methods A total of 154 consecutive patients diagnosed with bladder outlet obstruction secondary to BPH in our center from June 2018 to April 2019 were randomly divided into the PSEP group (n = 77) and the PVP group (n = 77) and were treated surgically with either PSEP or PVP. All patients were assessed preoperatively and followed up at 1, 6, and 12 months postoperatively. The international prostate symptom score,quality-of-life score, postvoid residual urine volume, maximum urine flow rate, prostate volume, prostate-specific antigen, and adverse events were compared. Results The lower urinary tract symptoms in both groups were significantly improved compared with the baseline at 1, 6, and 12 months postoperatively. The PSEP and PVP groups had an equivalent International Prostate Symptom Score, quality-of-life score, postvoid residual urine volume, maximum urine flow rate, prostate-specific antigen at each follow-up (P > 0.05). The median operative time in the PSEP group was significantly shorter than that in the PVP group (35 min vs. 47 min, P

IntroductionThere is limited evidence regarding particulate matter (PM)’s short-term effects on pulmonary tuberculosis (PTB) hospital admission. Our study aimed to determine the short-term associations of the exposure to ambient PM with aerodynamic diameters

Aero engines are the key power source for aerospace vehicles. Cermet turbine blades are the guarantee for the new-generation fighters to improve aero-engine overall performance. X-ray non-destructive reconstruction can obtain the internal structure and morphology of cermet turbine blades. However, the beam hardening effect causes artifacts in objects and affects the reconstruction quality, which is an issue that needs to be solved urgently. This study proposes a hardening-correction framework for industrial computed tomography (ICT) images based on iterative linear fitting. First, an iterative binarization was performed to improve the penetration length accuracy of the forward projection. Then, the proposed linear fitting technology combined with the Hermite function model is derived and analyzed to obtain suitable parameters of blade data. Finally, the fitting curves of the blade data, using the proposed method and the traditional polynomial fitting method, were analyzed and compared and were used to correct the engine turbine blade projection data to reconstruct different groups of tomographic images. Different groups of tomographic images were analyzed using three quantitative image quality evaluation indicators. The results show that the root-mean-square error (RMSE) of the tomographic image obtained by the proposed framework is 0.0133, which is lower than that of the compared method. The peak signal-to-noise ratio (PSNR) is 37.7050 dB and the feature structural similarity (FSIM) is 0.9881, which are both higher than that of the compared method. The proposed method improves the hardening-artifact-correction capability and can obtain higher-quality images, which provides new ideas for the development of imaging and detection of new-generation aero-engine turbine blades.

We update the H i surface density measurements for a subset of 17 THINGS galaxies by dealing with the short-spacing problem of the original Very Large Array (VLA) H i images. It is the same sample that Bigiel et al. used to study the relation between H i surface densities and star formation (SF) rate surface densities in galaxy outer disks, which are beyond the optical radius r _25 . For 10 galaxies, the update is based on combining original THINGS VLA H i images with H i images taken by the single-dish FAST in the FEASTS program. The median increment of H i surface densities in outer disks is 0.15–0.4 dex at a given new H i surface density. Several galaxies change significantly in the shape of radial profiles H i surface densities, and seven galaxies are now more than 1 σ below the H i size–mass relation. We update the H i star formation laws in outer disks. The median relation between the H i surface densities and SF rate surface densities based on pixel-wise measurements shifts downward by around 0.15 dex because the H i surface density values shift rightward, and the scatter increases significantly. The scatter of the relation, indicating the star-forming efficiency, exhibits a much stronger positive correlation with the stellar mass surface density than before. Thus, detecting the previously missed, diffuse H i due to the short-spacing problem of the Very Large Array observations is important in revealing the true condition and variation in SF possibly regulated by stellar feedbacks in the localized environment of outer disks.

Using K-nearest neighbor (KNN) to predict mortality is an important mean to positively affect patient health. However, it is difficult for KNN to use a single distance to accurately measure the distance of samples with discrete and continuous variables. Furthermore, the voting method applied in KNN cannot measure the impact of distance on results. To solve above problems, a KNN mortality prediction model with mixed weighted distance was proposed. First, the chi-square test and logistic regression with L1 regularization are used for feature selection and ranking. Next, a mixture of Value Difference Metric (VDM) and Manhattan distance is applied to calculate the distance. Then, the softmin function is chosen to weight the distance and finally give the category for testing sample. In the end, the data of 2 743 htart failure patients in the MIMIC-III public database were experimentally evaluated, which verifies that the improved algorithm has a good performance in mortality prediction.

Giant strains in (Bi0.5Na0.5)TiO3 based ceramics are usually attributed to electric field induced nonpolar to polar phase transition. Whether it is an ergodic relaxor R3c/P4mm ferroelectric (FE) to long-range ordered FE phase transformation or a reversible P4bm antiferroelectric (AFE) to FE phase transition is still unclear. Herein, lead-free (0.88-x)(Bi0.5Na0.5)TiO3-0.12BaTiO3-xNaNbO3 ceramics exhibit a composition-modulated FE tetragonal P4mm to relaxor AFE tetragonal P4bm phase transition, in which double hysteresis loop, sprout-shaped S-E curves, near-zero quasi-static d33 together with a large volume change suggest the AFE characteristics of P4bm phase. An interesting finding is that the reversibility of field-induced AFE P4bm phase to FE P4mm phase transition strongly depends on the NN content, from being completely irreversible at x = 0.01–0.02, to partially reversible at x = 0.03–0.05, and finally to completely reversible at x = 0.06–0.08. It is indicated that the variation of reversibility should be attributed to the change of relative free energy caused by decreasing the FE to AFE phase transition temperature with increasing the NN content.

Abstract Electrical discharge erosion in liquid media is a simple, effective technique to generate multi-scale metallic particles. An experimental investigation was conducted to determine the main machining parameters which contribute to particle size (PS) and size distribution (SD) in WEDM of bronze. Five factors, including three-level built-in processing patterns, wire speed and dielectric medium, are selected as control parameters using an orthogonal array L16(45) Taguchi method, PS and SD of produced powders are the measure of quality. The goal is to obtain micron-scale spherical metal powder with uniform particle size. Results show that cutting-section pattern is the most significant factor, and the electrolyte is the least. The PS and SD performance of the optimized powders is significantly improved by using Taguchi method. Spherical bronze powder with particle size of d10 11.05 μm, d50 31.13 μm and d90 67.48 μm are prepared using the optimized WEDM process parameter, which is A3–B4–C3–D1–E1 including dielectric medium water, cutting class 4, cutting division 3, cutting Sect. 1 and wire speed 200 μm/s. The research confirms that WEDM can be used to produce micron-scale metallic powders, providing cheap and high-quality metallic powders for the metal additive manufacturing industry.

Abstract Atherosclerosis is a maladaptive chronic inflammatory disease, which remains the leading cause of death worldwide. The NLRP3 inflammasome constitutes a major driver of atherosclerosis, yet the mechanism of action is poorly understood. Mitochondrial dysfunction is essential for NLRP3 inflammasome activation. However, whether activated NLRP3 inflammasome exacerbates mitochondrial dysfunction remains to be further elucidated. Herein, we sought to address these issues applying VX765, a well-established inhibitor of caspase 1. VX765 robustly restrains caspase 1-mediated interleukin-1β production and gasdermin D processing. Our study assigned VX765 a novel role in antagonizing NLRP3 inflammasome assembly and activation. VX765 mitigates mitochondrial damage induced by activated NLRP3 inflammasome, as evidenced by decreased mitochondrial ROS production and cytosolic release of mitochondrial DNA. VX765 blunts caspase 1-dependent cleavage and promotes mitochondrial recruitment and phosphorylation of Parkin, a key mitophagy regulator. Functionally, VX765 facilitates mitophagy, efferocytosis and M2 polarization of macrophages. It also impedes foam cell formation, migration and pyroptosis of macrophages. VX765 boosts autophagy, promotes efferocytosis, and alleviates vascular inflammation and atherosclerosis in both ApoE −/− and Ldlr −/− mice. However, these effects of VX765 were abrogated upon ablation of Nlrp3 in ApoE −/− mice. This work provides mechanistic insights into NLRP3 inflammasome assembly and this inflammasome in dictating atherosclerosis. This study highlights that manipulation of caspase 1 paves a new avenue to treatment of atherosclerotic cardiovascular disease.

Compared with antiferroelectric (AFE) orthorhombic R phases, AFE orthorhombic P phases in NaNbO3 (NN) ceramics have been rarely investigated, particularly in the field of energy-storage capacitors. The main bottleneck is closely related to the contradiction between difficultly-achieved stable relaxor AFE P phase and easily induced P-R phase transition during modifying chemical compositions. Herein, we report a novel lead-free AFE ceramic of (1-x)NN-x(Bi0.5K0.5)ZrO3 ((1-x)NN-xBKZ) with a pure AFE P phase structure, which exhibits excellent energy-storage characteristics, such as an ultrahigh recoverable energy density (Wrec) ∼4.4 J/cm3 at x = 0.11, a large powder density PD ∼104 MW/cm3 and a fast discharge rate t0.9–45 ns. The analysis of polarization-field response, Raman spectrum and transmission electron microscopy demonstrates that the giant amplification of Wrec by ≥ 177 % should be mainly ascribed to the simultaneously and effectively enhanced AFE P-phase stability and its relaxor characteristics, resulting in a diffused reversible electric field-induced AFE P-ferroelectric phase transition with concurrently increased driving electric fields. Different from most (1-x)NN-xABO3 systems, it was found that the reduced polarizability of B-site cations dominates the enhanced AFE P-phase stability in (1-x)NN-xBKZ ceramics, but the almost unchanged tolerance factor tends to cause the AFE R phase to be induced at a relatively high x value.

Background: Although inactivated COVID-19 vaccines are proven to be safe and effective in the general population, the dynamic response and duration of antibodies after vaccination in the real world should be further assessed. Methods: We enrolled 1067 volunteers who had been vaccinated with one or two doses of CoronaVac in Zhejiang Province, China. Another 90 healthy adults without previous vaccinations were recruited and vaccinated with three doses of CoronaVac, 28 days and 6 months apart. Serum samples were collected from multiple timepoints and analyzed for specific IgM/IgG and neutralizing antibodies (NAbs) for immunogenicity evaluation. Antibody responses to the Delta and Omicron variants were measured by pseudovirus-based neutralization tests. Results: Our results revealed that binding antibody IgM peaked 14–28 days after one dose of CoronaVac, while IgG and NAbs peaked approximately 1 month after the second dose then declined slightly over time. Antibody responses had waned by month 6 after vaccination and became undetectable in the majority of individuals at 12 months. Levels of NAbs to live SARS-CoV-2 were correlated with anti-SARS-CoV-2 IgG and NAbs to pseudovirus, but not IgM. Homologous booster around 6 months after primary vaccination activated anamnestic immunity and raised NAbs 25.5-fold. The neutralized fraction subsequently rose to 36.0% for Delta (p=0.03) and 4.3% for Omicron (p=0.004), and the response rate for Omicron rose from 7.9% (7/89)–17.8% (16/90). Conclusions: Two doses of CoronaVac vaccine resulted in limited protection over a short duration. The inactivated vaccine booster can reverse the decrease of antibody levels to prime strain, but it does not elicit potent neutralization against Omicron; therefore, the optimization of booster procedures is vital. Funding: Key Research and Development Program of Zhejiang Province; Key Program of Health Commission of Zhejiang Province/ Science Foundation of National Health Commission; Major Program of Zhejiang Municipal Natural Science Foundation; Explorer Program of Zhejiang Municipal Natural Science Foundation.

Heart failure (HF) is the final stage of the various heart diseases developing. The mortality rates of prognosis HF patients are highly variable, ranging from 5% to 75%. Evaluating the all-cause mortality of HF patients is an important means to avoid death and positively affect the health of patients. But in fact, machine learning models are difficult to gain good results on missing values, high dimensions, and imbalances HF data. Therefore, a deep learning system is proposed. In this system, we propose an indicator vector to indicate whether the value is true or be padded, which fast solves the missing values and helps expand data dimensions. Then, we use a convolutional neural network with different kernel sizes to obtain the features information. And a multi-head self-attention mechanism is applied to gain whole channel information, which is essential for the system to improve performance. Besides, the focal loss function is introduced to deal with the imbalanced problem better. The experimental data of the system are from the public database MIMIC-III, containing valid data for 10311 patients. The proposed system effectively and fast predicts four death types: death within 30 days, death within 180 days, death within 365 days and death after 365 days. Our study uses Deep SHAP to interpret the deep learning model and obtains the top 15 characteristics. These characteristics further confirm the effectiveness and rationality of the system and help provide a better medical service.

Abstract Allograft-specific regulatory T cells (Treg cells) are crucial for long-term graft acceptance after transplantation. Although adoptive Treg cell transfer has been proposed, major challenges include graft-specificity and stability. Thus, there is an unmet need for the direct induction of graft-specific Treg cells. We hypothesized a synergism of the immunotolerogenic effects of rapamycin (mTOR inhibition) and plerixafor (CXCR4 antagonist) for Treg cell induction. Thus, we performed fully-mismatched heart transplantations and found combination treatment to result in prolonged allograft survival. Moreover, fibrosis and myocyte lesions were reduced. Although less CD3+ T cell infiltrated, higher Treg cell numbers were observed. Noteworthy, this was accompanied by a plerixafor-dependent plasmacytoid dendritic cells-(pDCs)-mobilization. Furthermore, in vivo pDC-depletion abrogated the plerixafor-mediated Treg cell number increase and reduced allograft survival. Our pharmacological approach allowed to increase Treg cell numbers due to pDC-mediated immune regulation. Therefore pDCs can be an attractive immunotherapeutic target in addition to plerixafor treatment.

Yearly administration of influenza vaccine with recommendations can help control seasonal influenza epidemics in adults aged ≥60 years. Here, we describe the results of a prospective study observing the immunogenicity and persistence of induced immunity of a trivalent inactivated split-virion influenza vaccine (TIV) in adults aged ≥60 years during the 2018–2019 season in Taizhou City, Zhejiang Province in China. A total of 422 participants completed the study period. Vaccinated participants (284) received a single dose of TIV, but unvaccinated participants (138) didn’t receive any vaccine. Study participants vaccinated with TIV had significantly higher GMTs of Hemagglutination Inhibition (HI) antibodies against AH1N1, AH2N3, and B/Victoria strains (all p

Aiming at the time-consuming, laborious, and inefficient process of removing abnormal rape plants during breeding, combined with the agronomic requirements for planting rapeseed, a clamping manipulator was designed. This manipulator is mainly composed of hollow splints, grip-force sensors, connecting rods, cylinders and other components. Additionally, a removing test platform was built. Single-factor and Box-Behnken experiments were conducted. Taking the output air pressure, pulling angle and pulling speed as the test factors, the rape uprooted removal rate, rape removal breakage rate and pulling force were the test indicators. Mathematical models for multiple regression were established separately for each evaluation index, and analysis of variance was conducted. Objective optimization was performed using the Numerical component to obtain the optimal combination of operating parameters: output air pressure of 0.47 MPa, pulling angle of 68.8° and extraction speed of 8 cm/s. The field validation test showed that the uprooted removal rate was 83.33%, the removal breakage rate was 6.67% and the pulling force was 84.9 N at the output air pressure of 0.5 MPa, pulling angle of 70° and pulling speed of 8 cm/s. The validation test values are in good agreement with the parameter optimization values, indicating that the parameter optimization model is reasonable.

Despite the lack of blockchain systems being utilized in modern IoT environments, the prevalence of blockchain technology is increasing, due to its high level of security and accountability. The integration of blockchain technology and access control in a decentralized system for smart home networks is a promising solution to this issue. This paper compares the implementation of attribute-based access control (ABAC) with two popular blockchain platforms, Ethereum and Hyperledger Fabric, for a smart home internet of things (IoT) environment. We present a comprehensive summary of access-control and blockchain-access-control methods, to provide the necessary background for this study. Additionally, we present an original ABAC smart contract for Ethereum, and the modification of a pre-existing Hyperledger Fabric ABAC smart contract, for this comparison. Through the simulation of both implementations, the advantages and limitations will be considered, to determine which is better suited for a smart home IoT environment.

Ras-related GTP-binding protein A (RagA), encoded by RRAGA gene, initially senses the availability of cellular amino acids (e.g., leucine) and controls the translocation of mTORC1 to the lysosomal membrane. RagA overexpression appears to be associated with the onset of depression. To discover the biological roles of RagA, we employed the CRISPR/Cas9 system to generate a RRAGA gene knockout stem cell line from human induced pluripotent stem cell (iPSC) iPSN0003. Such RRAGA knockout iPSC cell line may help the development of new therapeutics for depression.

Abstract Background Clear cell renal cell carcinoma (ccRCC) is a common malignant tumour of the urinary tract. The major causes of poor prognosis are the lack of early diagnosis and metastasis. Accumulating research reveals that circular RNAs (circRNAs) can play key roles in the development and the progression of cancer. However, the role of circRNAs in ccRCC is still uncertain. Methods The circRNAs microarray (n = 4) was performed to investigate the circRNAs with differential expression in ccRCC tissues. The candidate circRNA was selected based on the cut‐off criteria, such as circRNA expression abundance, circRNA size and the design of divergent primers. The circ‐transportin‐3 (TNPO3) levels in ccRCC tissues were tested by quantitative real‐time (qRT)‐PCR (n = 110). The characteristics and subcellular localization of circ‐TNPO3 were identified via RNase R assay, qRT‐PCR and fluorescence in situ hybridization (FISH). Then, we explored the biological roles of circ‐TNPO3 in ccRCC via the function experiments in vitro and in vivo. RNA pull‐down, RNA immunoprecipitation, bioinformatic analysis, RNA‐FISH assays and rescue assays were applied to validate the interactions between circ‐TNPO3, insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) and serpin family H member 1 (SERPINH1) to uncover the underlying molecular mechanisms of circ‐TNPO3. Results We detected the obvious downregulation of circ‐TNPO3 in ccRCC compared to matched adjacent normal tissues (n = 110). The lower circ‐TNPO3 expression was found in ccRCC patients with distant metastasis, higher World Health Organization/International Society of Urologic Pathologists (WHO/ISUP) grade and more advanced tumour T stage. In vitro and in vivo, circ‐TNPO3 significantly suppressed the proliferation and migration of ccRCC cells. Mechanistically, we elucidated that circ‐TNPO3 directly bound to IGF2BP2 protein and then destabilized SERPINH1 mRNA. Moreover, IGF2BP2/SERPINH1 axis was responsible for circ‐TNPO3's function of inhibiting ccRCC metastasis. Epithelial splicing regulatory protein 1 (ESRP1) was probably involved in the biogenesis of circ‐TNPO3. Conclusions Circ‐TNPO3 can suppress ccRCC progression and metastasis via directly binding to IGF2BP2 protein and destabilizing SERPINH1 mRNA. Circ‐TNPO3 may act as a potential target for ccRCC treatment.

BackgroundMental health has become a major public health issue worldwide. Biological and epidemiological studies have suggested that diet and physical fitness play a role in the prevention or cure of mental disorders. However, further research is required to elucidate the relationship between diet, physical fitness, and mental health. The study aims to provide a theoretical basis for promoting an adolescent healthy lifestyle and preventing mental problems by exploring the relationship between physical fitness, calcium intake, calorie intake, and adolescent mental health.MethodsA cross-sectional study of a sample of adolescents (N = 253, 12–13 years) was conducted. The study involved adolescents from three middle schools in Central Jiangsu Province, including 136 boys and 117 girls. Weight, height, and body mass index were measured. Physical fitness was scored using the Chinese National Student Physical Fitness Standard. Diet data were collected using a weighed 7-day food diary to estimate energy intake and dietary calcium intake. The mental health status of the participants was assessed using the Chinese Middle School Student Mental Health Scale. A T-test and analysis of variance were used to analyze the differences of variables between different genders and body mass index, and Pearson correlation and stepwise multiple regression were used to explore the relationship between physical fitness, dietary intake, and mental health.ResultsThe height (165.13 ± 8.07), weight (55.24 ± 13.00), and strength quality (64.93 ± 21.66) of boys are higher than those of girls (161.67 ± 6.44,48.99 ± 8.97, 58.40 ± 23.75, P < 0.05), and the flexibility quality (74.59 ± 14.75) of girls is higher than that of boys (68.30 ± 20.84) (P < 0.05). There were significant differences in the total scores of speed and physical fitness (F values were 4.02187.73, 3.07, 5.95, 10.33, and 9.52, respectively, P < 0.05). There was a significant positive correlation between calcium intake, cardiopulmonary fitness, and mental health (r = 0.276, P < 0.01; r = 0.159, P < 0.05). Calcium intake and cardiopulmonary fitness could explain 8.4% of the changes in the mental health of adolescents aged 12–13(ΔR2 = 0.084, P < 0.05).ConclusionAdequate calcium intake and the improvement of cardiopulmonary fitness in adolescents aged 12–13 are essential for the good development of their mental health. Future research in this field should examine the prospective associations between multiple measures of physical fitness composition and other nutrients ingested and mental health outcomes, as well as intervention studies that seek to provide evidence of causality.

ASGR1 is a liver-specific surface marker that has been used to purify human pluripotent stem cell (PSC)-derived hepatocytes (iHeps). Furthermore, ASGR1+ iHeps represents a more mature subpopulation of iHeps. To utilize this marker for optimizing iHep differentiation and purification, we substituted the stop coden of ASGR1 with a fluorescent reporter protein mCherry in a human iPSC line iPSN0052 via CRISPR/Cas9-mediated homologus recombination. The generated CIBi010-A enableds us to monitor ASGR1 expression during hepatic differentiation and thus can be used to optimize our hepatic differentiation procedures.

Abstract A significant proportion of the land area of Heilongjiang Province, China, is composed of saline–alkaline soil, which severely inhibits maize growth. Although Trichoderma treatment is widely regarded as a promising strategy for improving the soil environment and promoting plant growth, the mechanism through which Trichoderma asperellum enhances maize resistance to saline–alkaline stress is not clear. In this study, we explored the effect of T. asperellum application at different concentrations to soil saline–alkaline environment on the seedlings of two maize cultivars, assessing the biochemical parameters related to oxidation resistance. Increasing spore densities of T. asperellum suspension effectively regulated the soil ion balance in the rhizosphere of maize seedlings, reduced the soil pH by 2.15–5.76% and sodium adsorption ratios by 22.70–54.13%, increased soil nutrient content and enzyme activity, and improved the soil environment for seedling growth. Additionally, T. asperellum treatment increased the maize seedling content of osmo-regulating substances and rate of glutathione:oxidised glutathione (43.86–88.25%) and ascorbate:oxidised ascorbate (25.26–222.32%) by affecting the antioxidant enzyme activity in the roots, increasing reactive oxygen species scavenging, and maintaining the osmotic balance and metabolic homeostasis under saline–alkaline stress. T. asperellum also improved the saline–alkaline tolerance of maize seedlings by improving the root growth characteristics. Moreover, results showed that Trichoderma applied at high concentration had the greatest effect. In conclusion, improvement in the saline–alkaline tolerance of maize seedlings by T. asperellum under saline–alkaline soil conditions may be achieved through diverse effects that vary among maize cultivars.

Intensive vegetable production has been characterized by high nitrogen (N) fertilizer input in southwest China. Optimizing the N fertilizer rate is the basis for the optimal management of regional N fertilizer. A two-year field experiment with five N fertilizer rates was conducted during 2019–2021 in southwest China, and the aim of this study was to identify the effects of different N application rates on yield, dry matter biomass (DMB), N uptake, N use efficiency (NUE) and soil mineral N (Nmin) residues for Chinese cabbage (Brassica chinensis L.) and further determine the critical plant N concentration and root-zone soil Nmin residues required to reach the maximum DMB of Chinese cabbage. Five N treatments were established: control without N input (CK); optimal N fertilizer rate decreased by 30% (70% OPT, 175 kg N ha−1), optimized N fertilizer rate (OPT, 250 kg N ha−1), optimal N fertilizer rate increased by 30% (130% OPT, 325 kg N ha−1) and farmers’ N fertilizer practice (FP, 450 kg N ha−1). The N source in all treatments was conventional urea (N ≥ 46.2%). The results showed that the total yield of Chinese cabbage followed a “linear-plateau” trend with an increasing N fertilizer rate. There was no significant difference in yield between the OPT, 130% OPT and FP treatments. The aboveground plant DMB and N uptake showed a ‘slow-fast-slow’ pattern with the growth period. There was no significant difference in aboveground plant DMB and N uptake between the OPT, 130% OPT and FP treatments. Moreover, the OPT treatment significantly increased the aboveground plant DMB and N accumulation by 29.6% and 40.5%, respectively, compared with the 70% OPT treatment. The OPT treatment significantly increased the NUE by 23.8%, 31.2% and 43.1% compared with that in the 70% OPT, 130% OPT and FP treatments, respectively. The linear-plateau model provided the best fit for the relationship among aboveground DMB of Chinese cabbage, plant N concentration and root-zone soil Nmin content. The critical root-zone soil Nmin and plant N concentrations were 94.1, 63.4 and 68.3 kg ha−1 and 34.4, 33.5 and 32.9 g kg−1 during the rosette, heading and harvest periods, respectively. In summary, compared to the FP treatment, the optimized N fertilizer rate (250 kg N ha−1) could significantly reduce the N application rate, maintain yield, increase aboveground plant DMB and N uptake, and improve NUE. Moreover, the study has great significance for guiding the green utilization of vegetable N fertilizer in southwest China.

Phase contrast computed tomography (PCCT) provides an effective non-destructive testing tool for weak absorption objects. Limited by the phase stepping principle and radiation dose requirement, sparse-view sampling is usually performed in PCCT, introducing severe artifacts in reconstruction. In this paper, we report a dual-domain (i.e., the projection sinogram domain and image domain) enhancement framework based on deep learning (DL) for PCCT with sparse-view projections. It consists of two convolutional neural networks (CNN) in dual domains and the phase contrast Radon inversion layer (PCRIL) to connect them. PCRIL can achieve PCCT reconstruction, and it allows the gradients to backpropagate from the image domain to the projection sinogram domain while training. Therefore, parameters of CNNs in dual domains are updated simultaneously. It could overcome the limitations that the enhancement in the image domain causes blurred images and the enhancement in the projection sinogram domain introduces unpredictable artifacts. Considering the grating-based PCCT as an example, the proposed framework is validated and demonstrated with experiments of the simulated datasets and experimental datasets. This work can generate high-quality PCCT images with given incomplete projections and has the potential to push the applications of PCCT techniques in the field of composite imaging and biomedical imaging.

Abstract Hydraulic pumps are a positive displacement pump whose working principle causes inherent output flow pulsation. Flow pulsation produces pressure pulsation when encountering liquid resistance. Pressure pulsation spreads in the pipeline and causes vibration, noise, damage, and even pipeline rupture and major safety accidents. With the development of airborne hydraulic systems with high pressure, power, and flow rate, the hazards of vibration and noise caused by pressure pulsation are also amplified, severely restricting the application and development of hydraulic systems. In this review paper, the mechanism, harm, and suppression method of pressure pulsation in hydraulic systems are analyzed. Then, the classification and characteristics of pulsation attenuators according to different working principles are described. Furthermore, the critical technology of simulation design, matching method with airborne piston pumps, and preliminary design method of pulsation attenuators are proposed. Finally, the development trend of pulsation attenuators is prospected. This paper provides a reference for the research and application of pressure pulsation attenuators.

The power consumption of digital circuits is proportional to the square of operation voltage and the demand for low power circuits reduces the operation voltage towards the threshold of MOSFETs. A weak voltage signal makes circuits vulnerable to noise and the optimization of circuit design requires modelling noise. Random Telegraph Noise (RTN) is the dominant noise for modern CMOS technologies and Monte Carlo modelling has been used to assess its impact on circuits. This requires statistical distributions of RTN amplitude and three different distributions were proposed by early works: Lognormal, Exponential, and Gumbel distributions. They give substantially different RTN predictions and agreement has not been reached on which distribution should be used, calling the modelling accuracy into questions. The objective of this work is to assess the accuracy of these three distributions and to explore other distributions for better accuracy. A novel criterion has been proposed for selecting distributions, which requires a monotonic reduction of modelling errors with increasing number of traps. The three existing distributions do not meet this criterion and thirteen other distributions are explored. It is found that the Generalized Extreme Value (GEV) distribution has the lowest error and meet the new criterion. Moreover, to reduce modelling errors, early works used bimodal Lognormal and Exponential distributions, which have more fitting parameters. Their errors, however, are still higher than those of the monomodal GEV distribution. GEV has a long distribution tail and predicts substantially worse RTN impact. The work highlights the uncertainty in predicting the RTN distribution tail by different statistical models.

Learning from demonstrations with Probabilistic Movement Primitives (ProMPs) has been widely used in robot skill learning, especially in human-robot collaboration. Although ProMP has been extended to multi-task situations inspired by the Gaussian mixture model, it still treats each task independently. ProMP ignores the common scenario that robots conduct adaptive switching of the collaborative tasks in order to align with the instantaneous change of human intention. To solve this problem, we proposed an alternate learning-based parameter estimation method and an empirical minimum variation-based decomposition strategy with projection points, combining with linear interpolation strategy for weights, based on a Gaussian mixture model framework. Alternate learning of weights and parameters in multi-task ProMP (MTProMP) allows the robot to obtain a smooth composite trajectory planning which crosses expected via points. Decomposition strategy reflects how the desired via point state is projected onto the individual ProMP component, rendering the minimum total sum of deviations between each projection point with the respective prior. Linear interpolation is used to adjust the weights among sequential via points automatically. The proposed method and strategy are successfully extended to multi-task interaction ProMPs (MTiProMP). With MTProMP and MTiProMP, the robot can be applied to multiple tasks in industrial factories and collaborate with the worker to switch from one task to another according to changing intentions of the human. Classical via points trajectory planning experiments and human-robot collaboration experiments are performed on the Sawyer robot. The results of experiments show that MTProMP and MTiProMP with the proposed method and strategy perform better.

AbstractHerein, the new collected well-testing temperature as well as continuous steady-state temperature logs were achieved for the analysis of deep thermal structural characteristics and current thermal states of various tectonic units in Tarim Basin. Generally, geothermal gradient fluctuates in 14.6-31.1°C/km, the heat flow ranges between 31.6 and 59.2 mW/m2 with the average heat flow of 43.2 mW/m2, and these values are typical of low heat flow background in Precambrian craton basins. Furthermore, estimated formation temperature spatial distributions at 6~8 km depth are the same and are mainly under the control of basement structural pattern. At 6000 m depth, temperature is 99-188°C, which become 126-242°C and 113-215°C at 7000 m and 8000 m depths, respectively. These findings confirmed that heat flow in Tarim Basin was relatively low with similar geothermal regimes to other Precambrian craton basins around the globe. In addition, 1D theoretical crustal thermal structures in Tarim Basin were established based on the solution of the equation of steady-state heat conduction. The findings revealed that “thermal” lithosphere maximum thickness in Tarim Basin is witnessed in Manjiaer sag. Tazhong uplift thermal state differs from those of Tabei uplift and Manjiaer sag. Tazhong mantle heat flow is 23.9 mW/m2, which accounts for 48.8% of surface heat flow. Hotter thermal states of Tazhong uplift generated temperatures as high as ∼690°C in Moho. Tarim Basin heat flow distribution reveals that crustal heat flow plays a more significant role in surface heat flow and possesses typical “hot crust and cold mantle” model thermal structure properties.

The Songnen Plain is an important agricultural base in China and one of the important areas of distribution of saline-alkaline soils in the cold region. Saline-alkaline soils severely restrict maize growth. This study was to potentially promote the soil nutrient in the maize rhizosphere, microbes diversity, and maize yield by Trichoderma asperellum in saline-alkaline soil of the cold region. In the present study, we applied different amounts of T. asperellum in field experiments for three consecutive years. High-throughput sequencing was used to analyse the impact of Trichoderma on microbes diversity in maize rhizosphere soils. Changes in crop yield and soil nutrients were also monitored. T. asperellum treatment significantly increased the relative abundance of beneficial microbes genera. In the control treatment, the pathogenic microbes were the dominant genera. Pearson's correlation analysis revealed that changes in the soil microbial community composition were closely related to soil nutrients and were highly correlated with T. asperellum treatment concentration. Further, T. asperellum treatment increased crop yield by 4.87-20.26%. These findings suggest that T. asperellum treatment optimised the microenvironment of the maize rhizosphere soil, alleviated microbial community degeneration in cold region saline-alkaline soil, and promoted maize growth.

In this study, a model for the development of the wide floodplain in the lower Yellow River Basin, in China was developed. This model includes flood control schemes using grading criteria, enables sediment deposition in partitioned zones, and allows free exchange between channel runoff and sediment. The wide floodplain located between the main channel and levees is divided into three typical regions: the tender, low, and high floodplains. Different ecological models should be applied when these floodplains are constructed. This paper describes the associated research ideas and methodology, and clarifies several key issues, including sediment prediction and regulation, land planning, land use, and a multi-dimensional framework of safeguard measures for industries on the lower Yellow River floodplain. A refined ecological development model is proposed for the lower Yellow River floodplain, and future work on ecological and sustainable development of the lower floodplain is suggested. To establish a comprehensive system integrating runoff and sediment resource regulation in the Yellow River Basin, future work should focus on runoff and sediment exchange mechanisms in the wandering lower reaches. Furthermore, it is necessary to improve theories on floodplain planning and ecological construction, and these theories should be integrated with the research findings on land development across the lower Yellow River floodplain.

Abstract Background This study sought to investigate the clinical characteristics of congenital diaphragmatic eventration (CDE) and to compare the efficacies of thoracoscopy and traditional open surgery in infants with CDE. Methods We retrospectively analyzed the clinical data of 125 children with CDE (90 boys, 35 girls; median age: 12.2 months, range: 1 h-7 years; body weight: 1.99–28.5 kg, median body weight: 7.87 ± 4.40 kg) admitted to our hospital in the previous 10 years, and we statistically analyzed their clinical manifestations and surgical methods. Results A total of 108 children in this group underwent surgery, of whom 67 underwent open surgery and 41 underwent thoracoscopic diaphragmatic plication. A total of 107 patients recovered well postoperatively, except for 1 patient who died due to respiratory distress after surgery. After 1–9.5 years of follow-up, 107 patients had significantly improved preoperative symptoms. During follow-up, the location of the diaphragm was normal, and no paradoxical movement was observed. Eleven of the 17 children who did not undergo surgical treatment did not have a decrease in diaphragm position after 1–6 years of follow-up. The index data on the operation time, intraoperative blood loss, chest drainage time, postoperative mechanical ventilation time, postoperative hospital stay and postoperative CCU admission time were better in the thoracoscopy group than in the open group. The difference between the two groups was statistically significant (P

Abstract Drugs targeting the fusion process of viral entry into host cells have been approved for clinical use in the treatment of AIDS. There remains a great need to improve the use of existing drugs for HIV therapy. Berberine is traditionally used to treat diarrhea, bacillary dysentery, and gastroenteritis in clinics, here our research shows that berberine is effective in inhibiting HIV-1 entry. Native polyacrylamide gel electrophoresis studies reveal that berberine can directly bind to both N36 and C34 to form a novel N36-berberine-C34 complex and effectively block the six-helix bundle formation between the N-terminal heptad repeat peptide N36 and the C-terminal heptad repeat peptide C34. Circular dichroism experiments show that binding of berberine produces conformational changes that damages the secondary structures of 6-HB. Computer-aided molecular docking studies suggest a hydrogen bond with T-639 and two polar bonds with Q-563 and T-639 are established, involving the oxygen atom and the C=O group of the indole ring. Berberine completely inhibits six HIV-1 clade B isolates and exhibits antiviral activities in a concentration-dependent manner with IC50 values varying from 5.5 to 10.25 µg/ml. This compound-peptide interaction may represent a mechanism of action of antiviral activities of berberine. As a summary, these studies successfully identify compound berberine as a potential candidate drug for HIV-1 treatment. As a summary, antiviral activity of berberine in combination with its use in clinical practice, this medicine can be used as a potential clinically anti-HIV drug.

Abstract Background Ischemia-reperfusion injury of the spinal cord (SCII) often leads to unalterable neurological deficits, which may be associated with apoptosis induced by oxidative stress and inflammation. Astaxanthin (AST) is a strong antioxidant and anti-inflammatory agent with multitarget neuroprotective effects. This study aimed to investigate the potential therapeutic effects of AST for SCII and the molecular mechanism. Methods Rat models of SCII with abdominal aortic occlusion for 40 min were carried out to investigate the effects of AST on the recovery of SCII. Tarlov’s scores were used to assess the neuronal function; HE and TUNEL staining were used to observe the pathological morphology of lesions. Neuron oxidative stress and inflammation were measured using commercial detection kits. Flow cytometry was conducted to assess the mitochondrial swelling degree. Besides, Western blot assay was used to detect the expression of PI3K/Akt/GSK-3β pathway-related proteins, as well as NOX2 and NLRP3 proteins. Results The results demonstrated that AST pretreatment promoted the hind limb motor function recovery and alleviated the pathological damage induced by SCII. Moreover, AST significantly enhanced the antioxidative stress response and attenuated mitochondrial swelling. However, AST pretreatment hardly inhibited the levels of proinflammatory cytokines after SCII. Most importantly, AST activated p-Akt and p-GSK-3β expression levels. Meanwhile, cotreatment with LY294002 (a PI3K inhibitor) was found to abolish the above protective effects observed with the AST pretreatment. Conclusion Overall, these results suggest that AST pretreatment not only mitigates pathological tissue damage but also effectively improves neural functional recovery following SCII, primarily by alleviating oxidative stress but not inhibiting inflammation. A possible underlying molecular mechanism of AST may be mainly attributed to the activation of PI3K/Akt/GSK-3β pathway.